Sexually Transmitted Infections最新文献

{"title":"Attitudes and prescribing practices on doxycycline postexposure prophylaxis (DoxyPEP) among Italian infectious diseases physicians: findings from a National SIMIT Survey.","authors":"Roberto Rossotti, Angelo Roberto Raccagni, Federico D'Amico, Emanuele Nicastri, Giovanni Mazzola, Antonio Cascio, Marco Falcone, Ivan Gentile, Andrea Giacomelli, Cristina Mussini, Roberto Parrella, Silvia Nozza","doi":"10.1136/sextrans-2025-056595","DOIUrl":"10.1136/sextrans-2025-056595","url":null,"abstract":"<p><strong>Objectives: </strong>Doxycycline postexposure prophylaxis (DoxyPEP) has emerged as a promising tool for reducing bacterial sexually transmitted infections (bSTIs), particularly among men who have sex with men. This study aims to investigate the attitudes and prescribing practices of Italian infectious disease (ID) physicians regarding DoxyPEP for the prevention of bSTIs.</p><p><strong>Methods: </strong>This is a cross-sectional survey conducted between October 2024 and March 2025 among ID specialists registered with the Italian Society of Infectious and Tropical Diseases. An anonymous online questionnaire assessed demographics, prescribing behaviour, attitudes and concerns regarding DoxyPEP. Favourability was rated on a visual analogue scale from 0 to 100. Descriptive and non-parametric statistics were used, and a Poisson regression model for predictors of favourable attitude was weighted according to the inverse of the probability of being sampled for responding to the survey.</p><p><strong>Results: </strong>Of 132 respondents, 44.0% reported prescribing DoxyPEP, primarily in STI or pre-exposure prophylaxis clinics and urban settings. Median favourability was 70/100 and was higher among DoxyPEP prescribers (80 vs 50, p<0.001). The main reasons for prescribing were repeated STIs and specific sexual behaviour. The most frequently cited concern was antimicrobial resistance (96.2%), followed by the perceived superiority of condoms in preventing bSTIs and DoxyPEP toxicity. Informal use of DoxyPEP without medical supervision was reported by 46.2%, but counselling was significantly lower among non-prescribers. Older age was independently associated with higher favourability (p=0.005).</p><p><strong>Conclusions: </strong>This national survey shows a favourable attitude towards DoxyPEP among Italian ID physicians. DoxyPEP prescription was reported by less than half of the respondents, suggesting limited real-world use in Italy, with a variability in physicians' concerns and attitudes towards this preventive strategy for bSTIs.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising HIV cases in the Philippines in 2025 demand urgent global attention.","authors":"Navera Shakeel, Hafsa Shahid","doi":"10.1136/sextrans-2025-056693","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056693","url":null,"abstract":"<p><p>HIV cases in the Philippines have surged dramatically, with 5101 new diagnoses reported in the first quarter of 2025-a 57% increase from the same period in 2024. Young individuals aged 15 to 34 years are the most affected, with 96% of new infections linked to sexual transmission. Alarmingly, there has also been a 12% rise in advanced HIV cases, reflecting delays in diagnosis and limited access to care. The country remains far from achieving UNAIDS 95-95-95 targets, with only 55% of people diagnosed, 66% on treatment and 40% achieving viral suppression. This letter calls for urgent public health action, including expanded testing, awareness campaigns, improved access to treatment and pre-exposure prophylaxis, and stronger surveillance systems. International collaboration is essential, and support from global health organisations is critical to reversing this trend and preventing wider regional consequences.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of antenatal syphilis remains positively associated with HIV in South African districts.","authors":"Tendesayi Kufa, Nosipho Shangase, Adrian Puren, Chris Kenyon","doi":"10.1136/sextrans-2025-056650","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056650","url":null,"abstract":"<p><strong>Background: </strong>Previous analyses from South Africa have found that the ecological association between the prevalence of HIV and syphilis switched from positive to negative in the wake of the HIV pandemic. This was attributed to the impact of HIV mortality on sexual network connectivity. We conducted an ecological analysis of HIV prevalence and syphilis seropositivity among all districts in South Africa in 2010 and 2022.</p><p><strong>Methods: </strong>We used Spearman's correlation to compare the weighted prevalence of HIV and syphilis per district using South Africa's 2022 Antenatal HIV Sentinel Survey. We calculated the change in the weighted syphilis and HIV prevalence per district between 2010 and 2022.</p><p><strong>Results: </strong>The district-level antenatal prevalence of HIV in 2022 was positively correlated with the prevalence of syphilis (Rho=0.42; p=0.0018). A comparison of the same scatter plot from 2010 revealed that the six districts with the highest HIV prevalence in 2010 had large increases in syphilis prevalence from 2010 (median 0.1%, IQR 0.0%-0.4%) to 2022 (median 5.2%, IQR 4.2-5.8%).</p><p><strong>Conclusions: </strong>The positive association between HIV and syphilis prevalence is compatible with an increase in sexual network connectivity in the districts with the largest increases in syphilis prevalence.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency department attendances by young people identified as at-risk of exploitation by a sexual health clinic.","authors":"Amy Haeffner, Tara Casey, Daniel Richardson","doi":"10.1136/sextrans-2025-056552","DOIUrl":"10.1136/sextrans-2025-056552","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"423"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphogranuloma venereum (LGV) <i>ompA</i>-subvariants of the Portuguese collection of <i>Chlamydia trachomatis</i>, 2007-2023.","authors":"Zohra Lodhia, Dora Cordeiro, Cristina Correia, Inês João, Teresa Carreira, Alexandra Nunes, Rita Ferreira, Sandra Schäfer, Elzara Aliyeva, Clara Portugal, Isabel Monge, Elsa Gonçalves, Susana Matos, Ana Paula Dias, Rita Corte-Real, Luís Vieira, Joao Paulo Gomes, Vítor Borges, Maria Jose Borrego","doi":"10.1136/sextrans-2024-056427","DOIUrl":"10.1136/sextrans-2024-056427","url":null,"abstract":"<p><strong>Background: </strong>Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by <i>Chlamydia trachomatis ompA</i>-genotypes L1-L3, with increasing numbers of detected cases across Europe. Here, we analysed diversity and temporal distribution of the LGV <i>ompA</i>-subvariants detected in Portugal between 2007 and 2023, in order to better understand the dissemination and diversification landscape of LGV strains.</p><p><strong>Methods: </strong>The collection of the Portuguese National Reference Laboratory includes 1188 LGV <i>ompA</i>-genotyped samples between 2007 and 2023. In-depth analysis of the diversity of LGV <i>ompA</i>-subvariants circulating in Portugal across the years was performed, identifying newly described subvariants and integrating this data in a comprehensive compilation with all representative LGV <i>ompA</i>-subvariants described globally.</p><p><strong>Results: </strong>L2 <i>ompA</i>-variant (L2/434/Bu) was consistently the most frequently detected in our collection, with annual proportions ranging from 34.0% to 82.9%, between 2016 and 2023. L2bV5 was the second most frequent followed by L2b, ranging from 5.0% to 27.9% and 2.6% to 23.7% across the years, respectively, from 2017 to 2023. We highlighted the emergence and considerable increase in circulation of L1-like <i>ompA</i>-subvariants in recent years, representing 13.7% of LGV sequences in 2023. We also identified 13 novel LGV <i>ompA</i>-subvariants that had not been described before, differing by up to three mutations from the respective genotype reference sequences.</p><p><strong>Conclusions: </strong>This study contributes to the worldwide picture of the LGV molecular epidemiology, highlighting the importance of long-term molecular surveillance to monitor the circulation and geographical spread of LGV and to timely identify and track new strains, such as the recently emerging L1-like <i>ompA</i>-subvariants.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"374-379"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of renal outcomes and management of PrEP users with estimated glomerular filtration rates less than 60 mL/min/1.73 m².","authors":"Victoria Tittle, Nicolo Girometti, Jonathan Joseph Goodfellow, Stephen Cole, Sheel Patel, Marta Boffito, Sheena McCormack, Rachael Jones","doi":"10.1136/sextrans-2024-056411","DOIUrl":"10.1136/sextrans-2024-056411","url":null,"abstract":"<p><p>This retrospective service evaluation reviews practical measures for pre-exposure prophylaxis (PrEP) users with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² Of 35 724 PrEP users, 361 had an eGFR <60 mL/min/1.73 m², of whom 16% required non-tenofovir disoproxil/emtricitabine PrEP formulations. Majority of cases required simple and conservative management, with repeat sampling and/or stopping of the supplements and/or recreational drugs.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"406-409"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ending nuclear weapons, before they end us.","authors":"Chris Zielinski","doi":"10.1136/sextrans-2025-056602","DOIUrl":"10.1136/sextrans-2025-056602","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"e1"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public health and clinical response to an mpox outbreak in Slovenia: case study, 2022-2023.","authors":"Danilo Češljarac, Kristina Brečko, Martin Štrumbelj, Sabrina Likar, Barbara Kokošar Ulčar, Mateja Zalaznik, Nataša Kejžar, Katarina Resman Rus, Miša Korva, Tatjana Avšič Županc, Eva Grilc, Andreja Murnik Rauh, Maja Mastnak, Anja Becner, Maruška Marovt, Mitja Lenart, Mojca Matičič","doi":"10.1136/sextrans-2024-056318","DOIUrl":"10.1136/sextrans-2024-056318","url":null,"abstract":"<p><strong>Objectives: </strong>The emergence of mpox outbreaks in non-endemic areas, characterised by human-to-human transmission and unique clinical presentations, poses challenges in containment efforts. This study aimed to analyse the 2022 outbreak in Slovenia and characterise the country's response to the outbreak.</p><p><strong>Methods: </strong>A retrospective, observational study analysed all confirmed mpox cases in Slovenia between 1 January 2022 and 31 December 2023 and specific public health measures and responses in the country to contain the mpox outbreak. Data were collected from clinical facilities, public health institutions and civil society organisations and analysed accordingly.</p><p><strong>Results: </strong>Of 149 suspected cases tested, 49 were confirmed, all cisgender men, predominantly men who have sex with men (93%), exhibiting skin lesions, with 20% being HIV infected and 62% reporting recently having sex abroad. Hospitalisation was required in 14%, no specific treatment was needed, and no fatalities occurred. After the rapid spread of mpox from May to mid-July 2022, only occasional cases were detected afterwards until the outbreak's termination in early September. Slovenia's containment strategy started immediately after the first case detection, involving rapid diagnostics and active case search, centralised case management and targeted public health measures. The LGBTIQ+ (Lesbian, Gay, Bisexual, Trans, Intersex, Queer and other sexual identities) community civil society organisation Legebitra played a critical role by launching awareness campaigns and promoting easily accessible vaccination. Despite its late start in September 2022, by the end of 2023, the vaccination campaign achieved coverage of 309 individuals.</p><p><strong>Conclusions: </strong>Slovenia's response to the 2022 mpox outbreak highlights prompt multisectoral collaboration, community engagement and timely public health interventions. Rapid diagnostics, centralised case management and targeted outreach likely contributed to containment. While vaccination had limited impact during the outbreak, its importance for long-term prevention cannot be overstated. As the global threat of mpox persists, continuous surveillance, cross-border cooperation and proactive vaccination strategies are recommended activities to address future challenges.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"410-413"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of prenatal care in pregnancies complicated by syphilis: trend, risk factors and outcomes.","authors":"Han-Yang Chen, Irene A Stafford","doi":"10.1136/sextrans-2024-056453","DOIUrl":"10.1136/sextrans-2024-056453","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the temporal trend and risk factors associated with lack of prenatal care and the association between lack of prenatal care and adverse outcomes in pregnancies complicated by syphilis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using US vital statistic data (2016-2022). We included non-anomalous, singleton live births delivered by pregnancies complicated by syphilis at 24-42 weeks of gestation in a hospital. The exposure variable was prenatal care (had care vs no care). We used Adequacy of Prenatal Care Utilization Index. Adverse outcomes were examined. The annual per cent change (APC) was calculated to assess the trend of lacking prenatal care. Multivariable Poisson regression models with robust error variance were used to examine the association. Adjusted relative risks (aRR) with 95% CIs were calculated.</p><p><strong>Results: </strong>Among the study population of 38 583 live births, 2417 (6.3%) lacked prenatal care. The rate of lacking prenatal care increased over time (APC=11.4; 95% CI 4.7 to 18.5). Maternal education, insurance, nulliparity, prepregnancy body mass index, prior preterm birth, smoking, diabetes, hepatitis C and year of delivery were associated with lacking prenatal care. Compared with individuals with prenatal care, those without care were associated with a higher risk of preterm birth <37 weeks (aRR 2.57; 95% CI 2.40 to 2.74) and <34 weeks (aRR 3.56; 95% CI 3.13 to 4.05). Compared with patients with adequate care, those without care were associated with a higher risk of preterm birth <37 weeks (aRR 5.07; 95% CI 4.59 to 5.60) and <34 weeks (aRR 6.42; 95% CI 5.32 to 7.75). Similar associations were shown in other adverse outcomes.</p><p><strong>Conclusions: </strong>Among pregnancies complicated by syphilis in the USA, there was an upward trend in lack of prenatal care from 2016 to 2022. Modifiable factors of lacking prenatal care were identified. The risks of adverse outcomes were higher among individuals without prenatal care.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"386-394"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Centenary Series - STIs Through the Ages: <b>The dawn of the syphilis pandemic in the Old World: history and geography of syphilis in the early sixteenth century</b>.","authors":"Massimo Galli, Luca Fois","doi":"10.1136/sextrans-2024-056351","DOIUrl":"10.1136/sextrans-2024-056351","url":null,"abstract":"<p><strong>Objective: </strong>To describe the first wave of the syphilis pandemic in the Old World.</p><p><strong>Methods: </strong>Summary and discussion of early and recent literary and documentary data describing the spread of syphilis in Europe at the end of the fifteenth and during the first decades of the sixteenth century.</p><p><strong>Results: </strong>From the second half of 1493, the spread of a disease that was clearly perceived as being sexually transmitted was the cause of considerable scandal and so much concern as to force Emperor Maximilian I to proclaim that it was the punishment for the sins of the affected as early as August 1495. Considered as new and unprecedented by most contemporaries and appearing just after the return of Columbus' first expedition, a heated controversy concerning the origin of the disease began almost immediately and, despite the findings of phylogenetic studies of Treponema sequences taken from modern specimens and early remains, still continues today. Called by many often nationalistic names (particularly French morbus or Neapolitan disease), syphilis affected millions of people in the early sixteenth century, limiting their reproductive capacity and life expectancy, and greatly reducing their quality of life.</p><p><strong>Conclusions: </strong>Regardless of its geographical and temporal origins, the characteristics of this true pandemic were typical of those induced by a new pathogen in a virgin population.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"355-360"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}