Sexually Transmitted Infections最新文献

{"title":"Interesting case of syphilis with atypical vegetative lesions.","authors":"Luca Pipitò, Roberta Gaudiano, Floriana Di Figlia, Edoardo Mandalà, Cinzia Calà, Giuseppina Capra, Antonio Cascio","doi":"10.1136/sextrans-2024-056367","DOIUrl":"10.1136/sextrans-2024-056367","url":null,"abstract":"<p><p>Syphilis is a re-emerging disease, and suspicion of syphilis infection should be considered in all cases with atypical skin manifestations, mainly when there is a history of unprotected sexual intercourse. Here, we describe a case of secondary syphilis in a woman aged 42 years, who presented with an atypical, painful and itchy skin rash with vegetative cerebriform lesions, which resolved after the administration of penicillin. Multiplex PCR targeting <i>Treponema pallidum</i> on vaginal and lesion swabs, along with syphilis serology, confirmed the diagnosis.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"278-279"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of improved partner notification on the transmission of HIV and <i>N. gonorrhoea</i> among men who have sex with men: a modelling study.","authors":"Maarten Reitsema, Jacco Wallinga, Birgit H B van Benthem, Eline L M Op de Coul, Ard Van Sighem, Maarten Schim van der Loeff, Maria Xiridou","doi":"10.1136/sextrans-2023-055772","DOIUrl":"10.1136/sextrans-2023-055772","url":null,"abstract":"<p><p><b>Objectives</b> Men who have sex with men (MSM) are disproportionally affected by HIV in the Netherlands. Partner notification (PN) is an important element in controlling the transmission of sexually transmitted infections (STIs) and HIV. We investigated the effects of improving PN on the transmission of HIV and <i>Neisseria gonorrhoeae</i> (NG) among MSM in the Netherlands. <b>Methods</b> We developed an agent-based model that describes the transmission of HIV and NG among MSM. In the baseline scenario, 14.3% and 29.8% of casual and steady partners of the index case get notified and tested for HIV/STI after 3 weeks (percentage notified and tested (PNT)). We examined the following scenarios: (1) increase PNT to 41% for both partner types; (2) decrease the time between the index and the partners tested to 1 week and (3) combine scenarios 1 and 2. Effects are expressed as cumulative change from the baseline simulation over 15 years. <b>Results</b> Increasing PNT could lead to a decrease in gonorrhoea cases of 45% (IQR 39.9% to 49.9%), with an increase in the number of HIV/STI tests of 4.4% (IQR 1.6% to 7.3%), but no change in HIV infections (-5.4%; IQR -21% to 7.9%). Decreasing the time between tests could lead to a change in new NG infections of -14.2% (IQR -17.2% to -10%), no change in HIV infections (8.2%; IQR -1.3% to 20%) or in the number of HIV/STI tests performed (-0.4%; IQR -1.5 to 0.6%). Scenario 3 led to a change in NG infections of -56.8% (IQR -63.8% to -47.4%), no change in HIV infections (11.5%; IQR -11.1% to 33.9%) or in the number of HIV/STI tests (-0.5%; IQR: -4.9% to 4.3%). <b>Conclusions</b> Increasing the percentage of sexual partners notified and tested for HIV/STI may have only a small effect on HIV but could reduce the number of new NG infections substantially. However, it could lead to an increase in the number of HIV/STI tests performed.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"236-241"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies increasing incidence in Bologna from 2013 to 2024: a retrospective analysis.","authors":"Corrado Zengarini, Martina Mussi, Michelangelo La Placa, Alessandro Pileri, Anna Lucia Virdi, Marco Chessa, Federico Bardazzi, Carlotta Gurioli, Michela Starace, Valeria Gaspari, Cosimo Misciali, Fortunato Cassalia, Bianca Maria Piraccini, Iria Neri","doi":"10.1136/sextrans-2024-056436","DOIUrl":"10.1136/sextrans-2024-056436","url":null,"abstract":"<p><strong>Objectives: </strong>Scabies infestation, caused by the <i>Sarcoptes scabiei</i> mite, has recently emerged as a public health concern in Western nations, with increased incidence worldwide. In Bologna, Italy, local health authorities report a rise in scabies diagnoses, although detailed data are limited. This study aimed to analyse the temporal trends of scabies cases diagnosed at S. Orsola Hospital's Dermatological Emergency Department, focusing on significant changes in incidence and seasonal variation over time.</p><p><strong>Methods: </strong>A retrospective observational study was conducted using data from October 2013 to September 2024, extracted from hospital records using ICD-9 (International Classification of Diseases, Ninth Revision) codes. Variables included monthly case counts, discharge date, patient age and nationality. All pruritic cases from the emergency department were evaluated in the dermatology unit, with diagnosis confirmed via dermoscopic or microscopic examination. Only first visits were included, excluding follow-up visits or post-therapy controls to avoid duplication. Monthly cases were aggregated to identify annual and seasonal trends. χ² tests assessed nationality distribution differences, and linear regression analysed annual trends. Seasonal variation was evaluated with the Kruskal-Wallis test.</p><p><strong>Results: </strong>A total of 1192 cases were diagnosed. The nationality distribution remained stable, with no significant differences between Italian-born and other nationalities. A significant upward trend in incidence was observed in recent years, with seasonal variation showing higher case counts in February, March and April, and the lowest in July and August.</p><p><strong>Conclusions: </strong>The increase in scabies cases in recent years and distinct seasonal peaks suggests that environmental and social factors may contribute to transmission in Bologna. Without demographic changes and known drug resistance, factors such as the rise in tourism and suboptimal accommodation conditions may play a role in transmission. Enhanced public health monitoring, awareness and targeted interventions are recommended to manage this trend effectively.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"256-258"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the COM-B model to facilitators and barriers to HIV and STI testing among people from Black African and Black Caribbean communities in the UK: a scoping review.","authors":"Ritu Khanna, Maya Gobin","doi":"10.1136/sextrans-2024-056259","DOIUrl":"10.1136/sextrans-2024-056259","url":null,"abstract":"<p><strong>Objective: </strong>Individuals from Black African and Black Caribbean communities (black communities) in the UK bear a disproportionate burden of HIV and sexually transmitted infections (STIs), while exhibiting lower testing rates. The aim of the scoping review was to summarise interventions developed to increase HIV/STI testing among black communities in the UK and describe the facilitators and barriers that influence testing uptake in these populations, according to the Capability Opportunity Motivation Behaviour (COM-B) approach.</p><p><strong>Methods: </strong>Six databases were systematically searched to identify quantitative, qualitative and mixed-method studies evaluating the effectiveness of HIV/STI testing interventions among black communities in the UK, published from 2000 onwards. The review was conducted in accordance with the Joanna Briggs Institute Framework of Evidence Synthesis and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Data were analysed using thematic analysis, and the factors were mapped onto the COM-B model components.</p><p><strong>Results: </strong>Twenty-two studies, of which 11 were available as abstracts only, were included. Twelve studies included testing provision and health promotion, six studies testing provision only and four health promotion only. Nineteen studies looked at HIV testing interventions only. Facilitators to testing included interventions that provided an understanding of STI and HIV risk, assured privacy for testers and normalised testing through integration into existing services and delivery in non-traditional settings by appropriately trained staff. Barriers to testing included interventions that were stigmatising through the choice of intervention settings and/or targeting of groups, low perceived risk and limited knowledge about infections among people from black communities, and limited engagement and partnership working with relevant community organisations and groups.</p><p><strong>Conclusion: </strong>Multifaceted interventions that include health promotion and opportunities for testing, co-designed with and by local communities, are crucial in addressing the range of barriers and facilitators experienced by people from black communities.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"259-268"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating equity reporting within systematic reviews of pre-exposure prophylaxis (PrEP).","authors":"Bethany Paris, Kelsi Batioja, Vanessa Lin, Micah Hartwell","doi":"10.1136/sextrans-2024-056306","DOIUrl":"10.1136/sextrans-2024-056306","url":null,"abstract":"<p><strong>Background: </strong>Pre-exposure prophylaxis (PrEP) is a medicine that can reduce HIV transmission. Given the disproportionate impact of HIV on minority communities, health equity is an important consideration in PrEP research. We aimed to assess equity reporting in systematic reviews of PrEP using the PROGRESS Plus framework.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed (MEDLINE), Embase and Cochrane databases for systematic reviews or meta analyses of PrEP usage. We then used the PROGRESS Plus framework to extract inclusion of the following domains: place of residence, race/ethnicity/culture/language, occupation, gender/sex, religion, education, socioeconomic status, social capital, age and disability.</p><p><strong>Results: </strong>After screening search articles, our sample included 36 systematic reviews and meta-analyses (SRMAs). 24 (66.7%) were conducted within the USA. Few (2/36, 5.6%) were found to mention adherence to any equity reporting framework. Place and gender/sex were the most reported elements of the framework with inclusion in 34 of 36 studies. Age (30/36, 83.3%) and race/ethnicity (24/36, 66.7%) were also commonly reported. All other criteria were reported in less than half of included SRMAs; religion had the lowest inclusion at 0/36 (0%), followed by disability (1/36, 2.8%). Among the 36 SRMAs, 19 (52.78%) did not conduct any subgroup analyses among domains; those most commonly analysed were gender/sex and age.</p><p><strong>Conclusion: </strong>Our study found nearly all SRMAs regarding HIV PrEP reported on gender/sex and age; however, other influential equity criteria were often overlooked. Further attention to the reporting of PROGRESS Plus items within these SRMAs may reduce barriers for PrEP utilisation, thus improving HIV prevention strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"224-228"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Centenary Series - STIs Through the Ages: <b>Treating the 'secret disease' in 17th century England</b>.","authors":"Anita Hoffmann","doi":"10.1136/sextrans-2024-056348","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056348","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 4","pages":"211-213"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The REPRIEVE study: implications for routine practice.","authors":"Miriam Ringshall, Duncan R Churchill","doi":"10.1136/sextrans-2024-056293","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056293","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 4","pages":"282"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based self-collection of biological samples, including vaginal swabs: a mixed methods study for Britain's fourth National Survey of Sexual Attitudes and Lifestyles (Natsal-4).","authors":"Clarissa Oeser, Pam Sonnenberg, Magnus Unemo, Katharine Sadler, Soazig Clifton, Jo Gibbs, Simon Beddows, Rebecca Hamilton, Abraham Roodt, Stephanie Migchelsen, Emily Dema, Alexandra David, Catherine H Mercer, Nigel Field","doi":"10.1136/sextrans-2024-056386","DOIUrl":"10.1136/sextrans-2024-056386","url":null,"abstract":"<p><strong>Objectives: </strong>The decennial National Surveys of Sexual Attitudes and Lifestyles (Natsal) provide general population prevalence estimates in Britain for key sexually transmitted infections (STIs) through biosampling. Since methodological choices can impact acceptability and response rates, we evaluated processes for Natsal-4, including face-to-face and remote interview arrangements, non-return of test results and vaginal swab collection in two pilot studies.</p><p><strong>Methods: </strong>The pilots were conducted during June to August 2021 and February to March 2022. Participants aged 16-59 years were invited to provide urine samples (cisgender men and trans/gender diverse) or three vaginal swabs (cisgender women; urine was requested if vaginal swabs were declined) following interview. Samples were self-collected at home and posted to the laboratory by the interviewer if the interview was face to face, or by the participant if they preferred to collect the sample later or the interview was remote. Process feedback was collected after the first pilot via qualitative interviews with participants and after both pilots through informal interviewer debriefing.</p><p><strong>Results: </strong>Of 261 participants interviewed (pilot 1=130; pilot 2=131), 161 (62%) consented to biosampling, of which 129 (49%) provided samples. A sample was received from 78/153 (51%) of women, of whom 60 (77%) provided vaginal swabs and 18 (23%) provided a urine sample. A urine sample was received from 51/108 (47%) cisgender men or trans/gender diverse participants. All samples collected immediately after face-to-face interviews were received (n=77), while 64% of samples from participants consenting to post samples after face-to-face interviews and 60% after remote interviews were received. Process feedback confirmed our methods were broadly acceptable.</p><p><strong>Conclusions: </strong>We demonstrated that our approach to biosampling and STI testing for a national sexual health survey was reasonably acceptable and feasible in the period coming out the COVID-19 pandemic. Self-collection of vaginal swabs for research, which provide higher testing sensitivity than urine, was feasible and acceptable in a home setting.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"252-255"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis prevalence among a large regional online postal self-sampling STI testing service (OPSS).","authors":"Sara Louise Day, Jessica Collins, Jonathan Spate, Sophie Jones, Efejiro Ashano, David Asboe","doi":"10.1136/sextrans-2024-056309","DOIUrl":"10.1136/sextrans-2024-056309","url":null,"abstract":"<p><strong>Objectives: </strong>In England, infectious syphilis diagnoses have reached the highest annual number since 1948. Fifty per cent of syphilis testing is now provided through online postal self-sampling sexually transmitted infection (STI) testing services (OPSS). To reduce the burden of syphilis, we need to understand the syphilis prevalence and transition to treatment rates among service users of OPSS. This report aims to estimate syphilis prevalence among people accessing Sexual Health London (SHL), a regional, National Health Service (NHS)-funded OPSS.</p><p><strong>Methods: </strong>Demographic, STI concurrency, sexual behaviour data and case outcomes were collected from SHL service users who received testing for syphilis between 8 March 2022 and 30 June 2023. Data were analysed to identify syphilis prevalence and transition to care rates.</p><p><strong>Results: </strong>458 520 syphilis tests were performed for 267 780 service users. 12 870 (2.8%) results were reactive. Their assigned case outcomes comprised: 10 048 (78.1%) past adequately treated syphilis; 971 (7.5%) treated for active syphilis; 1293 (10.1%) SHL results did not subsequently confirm and 558 (4.3%) had an unknown final outcome. Of unique users, 0.4% (940/267 780) received syphilis treatment at least once. They were: 89.3% aged ≥25 years, 87.3% male, 83.7% gay/bisexual. Co-infections identified were: chlamydia (14%), gonorrhoea (13.3%) and previously undiagnosed HIV (1.5%). 36.1% (339) took pre-exposure HIV prophylaxis, 30.1% engaged in sex parties/group sex and 26.8% had sex under the influence of drugs/alcohol. Individuals aged ≥35 years, of non-female gender, gay/bisexual, from indices of multiple deprivation (1-5) and from certain racially minoritised communities were statistically more likely to require treatment for syphilis than the overall testing population (p<0.05).</p><p><strong>Conclusion: </strong>Estimated syphilis prevalence (0.4%) was comparable to rates within national sexual health clinics and the demographic characteristics of those most affected by syphilis were also similar. Further work is required to improve the integration between NHS OPSS and sexual health clinics and to enable OPSS to more accurately input data on treatment and diagnoses towards national surveillance statistics.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"242-246"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-collected penile-meatal swabs are suitable for the detection of STIs in Ugandan men with high rates of STI coinfections.","authors":"Johan H Melendez, Adamaris Muñiz Tirado, Annet Onzia, Emmanuel Mande, Justin P Hardick, Rosalind Parkes-Ratanshi, Matthew M Hamill, Yukari C Manabe","doi":"10.1136/sextrans-2024-056330","DOIUrl":"10.1136/sextrans-2024-056330","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) are a global health challenge. Testing is not routinely performed in low- and middle-income countries (LMICs), which bear a disproportionate burden of STIs. Self-collected penile-meatal swabs (SCPMS) are an alternative to urine for STI testing, but data from LMICs are limited.</p><p><strong>Methods: </strong>Between October 2019 and September 2020, recruited participants with urethral discharge syndrome at government health facilities in Kampala, Uganda, provided urine and SCPMS. Samples were retrospectively analysed for <i>Chlamydia trachomatis</i> (CT), <i>Neisseria gonorrhoeae</i> (NG), <i>Mycoplasma genitalium</i> (MG) and <i>Trichomonas vaginalis</i> (TV) using Aptima assays. Paired SCPMS and urine samples with discordant STI results were analysed using real-time PCR assays.</p><p><strong>Results: </strong>Of the 250 participants, 66.8% (n=167), 22.8% (n=57), 12.8% (n=32) and 2.4% (n=6) tested positive for NG, CT, MG and TV, respectively, on testing of their SCPMS and urine samples. The overall agreement between urine and SCPMS for all STIs using the Aptima assays was 98.7% (987/1000). After adjudication with PCR assays, the agreement between urine and SCPMS for NG, CT, MG and TV was 100% (250/250), 97.6% (244/250), 99.6% (249/250), and 99.6% (249/250), respectively. There was no significant difference between SCPMS and urine (p=0.9996). For paired samples with one STI (n=164) or ≥2 STIs (n=39), concordance was 100% (656/656) and 97.2% (175/180), respectively. There was no association between number of STIs and agreement between sample types (p=0.8606).</p><p><strong>Conclusions: </strong>This study revealed a high level of agreement between SCPMS and urine for detection of STIs in symptomatic Ugandan men, even in the presence of multiple concurrent STIs. SCPMS may be a suitable alternative to urine, with ease of collection, transporting, and processing of samples.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"247-251"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}