Could tolerance explain an individual's eight episodes of gonococcal treatment failure with ceftriaxone? A case report.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Sexually Transmitted Infections Pub Date : 2025-09-08 DOI:10.1136/sextrans-2025-056591

Izumo Kanesaka, Thibaut Vanbaelen, Irith De Baetselier, Dorien Van den Bossche, Said Abdellati, Tessa de Block, Sheeba Santhini Manoharan-Basil, Chris Kenyon

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引用次数: 0

Abstract

Objectives: Describe the clinical evolution of a person with recurrent gonococcal cervicitis despite appropriate treatment and lack of reinfection.

Methods: We used the tolerance detection test to confirm that all three culture-positive gonococcal isolates were tolerant to ceftriaxone.

Results: Over a period of 6 months, a transgender man with gonococcal cervicitis experienced eight episodes of treatment failure despite receiving ceftriaxone 1 g intramuscularly on each occasion. The isolate remained susceptible to ceftriaxone throughout this period. His Neisseria gonorrhoeae infection was then successfully eradicated with a prolonged course of ceftriaxone.

Conclusions: We propose that bacterial tolerance be considered a possible cause of treatment failure in N. gonorrhoeae. A tolerance detection test can be used to diagnose tolerance.

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耐受性是否可以解释个体使用头孢曲松治疗淋球菌八次失败的原因？一份病例报告。

目的：描述一个人的临床演变与复发性宫颈淋球菌炎，尽管适当的治疗和缺乏再感染。方法：采用耐受性检测试验，证实3株培养阳性淋球菌对头孢曲松均有耐受性。结果：在6个月的时间里，一名患有淋球菌性宫颈炎的变性男子经历了8次治疗失败，尽管每次接受头孢曲松1 g肌肉注射。在此期间，分离株对头孢曲松仍然敏感。他的淋病奈瑟菌感染随后通过延长头孢曲松疗程成功根除。结论：我们认为细菌耐药性可能是淋病奈瑟菌治疗失败的原因之一。容差检测试验可用于诊断容差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexually Transmitted Infections 医学-传染病学

CiteScore

5.70

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Sexually Transmitted Infections is the world’s longest running international journal on sexual health. It aims to keep practitioners, trainees and researchers up to date in the prevention, diagnosis and treatment of all STIs and HIV. The journal publishes original research, descriptive epidemiology, evidence-based reviews and comment on the clinical, public health, sociological and laboratory aspects of sexual health from around the world. We also publish educational articles, letters and other material of interest to readers, along with podcasts and other online material. STI provides a high quality editorial service from submission to publication.