Royal Society Open Science最新文献_第7页

Emerging two-dimensional nanomaterial and its modifications for enhanced antiviral applications: a review. 新兴的二维纳米材料及其修饰增强抗病毒应用：综述。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-09-03 eCollection Date: 2025-09-01 DOI: 10.1098/rsos.242179

Raktim Chowdhury, Sirazam Munira Aishee, Nafisa Islam, Nirupam Aich, Shoeb Ahmed

{"title":"Emerging two-dimensional nanomaterial and its modifications for enhanced antiviral applications: a review.","authors":"Raktim Chowdhury, Sirazam Munira Aishee, Nafisa Islam, Nirupam Aich, Shoeb Ahmed","doi":"10.1098/rsos.242179","DOIUrl":"10.1098/rsos.242179","url":null,"abstract":"Highly resilient pathogens, especially viruses and antibiotic-resistant bacteria, present formidable challenges to public health due to their ability to evade conventional treatments. Traditional microbial disinfection methods, such as chemical deactivation and physical filtration, often fail to effectively neutralize viruses, thus leading to harmful by-products. In light of these limitations, there is a growing need for innovative solutions to address viral disinfection. Photocatalytic microbial disinfection has emerged as a promising approach, primarily explored for bacterial pathogens. However, its antiviral potential remains underinvestigated. Two-dimensional (2D) nanomaterials, with their unique physico-chemical properties, represent a breakthrough in photocatalytic technology, offering advantages such as high surface area, tunable optical characteristics and enhanced generation of reactive oxygen species (ROS). This review assesses the photocatalytic properties of emerging 2D materials-such as graphene, transition metal dichalcogenides (TMDs), graphitic carbon nitride (g-C3N4), black phosphorus (BP) and MXenes-focusing on their potential for antiviral applications. While much of the current research emphasizes antibacterial activity, this review explores how functionalization, doping and composite formation of these materials could enhance their antiviral capabilities, offering a novel avenue for combating viral pathogens and addressing global health challenges.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 9","pages":"242179"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tusks, testosterone and personality in male Asian elephants (Elephas maximus). 雄性亚洲象的象牙、睾丸素和个性。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250490

Hoedric Huguet, Martin W Seltmann, Win Htut, Michael Briga, Carly Lynsdale, Virpi Lummaa

{"title":"Tusks, testosterone and personality in male Asian elephants (Elephas maximus).","authors":"Hoedric Huguet, Martin W Seltmann, Win Htut, Michael Briga, Carly Lynsdale, Virpi Lummaa","doi":"10.1098/rsos.250490","DOIUrl":"10.1098/rsos.250490","url":null,"abstract":"Male Asian elephants exhibit phenotypic diversity in tusk development, with long, short and tuskless bulls varying in frequency among different populations. Although the factors that maintain tusk variation in Asian elephants remain unclear, tusks are considered a secondary sexual characteristic probably influenced by sexual selection. In this study, we examined the relationship between tusk diversity, faecal testosterone metabolite (FTM) and personality in male Asian elephants aged 5-60 years living in semi-captive conditions within their native habitat in Myanmar. Males with different tusk types did not display differences in FTM levels or in scores for the three main personality factors, but there were some distinctions in the trait loadings within each factor: attentiveness, activity and dominance loaded more strongly for long-tusk males, while traits like obedience, slowness and aggression showed stronger associations in short-tusk males. Our study suggests that the differences between long- and short-tusk males in testosterone levels and personality traits were, respectively, negligible and nuanced, emphasizing the complexity of tusk expression and evolution in Asian elephants.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250490"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CardioFit: a WebGL-based tool for fast and efficient parametrization of cardiac action potential models to fit user-provided data. CardioFit：一个基于webgl的工具，用于快速有效地对心脏动作电位模型进行参数化，以适应用户提供的数据。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250048

Darby I Cairns, Maxfield Roth Comstock, Flavio H Fenton, Elizabeth M Cherry

{"title":"CardioFit: a WebGL-based tool for fast and efficient parametrization of cardiac action potential models to fit user-provided data.","authors":"Darby I Cairns, Maxfield Roth Comstock, Flavio H Fenton, Elizabeth M Cherry","doi":"10.1098/rsos.250048","DOIUrl":"10.1098/rsos.250048","url":null,"abstract":"Cardiac action potential models allow examination of a variety of cardiac dynamics, including how behaviour may change under specific interventions. To study a specific scenario, including patient-specific cases, model parameter sets must be found that accurately reproduce the dynamics of interest. To facilitate this complex and time-consuming process, we present CardioFit, an interactive browser-based tool that uses the particle swarm optimization (PSO) algorithm implemented in JavaScript and takes advantage of the WebGL API for hardware acceleration. Our tool allows rapid customization and can find low-error fittings to user-provided voltage time series or action potential duration data from multiple cycle lengths in a few iterations (10-32), corresponding to a runtime of a few seconds on most machines. Additionally, our tool focuses on ease of use and flexibility, providing a webpage interface that allows users to select a subset of parameters to fit, set the range of values each parameter is allowed to assume, and control the PSO algorithm hyperparameters. We demonstrate our tool's utility by fitting a variety of models to different datasets, showing how convergence is affected by model choice, dataset properties and PSO algorithmic settings, and explaining new insights gained about the physiological and dynamical roles of the model parameters.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250048"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Companion pigs alternate orientation between humans and snout-inaccessible targets. 同伴猪在人类和鼻子无法接近的目标之间交替定位。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.242178

Paula Pérez Fraga, Fanni Lehoczki, Attila Andics

{"title":"Companion pigs alternate orientation between humans and snout-inaccessible targets.","authors":"Paula Pérez Fraga, Fanni Lehoczki, Attila Andics","doi":"10.1098/rsos.242178","DOIUrl":"10.1098/rsos.242178","url":null,"abstract":"Previous research on intensely human-socialized pigs found no evidence for orientation alternations to direct human attention to an inaccessible target, the benchmark behaviour that in many other species has been reported to evidence capacity for functionally referential communication with humans. However, the unsolvable task paradigms that are typically used may mask communicative capacities by promoting manipulative behaviours in animals with strong independent problem-solving tendencies, like pigs. Here, using a novel out-of-reach paradigm that does not induce manipulative biases, we reassessed the capability of pigs for functionally referential communication with humans. We compared the emergence of orientation alternations between a human and an elevated, physically inaccessible target in adult companion pigs and dogs, a species characterized by more human-dependent problem-solving. We found that with these settings, pigs attempted to solve the task independently even less often than dogs and, similarly to dogs, pigs also exhibited orientation alternations. This is the first report demonstrating human-oriented functionally referential communicative behaviours in pigs, suggesting that this capacity may be more widespread across mammals than previously thought.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"242178"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tonkean macaques do not prefer the helper or the hinderer in the hill paradigm. 东京猕猴不喜欢山丘范式中的帮助者或阻碍者。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250488

Marie Hirel, Hélène Meunier, Hannes Rakoczy, Julia Fischer, Stefanie Keupp

{"title":"Tonkean macaques do not prefer the helper or the hinderer in the hill paradigm.","authors":"Marie Hirel, Hélène Meunier, Hannes Rakoczy, Julia Fischer, Stefanie Keupp","doi":"10.1098/rsos.250488","DOIUrl":"10.1098/rsos.250488","url":null,"abstract":"Evaluating others' prosocial tendencies can benefit individuals by allowing them to interact with prosocial individuals and avoid antisocial ones. The ontogeny of humans' strong prosocial preference has been widely investigated using the hill paradigm. Infants' preference for helper over hinderer agents was measured after they watched a scene in which the helper agent pushed a climber up a hill while the hinderer agent pushed the climber down the hill. Bonobos tested with the hill paradigm preferred the hinderer over the helper, contrasting previous findings for other nonhuman primates. In this study, we explored whether another primate species would exhibit a hinderer preference using the same procedure as the one used with bonobos. Tonkean macaques (Macaca tonkeana) did not prefer the helper over the hinderer (or vice versa). While the small sample size (n = 12) and low attentional level observed in our subjects limit interpretation, this finding contributes to a broader critical thinking on the relevance of the hill paradigm to investigate prosocial preferences and on methodological limitations when testing nonhuman animals. Studies using various experimental paradigms with conspecifics or human actors as social agents are needed to further investigate the social evaluation of prosocial behaviours in primates.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250488"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of biogenic silver particle synthesis for methylene blue degradation. 降解亚甲基蓝的生物源银颗粒合成优化。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250402

Gülçin Demirel Bayik, Busenur Baykal

{"title":"Optimization of biogenic silver particle synthesis for methylene blue degradation.","authors":"Gülçin Demirel Bayik, Busenur Baykal","doi":"10.1098/rsos.250402","DOIUrl":"10.1098/rsos.250402","url":null,"abstract":"This study presents an optimization of the sustainable synthesis of silver particles (AgPs) derived from hazelnut leaves employing a full factorial design. Four synthesis parameters were systematically evaluated at two levels: the water-to-leaf ratio (LW), extract-to-AgNO₃ ratio (EAg), AgNO₃ molarity (Mol), and plant leaf size (LS). Statistical analysis revealed that LW and the interaction between EAg and Mol are significant factors influencing the synthesis yield of AgPs. In contrast, Mol, LS and the EAg × Mol interaction were determined to be the key factors affecting the efficiency of dye degradation. The optimized AgPs demonstrated enhanced degradation kinetics, following a pseudo-second-order model (k 2 = 67 × 10⁻³ mg g⁻¹ min⁻¹, R² = 0.99) and fitting well with Langmuir-Hinshelwood kinetics (k app = 5.9 min⁻¹, R² = 0.88). Scanning electron microscopy with energy-dispersive X-ray (EDX) analysis and particle size analysis confirmed that AgPs optimized for dye degradation possessed smaller particle sizes and larger surface areas (0.201 m² g-1 versus 0.113 m² g-1), which contributed to improved catalytic performance. EDX analysis revealed a higher carbon and oxygen content in these AgPs, indicating the presence of surface functional groups that promote adsorption. Although the overall degradation efficiency of AgPs was slightly lower than that of certain other nanoparticle systems, their kinetic performance was comparable. This study emphasizes the critical role of synthesis optimization in enhancing catalytic activity and highlights AgPs as a promising eco-friendly catalyst for wastewater treatment applications.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250402"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring the common hamster's farmland habitat-how crop associations might benefit Cricetus cricetus hibernation and reproduction. 恢复普通仓鼠的农田栖息地——作物关联如何有利于仓鼠的冬眠和繁殖。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250499

Timothée Gérard, Hugo Chignec, Aurélie Saussais, Chantal Poteaux, Emilie Long, Jean-Patrice Robin, Sandrine Zahn, Caroline Habold

{"title":"Restoring the common hamster's farmland habitat-how crop associations might benefit Cricetus cricetus hibernation and reproduction.","authors":"Timothée Gérard, Hugo Chignec, Aurélie Saussais, Chantal Poteaux, Emilie Long, Jean-Patrice Robin, Sandrine Zahn, Caroline Habold","doi":"10.1098/rsos.250499","DOIUrl":"10.1098/rsos.250499","url":null,"abstract":"Biodiversity decline is particularly pronounced in agricultural areas, where intensive farming practices have severely altered the ecosystems. In Alsace (France), this has led to the decline of the common hamster (Cricetus cricetus), a farmland-inhabiting hibernator. Previous work in laboratory conditions showed that diversifying the hamsters' diet through crop association is a promising strategy to improve their hibernation and reproductive success. However, little is known about the effect of such crop associations in the wild. In this study, we monitored the hibernation behaviour (in laboratory cages) and reproductive success (in mesocosms) of hamsters exposed to four different crop associations of variable nutritional content, selected for their technical and economic benefits for farmers. Hamster hibernation behaviour depended mainly on the ingested energy and only marginally on the nutritional quality of the diet. Hamsters on lipid-rich diets showed a higher body mass before reproduction. All hamsters successfully reproduced in semi-natural conditions, even in wheat monoculture, where food supplements (weeds, invertebrates) prevented protein deficiencies. Associations richer in proteins and lipids such as legume-oleaginous crop mixes doubled reproductive outputs and increased pup growth. These results should help to improve hamster conservation measures and promote farmland biodiversity.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250499"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular flexibility of hyaluronic acid has a profound effect on invasion of cancer cells. 透明质酸的分子柔韧性对癌细胞的侵袭有深远的影响。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.251036

Uliana Bashtanova, Agne Kuraite, Rakesh Rajan, Melinda Duer

{"title":"Molecular flexibility of hyaluronic acid has a profound effect on invasion of cancer cells.","authors":"Uliana Bashtanova, Agne Kuraite, Rakesh Rajan, Melinda Duer","doi":"10.1098/rsos.251036","DOIUrl":"10.1098/rsos.251036","url":null,"abstract":"Extracellular hyaluronic acid (HA) has been shown to be important in cancer; low-molecular-weight HA typically correlates with cancer progression, high-molecular-weight HA with homeostasis. Here we show that even high-molecular-weight HA can induce cancer cell migration when it is highly diluted. HA-induced cell signalling is primarily through HA binding to the cell surface receptor, CD44. We show by NMR spectroscopy that at high dilution, high-molecular-weight HA molecules access the conformations needed for strong binding to CD44 on the tens of nanosecond time scale, the relevant time scale for induction of CD44 signalling. We further show that, by contrast, at higher concentrations, high-molecular-weight HA molecules have insufficient flexibility for strong CD44 binding. The high dilution HA condition correlates with profound changes in brain cancer cell morphology and proteome which supports cancer cell invasion. We hypothesize that the flexibility of HA molecules is central to HA-mediated cell signalling and that this concept can explain previous observations that the outcome of HA-mediated signalling depends on the HA molecular weight. HA dilution leading to stronger HA signalling may be important in understanding the role that oedema plays in cancer recurrence after primary surgery.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"251036"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures. 来自黄杆菌的PNGaseL靶向多种n -聚糖结构。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-27 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.251012

Cassie R Bakshani, Paulina A Urbanowicz, Conchi Badia Tortosa, Javier M Melo Diaz, Magdalena Kujawska, Taiwo O Ojuri, Lindsay J Hall, Daniel I R Spencer, David N Bolam, Lucy I Crouch

{"title":"PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures.","authors":"Cassie R Bakshani, Paulina A Urbanowicz, Conchi Badia Tortosa, Javier M Melo Diaz, Magdalena Kujawska, Taiwo O Ojuri, Lindsay J Hall, Daniel I R Spencer, David N Bolam, Lucy I Crouch","doi":"10.1098/rsos.251012","DOIUrl":"10.1098/rsos.251012","url":null,"abstract":"Peptide:N-glycosidases (PNGases) are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterized enzyme of this family and is widely used in glycobiology to allow study of the N-glycome of a specific protein, cell and tissues, for instance. Despite this, PNGaseF has limitations in the types of N-glycan structures it can target. In this study, we explored the specificities of six uncharacterized PNGases selected from diverse parts of the PNGaseF superfamily. One of these enzymes, PNGaseL from Flavobacterium akiainvivens, is the highlight of this study due to its very broad specificity, exemplified by its ability to cleave mammalian-, plant- and invertebrate-type complex N-glycans as well as high-mannose N-glycans. A detailed biochemical and structural characterization was carried out against a variety of substrates to illustrate the advanced capability of PNGaseL in comparison to the canonical PNGaseF and PNGaseA enzymes. To determine the optimal reaction conditions, assess stability and define limitations of PNGaseL, a series of validation studies were performed. The data reveal that PNGaseL has potential utility in a range of glycobiology applications that are superior to the current commercially available options.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"251012"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential benefits of adaptive control strategies are outweighed by costs of infrequent, but dramatically larger disease outbreaks. 适应性控制策略的潜在益处被不频繁但规模大得多的疾病暴发的成本所抵消。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-08-21 eCollection Date: 2025-08-01 DOI: 10.1098/rsos.250598

Samuel M Smith, Colleen T Webb, Stefan Sellman, Tom Lindström, Lindsay M Beck-Johnson

{"title":"Potential benefits of adaptive control strategies are outweighed by costs of infrequent, but dramatically larger disease outbreaks.","authors":"Samuel M Smith, Colleen T Webb, Stefan Sellman, Tom Lindström, Lindsay M Beck-Johnson","doi":"10.1098/rsos.250598","DOIUrl":"10.1098/rsos.250598","url":null,"abstract":"Understanding underlying transmission dynamics is necessary to effectively control an infectious disease outbreak. In the likely event that managers do not know where to target control resources because drivers of transmission are unknown, it may be desirable to tailor control strategies to a given outbreak by implementing control actions gradually in response to changes in the outbreak (adaptive) rather than all at once (fixed). Adaptive control strategies may also prevent over-reaction and thus causing unnecessary socioeconomic harm. However, it remains unclear whether the benefits of adaptive control strategies outweigh the potential of under-reacting and causing larger outbreaks. To weigh this trade-off, we used a validated national scale foot and mouth disease transmission model to compare how adaptive and fixed control strategies as well as various attributes of the control process affect outbreak size. We find that adaptive control strategies do not cost less for the vast majority of outbreaks, but infrequently result in much larger and more costly outbreaks owing to decision-making time and case reporting lags. This study emphasizes the cost of under-reacting to a disease outbreak and that minimizing decision-making time should be a key consideration when developing outbreak response guidelines.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 8","pages":"250598"},"PeriodicalIF":2.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0