Sexually Transmitted Infections最新文献

{"title":"Prevalence and potential implications of HPV infection in transgender women with gender reaffirming genital surgery: a systematic literature review and meta-analysis.","authors":"Hana Elasifer, Gabriel Toledo, Catriona Graham, Kate Cuschieri","doi":"10.1136/sextrans-2024-056255","DOIUrl":"10.1136/sextrans-2024-056255","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is a common infection of the anogenital tract. Although most infections clear, persistent infections with oncogenic types can predispose to cancer. While the natural history of anogenital HPV infection in cisgendered women is relatively well understood, there are significant knowledge gaps regarding HPV prevalence and clinical implications of genital HPV infection in transgender women (TGW) with neovagina(s).</p><p><strong>Methods: </strong>A systematic review, including meta-analysis, of studies available in the literature with data on HPV prevalence in TGW with neovaginas was performed. Additionally, a narrative analysis of the clinical manifestations of genital HPV infections in TGW with neovagina(s) was performed.</p><p><strong>Results: </strong>21 studies were included; six focused on the prevalence of HPV in TGW, and data were pooled in a meta-analysis of prevalence; 15 were case reports/series, which were included in a narrative analysis of clinical implications. The meta-analysis showed the prevalence of genital HPV in TGW with neovaginas was 15% (95% CI 9% to 21%). The most frequently detected HPV type was HPV 16. 18 TGW were included in case reports/series and the median age was 42; 12 presented with condylomata acuminata and six had squamous carcinoma.</p><p><strong>Conclusion: </strong>Data on genital HPV prevalence in TGW with neovaginas are sparse, with many studies having small denominators. We report higher HPV prevalence compared with cisgendered women. Symptomatic genital HPV infection in TGW with neovaginas was largely associated with benign condylomata, although some carcinoma was detected. Future longitudinal studies are required to elucidate the clinical impact of genital HPV infection and examine its implications in TGW with neovaginas in order to inform prevention and management strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"269-277"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging risk of sexual transmission of Oropouche virus.","authors":"Ashutosh Pareek, Runjhun Singhal, Aaushi Pareek, Ranjit Sah, Alfonso J Rodriguez-Morales, Vasso Apostolopoulos","doi":"10.1136/sextrans-2024-056418","DOIUrl":"10.1136/sextrans-2024-056418","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"280-281"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton pump inhibitors (PPIs) and sexually transmissible enteric infections in men who have sex with men: PPI-stewardship.","authors":"Callum Chessell, Deborah Williams, Daniel Richardson","doi":"10.1136/sextrans-2025-056594","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056594","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gonococcal infection in a canal along the medial penile raphe.","authors":"Lise Gether, Diljit Kaur-Knudsen, Jesper Elberling","doi":"10.1136/sextrans-2025-056585","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056585","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreasing trends of syphilis among people with HIV at a university hospital before implementation of doxycycline prophylaxis for syphilis: implications for targeted syphilis prevention.","authors":"Kai-Hsiang Chen, Kuan-Yin Lin, Yu-Shan Huang, Sung-Hsi Huang, Wang-Da Liu, Tzong-Yow Wu, Yu-Chung Chuang, Aristine Cheng, Li-Hsin Su, Hsin-Yun Sun, Chien-Ching Hung","doi":"10.1136/sextrans-2024-056385","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056385","url":null,"abstract":"<p><strong>Objectives: </strong>Syphilis remains a public health challenge, particularly among people with HIV (PWH). This study aimed to examine the trends of syphilis and associated factors among PWH in Taiwan, 2016-2023, before the implementation of doxycycline postexposure prophylaxis (DoxyPEP).</p><p><strong>Methods: </strong>PWH aged 18 years or older who sought HIV care at a university hospital and had at least two serological tests for syphilis during the study period were included. Annual incidence rates of syphilis were calculated as the number of new syphilis cases per 100 person-years of follow-up (PYFU), while the prevalence was defined as the proportion of PWH who had a positive rapid plasma reagin (RPR) titre. Reinfection was defined as a ≥4 fold increase in RPR titre following a prior syphilis diagnosis. Multivariable logistic regression was used to identify factors associated with syphilis acquisition.</p><p><strong>Results: </strong>Among 3828 PWH, a total of 3201 incident syphilis cases were recorded during a total of 23 385.1 PYFU. The incidence rate decreased significantly from 16.78 per 100 PYFU in 2016 to 11.14 per 100 PYFU in 2023, a 33.6% reduction. The prevalence peaked at 45.0% in 2019 before declining to 41.6% in 2023. Reinfections constituted 66.3-85.0% of incident cases annually. Factors associated with acquiring syphilis included younger age (adjusted OR (AOR), per 10-year increase, 0.71; 95% CI, 0.67 to 0.75), men who have sex with men (AOR, 1.75; 95% CI, 1.32 to 2.32), a previous syphilis history (AOR, 7.26; 95% CI, 6.48 to 8.14) and no follow-up RPR data in the preceding year(s) (AOR, 3.02; 95% CI, 2.08 to 4.38).</p><p><strong>Conclusions: </strong>While the declines in incidence and prevalence of syphilis among PWH before the implementation of DoxyPEP were likely driven by an ageing population in Taiwan, regular serological testing for syphilis remains imperative for early diagnosis and treatment of syphilis to prevent further transmission.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital lesions of unusual aetiology in a male patient: case report.","authors":"Carlo Bieńkowski, Agata Skrzat-Klapaczyńska, Agnieszka Bednarska, Justyna D Kowalska","doi":"10.1136/sextrans-2025-056533","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056533","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to HIV testing among African and Caribbean heritage communities: a mixed methods study.","authors":"Temilola Adeniyi, Jeremy Horwood, Marsha Doran, Khabo Piggott, Aisha-Monic Namurach, Lindsey Harryman, Emmy Oldenbourg, Miryam Kiflu, Nathan Speare, Mary Griffin, Matthew Wilson, Mark Febrache, Rachel Allbless, David Dravie-John, Joanna Copping, Frank De Vocht, Scott Walter, Fiona Fox","doi":"10.1136/sextrans-2025-056491","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056491","url":null,"abstract":"<p><strong>Objectives: </strong>African and Caribbean heritage (ACH) communities in the UK face disproportionately high rates of HIV and often experience delayed diagnoses, worsening health inequities. Increasing HIV testing in these communities is essential to address these disparities and support the UK's HIV reduction targets. This study examines barriers and facilitators to HIV testing among Bristol's ACH community, a high-prevalence area with significant rates of late diagnoses, filling a critical gap in context-specific data.</p><p><strong>Methods: </strong>Using a mixed-methods approach, this study combined 29 in-depth interviews and 41 online surveys, capturing ACH community members' views on HIV stigma, healthcare trust and testing experiences. Data were thematically analysed and mapped to the Social Ecological Model (SEM) framework, with community researchers conducting data collection and analysis to enhance participants' engagement and trust and contribute to a deeper contextual analytical understanding.</p><p><strong>Results: </strong>Findings highlight significant barriers across SEM levels: individual-level knowledge gaps and stigma, interpersonal confidentiality concerns within tight knit communities, community-level taboos and distrust and organisational barriers, such as discriminatory healthcare experiences. Effective facilitators included culturally specific services, flexible testing options, community-driven outreach and increased healthcare representation, all of which fostered greater trust and engagement in testing.</p><p><strong>Conclusion: </strong>The study underscores the importance of culturally aligned interventions, including representation within and training in cultural competence for healthcare providers and community co-production in service design. Implementing such strategies could reduce late diagnoses and support the normalisation of routine HIV testing in ACH communities, ultimately contributing to health equity. Future research should explore gender and age-specific barriers, while assessing the long-term impact of community-led interventions to inform national HIV policy and public health strategies for marginalised communities in the UK.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring alternative therapeutic options for multidrug-resistant <i>N. Gonorrhoeae</i>: the potential of 7,8-dihydroxyflavone.","authors":"Yuqiu Qi, Qinghui Xie, Jingxia Lin, Ran Zhang, Yingxian Tang, Zhuo Wang, Xiaomian Lin","doi":"10.1136/sextrans-2024-056362","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056362","url":null,"abstract":"<p><strong>Objectives: </strong><i>Neisseria gonorrhoeae</i> (NG), a bacterium characterised by multidrug resistance, is traditionally treated with ceftriaxone, either as a monotherapy or in conjunction with azithromycin. However, the emergence of strains resistant to these antibiotics presents a considerable challenge to current therapeutic approaches, which necessitates the exploration of alternative treatment strategies.</p><p><strong>Methods: </strong>Agar dilution and broth microdilution to determine the minimum inhibitory concentrations (MICs) of antibiotics and 7,8-dihydroxyflavone. The development of 7,8-dihydroxyflavone drug resistance was detected under the treatment of sublethal concentration for 30 passages. Genotypic analysis was conducted to examine <i>penA</i>, <i>23S rRNA</i> alleles and multilocus sequence typing.</p><p><strong>Results: </strong>55 clinical NG isolates emphasised the high-level rates of the current antimicrobial resistance, with a notable prevalence of the <i>penA</i>-60.001 FC428 clone and high-level azithromycin-resistant clones characterised by the <i>23S rRNA</i>-1 (A2059G) and <i>23S rRNA</i>-2 (C2611T) alleles. Among the strains that are representative of clinical circulation, 7,8-dihydroxyflavone demonstrated inhibitory activity, with MIC₅₀ and MIC₉₀ values of 10 mg/L and 20 mg/L, respectively, which are unlikely to induce drug resistance in NG.</p><p><strong>Conclusions: </strong>7,8-dihydroxyflavone may represent a promising antimicrobial agent in the context of escalating antibiotic resistance.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diving into pooling: an efficient strategy for STI screening in individuals at increased risk.","authors":"Isabel Aparicio-Calvente, Silvia Capilla, Gladys Virginia Guédez-López, Marta Navarro","doi":"10.1136/sextrans-2025-056518","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056518","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy for multidrug-resistant <i>Mycoplasma genitalium</i> infections: a case series.","authors":"Thibaut Vanbaelen, Diana Huis In 't Veld, Benjamin J Visser, Irith De Baetselier, Jens Tomas Van Praet, Sheeba Santhini Manoharan-Basil, Dorien Van den Bossche, Chris Kenyon","doi":"10.1136/sextrans-2025-056517","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056517","url":null,"abstract":"<p><strong>Objectives: </strong>In Belgium, approximately a quarter of <i>Mycoplasma genitalium</i> infections are resistant to both macrolides and fluoroquinolones-termed multidrug-resistant (MDR) infections. The optimal treatment approach for these MDR infections remains uncertain. Combination therapy has shown promise in treating other MDR pathogens by enhancing efficacy and reducing resistance development. We report the first five cases of MDR <i>M. genitalium</i> urethritis successfully treated with a novel combination therapy regimen consisting of minocycline, metronidazole, methenamine and pristinamycin ('M3P').</p><p><strong>Methods: </strong>We describe a case series of five individuals treated with M3P as salvage therapy for <i>M. genitalium</i> urethritis. Clinical data, laboratory findings, resistance profiles and treatment outcomes were reviewed.</p><p><strong>Results: </strong>All five men with macrolide-resistant and fluoroquinolone-resistant <i>M. genitalium</i> urethritis received M3P for a minimum of 14 days. Two men received an extended 28-day M3P regimen, in which minocycline and methenamine were given for 28 days. All five patients experienced clinical and microbiological cure. Adverse effects were minimal and transient, with one patient reporting increased urinary frequency during treatment and another reporting mild dyspepsia.</p><p><strong>Conclusions: </strong>This case series demonstrates the potential efficacy of M3P as a novel salvage therapy for MDR <i>M. genitalium</i> urethritis, particularly where standard therapies have failed. The combination of pristinamycin, methenamine, and other agents may synergistically reduce bacterial load and increase efficacy. Further, in vitro and clinical studies are required to assess the optimal treatment strategies for MDR <i>M. genitalium</i>.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}