New Phytologist最新文献

{"title":"Correction to ‘Receptor-like cytoplasmic kinase MdPBL34 phosphorylates melatonin biosynthetic enzyme MdSNAT5 to trigger disease resistance to apple Alternaria blotch’","authors":"","doi":"10.1111/nph.70610","DOIUrl":"https://doi.org/10.1111/nph.70610","url":null,"abstract":"<p><b>Tianci Yan, Zehui Hu, Tong Zhang, Ruoxue Li, Yixue Bai, Handong Song, Chanyu Wang, Changjian Dai, Qian Deng, Xin Liu, Silong Dong, Peiyun Xiao, Bingcan Lv, Hongpeng Zhao, Zhaoyang Zhou, Chao Yang, Baoxiu Qi, Jun Liu, Yan Guo, Jin Kong. 2025</b>. Receptor-like cytoplasmic kinase MdPBL34 phosphorylates melatonin biosynthetic enzyme MdSNAT5 to trigger disease resistance to apple Alternaria blotch. <i>New Phytologist</i> <b>248</b>: 193–210. doi: 10.1111/nph.70410.</p>\u0000<p>In this article, one of the grant numbers from the National Key Research &amp; Development Program of China was incorrect. The corrected Acknowledgements text is provided below.</p>\u0000<p>We apologise for this error.</p>\u0000<p><b>Corrected Acknowledgements section</b></p>\u0000<p>The work was supported by the National Key Research &amp; Development Program of China (2022YFF1003100; 2023YFD2301000-3), the National Natural Science Fund (32172540), Sanya Yazhou Bay Science and Technology City (SYND-2021-08), a Hainan Province Science and Technology Special Fund (ZDYF2021XDNY161), the 2115 Talent Development Program of China Agricultural University, and the 111 Project (B17043), and the Beijing Municipal Science and Technology Project (Z231100003723002).</p>","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"3 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYB46 integrates cuticle and cell wall remodeling to coordinate drought tolerance and pathogen resistance in Arabidopsis.","authors":"Shurong Jin,Yuyang Song,Yuxin Wang,Yanjun Guo,Shaopeng Fan,Qiaoqiao Gan,Na Luo,Yijie Fan,Yu Ni","doi":"10.1111/nph.70619","DOIUrl":"https://doi.org/10.1111/nph.70619","url":null,"abstract":"The plant cuticle and cell wall form a dynamic barrier against environmental stresses. While MYB46 is a known regulator of secondary cell wall biosynthesis, its role in cuticle formation and the interplay between these two structural barriers in stress responses remained unexplored. This study investigated whether MYB46 modulates cuticle biosynthesis and permeability, influencing drought tolerance and pathogen resistance in Arabidopsis. We generated MYB46 loss-of-function mutants (myb46-3, myb46-4) and overexpression lines. Cuticle permeability, cutin/wax compositions in stems and leaves, and associated gene expression profiles and direct transcriptional regulation by MYB46 were analyzed. MYB46 mutants exhibited reduced cutin/wax accumulation and increased cuticle permeability. This led to enhanced resistance to Botrytis cinerea via upregulation of defense-related genes (e.g. cell wall-bound peroxidases and PAD3) but resulted in decreased drought tolerance. Conversely, MYB46 overexpression reinforced cuticle integrity, increased cutin/wax accumulation, and improved drought tolerance without affecting disease susceptibility. MYB46 directly activated cuticle biosynthesis genes (LACS1, LACS2, KCS1, KCS19, CER1), linking it to cuticle regulation. These findings establish MYB46 as a dual regulator integrating cuticle and cell wall remodeling, balancing structural defense against pathogens with adaptive responses to drought. This highlights its pivotal role in coordinating stress adaptation mechanisms in Arabidopsis.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"28 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allelic variations and interactive feedback in major regulators of plant architecture confer high-altitude adaptation in Arabidopsis thaliana.","authors":"Han Zhang,Meng Liu,Shangling Lou,Yu Han,Bao Liu,Songyi Yang,Xiaoqin Feng,Landi Feng,Hao Lin,Yudan Zheng,Yan Song,Jin Yan,Jing Hou,Xuemeng Gao,Shaobo Gu,Yingjun Yao,Xiang Guo,Xuejing Liu,Ruyun Liang,Mengyun Guo,Jianquan Liu,Xiangdong Fu,Huanhuan Liu","doi":"10.1111/nph.70628","DOIUrl":"https://doi.org/10.1111/nph.70628","url":null,"abstract":"Ideal plant architectures are crucial for adapting to environmental changes, yet the molecular mechanisms behind high-altitude plant adaptations remain elusive. We characterized the dwarf and highly branched traits of the Tibet ecotype of Arabidopsis thaliana (L.) Heynh. Quantitative trait locus (QTL) analysis revealed that GA5 and BRC1, as major genes regulating plant height and branching, respectively, underlie the variation in plant architecture of the Tibet ecotype. Loss-of-function of GA5 disrupts gibberellin biosynthesis, leading to dwarfism, and natural variations in the BRC1 promoter reduce its expression, promoting branching. A positive feedback loop formed by GA5 and BRC1 via the DELLA-SPL9 module balances plant height and branching. Additionally, alleles of GA5 and BRC1 exhibit contrasting sensitivity to UV-B radiation and low temperatures, suggesting that they have experienced strong ecological selections at high altitudes. Our findings reveal that GA5 and BRC1 form a feedback regulatory module that coordinately regulates the balance between plant height and branching, thereby governing developmental adaptation to high-altitude environments.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"17 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clathrin-mediated endocytosis regulates root endodermal suberization via ROS.","authors":"Javier Martinez Pacheco,Wolfgang Busch","doi":"10.1111/nph.70614","DOIUrl":"https://doi.org/10.1111/nph.70614","url":null,"abstract":"Endomembrane trafficking (ET) plays a crucial role in plant adaptation to environmental stresses, yet its involvement in endodermal root suberization remains poorly understood. Here, we show that disruption of clathrin-mediated endocytosis (CME) or canonical exocytosis led to an ectopic suberin deposition in the Arabidopsis root endodermis toward the root tip. Genetic disruption of endocytosis phenocopied the effects of the CME inhibitor ES9-17, while genetic disruption of clathrin-independent endocytosis led to reduced suberization, suggesting distinct, pathway-specific roles in regulating suberin deposition. Ectopic suberization upon CME inhibition required the CIFs-SGN3-SGN1-RBOHF/D signaling axis, independent of abscisic acid. Notably, CME disruption led to the accumulation of RBOHF in the plasma membrane, driving NADPH oxidase-dependent H2O2 accumulation in the endodermis. Scavenging H2O2 or inhibiting NADPH oxidases abolished ET disruption-induced suberization, while exogenous H2O2 promoted it. Conversely, peroxidase activity inhibition reduced basal suberization but failed to suppress ET disruption-induced enhanced suberization, implicating reactive oxygen species (ROS) as a dominant driver. Our findings reveal a dual ET regulatory mechanism: exocytosis inhibition leads to suberization independently of known pathways, while CME impairment acts via RBOHF-mediated ROS to increase suberization on the endodermis. This study reveals that ET can control endodermal root suberization in Arabidopsis, linking membrane trafficking to apoplastic barrier formation through reactive oxygen species.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"99 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mid-SUN-POD1 complex ensures the structural integrity of ER bodies required for herbivore defense in Arabidopsis.","authors":"Fumika Ikeda,Taku Ohtsubo,Shitomi Nakagawa,Toshiyuki Suzuki,Noriyuki Miyoshi,Emmanuel Vanrobays,Christophe Tatout,Tomoo Shimada,Kentaro Tamura","doi":"10.1111/nph.70613","DOIUrl":"https://doi.org/10.1111/nph.70613","url":null,"abstract":"Specialized endoplasmic reticulum (ER) bodies in Brassicaceae plants facilitate defense against herbivores by storing β-glucosidases that activate toxic compounds upon tissue damage. The mechanisms ensuring the structural integrity and enzymatic activities of the ER body are unknown. In this study, we investigated the role of the mid-SUN-POD1 complex in ER-body function. Using Arabidopsis thaliana sun3 sun4 sun5 triple mutants and POLLEN DEFECTIVE IN GUIDANCE1 (POD1)-knockdown lines, we examined ER-body morphology through confocal microscopy, assessed glucosinolate degradation via LC-MS, and evaluated herbivore resistance through woodlice (Armadillidium vulgare) feeding assays. Both sun3 sun4 sun5 and POD1-knockdown plants exhibited fragmented ER bodies, constitutive ER stress, and increased susceptibility to herbivores, despite normal accumulation of ER-body proteins. The defects in ER-body morphology directly impaired the defense function of these structures rather than affecting protein abundance. The mid-SUN-POD1 complex is critical for ER-body morphogenesis and antiherbivore defense in Arabidopsis. Our findings demonstrate how this conserved ER membrane regulatory system contributes to the function of specialized ER-derived organelles and their role in plant defense.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"69 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nectar, the original cocktail: an introduction to a Virtual Issue","authors":"Yan Gong,&nbsp;Elena M. Kramer,&nbsp;Irene T. Liao,&nbsp;Rahul Roy","doi":"10.1111/nph.70585","DOIUrl":"https://doi.org/10.1111/nph.70585","url":null,"abstract":"&lt;p&gt;The interaction between flowering plants (angiosperms) and their animal pollinators is one of the most studied mutualisms between animals and plants. In both ancient Greece and Chinese culture, nectar is referenced as divine and heavenly blessed. In Homer's &lt;i&gt;Iliad&lt;/i&gt;, nectar is described as the drink of the gods and, similarly, in ancient Chinese folklore, 甘露 (gān lù, literally ‘sweet dew’) is believed to be a heavenly elixir with the power to grant immortality. While these references likely do not refer to floral nectar as we understand it today, they underscore the cultural significance historically attributed to nectar-like substances.&lt;/p&gt;&lt;p&gt;Entering the modern scientific era, Charles Darwin, fascinated by what he called the ‘abominable mystery’ of the prolific evolution of flowering plants, suggested that nectar and nectaries evolved as adaptations to attract pollinators for outcrossing. He famously predicted the existence of a long-tongued moth capable of reaching nectar in the extended floral spur of &lt;i&gt;Angraecum sesquipedale&lt;/i&gt; (Darwin, &lt;span&gt;1877&lt;/span&gt;), which was later confirmed by the discovery of &lt;i&gt;Xanthopan morganii praedicta&lt;/i&gt; (Nilsson, &lt;span&gt;1988&lt;/span&gt;; Wasserthal, &lt;span&gt;1997&lt;/span&gt;). Building on Darwin's insights, subsequent botanical characterization has extensively documented and examined the structures of nectaries while ecological studies have examined the functions of nectar in nearly all major taxa of angiosperms with great detail (Bernardello, &lt;span&gt;2007&lt;/span&gt;; Nicolson &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2007&lt;/span&gt;; Erbar, &lt;span&gt;2014&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;Despite the widespread occurrence of nectar secretion and the remarkable structural diversity of nectaries among flowering plants, little is known about the ecological significance of each of the nectar components, and molecular and genetic studies of nectary biology have been limited to a few model species, including &lt;i&gt;Arabidopsis&lt;/i&gt;, &lt;i&gt;Nicotiana&lt;/i&gt;, &lt;i&gt;Petunia&lt;/i&gt;, &lt;i&gt;Cucurbita&lt;/i&gt;, and &lt;i&gt;Gossypium&lt;/i&gt; (Bowman &amp; Smyth, &lt;span&gt;1999&lt;/span&gt;; Ren &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2007&lt;/span&gt;; Kram &amp; Carter, &lt;span&gt;2009&lt;/span&gt;; Liu &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2009&lt;/span&gt;; Morel &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2018&lt;/span&gt;; Solhaug &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2019&lt;/span&gt;; Hu &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2020&lt;/span&gt;; Chatt &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2021&lt;/span&gt;). Studies using these genetic models have uncovered key regulators of nectary development, major processing genes of nectar sugar, and detailed chemical compositions of nectar (Bowman &amp; Smyth, &lt;span&gt;1999&lt;/span&gt;; Kram &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2009&lt;/span&gt;; Ruhlmann &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2010&lt;/span&gt;; Lin &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2014&lt;/span&gt;; Morel &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2018&lt;/span&gt;; Hu &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2020&lt;/span&gt;; Pei &lt;i&gt;et al&lt;/i&gt;., &lt;span&gt;2021&lt;/span&gt;). Yet, many fundamental questions remain unanswered. Is nectary development in independently evolved nectaries regulated by the same genetic networks? How is diversity in nectar composition generated and governed across taxa? Wh","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"248 3","pages":"1101-1104"},"PeriodicalIF":8.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nph.onlinelibrary.wiley.com/doi/epdf/10.1111/nph.70585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could photoperiodic responses have evolved before the emergence of circadian clocks?","authors":"Maria Luísa Jabbur,Carl Hirschie Johnson","doi":"10.1111/nph.70598","DOIUrl":"https://doi.org/10.1111/nph.70598","url":null,"abstract":"Plants use photoperiod (i.e. day length) as a seasonal cue for timing when to flower. This ability, known as photoperiodism, also underlies phenomena such as migration, seasonal reproduction, and hibernation in animals. Because a circadian (daily) clock underlies the day/night length timing mechanism in most organisms, it has been generally assumed that circadian rhythms evolved before the ability to measure the photoperiod. Our recent discovery that adaptive photoperiodic responses extend as far back as bacteria, with cyanobacteria showing a photoperiodic response remarkably similar to those of eukaryotes, has led us to question this assumption. In this Tansley insight, we put forward a new hypothesis for how photoperiodism might have evolved which is based on the evolutionary implications of bacteria being capable of photoperiodic responses.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"114 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A jasmonate-mediated MAPK cascade regulates rice structural defense against brown planthoppers.","authors":"Siwen Wu,Yumeng Chen,Yingjie Gan,Lanlan Wang,Xinjue Wang,Gaochen Jin,Lei-Lei Li,Jing Lu,Yonggen Lou,Juan Xu,Ran Li","doi":"10.1111/nph.70612","DOIUrl":"https://doi.org/10.1111/nph.70612","url":null,"abstract":"Mitogen-activated protein kinase (MAPK) cascades are multi-step signaling pathways that enable plants to respond to diverse environmental challenges. However, the precise mechanisms and components of MAPK cascades involved in defense responses against herbivores remain poorly understood. Here, we studied the biological function and regulatory mechanism of a herbivore-elicited MAPK cascade by transcriptional activation assays, genetic analysis, protein-protein interaction assays, comparative transcriptome analysis, and chemical quantification. We identified three tandemly arrayed MAPK kinase kinase (MKKK) genes (MKKK55, MKKK62, and MKKK70) on rice Chromosome 1, upregulated in response to brown planthopper (BPH) infestation. These genes are transcriptionally regulated by MYC2, the core regulator of jasmonate (JA) signaling in rice. These MKKKs, together with MKK3 and MPK7/14, form a MAPK cascade that mediates rice responses to herbivore attack. Mutations in any component genes increase rice susceptibility to BPH infestation. Mechanistically, this MAPK signaling cascade enhances physical defenses in rice by increasing cellulose deposition in sclerenchyma cell walls through the regulation of cellulose synthase genes. This study highlights the role of the MYC2-MKKK55/62/70-MKK3-MPK7/14 module in mediating a sector of JA-dependent rice defense against herbivores.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"65 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actin filaments drive spindle positioning in Arabidopsis meiosis II.","authors":"Yingrui Ma,Hua Jiang","doi":"10.1111/nph.70625","DOIUrl":"https://doi.org/10.1111/nph.70625","url":null,"abstract":"","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"100 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size-related decline in dryland shrubs is related to reductions in hydraulic efficiency and carbon assimilation and not nonstructural carbohydrate depletion.","authors":"Hongxia Zhang,Kevin R Hultine,Xinrong Li,Jianqiang Huo,Jingyao Sun,Nate G McDowell","doi":"10.1111/nph.70615","DOIUrl":"https://doi.org/10.1111/nph.70615","url":null,"abstract":"Plant growth and survival are fundamentally constrained by water transport from roots to leaves, impacting carbon assimilation and associated labile carbon pools. However, physiological constraints on growth and survival vary with plant age, due to changes in metabolic sinks and increases in hydraulic path length from rhizosphere to canopy. We investigated crown dieback, growth, hydraulics, carbon assimilation and nonstructural carbohydrate (NSC) storage in relation to increasing basal diameter of two dominant shrub species (Caragana korshinskii and Artemisia ordosica) at the southeastern edge of the Tengger Desert, China. The aim was to identify mechanisms of decreased performance with plant size in dryland shrubs. Clear contrasts in stomatal regulation of leaf water potentials were detected between species. Despite these contrasts, radial growth, hydraulic transport efficiency (Ks), and carbon assimilation similarly declined in both species with increasing plant size, while NSC reserves remained unchanged. Xylem embolism (percentage loss of conductivity) increased with plant size, resulting in significant reductions in carbon assimilation in both species. Results indicate that hydraulic and potentially carbon assimilation constraints, rather than NSC depletion, govern growth-related dryland shrub decline. These findings improve our understanding of how population demography impacts dryland forest response to climate change.","PeriodicalId":214,"journal":{"name":"New Phytologist","volume":"1 1","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}