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Leveraging advances in machine learning for the robust classification and interpretation of networks. 利用机器学习的进步对网络进行鲁棒分类和解释。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.240458
Raima Carol Appaw, Nicholas M Fountain-Jones, Michael A Charleston
{"title":"Leveraging advances in machine learning for the robust classification and interpretation of networks.","authors":"Raima Carol Appaw, Nicholas M Fountain-Jones, Michael A Charleston","doi":"10.1098/rsos.240458","DOIUrl":"https://doi.org/10.1098/rsos.240458","url":null,"abstract":"<p><p>The ability to simulate realistic networks based on empirical data is an important task across scientific disciplines, from epidemiology to computer science. Often, simulation approaches involve selecting a suitable network generative model such as Erdös-Rényi or small-world. However, few tools are available to quantify if a particular generative model is suitable for capturing a given network structure or organization. We utilize advances in interpretable machine learning to classify simulated networks by our generative models based on various network attributes, using both primary features and their interactions. Our study underscores the significance of specific network features and their interactions in distinguishing generative models, comprehending complex network structures and the formation of real-world networks.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"240458"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting the effects of helper intentions on gratitude and indebtedness: Replication and extensions Registered Report of Tsang (2006). 重新审视帮助者意向对感激和负债的影响:复制与扩展(2006)。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.250508
Chi Fung Chan, Hiu Ching Lim, Fung Yee Lau, Wing Ip, Chak Fong Shannon Lui, Katy Yuen Yan Tam, Gilad Feldman
{"title":"Revisiting the effects of helper intentions on gratitude and indebtedness: Replication and extensions Registered Report of Tsang (2006).","authors":"Chi Fung Chan, Hiu Ching Lim, Fung Yee Lau, Wing Ip, Chak Fong Shannon Lui, Katy Yuen Yan Tam, Gilad Feldman","doi":"10.1098/rsos.250508","DOIUrl":"https://doi.org/10.1098/rsos.250508","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Gratitude and indebtedness are common emotions in response to a favour, yet research suggests that they are experienced differently depending on the situation. Tsang (Tsang JA. 2006 The effects of helper intention on gratitude and indebtedness. &lt;i&gt;Motiv. Emot.&lt;/i&gt; &lt;b&gt;30&lt;/b&gt;, 198-204. (doi:10.1007/s11031-006-9031-z)), found that gratitude for a favour depended on perceived helper intention, whereas indebtedness did not. Perceived benevolent helper intentions were associated with higher gratitude from beneficiaries compared to selfish ones, yet had no associations with indebtedness. In a registered report with a United States Prolific student sample (&lt;i&gt;n&lt;/i&gt; = 759), we conducted a replication and extensions of studies 2 and 3 from Tsang, 2006. In the original studies, Tsang found support for the impact of the helper's intention on gratitude (study 2: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.20 [0.08, 0.32]; study 3: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.14 [0.03, 0.26]), but not for indebtedness (study 2: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.01 [0.00, 0.08]; study 3: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.00 [0.00, 0.03]). In our replications, we found support for the impact of helper's intention on gratitude (study 2: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.33 [0.28, 0.37]; study 3: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.16 [0.12, 0.20]), and-as expected-no support for an effect on indebtedness (study 2: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.00 [0.00, 0.01]; study 3: &lt;math&gt; &lt;mstyle&gt; &lt;mrow&gt;&lt;msubsup&gt;&lt;mi&gt;η&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msubsup&gt; &lt;/mrow&gt; &lt;/mstyle&gt; &lt;/math&gt; = 0.01 [0.00, 0.01]). We concluded a successful replication, that helping intent was more strongly associated with gratitude than with indebtedness. Extending the replication, we found evidence for the impact of helper intention on perceived expectations for reciprocity (&lt;i&gt;d&lt;/i&gt; = 1.51 [1.31, 1.71]), and reciprocity inclination (&lt;i&gt;d&lt;/i&gt; = 0.66 [0.48, 0.84]), and for opposite associations of perceived reciprocity expectations with gratitude (&lt;i&gt;r&lt;/i&gt; = -0.28 [-0.35, -0.22]) and indebtedness (&lt;i&gt;r&lt;/i&gt; = 0.17 [0.10, 0.24]). Materials, data and code are available on: https://osf.io/ghfy4/. This registered report has been officially endorsed by the Peer Community in Registered Reports: https://doi.org/10.24072/pci.rr.100788","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"250508"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing for normality in regression models: mistakes abound (but may not matter). 回归模型的正态性测试:错误比比皆是(但可能无关紧要)。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241904
Stephen Midway, J Wilson White
{"title":"Testing for normality in regression models: mistakes abound (but may not matter).","authors":"Stephen Midway, J Wilson White","doi":"10.1098/rsos.241904","DOIUrl":"https://doi.org/10.1098/rsos.241904","url":null,"abstract":"<p><p>This study examines the misuse of normality tests in linear regression within ecology and biology, focusing on common misconceptions. A bibliometric review found that over 70% of ecology papers and 90% of biology papers incorrectly applied normality tests to raw data instead of model residuals. To assess the impact of this error, we simulated datasets with normal, interval, and skewed distributions across various sample and effect sizes. We compared statistical power between two approaches: testing the whole dataset for normality (incorrect) versus testing model residuals (correct) to determine whether to use a parametric (<i>t</i>-test) or nonparametric (Mann-Whitney U test) method. Our results showed minimal differences in statistical power between the approaches, even when normality was incorrectly tested on raw data. However, when residuals violated the normality assumption, using the Mann-Whitney U test increased statistical power by 3-4%. Overall, the study suggests that, while correctly testing residuals for normality enhances model performance, the impact of testing raw data is negligible in terms of power loss, especially with large sample sizes. The findings highlight the need for more awareness of proper statistical practices, especially in evaluating the assumptions of linear models.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241904"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy-based analysis of biochemical oscillators using bond graphs and linear control theory. 利用键合图和线性控制理论的基于能量的生化振荡器分析。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241791
Peter Gawthrop, Michael Pan
{"title":"Energy-based analysis of biochemical oscillators using bond graphs and linear control theory.","authors":"Peter Gawthrop, Michael Pan","doi":"10.1098/rsos.241791","DOIUrl":"https://doi.org/10.1098/rsos.241791","url":null,"abstract":"<p><p>The bond graph approach has been recognized as a useful conceptual basis for understanding the behaviour of living entities modelled as a system with hierarchical interacting parts exchanging energy. One such behaviour is oscillation, which underpins many essential biological functions. In this paper, energy-based modelling of biochemical systems using the bond graph approach is combined with classical feedback control theory to give a novel approach to the analysis, and potentially synthesis, of biochemical oscillators. It is shown that oscillation is dependent on the interplay between <i>active</i> and <i>passive</i> feedback and this interplay is formalized using classical frequency-response analysis of feedback systems. In particular, the <i>phase margin</i> is suggested as a simple scalar indicator of the presence or absence of oscillations; it is shown how this indicator can be used to investigate the effect of both the structure and parameters of biochemical system on oscillation. It follows that the combination of classical feedback control theory and the bond graph approach to systems biology gives a novel analysis and design methodology for biochemical oscillators. The approach is illustrated using an introductory example similar to the Goodwin oscillator, the Sel'kov model of glycolytic oscillations and the repressilator.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241791"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectrical synchronization of Picea abies during a solar eclipse. 日食期间云杉树的生物电同步。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241786
Alessandro Chiolerio, Monica Gagliano, Silvio Pilia, Paolo Pilia, Giuseppe Vitiello, Mohammad Dehshibi, Andrew Adamatzky
{"title":"Bioelectrical synchronization of <i>Picea abies</i> during a solar eclipse.","authors":"Alessandro Chiolerio, Monica Gagliano, Silvio Pilia, Paolo Pilia, Giuseppe Vitiello, Mohammad Dehshibi, Andrew Adamatzky","doi":"10.1098/rsos.241786","DOIUrl":"https://doi.org/10.1098/rsos.241786","url":null,"abstract":"<p><p>Regular light-dark cycles greatly affect organisms, and events like eclipses induce distinctive physiological and behavioural shifts. While well documented in animals, plant behaviour during eclipses remains largely unexplored. Here, we monitored multiple spruce trees to assess their individual and collective bioelectrical responses to a solar eclipse. Trees anticipated the eclipse, synchronizing their bioelectrical behaviour hours in advance. Older trees displayed greater anticipatory behaviour with early time-asymmetry and entropy increases. These results reveal a relationship between trees, shaped by individual age and physiology as well as collective history. This highlights the significance of synchrony in plants, offering new insights into coordinated behaviours in nature.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241786"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recalibration of perceived agency transfers across modalities. 跨模式的感知代理转移的重新校准。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.231962
Belkis Ezgi Arikan, Kielan Yarrow, Katja Fiehler
{"title":"Recalibration of perceived agency transfers across modalities.","authors":"Belkis Ezgi Arikan, Kielan Yarrow, Katja Fiehler","doi":"10.1098/rsos.231962","DOIUrl":"https://doi.org/10.1098/rsos.231962","url":null,"abstract":"<p><p>We experience our actions and their sensory consequences as synchronous despite small sensorimotor delays. This is attained by an adaptation process in which the sensorimotor system recalibrates temporal discrepancies between actions and their feedback, as long as causality is maintained (i.e. feedback follows action). Predictive motor mechanisms boost action-feedback binding, aiding in adaptation. Sensorimotor temporal recalibration is therefore closely linked with perceived control over the action and its sensory feedback (sense of agency, SoA). Interestingly, recalibration can also transfer to another sense, indicating a generalized mechanism that adjusts the timing of action-feedback events. It is unclear whether recalibration of perceived agency is driven by a similar mechanism. Here, we investigated cross-modal transfer of perceived agency and simultaneity in a sensorimotor recalibration task. In an adaptation phase, participants executed button presses leading to an immediate or lagged (150 ms) occurrence of a Gabor patch. Subsequently, they were asked to make simultaneity or agency judgements for action-feedback pairs (Gabor patch or tone) with variable response-stimulus asynchronies (RSAs). We found adaptation of synchrony and agency judgements with transfer of recalibration for agency judgements. Our findings suggest flexible recalibration of perceived agency, suggesting SoA is not inferred solely on a match with modality-specific motor predictions.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"231962"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publication bias is bad for science if not necessarily scientists. 发表偏见对科学是有害的,如果对科学家不一定有害的话。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.240688
Remco Heesen, Liam Kofi Bright
{"title":"Publication bias is bad for science if not necessarily scientists.","authors":"Remco Heesen, Liam Kofi Bright","doi":"10.1098/rsos.240688","DOIUrl":"https://doi.org/10.1098/rsos.240688","url":null,"abstract":"<p><p>It might seem obvious that the scientific process should not be biased. We strive for reliable inference, and systematically skewing the results of inquiry apparently conflicts with this. Publication bias-which involves only publishing certain types of results-seems particularly troubling and has been blamed for the replication crisis. While we ultimately agree, there are considerable nuances to take into account. Using a Bayesian model of scientific reasoning we show that a scientist who is aware of publication bias can (theoretically) interpret the published literature so as to avoid acquiring biased beliefs. Moreover, in some highly specific circumstances she might prefer not to bother with policies designed to mitigate or reduce the presence of publication bias-it would impose a cost in time or effort that she would not see any benefit in paying. However, we also argue that science as a social endeavour is made worse off by publication bias. This is because the social benefits of science are largely secured via go-between agents, various non-experts who nonetheless need to make use of or convey the results of scientific inquiry if its fruits are to be enjoyed by society at large. These are unlikely to be well-informed enough to account for publication bias appropriately. As such, we conclude, the costs of having to implement policies like mandatory pre-registration are worth imposing on scientists, even if they would perhaps not view these costs as worth paying for their own sake. The benefits are reaped by the go-between agents, and we argue that their perspective is quite properly favoured when deciding how to govern scientific institutions.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"240688"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual yeast cells signal at different levels but each with good precision. 单个酵母细胞在不同的水平上发出信号,但每个细胞都有很好的精度。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241025
Steven S Andrews, Roger Brent
{"title":"Individual yeast cells signal at different levels but each with good precision.","authors":"Steven S Andrews, Roger Brent","doi":"10.1098/rsos.241025","DOIUrl":"https://doi.org/10.1098/rsos.241025","url":null,"abstract":"<p><p>Different isogenic cells exhibit different responses to the same extracellular signals. Several authors assumed that this variation arose from stochastic signalling noise with the implication that single eukaryotic cells could not detect their surroundings accurately, but work by us and others has shown that the variation is dominated instead by persistent cell-to-cell differences. Here, we analysed previously published data to quantify the sources of variation in pheromone-induced gene expression in <i>Saccharomyces cerevisiae</i>. We found that 91% of response variation was due to stable cell-to-cell differences, 8% from experimental measurement error, and 1% from signalling noise and expression noise. Low noise enabled precise signalling; individual cells could transmit over 3 bits of information through the pheromone response system and so respond differently to eight different pheromone concentrations. Additionally, if individual cells could reference their responses against constitutively expressed proteins, then cells could determine absolute pheromone concentrations with 2 bits of accuracy. These results help explain how individual yeast cells can accurately sense and respond to different extracellular pheromone concentrations.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241025"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A heretical point of view in masonry structures dynamics. 砖石结构动力学的异教观点。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241148
Mario Argenziano, Enrico Babilio, Yoshiki Ikeda, Massimiliano Fraldi
{"title":"A <i>heretical</i> point of view in masonry structures dynamics.","authors":"Mario Argenziano, Enrico Babilio, Yoshiki Ikeda, Massimiliano Fraldi","doi":"10.1098/rsos.241148","DOIUrl":"https://doi.org/10.1098/rsos.241148","url":null,"abstract":"<p><p>Protection from static and dynamic actions is an urgent matter for masonry buildings, which constitute the majority of the world's architectural heritage. For this reason, the search for best strategies to analyse the mechanical responses of such structures under both dead and seismic loads has been at the centre of a vivid debate within the scientific community for decades. Although many different approaches and computational methods have been proposed in the literature over the years, most of them make reference to no-tension materials, starting from the pioneering work by Heyman in the framework of limit analysis. However, implementing the hypothesis of masonry walls made by rigid blocks interacting through no-tension interfaces often leads to inconsistent results due to possible interpenetrating elements. In dynamic simulations, undesired blocks' interpenetration forces algorithms to continuously check the compatibility and to eventually stop and restart the analysis with somehow arbitrary initial conditions. By introducing well-established hyperelastic and friction laws at bricks' interfaces, we propose a <i>heretical</i> strategy that overcomes some difficulties of the above-mentioned approaches, recovering physical consistency and avoiding any interpenetrations.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241148"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density. 神经胶质瘤细胞群对辐照的时间反应:剂量和细胞密度影响的建模。
IF 2.9 3区 综合性期刊
Royal Society Open Science Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI: 10.1098/rsos.241917
Marianne Billoir, Delphine Crepin, Stéphane Plaszczynski, Basile Grammaticos, Olivier Seksek, Mathilde Badoual
{"title":"The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density.","authors":"Marianne Billoir, Delphine Crepin, Stéphane Plaszczynski, Basile Grammaticos, Olivier Seksek, Mathilde Badoual","doi":"10.1098/rsos.241917","DOIUrl":"https://doi.org/10.1098/rsos.241917","url":null,"abstract":"<p><p>Time-lapse fluorescence microscopy experiments were performed to track the cell density of F98 glioma cells under varying radiation doses and initial cell densities. Based on these results, a compartmental model characterizing the temporal response of a cancerous cell population to single-dose radiation therapy was developed. This model reproduces very well all the experimental data, with only three free parameters (and four others that are fixed). It allows us to have access and follow the evolution of different cell populations after irradiation, in particular, the senescent and repaired cell populations. From these different cell populations, surviving fractions could also be estimated. Most importantly, our model allows us to analyze and quantify an inhibition effect (or cohort effect) of the dead and senescent cell populations on the regrowth of the repaired one.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 4","pages":"241917"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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