Sexually Transmitted Infections最新文献

{"title":"Sexually transmitted infections and sexual practices with non-work partners, among female sex workers attending a sexual health clinic in Melbourne, 2011-2020.","authors":"Ei T Aung, Chatnapa Yodkitudomying, Christopher K Fairley, Tiffany Phillips, Lenka Vodstrcil, Catriona S Bradshaw, Marcus Y Chen, Eric P F Chow","doi":"10.1136/sextrans-2024-056390","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056390","url":null,"abstract":"<p><strong>Background: </strong>Few studies have examined the sexual practices of female sex workers (FSWs) outside of their sex work and their association with the detection of bacterial sexually transmitted infections (STIs). This study aimed to investigate the annual trends in the number of non-work sexual partners and condom use among FSWs and their association with STIs.</p><p><strong>Methods: </strong>We conducted a repeated cross-sectional study of FSWs attending a sexual health clinic in Melbourne for the first time between January 2011 and December 2020. Data on sexual practices with non-work male and female sexual partners, condom use and STI diagnoses among FSWs were extracted.</p><p><strong>Results: </strong>Of the 3075 FSWs included in the analysis, 70% (n=2167) reported having non-work sexual partners in the past 12 months, 66% (n=2041) reported having non-work male sexual partners, 20% (n=608) reported having non-work female sexual partners and 18% (n=556) reported having both non-work male and female sexual partners. From 2011 to 2020, the proportion of FSWs who had non-work casual male sexual partners increased from 37% (115/315) to 61% (69/113) (p_trend<0.001). Condomless sex with non-work casual male sexual partners increased from 43% (50/115) to 67% (46/69) (p_trend<0.001). The positivity of any STIs increased from 5% (16/312) to 13% (14/110) (p_trend<0.001). Multivariable analyses showed that FSWs who had condomless sex with non-work casual male sexual partners had higher odds of having any STIs (adjusted OR 1.41; 95% CI: 1.01, 1.95) compared with those who consistently used condoms with these sexual partners.</p><p><strong>Conclusion: </strong>Our study highlights a shift in the sexual practices of FSWs outside of sex work, in line with the trends observed in the general population. These changes may contribute to changes in STI transmission dynamics in this population. Overall, we found that the STI positivity in FSWs is low.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of chlamydia and gonorrhoea among Kenyan adolescents.","authors":"Hong-Ha M Truong, Beatrice Otieno, Kevin Kadede, Damaris Odeny, Maurice Opiyo, Marion Hewa, Fidel Opondo, Elsa Heylen, Sayo Amboka, Hanningtone Odhiambo, David Ogolla, Lara Miller, Craig R Cohen, Elizabeth A Bukusi","doi":"10.1136/sextrans-2024-056333","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056333","url":null,"abstract":"<p><strong>Objectives: </strong>Sexually transmitted infections (STIs) diagnoses in Kenya are based on the identification of characteristic symptoms or syndromes without laboratory testing. Syndromic management likely underestimates STI prevalence due to undiagnosed asymptomatic infection. We assessed the prevalence and factors associated with chlamydia and gonorrhoea infections among adolescent boys and girls participating in <i>Maneno Yetu</i>, a sexual and reproductive health study in Kenya.</p><p><strong>Methods: </strong>Adolescents aged 15-19 years residing in informal settlements in Kisumu were eligible to participate in a cross-sectional survey. Participants were recruited using respondent-driven sampling. Urine specimens were tested using the Molecular Xpert CT/NG test. Associations were assessed by multivariate logistic regression.</p><p><strong>Results: </strong>STI testing was offered to 1238 adolescents who reported having sex and 1167 accepted. Of the 1159 adolescents who had interpretable STI test results, 53% were girls and 74% were 18-19 years old. STI prevalence was 9.6% overall and higher among girls than boys (12.5% vs 6.3%; p<0.001). Of 111 adolescents who tested positive, 96 had chlamydia, 9 had gonorrhoea, 6 had both chlamydia and gonorrhoea, and 73 reported never experiencing any STI symptoms. Girls were twice more likely than boys to test positive for an STI after controlling for other demographic characteristics, sexual behaviour and STI-related characteristics (aOR=2.01, 95% CI 1.25, 3.24).</p><p><strong>Conclusions: </strong>Nearly 10% of adolescents were diagnosed with chlamydia or gonorrhoea. STI prevalence was two times higher among girls than boys. Two-thirds of adolescents with a positive STI test result did not report experiencing symptoms and thus would have been missed by syndromic management. Undiagnosed and untreated STIs can result in onward transmission and significantly impact their reproductive health. Our findings lend support for expanding STI testing services in resource-constrained settings and developing point-of-care diagnostic assays that are rapid, inexpensive and accurate to address the STI epidemic and reduce the risk of sequelae.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-collection for high-risk HPV-RNA detection among HIV-seropositive and HIV-seronegative women engaged in sex work in Kenya.","authors":"Fan Lee, Jessica Yasmine Islam, Michael Musila Mutua, Emmanuel Kabare, Griffins Manguro, Wairimu Waweru, Kishor N Mandaliya, Juma Shafi, R Scott McClelland, Jennifer S Smith","doi":"10.1136/sextrans-2024-056159","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056159","url":null,"abstract":"<p><strong>Background: </strong>Evidence of self-collection human papillomavirus (HPV)-RNA testing in cervical cancer screening is limited among women with HIV (WHIV). Most studies are in low-risk patient populations in high-income countries. We examine the prevalence of high-risk HPV (hrHPV) using the APTIMA HPV-RNA assay on self-collected versus provider-collected specimens, and the associated risk factors for high-grade cervical intraepithelial neoplasia (CIN2/3) among women engaged in sex work in Kenya. Among WHIV, we examine the performance of both collection methods for the detection of CIN2/3.</p><p><strong>Methods: </strong>Participants were aged ≥18 years, non-pregnant and had no previous treatment for cervical precancer. The screening process included self-collection of cervicovaginal samples using a Viba cytobrush (Rovers), provider-collected cervical samples, visual inspection with acetic acid (VIA) and Pap smear. The APTIMA HPV Assay (Hologic) was used to detect E6/E7 oncogene RNA of 14 hrHPV types in both self-collected and on provider-collected samples. Risk factors for CIN2/3 were determined via multivariable logistic regression. We estimated test characteristics for each screening method for CIN2/3 detection.</p><p><strong>Results: </strong>A total of 400 women (194 WHIV, 206 women without HIV) underwent screening between 2013 and 2018, with 399 valid HPV results. WHIV had a higher prevalence of hrHPV by self-collection compared with women without HIV (44.0% vs 29.6%, p<0.05) and CIN2/3 (19.0% vs 9.7%, p<0.05). After adjusting for age and HIV status, hrHPV-positivity increased the risk of CIN2/3 by 13 to 20 times. Among WHIV, the sensitivity for CIN2/3 detection was similar between self-collection (85% (66-96)) and provider-collection (93% (76-99)), both of which were higher than the sensitivity of high-grade cytology (high-grade squamous intraepithelial lesion cut-off) (47% (95% CI 23 to 72)). The specificity for both collection methods (self: 66% (95% CI 57 to 75) and provider: 67% (95% CI 58 to 75)) was lower than cytology (85% (95% CI 78 to 91)).</p><p><strong>Conclusion: </strong>Self-collection for HPV-RNA testing performed similarly to provider-collection among WHIV. For WHIV, while the higher sensitivity of HPV-RNA testing compared with cytology for the detection of clinically relevant cervical disease is important, the lower specificity supports the inclusion of a triage test in the screening algorithm.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates to the notifiable disease legislation in England to facilitate surveillance of selected STI-related complications.","authors":"Hamish Mohammed, Kate Folkard, Matt Phillips, David Phillips, Helen Fifer, Katy Sinka","doi":"10.1136/sextrans-2025-056500","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056500","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency department attendances by young people identified as at-risk of exploitation by a sexual health clinic.","authors":"Amy Haeffner, Tara Casey, Daniel Richardson","doi":"10.1136/sextrans-2025-056552","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056552","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics and antibiotic susceptibility of <i>Neisseria gonorrhoeae</i> isolates from Greece during 2009-2023.","authors":"Eirini Siatravani, Anna-Danai Panopoulou, Michalis Polemis, Stella-Eugenia Chryssou, Ioannis Moschos, Ioanna Magaziotou, Apostolos Beloukas, Eva Tzelepi, Vivi Miriagou","doi":"10.1136/sextrans-2024-056279","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056279","url":null,"abstract":"<p><strong>Objectives: </strong>To monitor epidemiological characteristics and antibiotic susceptibility trends of <i>Neisseria gonorrhoeae</i> in Greece during 2009-2023.</p><p><strong>Methods: </strong>Microbiological and epidemiological data for 1756 gonococci received by the Greek National Reference Centre for <i>Neisseria gonorrhoeae</i> were evaluated. Strains were isolated consecutively from gonorrhoea cases in hospitals throughout Greece. Minimum inhibitory concetrations of antibiotics were determined by E-test. Plasmid content analysis was performed for penicillinase-producing isolates (PPNG) and for isolates exhibiting tetracycline resistance (TRNG). <i>tetM</i>, <i>penA, gyrA</i> and <i>parC</i> genes were identified by PCR and RFLP/sequencing. Isolates were subjected to serotyping. Genomic analysis by pulsed-field gel electrophoresis (PFGE) was performed for extended-spectrum cephalosporin (ESC)-resistant isolates.</p><p><strong>Results: </strong>Only 2.8% of the isolates were fully susceptible to all antibiotics. High rates of resistance were observed for penicillin G (27.5%), tetracycline (59.2%) and ciprofloxacin (68.8%). PPNG and/or TRNG isolates accounted for 26% of the total sample, the majority (81.6%) being simultaneously quinolone-resistant (QRNG). The isolation frequency of QRNG isolates was stably high as in previous years. Interestingly, a proportion of QRNG isolates exhibited cross-resistance to all antibiotics except spectinomycin. Azithromycin resistance is showing an increasing trend since 2021 at alarming levels (32.7% in 2023). The percentage of isolates exhibiting decreased susceptibility to ESCs (CDS) remained stable until 2019, whereas no CDS strains were isolated from 2020 to 2023. Spectinomycin was active against all isolates. Serotyping results revealed a strong association of quinolone resistance with Bpyut, Bpyust and Bropyst serovars and I/S phenotypes with Bpyvut and Byut serovars. PFGE showed that CDS isolates were classified into eight groups, with the majority clustered in three main clones including the predominant CDS clone isolated during 2001-2008.</p><p><strong>Conclusions: </strong>The gonococcal population showed a continuous change in the resistance phenotypes and predominating clones during 2009-2023 underlining the need for continuous monitoring of the traits of this pathogen.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of hepatitis delta virus RNA in cervical swab and seminal plasma of chronic hepatitis delta patients.","authors":"Saruul Enkhjargal, Oyungerel Lhagva-Ochir, Altangerel Purvee, Galtbayar Artbazar, Maria Paola Anolli, Anir Enkhbat, Nomin Ariungerel, Maral Enkhtur, Oyungerel Ravjir, Nyamtsengel Vangan, Naranjargal Dashdorj, Odgerel Oidovsambuu","doi":"10.1136/sextrans-2024-056364","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056364","url":null,"abstract":"<p><strong>Objectives: </strong>Hepatitis delta virus (HDV) is the smallest human virus that causes the most severe form of viral hepatitis. However, the virus's biological features, transmission routes and causes of endemicity in particular populations are not yet fully understood. HDV shares the hepatitis B virus (HBV) parenteral mode of transmission with HBV; therefore, sexual transmissions are also possible. However, data on sexual transmission of HDV are limited.</p><p><strong>Methods: </strong>This study included 60 patients with chronic HBV/HDV coinfection. The median age (IQR) of patients was 35 (23-47) years, and all were Mongolian. HDV-RNA, HBV-DNA and hepatitis B surface antigens were tested in serum, seminal plasma and cervical swab samples collected at the Liver Centre, Mongolia. Binary logistic regression analysis was used to create a model that predicts the possibility of HDV detection in seminal plasma and cervical swab samples based on HDV-RNA levels in serum samples.</p><p><strong>Results: </strong>HDV-RNA was detected in cervical swab samples from 24 of 30 patients (80%) and in seminal plasma from 15 of 30 patients (50%) (Fisher's exact test, p=0.03). Patients with detectable HDV-RNA in either seminal or cervical fluid samples showed higher levels of HDV-RNA in serum ((females: 6.44 vs 4.21 log IU/mL (p<0.0001); males: 6.69 vs 5.65 log IU/mL (p<0.0001)). A correlation between HDV-RNA levels in the serum was identified in females (r=0.56, p=0.004; 95% CI 0.206 to 0.788) but not in males (r=0.38, p=0.15, 95% CI -0.15 to 0.75). The regression model identified threshold points of serum HDV-RNA levels that can be used to predict HDV-RNA detection in seminal plasma and cervical swabs.</p><p><strong>Conclusions: </strong>HDV-RNA can be detected in cervical swabs and seminal plasma of patients with HBV/HDV coinfection, and the detection was more common in females than in males. The probability of HDV-RNA detection in male seminal plasma and female cervical swab samples can be predicted based on the HDV viral load in serum.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of current clinical guidelines for the management of sexually transmissible enteric infections using the AGREE II toolkit.","authors":"Callum Chessell, Ben Erin, Matthew Dempsey, Deborah Williams, Daniel Richardson","doi":"10.1136/sextrans-2025-056497","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056497","url":null,"abstract":"<p><strong>Background: </strong>Clinical guidelines for sexually transmissible enteric infections can provide a framework for testing, management, antimicrobial stewardship and public health control. This review aimed to evaluate the currently available clinical guidelines and to highlight any areas for improvement.</p><p><strong>Method: </strong>A comprehensive online search for clinical guidelines was performed and reported using Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines, followed by evaluation using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool by three independent reviewers. An AGREE II domain score of >60% is the threshold for sufficient quality, and each guideline was rated high, average or low based on the domain percentages (five domains scoring >60%=high, 3-4 domains scoring >60%=average and ≤2 domains scoring>60%=low). Two authors developed a bespoke quality framework for sexually transmissible enteric infection guidelines and this was used to evaluate each guideline.</p><p><strong>Results: </strong>Six clinical guidelines were identified from the UK (British Association for Sexual Health and HIV (UK-BASHH)), USA (Centers for Disease Control and Prevention (USA-CDC)), Europe (International Union against Sexually Transmitted Infections (Europe-IUSTI)), Canada-government, Brazil-government and Australia (Australasia Society for HIV, Viral Hepatitis, and Sexual Health Medicine (Australia-ASHM)). The overall AGREE II score was 56% (IQR 43-67) (domain 1 (scope and purpose) 67% (IQR=42-67), domain 2 (stakeholder involvement) 46% (IQR 34-62), domain 3 (rigour of development) 42% (IQR 22-49), domain 4 (clarity of presentation) 80% (IQR 57-89), domain 5 (applicability) 23% (IQR 11-30) and domain 6 (editorial independence) 67% (IQR 56-84)). The median global scores (out of 7) and rating (low, medium and high) were UK-BASHH (5/7, high), USA-CDC (5/7, average), Europe-IUSTI (4/7, average), Canada government (4/7, low), Brazil government (3/7, low) and Australia-ASHM (1/7, low). All six guidelines recommended testing using molecular platforms: UK-BASHH, USA-CDC and Europe-IUSTI recommended offering sexual health interventions and STI testing; the UK-BASHH and Australia-ASHM did not recommend empirical antimicrobials, and the Europe-IUSTI and Brazil government guidelines made specific antimicrobial recommendations, including macrolides, quinolones and cephalosporins.</p><p><strong>Conclusion: </strong>Future clinical guidelines for sexually transmissible enteric infections require consistency and to improve their applicability, rigour of development, stakeholder involvement and recommendations for sexual health interventions, sexually transmitted infection testing, partner notification, handwashing and food handlers' advice and antimicrobial treatment.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lefamulin for <i>Mycoplasma genitalium</i> treatment failure in Australia and the USA: a case series and pilot open-label parallel arm randomised trial.","authors":"Meena S Ramchandani, Erica L Plummer, Anika Parker, Lenka A Vodstrcil, Olusegun O Soge, Ivette Aguirre, Joong Kim, James P Hughes, Lindley A Barbee, Jørgen Skov Jensen, Lisa E Manhart, Catriona S Bradshaw","doi":"10.1136/sextrans-2024-056338","DOIUrl":"10.1136/sextrans-2024-056338","url":null,"abstract":"<p><strong>Objectives: </strong><i>Mycoplasma genitalium</i> (MG) causes urethritis and is associated with cervicitis, pelvic inflammatory disease and preterm delivery. Antimicrobial resistance is widespread and cure rates are declining. Lefamulin, a novel pleuromutilin, may be effective in cases of treatment failure.</p><p><strong>Methods: </strong>Under compassionate access in Australia and a pilot open-label parallel arm randomised clinical trial in the USA, patients with urogenital MG infection and microbiological treatment failure or contraindications to moxifloxacin were treated with lefamulin monotherapy (600 mg orally two times per for 7 days) or sequential doxycycline-lefamulin (doxycycline 100 mg orally two times per day for 7 days followed by lefamulin for 7 days) (1:1 randomisation in the USA). Two additional regimens were also evaluated in Australia: combination therapy with doxycycline plus lefamulin for 7 days and extended lefamulin therapy with doxycycline for 7 days followed by lefamulin for 14 days. Microbiological cure (negative MG NAAT) was assessed 21-35 days after completing lefamulin. Sustained cure was assessed 42-49 days after treatment.</p><p><strong>Results: </strong>Seventeen heavily pretreated Australian (seen between October 2020 and December 2023) and 11 US cases (recruited between April 2022 and February 2023; 5 randomised to lefamulin monotherapy, 6 randomised to sequential doxycycline-lefamulin) received lefamulin-containing regimens. Sequential doxycycline-lefamulin demonstrated microbiological cure 21-35 days post-treatment in 6 of 12 (50%) Australian and US patients. Three of five (60%) US patients but none of five (0%) Australian patients were cured with lefamulin monotherapy. Combination therapy with doxycycline and lefamulin was ineffective (n=0/2), but extended lefamulin therapy cured two of three (67%). Gastrointestinal side effects occurred in 77% (Australia) and 91% (USA).</p><p><strong>Conclusion: </strong>While cure rates were low, lefamulin was effective in some individuals with MG treatment failure. Additional antibacterial agents for multidrug-resistant infections are needed.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"101-108"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Centenary Series - STIs Through the Ages: <b>NAAFI tea and the bromide myth</b>.","authors":"Alan Dronsfield, Anna Simmons","doi":"10.1136/sextrans-2024-056393","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056393","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 2","pages":"71-72"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}