Sexually Transmitted Infections最新文献

{"title":"<i>Clostridioides difficile</i> infection following self-directed post-exposure antibiotic use for STI prevention.","authors":"Angelo Roberto Raccagni, Flavia Passini, Elena Bruzzesi, Flavia Badalucco Ciotta, Simona Bossolasco, Antonella Castagna, Silvia Nozza","doi":"10.1136/sextrans-2025-056479","DOIUrl":"10.1136/sextrans-2025-056479","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"422"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research news in clinical context.","authors":"Marina Daskalopoulou, Rachel Herbert, Sonia Raffe, Giovanni Villa","doi":"10.1136/sextrans-2024-056420","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056420","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 6","pages":"424-425"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline prophylaxis for bacterial sexually transmitted infection prevention in Vietnam: awareness, attitudes and willingness to use among men who have sex with men using HIV-PrEP.","authors":"Hao T M Bui, Paul C Adamson, Jeffrey D Klausner, Giang M Le, Pamina M Gorbach","doi":"10.1136/sextrans-2024-056449","DOIUrl":"10.1136/sextrans-2024-056449","url":null,"abstract":"<p><strong>Objectives: </strong>Doxycycline prophylaxis shows promise for bacterial sexually transmitted infection (STI) prevention, but data primarily come from high-income countries. This study assessed awareness, willingness and factors associated with willingness to use doxycycline for bacterial STI prevention among men who have sex with men (MSM) using HIV pre-exposure prophylaxis (HIV-PrEP) in Vietnam.</p><p><strong>Methods: </strong>Between 25 January and 4 February 2024, a cross-sectional study recruited males aged ≥18 years who reported having sex with men in the past 12 months from 11 HIV-PrEP clinics in Hanoi and Ho Chi Minh City. Self-administered surveys were conducted, and multivariable logistic regression was applied to identify factors associated with willingness to use doxycycline prophylaxis.</p><p><strong>Results: </strong>Among 350 participants, the median age was 25 (IQR 21-30), and 10.6% self-reported a bacterial STI diagnosis in the past 12 months. In the previous 6 months, the median number of sex partners was 2 (IQR 1-4), 53.1% reported condomless anal sex. Awareness of doxycycline was low (20.2%; 65/322); however, 75.4% (264/350) expressed willingness to use it, with 63.6% (168/264) preferring doxyPrEP. Participants who disclosed HIV-PrEP use to all sex partners (adjusted OR (aOR) 4.17; 95% CI 1.84, 9.46) and those with higher perceived STI risk (aOR 1.12; 95% CI 1.03, 1.22) were more likely to report willingness to use doxycycline prophylaxis. Concerns about daily medication (aOR 0.43; 95% CI 0.24, 0.81) and fear of judgement from peers (aOR 0.41; 95% CI 0.21, 0.81) were associated with lower willingness.</p><p><strong>Conclusions: </strong>Knowledge of doxycycline prophylaxis among MSM on HIV-PrEP in Vietnam was low. However, most expressed willingness to use it, with two-thirds preferring doxyPrEP. Findings highlight the need to disseminate information on doxycycline prophylaxis for bacterial STI prevention, monitoring the usage and evaluating comparative effectiveness of doxyPEP and doxyPrEP to guide implementation efforts in Vietnam.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"367-373"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics and antibiotic susceptibility of <i>Neisseria gonorrhoeae</i> isolates from Greece during 2009-2023.","authors":"Eirini Siatravani, Anna-Danai Panopoulou, Michalis Polemis, Stella-Eugenia Chryssou, Ioannis Moschos, Ioanna Magaziotou, Apostolos Beloukas, Eva Tzelepi, Vivi Miriagou","doi":"10.1136/sextrans-2024-056279","DOIUrl":"10.1136/sextrans-2024-056279","url":null,"abstract":"<p><strong>Objectives: </strong>To monitor epidemiological characteristics and antibiotic susceptibility trends of <i>Neisseria gonorrhoeae</i> in Greece during 2009-2023.</p><p><strong>Methods: </strong>Microbiological and epidemiological data for 1756 gonococci received by the Greek National Reference Centre for <i>Neisseria gonorrhoeae</i> were evaluated. Strains were isolated consecutively from gonorrhoea cases in hospitals throughout Greece. Minimum inhibitory concetrations of antibiotics were determined by E-test. Plasmid content analysis was performed for penicillinase-producing isolates (PPNG) and for isolates exhibiting tetracycline resistance (TRNG). <i>tetM</i>, <i>penA, gyrA</i> and <i>parC</i> genes were identified by PCR and RFLP/sequencing. Isolates were subjected to serotyping. Genomic analysis by pulsed-field gel electrophoresis (PFGE) was performed for extended-spectrum cephalosporin (ESC)-resistant isolates.</p><p><strong>Results: </strong>Only 2.8% of the isolates were fully susceptible to all antibiotics. High rates of resistance were observed for penicillin G (27.5%), tetracycline (59.2%) and ciprofloxacin (68.8%). PPNG and/or TRNG isolates accounted for 26% of the total sample, the majority (81.6%) being simultaneously quinolone-resistant (QRNG). The isolation frequency of QRNG isolates was stably high as in previous years. Interestingly, a proportion of QRNG isolates exhibited cross-resistance to all antibiotics except spectinomycin. Azithromycin resistance is showing an increasing trend since 2021 at alarming levels (32.7% in 2023). The percentage of isolates exhibiting decreased susceptibility to ESCs (CDS) remained stable until 2019, whereas no CDS strains were isolated from 2020 to 2023. Spectinomycin was active against all isolates. Serotyping results revealed a strong association of quinolone resistance with Bpyut, Bpyust and Bropyst serovars and I/S phenotypes with Bpyvut and Byut serovars. PFGE showed that CDS isolates were classified into eight groups, with the majority clustered in three main clones including the predominant CDS clone isolated during 2001-2008.</p><p><strong>Conclusions: </strong>The gonococcal population showed a continuous change in the resistance phenotypes and predominating clones during 2009-2023 underlining the need for continuous monitoring of the traits of this pathogen.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"395-404"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates to the notifiable disease legislation in England to facilitate surveillance of selected STI-related complications.","authors":"Hamish Mohammed, Kate Folkard, Matt Phillips, David Phillips, Helen Fifer, Katy Sinka","doi":"10.1136/sextrans-2025-056500","DOIUrl":"10.1136/sextrans-2025-056500","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"353-354"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus vaccination uptake among men who have sex with men living with HIV.","authors":"Conor Moran, Jaime Garcia-Iglesias, Colm Kerr","doi":"10.1136/sextrans-2024-056361","DOIUrl":"10.1136/sextrans-2024-056361","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is a very common sexually transmitted infection. Persistent infection with high-risk subtypes can lead to a variety of cancers. Men who have sex with men (MSM), particularly those who are living with HIV (MSMLWH), have a high prevalence of HPV infection and are at greatest risk of HPV-related diseases such as anal cancer. HPV vaccines are effective in preventing new infections, and many countries have implemented HPV vaccination for MSM.</p><p><strong>Methods: </strong>This systematic review aimed to examine HPV vaccine uptake among MSM and MSMLWH. Quantitative studies published between 2010 and 2022 were screened and included if they detailed HPV vaccination uptake data for MSM and MSMLWH. Identified studies were screened using Covidence, data were extracted from the final included studies and narratively synthesised, and risk of bias of studies was assessed using the Joanna Briggs Institute Checklist tool for prevalence studies.</p><p><strong>Results: </strong>There were 19 studies all from high-income countries, included in the final review. This review showed a wide variety of HPV vaccine uptake, ranging from 2.7% to 91.5% for HIV-negative MSM and among MSMLWH ranging from 5.6% to 90%. Although limited by the heterogeneity of studies and settings, there was evidence of a consistent, steady increase in HPV vaccination particularly among younger men. MSMLWH generally had higher rates of HPV vaccination, but overall HPV vaccine uptake remained suboptimal.</p><p><strong>Conclusion: </strong>MSMLWH are at high risk of HPV-related disease. Despite an available and efficacious vaccine in many countries, this review showed overall rates of HPV vaccination uptake remain inadequate. Further research and policy should aim to address and overcome barriers to HPV vaccination.PROSPERO registration numberCRD42023382251.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"414-421"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-related microaggressions and depressive symptoms among people living with HIV: the mediating roles of internalised stigma and coping with shame.","authors":"Aliye Canan Taşlıoğlu Sayıner, Bulent Turan, Arzu Nazlı, Deniz Özer, Hamed Abdollahpour Ranjbar, Salih Atakan Nemli, Ahmad Nejat Ghaffari, Merve Mert Vahabi, Nur Miray Ayhan, Deniz Gokengin, Andrea Norcini Pala","doi":"10.1136/sextrans-2024-056354","DOIUrl":"10.1136/sextrans-2024-056354","url":null,"abstract":"<p><strong>Objectives: </strong>Overtly experienced HIV-related stigma is associated with depressive symptoms for people living with HIV (PLWH). Research suggests that an important mediating mechanism in this association is internalised stigma, where PLWH accept negative societal views about HIV, apply them to themselves and develop a negative view of themselves. Microaggressions are subtle and indirect discriminatory behaviours and, like overtly experienced stigma, may also contribute to depressive symptoms. We tested this hypothesis and examined the mediating roles of internalised stigma and maladaptive ways of coping with shame in the association between microaggressions and depressive symptoms among PLWH in Türkiye.</p><p><strong>Methods: </strong>This study examines the serial mediating roles of internalised HIV stigma and shame-related coping strategies (ie, withdrawal and self-attack) in the association between HIV-related microaggressions and depressive symptoms among PLWH. PLWH in Izmir, Türkiye (N=308) completed validated scales measuring experiences of microaggressions, internalised HIV stigma, coping strategies related to shame and depression symptoms.</p><p><strong>Results: </strong>Structural equation modelling results suggest that internalised HIV stigma significantly mediates the relationship between HIV-related microaggressions and depression symptoms. Furthermore, serial mediation analysis suggests that withdrawal and self-attack strategies of coping with shame mediate the association between internalised HIV stigma and depressive symptoms. Thus, internalised HIV stigma and shame-related coping strategies may partially stem from experiencing HIV-related microaggressions and may negatively affect the mental health of PLWH.</p><p><strong>Conclusions: </strong>Findings highlight the importance of assessing subtle forms of discrimination (ie, microaggressions) given their negative impact on the self-concept of PLWH. In addition to addressing negative attitudes and behaviours against PLWH in society, interventions that help PLWH cope with shame-related experiences might improve their mental health.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"380-385"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and symptoms associated with <i>Mycoplasma genitalium</i> infections among heterosexual men in Hanoi, Vietnam.","authors":"Hoai Bac Nguyen, Huynh Dang Khoa Nguyen, Minh Quan Pham, Cao Thang Nguyen, Paul C Adamson","doi":"10.1136/sextrans-2024-056396","DOIUrl":"10.1136/sextrans-2024-056396","url":null,"abstract":"<p><strong>Background: </strong><i>Mycoplasma genitalium</i> (MG) is a critical pathogen of sexually transmitted infections (STIs) in men, associated with high antibiotic resistance. Understanding the clinical characteristics of MG infections can improve testing and treatment guidelines.</p><p><strong>Aims: </strong>To investigate the clinical features and characteristics of asymptomatic, acute and chronic MG infections in heterosexual males.</p><p><strong>Methods: </strong>From January 2018 to September 2023, men diagnosed with urethral STIs using multiplex real-time PCR were enrolled into this cross-sectional study. Testing indications included males with urethritis, suspected STIs and asymptomatic screening. Based on clinical symptoms, participants were classified as acute, chronic or asymptomatic groups. An electronic-based survey was administered to assess demographic, behavioural and clinical information. Univariate and multivariate logistic regression were performed to assess for factors associated with the presence of symptoms.</p><p><strong>Result: </strong>Among the 2102 men who have sex with women and were tested for STI, 879 records met the eligibility criteria for further analysis; MG was detected in 14.6% of the 2102 cases. Most patients presented with acute urethral symptoms (75.6%). Among men infected with MG, mono-infection accounted for 52.8%, while <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> co-infections occurred in 39.3% and 21.3%, respectively. Co-infections were more prevalent among acute urethritis compared with chronic urethritis or asymptomatic groups. Multivariable analysis revealed associations between chronic symptoms with absence of urethral discharge (aOR 0.31; 95% CI 0.2 to 0.47), previous antibiotic use (aOR 6.83; 95% CI 4.47 to 10.4), marriage (aOR 1.66; 95% CI 1.09 to 2.51) and history of STIs (aOR 2.08; 95% CI 1.24 to 3.49).</p><p><strong>Conclusion: </strong>Our study revealed a 14.6% prevalence of MG among individuals tested for STIs. Most patients presented with acute urethral symptoms, while chronic symptoms were associated with marriage, antibiotic use history and previous STIs. Routine MG screening of asymptomatic patients is not recommended, but improved access to diagnostics and further research is needed for clinical practice in low-resource settings.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"361-366"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2025 UK 4CMenB vaccine programme for GBMSM at high risk of gonorrhoea.","authors":"Shamez N Ladhani, Helen Fifer","doi":"10.1136/sextrans-2025-056681","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056681","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 6","pages":"426"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial treatment options for extensively drug-resistant (XDR) shigellosis in men who have sex with men.","authors":"Daniel Richardson, Lucy Rabuszko, Lewis C E Mason, P Malaka De Silva, Shay Khan, Holly D Mitchell, Claire Jenkins, Kate S Baker","doi":"10.1136/sextrans-2025-056612","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056612","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}