多西环素预防在越南细菌性传播感染的预防：使用HIV-PrEP的男男性行为者的意识、态度和使用意愿。

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Sexually Transmitted Infections Pub Date : 2025-02-06 DOI:10.1136/sextrans-2024-056449

Hao T M Bui, Paul C Adamson, Jeffrey D Klausner, Giang M Le, Pamina M Gorbach

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引用次数: 0

摘要

目的：强力霉素预防有望预防细菌性传播感染（STI），但数据主要来自高收入国家。本研究评估了越南使用艾滋病毒暴露前预防（HIV- prep）的男男性行为者（MSM）使用多西环素预防细菌性性传播感染的意识、意愿和相关因素。方法：在2024年1月25日至2月4日期间，一项横断面研究从河内和胡志明市的11个HIV-PrEP诊所招募了年龄≥18岁且报告在过去12个月内与男性发生过性行为的男性。进行了自我管理的调查，并应用多变量逻辑回归来确定与使用强力霉素预防的意愿相关的因素。结果：在350名参与者中，中位年龄为25岁（IQR 21-30）， 10.6%的人在过去12个月内自我报告细菌性性传播感染诊断。前6个月性伴侣中位数为2 (IQR 1-4)， 53.1%报告无套肛交。多西环素的知晓率较低(20.2%；65/322);然而，75.4%（264/350）的人表示愿意使用它，63.6%（168/264）的人更喜欢doxyPrEP。向所有性伴侣透露HIV-PrEP使用情况的参与者(调整OR (aOR) 4.17；95% CI 1.84, 9.46)和感知性传播感染风险较高的患者(aOR 1.12；95% CI 1.03, 1.22)更有可能报告愿意使用强力霉素预防。对日常用药的担忧(aOR 0.43；95% CI 0.24, 0.81)和对同伴评判的恐惧(aOR 0.41；95% CI 0.21, 0.81)与较低的意愿相关。结论：越南HIV-PrEP人群对多西环素预防知识的知晓程度较低。然而，大多数人表示愿意使用它，三分之二的人更喜欢doxyPrEP。研究结果强调，有必要传播多西环素预防细菌性性传播感染的信息，监测多西环素pep和多西环素prep的使用情况，并评估其相对有效性，以指导越南的实施工作。

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Doxycycline prophylaxis for bacterial sexually transmitted infection prevention in Vietnam: awareness, attitudes and willingness to use among men who have sex with men using HIV-PrEP.

Objectives: Doxycycline prophylaxis shows promise for bacterial sexually transmitted infection (STI) prevention, but data primarily come from high-income countries. This study assessed awareness, willingness and factors associated with willingness to use doxycycline for bacterial STI prevention among men who have sex with men (MSM) using HIV pre-exposure prophylaxis (HIV-PrEP) in Vietnam.

Methods: Between 25 January and 4 February 2024, a cross-sectional study recruited males aged ≥18 years who reported having sex with men in the past 12 months from 11 HIV-PrEP clinics in Hanoi and Ho Chi Minh City. Self-administered surveys were conducted, and multivariable logistic regression was applied to identify factors associated with willingness to use doxycycline prophylaxis.

Results: Among 350 participants, the median age was 25 (IQR 21-30), and 10.6% self-reported a bacterial STI diagnosis in the past 12 months. In the previous 6 months, the median number of sex partners was 2 (IQR 1-4), 53.1% reported condomless anal sex. Awareness of doxycycline was low (20.2%; 65/322); however, 75.4% (264/350) expressed willingness to use it, with 63.6% (168/264) preferring doxyPrEP. Participants who disclosed HIV-PrEP use to all sex partners (adjusted OR (aOR) 4.17; 95% CI 1.84, 9.46) and those with higher perceived STI risk (aOR 1.12; 95% CI 1.03, 1.22) were more likely to report willingness to use doxycycline prophylaxis. Concerns about daily medication (aOR 0.43; 95% CI 0.24, 0.81) and fear of judgement from peers (aOR 0.41; 95% CI 0.21, 0.81) were associated with lower willingness.

Conclusions: Knowledge of doxycycline prophylaxis among MSM on HIV-PrEP in Vietnam was low. However, most expressed willingness to use it, with two-thirds preferring doxyPrEP. Findings highlight the need to disseminate information on doxycycline prophylaxis for bacterial STI prevention, monitoring the usage and evaluating comparative effectiveness of doxyPEP and doxyPrEP to guide implementation efforts in Vietnam.

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来源期刊

Sexually Transmitted Infections 医学-传染病学

CiteScore

5.70

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Sexually Transmitted Infections is the world’s longest running international journal on sexual health. It aims to keep practitioners, trainees and researchers up to date in the prevention, diagnosis and treatment of all STIs and HIV. The journal publishes original research, descriptive epidemiology, evidence-based reviews and comment on the clinical, public health, sociological and laboratory aspects of sexual health from around the world. We also publish educational articles, letters and other material of interest to readers, along with podcasts and other online material. STI provides a high quality editorial service from submission to publication.