Sexually Transmitted Infections最新文献

{"title":"Interrelationship between chemsex engagement and PrEP (pre-exposure prophylaxis) experience in men who have sex with men: a community-based cross-sectional study.","authors":"Ngai Sze Wong, Sze Long Chung, Krystal Chi-Kei Lee, Shui-Shan Lee","doi":"10.1136/sextrans-2024-056331","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056331","url":null,"abstract":"<p><strong>Background: </strong>Chemsex engagement is known to be associated with higher-risk sexual behaviour, HIV and sexually transmitted infection (STI). To reduce HIV infection risk, pre-exposure prophylaxis (PrEP) is increasingly used in the men who have sex with men (MSM) community. This study aims to examine the interrelationship between chemsex engagement and PrEP use in MSM.</p><p><strong>Methods: </strong>This is a cross-sectional study with the recruitment of MSM in the community in Hong Kong. Participating MSM were invited to complete an online survey which included PrEP (experienced or naïve) use, chemsex engagement history and HIV test results. Chemsex engagement referred to use of specific drugs (methamphetamine and/or gamma-hydroxybutyrate) before and/or during sex. Characteristics of MSM with and without history of chemsex engagement were examined in bivariable and multivariable logistic regression. In a case-control analysis with a 1:1 ratio of PrEP-naïve and PrEP-experienced MSM, the association of chemsex engagement with history of PrEP use was examined in bivariable and multivariable logistic regression.</p><p><strong>Results: </strong>Between February 2022 and January 2024, 338 eligible MSM were recruited. A higher proportion of MSM engaged in chemsex reported history of PrEP use and group sex. Prevalence of ever chemsex engagement was significantly higher in PrEP-experienced (29%) than PrEP-naïve MSM (9%) (adjusted OR=2.69, 95% CI 1.28 to 5.67), after adjustment for confounders of age, history of STI testing, multiple sex partnership and inconsistent condom use. The history of chemsex engagement in the past 6 months was associated positively with ever and recent (6 months) use of PrEP. Five out of seven PrEP-naïve MSM who had engaged in chemsex in the past 6 months indicated their intention to take PrEP.</p><p><strong>Conclusions: </strong>Chemsex engagement was positively associated with PrEP use while most of the PrEP-naïve MSM who had recently engaged in chemsex expressed interest to start PrEP. PrEP service could be an important community platform for chemsex intervention.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating equity reporting within systematic reviews of pre-exposure prophylaxis (PrEP).","authors":"Bethany Paris, Kelsi Batioja, Vanessa Lin, Micah Hartwell","doi":"10.1136/sextrans-2024-056306","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056306","url":null,"abstract":"<p><strong>Background: </strong>Pre-exposure prophylaxis (PrEP) is a medicine that can reduce HIV transmission. Given the disproportionate impact of HIV on minority communities, health equity is an important consideration in PrEP research. We aimed to assess equity reporting in systematic reviews of PrEP using the PROGRESS Plus framework.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed (MEDLINE), Embase and Cochrane databases for systematic reviews or meta analyses of PrEP usage. We then used the PROGRESS Plus framework to extract inclusion of the following domains: place of residence, race/ethnicity/culture/language, occupation, gender/sex, religion, education, socioeconomic status, social capital, age and disability.</p><p><strong>Results: </strong>After screening search articles, our sample included 36 systematic reviews and meta-analyses (SRMAs). 24 (66.7%) were conducted within the USA. Few (2/36, 5.6%) were found to mention adherence to any equity reporting framework. Place and gender/sex were the most reported elements of the framework with inclusion in 34 of 36 studies. Age (30/36, 83.3%) and race/ethnicity (24/36, 66.7%) were also commonly reported. All other criteria were reported in less than half of included SRMAs; religion had the lowest inclusion at 0/36 (0%), followed by disability (1/36, 2.8%). Among the 36 SRMAs, 19 (52.78%) did not conduct any subgroup analyses among domains; those most commonly analysed were gender/sex and age.</p><p><strong>Conclusion: </strong>Our study found nearly all SRMAs regarding HIV PrEP reported on gender/sex and age; however, other influential equity criteria were often overlooked. Further attention to the reporting of PROGRESS Plus items within these SRMAs may reduce barriers for PrEP utilisation, thus improving HIV prevention strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug-resistant urethritis caused by <i>Haemophilus parainfluenzae</i>: susceptibility pattern and fosfomycin as an alternative treatment.","authors":"Berta Isabel Fidalgo, Jordi Iglesies, David García, Andrea Vergara, Irene Fuertes de Vega, Laura Horvath, Yuliya Zboromyrska, Jordi Bosch, Ana González, José Riera-Monroig, Ignasi Roca, Marina Alguacil, Climent Casals-Pascual, Cristina Pitart, Josep Mallolas, José Luis Blanco, Mateu Espasa","doi":"10.1136/sextrans-2024-056142","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056142","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the COM-B model to facilitators and barriers to HIV and STI testing among people from Black African and Black Caribbean communities in the UK: a scoping review.","authors":"Ritu Khanna, Maya Gobin","doi":"10.1136/sextrans-2024-056259","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056259","url":null,"abstract":"<p><strong>Objective: </strong>Individuals from Black African and Black Caribbean communities (black communities) in the UK bear a disproportionate burden of HIV and sexually transmitted infections (STIs), while exhibiting lower testing rates. The aim of the scoping review was to summarise interventions developed to increase HIV/STI testing among black communities in the UK and describe the facilitators and barriers that influence testing uptake in these populations, according to the Capability Opportunity Motivation Behaviour (COM-B) approach.</p><p><strong>Methods: </strong>Six databases were systematically searched to identify quantitative, qualitative and mixed-method studies evaluating the effectiveness of HIV/STI testing interventions among black communities in the UK, published from 2000 onwards. The review was conducted in accordance with the Joanna Briggs Institute Framework of Evidence Synthesis and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Data were analysed using thematic analysis, and the factors were mapped onto the COM-B model components.</p><p><strong>Results: </strong>Twenty-two studies, of which 11 were available as abstracts only, were included. Twelve studies included testing provision and health promotion, six studies testing provision only and four health promotion only. Nineteen studies looked at HIV testing interventions only. Facilitators to testing included interventions that provided an understanding of STI and HIV risk, assured privacy for testers and normalised testing through integration into existing services and delivery in non-traditional settings by appropriately trained staff. Barriers to testing included interventions that were stigmatising through the choice of intervention settings and/or targeting of groups, low perceived risk and limited knowledge about infections among people from black communities, and limited engagement and partnership working with relevant community organisations and groups.</p><p><strong>Conclusion: </strong>Multifaceted interventions that include health promotion and opportunities for testing, co-designed with and by local communities, are crucial in addressing the range of barriers and facilitators experienced by people from black communities.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging risk of sexual transmission of Oropouche virus.","authors":"Ashutosh Pareek, Runjhun Singhal, Aaushi Pareek, Ranjit Sah, Alfonso J Rodriguez-Morales, Vasso Apostolopoulos","doi":"10.1136/sextrans-2024-056418","DOIUrl":"10.1136/sextrans-2024-056418","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated global and regional incidence and prevalence of herpes simplex virus infections and genital ulcer disease in 2020: mathematical modelling analyses.","authors":"Manale Harfouche, Sawsan AlMukdad, Asalah Alareeki, Aisha M M Osman, Sami Gottlieb, Jane Rowley, Laith J Abu-Raddad, Katharine J Looker","doi":"10.1136/sextrans-2024-056307","DOIUrl":"10.1136/sextrans-2024-056307","url":null,"abstract":"<p><strong>Objectives: </strong>Genital herpes simplex virus (HSV) type 1 and 2 infections are lifelong and can cause symptomatic genital ulcer disease (GUD). HSV-2 almost always causes sexually transmitted genital infection, while HSV-1 mainly causes oral infection but can be sexually transmitted to cause genital infection. This study estimated genital infection with both HSV types and associated GUD globally in 2020, breaking down the data by WHO region and sex for females and males.</p><p><strong>Methods: </strong>A calibrated mathematical model was employed to generate estimates for the incidence and prevalence of HSV-2 infection, genital HSV-1 infection, and GUD caused by both HSV types. Estimates for non-genital infections caused by HSV-1 were also generated. Model input was derived from a comprehensive systematic review and meta-analyses of HSV prevalence data for all WHO regions.</p><p><strong>Results: </strong>Globally in 2020 there were 25.6 million (95% uncertainty interval (UI) 23.1-29.4 million) people aged 15-49 years with new HSV-2 infections, and 519.5 million (95% UI 464.3-611.3 million), or 13.3% (95% UI 11.9-15.6%), with existing (prevalent) HSV-2 infections. In addition, there were 16.8 million (95% UI 10.6-22.4 million) people aged 15-49 years with new genital HSV-1 infections and 376.2 million (95% UI 235.6-483.5 million), or 10.2% (95% UI 6.4-13.1%), with prevalent genital HSV-1 infections. The estimated number of people aged 15-49 years with at least one episode of HSV-attributable GUD in 2020 was 187.9 million (95% UI 116.0-291.8 million) for HSV-2, and 16.7 million (95% UI 9.3-25.2 million) for HSV-1, totalling 204.6 million (95% UI 132.3-306.5 million).</p><p><strong>Conclusion: </strong>Genital HSV infections have a high incidence and prevalence worldwide, contributing to a significant GUD disease burden. New prevention and treatment measures, such as prophylactic and therapeutic HSV vaccines, are needed critically to control HSV infections and reduce the associated disease burden.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in <i>Neisseria gonorrhoeae</i> infections after ending COVID-19 lockdown measures in Amsterdam, the Netherlands.","authors":"Buhari Teker, Maarten F Schim van der Loeff, Anders Boyd, Elske Hoornenborg, Arjen J Stam, Henry J C de Vries, Vita Willemijn Jongen","doi":"10.1136/sextrans-2024-056276","DOIUrl":"10.1136/sextrans-2024-056276","url":null,"abstract":"<p><strong>Objective: </strong>Various European countries noted increasing <i>Neisseria gonorrhoeae</i> (Ng) positivity among cis-gender women and heterosexual men. We assessed changes over time in Ng among men who exclusively have sex with men (MSM), men who exclusively have sex with women (MSW), men who have sex with men and women (MSMW), women and transgender and gender diverse people (TGP).</p><p><strong>Methods: </strong>We analysed data collected between 2018 and 2023 at the Centre for Sexual Health, Amsterdam. We modelled temporal changes in Ng positivity rates (ie, number of positive results per 100 tests) using relative risk regression with a covariate representing three time periods: pre-COVID-19 (1 January 2018-12 March 2020), during COVID-19 (13 March 2020-1 March 2022), and post-COVID-19 (2 March 2022-31 December 2023).</p><p><strong>Results: </strong>We included 110 878 consultations pre-COVID-19, 84 917 during COVID-19 and 108 282 post-COVID-19. Positivity rates of Ng went from 12.4% to 13.0% in MSM, 1.7% to 2.3% in MSW, 6.7% to 9.9% in MSMW, 1.3% to 2.9% in women and 8.1% to 10.4% in TGP pre-COVID-19 and post-COVID-19, respectively. Significant increases were observed among MSW (relative risk (RR)=1.31,95% CI 1.12 to 1.53), MSMW (RR=1.47, 95% CI 1.26 to 1.72) and women (RR=2.25, 95% CI 2.03 to 2.49). An increased number of sexual partners and inconsistent condom use were associated with an increased Ng risk.</p><p><strong>Conclusion: </strong>A substantial relative increase in Ng risk among MSW, MSMW and women, but not MSM or TGP, was observed post-COVID-19. Changes in sexual behaviour were associated with these changes. Continuous surveillance of Ng in heterosexual individuals is needed to monitor changes, alongside implementing prevention strategies for sexually transmitted infections.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for online or in-person STI testing vary by where a person lives and their cultural background: a survey of young Australians.","authors":"Ethan T Cardwell, Olivia Walsh, Shanton Chang, Jacqueline Coombe, Christopher K Fairley, Jane S Hocking, Fabian Yuh Shiong Kong, Teralynn Ludwick","doi":"10.1136/sextrans-2024-056292","DOIUrl":"10.1136/sextrans-2024-056292","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives are to explore the acceptability of online sexually transmitted infection (STI) testing services among young Australians (16-29 years) and how this may vary between sociodemographic populations.</p><p><strong>Methods: </strong>A cross-sectional, online survey (using both closed and open-ended questions) of Australians aged 16-29 years. Of 905 participants, 781 (86%) responded to the question on preference for online versus in-person STI testing and are included in this analysis. Logistic regression was used to identify sociodemographic factors associated with STI testing preferences (online vs in-person). Adjusted ORs (AOR) are reported for each sociodemographic factor. Content analysis was used to code open-ended responses explaining the reasons for the participant's testing preference.</p><p><strong>Results: </strong>Among the participants, 75% (588/781) preferred online testing over in-person testing. 677 (87%) provided reasons for their preference in an associated, open-ended question. Multivariable analysis found that the odds of preferring online services were significantly increased for those living in rural compared with metropolitan areas (AOR=1.7, 1.0-2.9). The odds of preferring online testing over in-person testing were significantly decreased for those of Asian descent (AOR=0.4, 0.2-0.6) and for those who reported having previously tested for an STI (0.6, 0.4-0.9). Convenience and privacy were key factors from the content analysis underlining preferences for online testing services but tended to be voiced by participants with certain sociodemographic characteristics (ie, men who have sex with men and older participants). Factors related to trust and convenience underscored preferences related to in-person testing.</p><p><strong>Conclusions: </strong>It is clear that there is considerable interest among young people in using online STI testing, but it may not be right for all individuals. Understanding what factors associated with online testing are valued by young users can help inform marketing strategies that highlight these value propositions in their messaging. Further research is needed to engage young people and develop a high-quality, usable online service.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High frequency of anal high-risk human papillomavirus and abnormal cytology in men living with HIV in Chile.","authors":"Tomás Reyes-Barros, Patricia García-Cañete, Pablo Zoroquiain-Vélez, Javier Hernández-Pizarro, Óscar Corsi-Sotelo, María Elena Ceballos-Valdivielso","doi":"10.1136/sextrans-2024-056305","DOIUrl":"10.1136/sextrans-2024-056305","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-collected penile-meatal swabs are suitable for the detection of STIs in Ugandan men with high rates of STI coinfections.","authors":"Johan H Melendez, Adamaris Muñiz Tirado, Annet Onzia, Emmanuel Mande, Justin P Hardick, Rosalind Parkes-Ratanshi, Matthew M Hamill, Yukari C Manabe","doi":"10.1136/sextrans-2024-056330","DOIUrl":"10.1136/sextrans-2024-056330","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) are a global health challenge. Testing is not routinely performed in low- and middle-income countries (LMICs), which bear a disproportionate burden of STIs. Self-collected penile-meatal swabs (SCPMS) are an alternative to urine for STI testing, but data from LMICs are limited.</p><p><strong>Methods: </strong>Between October 2019 and September 2020, recruited participants with urethral discharge syndrome at government health facilities in Kampala, Uganda, provided urine and SCPMS. Samples were retrospectively analysed for <i>Chlamydia trachomatis</i> (CT), <i>Neisseria gonorrhoeae</i> (NG), <i>Mycoplasma genitalium</i> (MG) and <i>Trichomonas vaginalis</i> (TV) using Aptima assays. Paired SCPMS and urine samples with discordant STI results were analysed using real-time PCR assays.</p><p><strong>Results: </strong>Of the 250 participants, 66.8% (n=167), 22.8% (n=57), 12.8% (n=32) and 2.4% (n=6) tested positive for NG, CT, MG and TV, respectively, on testing of their SCPMS and urine samples. The overall agreement between urine and SCPMS for all STIs using the Aptima assays was 98.7% (987/1000). After adjudication with PCR assays, the agreement between urine and SCPMS for NG, CT, MG and TV was 100% (250/250), 97.6% (244/250), 99.6% (249/250), and 99.6% (249/250), respectively. There was no significant difference between SCPMS and urine (p=0.9996). For paired samples with one STI (n=164) or ≥2 STIs (n=39), concordance was 100% (656/656) and 97.2% (175/180), respectively. There was no association between number of STIs and agreement between sample types (p=0.8606).</p><p><strong>Conclusions: </strong>This study revealed a high level of agreement between SCPMS and urine for detection of STIs in symptomatic Ugandan men, even in the presence of multiple concurrent STIs. SCPMS may be a suitable alternative to urine, with ease of collection, transporting, and processing of samples.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}