Sexually Transmitted Infections最新文献

{"title":"The Centenary Series - STIs Through the Ages: <i><b>'The Sins of the Fathers are Visited upon the Children': the history of congenital syphilis</b></i>.","authors":"Ioanna Tsigkouli","doi":"10.1136/sextrans-2024-056410","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056410","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 5","pages":"283-286"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>One way or another, you are not going to fit</i>: trans and gender diverse people's perspectives on sexual health services in the United Kingdom.","authors":"Tom Witney, Greta Rait, John Saunders, Lorna Hobbs, Laura Mitchell, Jay Stewart, Lorraine K McDonagh","doi":"10.1136/sextrans-2024-056231","DOIUrl":"10.1136/sextrans-2024-056231","url":null,"abstract":"<p><strong>Objectives: </strong>Trans and/or gender diverse (T/GD) people in the UK are less likely to access sexual health services (SHS) than cisgender people and are more likely to report negative experiences. The British Association for Sexual Health and HIV (BASHH) developed expert recommendations for T/GD-inclusive SHS, but these lack service user perspectives. This study addressed this gap by asking T/GD people how SHS could be T/GD-inclusive.</p><p><strong>Methods: </strong>Semistructured interviews (n=33) and focus groups (n=26) were conducted with T/GD people aged 17-71 years old recruited through community organisations and social media, exploring experiences of SHS and inclusivity. Study design, materials and analysis were informed by T/GD people and an advisory committee of charities and sexual health clinicians. Data were analysed using thematic analysis, managed using NVivo.</p><p><strong>Results: </strong>Participants often expected that SHS were not set up for T/GD people. This was reinforced by poor experiences in other healthcare settings and the lack of information on NHS websites. Some participants had been denied care because they were 'too complex'. Participants wanted to know that SHS had engaged with the needs of T/GD people and looked for hallmarks of inclusivity, such as Trans Pride flags in reception areas. Some participants wanted specialist T/GD services, but others preferred to access general SHS. Staff attitudes were a key factor underpinning inclusivity. Anticipating having their identity questioned or needs dismissed, participants sought kindness and openness. Although the needs of T/GD people are diverse and different from cisgender service users, participants stressed that SHS staff already had the skills to deliver sensitive person-centred care and emphasised the value of inclusive SHS.</p><p><strong>Conclusion: </strong>These findings provide insight into what a sample of T/GD people in the UK consider important for T/GD-inclusive SHS. Participants' suggestions align with and reinforce BASHH expert recommendations. Importantly, they highlight the need for ongoing engagement to deliver T/GD-inclusive SHS.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"287-293"},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in syphilis and syphilitic uveitis among South Korean adults in 2010-2019: a nationwide cohort study.","authors":"EunAh Kim, Soorack Ryu, Su Jeong Song","doi":"10.1136/sextrans-2024-056417","DOIUrl":"10.1136/sextrans-2024-056417","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate the epidemiology, clinical manifestations, and diagnostic and management patterns of ocular syphilis in South Korea.</p><p><strong>Methods: </strong>This retrospective nationwide cohort study analysed health claim data from 2010 to 2019 for individuals aged ≥20 years diagnosed with syphilis, with follow-up through 2021. Age- and sex-adjusted incidence and prevalence rates were calculated for ocular conditions including anterior uveitis, posterior uveitis, panuveitis and optic neuritis. Diagnostic and management trends were evaluated, and multivariate Cox regression analyses assessed the impact of demographic factors and comorbidities.</p><p><strong>Results: </strong>From 2010 to 2019, the incidence rate of syphilis increased from 99.1 to 136.1 per 100 000. Among the 448 085 syphilis cases, 5118 developed anterior uveitis, 777 posterior uveitis, 551 panuveitis and 80 optic neuritis. While all types of uveitis showed increasing trends, anterior uveitis exhibited the steepest rise from 0.18 per 100 000 in 2010 to 1.40 per 100 000 in 2021. Diagnostic practices for ocular syphilis included 80.4% for dilated fundus examination, 73.7% for fundus photography and 11.0% for fluorescein angiography. Laser photocoagulation and vitrectomy were performed in 5.7% and 4.5% of patients with uveitis, respectively. Multivariate analyses showed that each additional year of age increased the risk for anterior and posterior uveitis by 4% and optic neuritis by 2%. Hypertension, diabetes mellitus and dyslipidaemia increased the risk of one or more ocular syphilis manifestations.</p><p><strong>Conclusion: </strong>In 2010-2019, the incidence of syphilis in South Korea significantly increased, with rates higher than previous studies. Age, sex and metabolic comorbidities were associated with an increased risk of ocular syphilis. These results indicate the need for vigilance in screening for ocular syphilis, and the importance of comprehensive eye examinations in patients with syphilis.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"313-319"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community engagement for HPV vaccination in Nigeria.","authors":"Assanatou Bamogo, Agatha E Wapmuk, Semilore P Osunsanmi, Eneyi Kpokiri, Titilola A Gbaja-Biamila, Juliet Iwelunmor, Oliver Ezechi, Jennifer S Smith, Joseph D Tucker","doi":"10.1136/sextrans-2025-056496","DOIUrl":"10.1136/sextrans-2025-056496","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"344-345"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Findings from trans-inclusive sexual health screening efforts.","authors":"Betty Swindells, Peter Endicott, Michelle O'Hora, Frances Lander, Tara Suchak, Marta Boffito","doi":"10.1136/sextrans-2024-056455","DOIUrl":"10.1136/sextrans-2024-056455","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"340-341"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-collection for high-risk HPV-RNA detection among HIV-seropositive and HIV-seronegative women engaged in sex work in Kenya.","authors":"Fan Lee, Jessica Yasmine Islam, Michael Musila Mutua, Emmanuel Kabare, Griffins Manguro, Wairimu Waweru, Kishor N Mandaliya, Juma Shafi, R Scott McClelland, Jennifer S Smith","doi":"10.1136/sextrans-2024-056159","DOIUrl":"10.1136/sextrans-2024-056159","url":null,"abstract":"<p><strong>Background: </strong>Evidence of self-collection human papillomavirus (HPV)-RNA testing in cervical cancer screening is limited among women with HIV (WHIV). Most studies are in low-risk patient populations in high-income countries. We examine the prevalence of high-risk HPV (hrHPV) using the APTIMA HPV-RNA assay on self-collected versus provider-collected specimens, and the associated risk factors for high-grade cervical intraepithelial neoplasia (CIN2/3) among women engaged in sex work in Kenya. Among WHIV, we examine the performance of both collection methods for the detection of CIN2/3.</p><p><strong>Methods: </strong>Participants were aged ≥18 years, non-pregnant and had no previous treatment for cervical precancer. The screening process included self-collection of cervicovaginal samples using a Viba cytobrush (Rovers), provider-collected cervical samples, visual inspection with acetic acid (VIA) and Pap smear. The APTIMA HPV Assay (Hologic) was used to detect E6/E7 oncogene RNA of 14 hrHPV types in both self-collected and on provider-collected samples. Risk factors for CIN2/3 were determined via multivariable logistic regression. We estimated test characteristics for each screening method for CIN2/3 detection.</p><p><strong>Results: </strong>A total of 400 women (194 WHIV, 206 women without HIV) underwent screening between 2013 and 2018, with 399 valid HPV results. WHIV had a higher prevalence of hrHPV by self-collection compared with women without HIV (44.0% vs 29.6%, p<0.05) and CIN2/3 (19.0% vs 9.7%, p<0.05). After adjusting for age and HIV status, hrHPV-positivity increased the risk of CIN2/3 by 13 to 20 times. Among WHIV, the sensitivity for CIN2/3 detection was similar between self-collection (85% (66-96)) and provider-collection (93% (76-99)), both of which were higher than the sensitivity of high-grade cytology (high-grade squamous intraepithelial lesion cut-off) (47% (95% CI 23 to 72)). The specificity for both collection methods (self: 66% (95% CI 57 to 75) and provider: 67% (95% CI 58 to 75)) was lower than cytology (85% (95% CI 78 to 91)).</p><p><strong>Conclusion: </strong>Self-collection for HPV-RNA testing performed similarly to provider-collection among WHIV. For WHIV, while the higher sensitivity of HPV-RNA testing compared with cytology for the detection of clinically relevant cervical disease is important, the lower specificity supports the inclusion of a triage test in the screening algorithm.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"301-306"},"PeriodicalIF":3.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'It does fill me with a bit of unease': a qualitative study of the acceptability, facilitators and barriers to reducing the frequency of screening for asymptomatic sexually transmitted infections among gay, bisexual and other men who have sex with men.","authors":"William Berners-Lee, Melissa Cabecinha, James Bell, Dawn Phillips, Tom Witney, Caisey V Pulford, Fabiana Lorencatto, Helen Fifer, Kirsty Foster, Hamish Mohammed, Katy Sinka, Deborah Williamson, Greta Rait, Kate Folkard, John Saunders","doi":"10.1136/sextrans-2025-056556","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056556","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to explore the acceptability of reducing the frequency of asymptomatic <i>Chlamydia trachomatis</i> (Ct) and <i>Neisseria gonorrhoeae</i> (Ng) screening among gay, bisexual, and other men who have sex with men (GBMSM)(Although the term GBMSM is used for convenience, the study also includes nonbinary people who were assigned male at birth who have sex with men.). Additionally, it sought to identify barriers and facilitators to implementing such changes and to develop potential interventions that could support a shift in current screening guidelines.</p><p><strong>Methods: </strong>This qualitative study explored stakeholder perspectives on reducing screening frequency and identified potential interventions that could support future guideline changes of this kind. Semistructured interviews were conducted with 22 GBMSM and 8 professional stakeholders. Data were thematically analysed using the Capabilty, Opportunity, Motivation - Behaviour (COM-B) and Theoretical Domains Framework (TDF). TDF domains were mapped to behaviour change techniques to inform intervention development. Candidate interventions were refined based on acceptability, practicability, effectiveness, affordability, side effects, equity.</p><p><strong>Results: </strong>Overall, GBMSM stakeholder responses to discontinuing asymptomatic Ng and Ct screening tended to be negative, while professional stakeholder opinions were mixed. Reducing the recommended screening frequency to 6 monthly was generally more acceptable to both groups. Barriers and facilitators to guideline changes included issues of knowledge and trust, social influence and identity, context and resources, concerns about consequences and emotional responses and habit. Ten candidate interventions were suggested. These involve providing information, social support, behavioural substitutions and feedback as well as facilitating discussions to resolve concerns.</p><p><strong>Conclusion: </strong>Any reduction in the recommended frequency of asymptomatic screening will encounter a range of interrelated barriers, including knowledge gaps, social influences and emotional factors. We identified evidence-based interventions that could improve acceptance and minimise unintended consequences. Future research should incorporate stakeholder workshops to refine these strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncertain pathogenicity of <i>Pasteurella bettyae</i> in genital and extra-genital sites: insights from a French series of 25 cases.","authors":"Jean Berset de Vaufleury, Marie Danset, Françoise Truchot, François Durupt, Olivier Dauwalder, Laurie Gouillon, Matthieu Godinot","doi":"10.1136/sextrans-2025-056567","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056567","url":null,"abstract":"<p><p><i>Pasteurella bettyae</i> is suggested as an emerging sexually transmitted pathogen in men who have sex with men. We analysed 25 cases, revealing a wider distribution and frequent concomitant infections. Our findings challenge its primary pathogenic role, suggesting it may act as an opportunistic coloniser.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with the presence of stigma towards people living with HIV among healthcare workers in Poland.","authors":"Martyna Cholewik, Filip Fijołek, Zofia Moskal, Carlo Bieńkowski, Justyna D Kowalska, Agata Skrzat-Klapaczyńska","doi":"10.1136/sextrans-2025-056536","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056536","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV constantly face stigma and discrimination. The role of healthcare workers in fighting stigmatisation, especially self-stigmatisation, remains a key component.</p><p><strong>Materials and methods: </strong>A cross-sectional survey study was designed to measure HIV knowledge and attitudes in various healthcare settings in Europe and Central Asia. Responses from Poland were analysed separately and stratified by profession, length of work, experience with patients with HIV and gender.</p><p><strong>Results: </strong>A total of 134 questionnaires were collected. The median age of participants was 41. Most of the participants were female (70.9%), doctors (57.9%), working for more than 10 years (73.9%) and working in a hospital (66.2%). Most of the respondents did not take care of people living with HIV in the year before implementing the survey (56.7%). At the same time, the majority presented up-to-date knowledge and assessment of risks arising from HIV transmission, along with acceptance and willingness to provide services. Healthcare professionals working for over 10 years were less concerned about contact with people living with HIV. Physicians, compared with other healthcare workers, presented less stigma and were less worried about contact with people living with HIV. Men and those who cared for more than five people with HIV also presented less discrimination against people living with HIV.</p><p><strong>Conclusions: </strong>The majority of Polish healthcare workers who responded to the survey presented a willingness to support and provide services for people living with HIV and/or at risk of HIV. However, there is still space for improvement in education, especially among non-doctors working in healthcare settings.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder perspectives on integrating doxycycline postexposure prophylaxis into Kenyan HIV PrEP programmes.","authors":"Felix Ong'era Mogaka, Benn Kwach, Alfred Odira, Gabrielle O'Malley, Mary Hearst, Elizabeth A Bukusi, Jenell Stewart","doi":"10.1136/sextrans-2025-056535","DOIUrl":"10.1136/sextrans-2025-056535","url":null,"abstract":"<p><strong>Objectives: </strong>Doxycycline postexposure prophylaxis (doxyPEP) is an efficacious sexually transmitted infection (STI) prevention strategy. Implementation guidelines recommend a focus on people with prior STIs and/or those taking HIV pre-exposure prophylaxis (PrEP), but trial results are insufficient for interventions to enter guidelines and clinical practice. The purpose of this paper is to describe potential barriers and facilitators for successful implementation strategies of doxyPEP in resource-limited settings.</p><p><strong>Methods: </strong>This qualitative study explored the perceived acceptability, feasibility and sustainability of integrating doxyPEP for STI prevention into Kenyan HIV PrEP programmes. Semistructured interviews were conducted with policymakers, healthcare providers and HIV PrEP users. The interviews were recorded, transcribed and translated to English. Analysis was completed using Dedoose software using deductive reasoning based on the Consolidated Framework for Implementation Research.</p><p><strong>Results: </strong>Forty interviews (7 policymakers, 16 HIV PrEP users, 17 healthcare providers) were conducted between August 2022 and April 2023. Collectively, study participants found doxyPEP to be an acceptable strategy and understood its potential use among HIV PrEP users. However, participants noted several considerations such as the relative advantage, quality and evidence strength, and tension for change alongside the needs, resources and knowledge of the recipient. Integrating doxyPEP into HIV PrEP programmes was deemed feasible, but there were concerns over long-term sustainability, antimicrobial resistance (AMR), surveillance, cost, pill burden and compatibility, and high workload for HIV PrEP providers. Establishing sustainable practice needs to consider costs, external policies, incentives to participate and engaging providers and recipients in the process.</p><p><strong>Conclusion: </strong>Kenyan HIV/STI policymakers, healthcare providers and HIV PrEP users perceived doxyPEP for STI prevention to be acceptable and feasible when addressing local contextual factors. Potential for sustainability was recognised if programmes can address concerns, including AMR, pill burden and additional workload for health professionals, prior to the implementation of doxyPEP into HIV PrEP programmes.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}