Chlamydia trachomatis genovariant L2b in men who have sex with men in Taiwan, 2020-2023.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Sexually Transmitted Infections Pub Date : 2025-04-24 DOI:10.1136/sextrans-2024-056477

Chin-Shiang Tsai, Bo-Yang Tsai, Sung-Hsi Huang, Miao-Hui Huang, Guan-Jou Chen, Chi-Ying Lin, Chien-Ching Hung, Wen-Chien Ko

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引用次数: 0

Abstract

Objectives: Lymphogranuloma venereum (LGV) caused by Chlamydia trachomatis genotypes L1-L3 has been resurging among men who have sex with men (MSM) and people with HIV (PWH) in Western countries. While historically attributed to tropical regions, rectal LGV has been rarely recognised in Asia, with Taiwan recently becoming the second Asian country to report cases.

Methods: A multicentre, laboratory-based surveillance was conducted from January 2020 to December 2023 in Taiwan. Specimens were collected from MSM through syndromic testing and screening of high-risk populations. C. trachomatis was identified using commercial multiplex PCR assays, with genotyping performed through ompA gene sequencing. LGV-positive samples underwent multilocus sequence typing (MLST) following established protocols.

Results: Among 446 C. trachomatis-positive samples, 391 (87.7%) underwent successful ompA sequencing. Genovariant L2b accounted for 9.7% of cases, predominantly among PWH with rectal chlamydia (18.2%). PWH accounted for 85.7% of all genovariant L2b cases. Of 38 genovariant L2b samples from 35 cases, 34 (84.2%) samples completed MLST, revealing sequence type (ST) 53 as the predominant strain (74%). ST39 and ST63 were identified as unreported STs in Western countries, along with previously reported ST58. The four identified STs formed a cluster.

Conclusions: Our findings indicate the clonal spread of C. trachomatis L2b-ST53 among MSM in Taiwan, primarily affecting PWH. The predominance of ST53 suggests potential international and domestic spread, indicative of the need for enhanced surveillance.

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2020-2023年台湾男男性行为人群沙眼衣原体基因变异L2b

目的：在西方国家，由沙眼衣原体基因型L1-L3引起的性病性淋巴肉芽肿（LGV）在男男性行为者（MSM）和HIV感染者（PWH）中再次出现。直肠LGV历来被认为多发于热带地区，但在亚洲很少被发现，台湾最近成为第二个报告病例的亚洲国家。方法：2020年1月至2023年12月在台湾开展多中心实验室监测。通过综合征检测和高危人群筛查从男男性行为者中采集标本。沙眼衣原体采用商业多重PCR鉴定，并通过ompA基因测序进行基因分型。lgv阳性样本按照既定方案进行多位点序列分型（MLST）。结果：在446份沙眼衣原体阳性样本中，391份（87.7%）成功进行了ompA测序。基因变异L2b占9.7%的病例，主要是直肠衣原体PWH（18.2%）。PWH占所有基因变异L2b病例的85.7%。35例38份基因变异L2b样本中，34份（84.2%）样本完成MLST，序列型（ST） 53为优势菌株（74%）。ST39和ST63被确定为西方国家未报告的STs，以及先前报告的ST58。这四个已确定的STs组成了一个集群。结论：沙眼衣原体L2b-ST53在台湾男男性接触者中的克隆性传播，主要影响PWH。ST53的优势表明可能在国际和国内传播，表明需要加强监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexually Transmitted Infections 医学-传染病学

CiteScore

5.70

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Sexually Transmitted Infections is the world’s longest running international journal on sexual health. It aims to keep practitioners, trainees and researchers up to date in the prevention, diagnosis and treatment of all STIs and HIV. The journal publishes original research, descriptive epidemiology, evidence-based reviews and comment on the clinical, public health, sociological and laboratory aspects of sexual health from around the world. We also publish educational articles, letters and other material of interest to readers, along with podcasts and other online material. STI provides a high quality editorial service from submission to publication.