Saudi Medical Journal最新文献_第2页

Estimating Radiation Dose and Proposing Institutional Diagnostic Reference Levels for Paediatric Fluoroscopy of Micturating Cystourethrogram: Age- and Weight - Specific Comparisons. 估计放射剂量和建议机构诊断参考水平的儿科透视排尿膀胱输尿管图：年龄和体重特异性比较。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-10-01 Epub Date: 2026-09-10 DOI: 10.15537/1658-3175.8852

Khalid M Aloufi

{"title":"Estimating Radiation Dose and Proposing Institutional Diagnostic Reference Levels for Paediatric Fluoroscopy of Micturating Cystourethrogram: Age- and Weight - Specific Comparisons.","authors":"Khalid M Aloufi","doi":"10.15537/1658-3175.8852","DOIUrl":"10.15537/1658-3175.8852","url":null,"abstract":"Objective: To compare age- and weight-specific methods used to estimate radiation doses and to propose institutional diagnostic reference levels (DRLs) for paediatric fluoroscopy of micturating cystourethrogram (MCUG).Methods: In this retrospective study, MCUG fluoroscopy parameters were gathered for 100 paediatric patients from July 2025 to January 2026. The data included the MCUG paediatric procedures for patients aged 0-15 years. The data were categorized into paediatric weight- and age-specific groups. Paediatric weight-specific groups were ≤ 5, 5 < - 10, 10 < - 20, and >20 kg, and paediatric age-specific groups were ≤ 1, 1 < - 5, 5 < - 10, and < 10 - 15 years old.Results: Differences were observed in dose area product (DAP) and DRL results for age- and weight-specific methods, especially for paediatric age groups of 1 < - 5 and 5< - 10 years old compared with paediatric weight groups of 5 < -10 kg and 10 < - 20 kg (p = 0.037 and 0.035). The proposed institutional DRLs for the MCUG fluoroscopy were 22.1, 63, 169, and 457 μGyċm2 for paediatric weight groups of ≤ 5, 5 < - 10, 10 < - 20, and >20 kg. The estimated effective doses reached 0.81, 2.18, 2.08, and 2.5 mSv.Conclusion: The paediatric weight-specific method shows realistic and lower DAP and DRL values. The results of DRLs for the MCUG fluoroscopy were acceptable when compared with literature results.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 10","pages":"1634-1639"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings. 中枢性性性早熟女孩的头颅MRI：临床特征和异常结果的预测因素。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-10-01 Epub Date: 2026-09-10 DOI: 10.15537/1658-3175.8855

Fahad N Al Juraibah, Mashael M Alharbi, Reem D Alharbi, Joud S Albaraki, Sarah S AlDharman, Hala A Alghamdi, Nagarajkumar Yenugadhati, Abdullah I Alhammad, Angham N Almutair, Ibrahim A Al Alwan

{"title":"Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings.","authors":"Fahad N Al Juraibah, Mashael M Alharbi, Reem D Alharbi, Joud S Albaraki, Sarah S AlDharman, Hala A Alghamdi, Nagarajkumar Yenugadhati, Abdullah I Alhammad, Angham N Almutair, Ibrahim A Al Alwan","doi":"10.15537/1658-3175.8855","DOIUrl":"10.15537/1658-3175.8855","url":null,"abstract":"Objectives: To describe the clinical profile of girls with central precocious puberty (CPP) and determine the factors associated with abnormal cranial magnetic resonance imaging (MRI) findings.Methods: This retrospective study included girls aged 8 years or younger with a diagnosis of CPP who received care at King Abdullah Specialized Children's Hospital in Riyadh, Kingdom of Saudi Arabia, between 2015 and 2023. Data on clinical presentation, biochemical results, imaging findings, and treatment were obtained from medical records. Logistic regression analysis was performed to determine variables associated with MRI utilization and the occurrence of abnormal MRI findings.Results: The cohort comprised 70 girls with CPP. The median age at breast development was 7.12 years, and pubertal onset occurred at ≥6 years in 84.3% of patients. Cranial MRI was obtained in 43 patients (61.4%), and abnormal findings were identified in 17 patients (24.3%). Pituitary gland enlargement (n = 6) and hypothalamic hamartoma (n = 4) were the most frequent abnormalities. Girls with a bone age-to-chronological age ratio <1 year had lower odds of undergoing MRI (OR = 0.18, p-value = 0.009). Higher BMI z-scores were independently associated with abnormal MRI findings (OR = 1.95, p-value = 0.043). Other clinical and biochemical variables were not significantly associated with abnormal MRI results. GnRH analogue therapy was initiated in 81.4% of patients.Conclusion: Abnormal cranial MRI findings were identified in nearly one-quarter of girls with CPP. Higher BMI z-scores were associated with abnormal MRI findings, whereas age at puberty onset and other clinical variables did not reliably predict intracranial abnormalities.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 10","pages":"1657-1664"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender Differences in Primary Care Utilization and Determinants of General Practitioner Visits Among Saudi Females: A Cross-Sectional Analysis Using World Health Survey in the Kingdom of Saudi Arabia 2019. 沙特女性初级保健利用的性别差异和全科医生就诊的决定因素：2019年沙特阿拉伯王国世界卫生调查的横断面分析

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8843

Ali M Alzahrani, Holly C Felix, Abdulrhman A Alzhrani

{"title":"Gender Differences in Primary Care Utilization and Determinants of General Practitioner Visits Among Saudi Females: A Cross-Sectional Analysis Using World Health Survey in the Kingdom of Saudi Arabia 2019.","authors":"Ali M Alzahrani, Holly C Felix, Abdulrhman A Alzhrani","doi":"10.15537/1658-3175.8843","DOIUrl":"10.15537/1658-3175.8843","url":null,"abstract":"Objective: To document the number of visits Saudi adults have with general practitioners (GP) or family medicine doctors (FD), determine if there is an association between GP/FD visits and sex, and then identify factors associated with GP/FD visits among Saudi females.Methods: A cross-sectional analysis was conducted using data from the 2019 World Health Survey in the Kingdom of Saudi Arabia (KSAWHS 2019), a nationally representative household survey. The outcome variable was number of visits to GP/FD. Survey-weighted negative binomial regression was applied.Results: From April to July 2019, 8,912 individuals participated in the KSAWHS 2019 individual questionnaire, of whom 7,677 were Saudi nationals aged 15 years and older, had completed responses and were included in this study. Females had more GP visits than males (incidence rate ratio [IRR] = 1.26; 95% confidence interval [CI] 1.06-1.49). Among females, higher use associated with having access to a private car (IRR 3.87, 95% CI 3.20-4.68, p < 0.001), living in rural areas (IRR 1.30, 95% CI 1.08-1.57, p = 0.005), being currently married (IRR 1.58, 95% CI 1.17-2.13, p = 0.003), and being separated/divorced/widowed (IRR 2.11, 95% CI 1.44-3.07, p < 0.001).Conclusion: These nationally representative findings provide a baseline for monitoring future trends and evaluating health-system reforms.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1524-1529"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Chimeric Antigen Receptor Regulatory T Cells in Promoting Immune Tolerance in Solid Organ Transplantation: Mechanisms and Therapeutic Potential. 嵌合抗原受体调节性T细胞在促进实体器官移植免疫耐受中的作用：机制和治疗潜力。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8836

Maher S Alwethaynani

{"title":"The Role of Chimeric Antigen Receptor Regulatory T Cells in Promoting Immune Tolerance in Solid Organ Transplantation: Mechanisms and Therapeutic Potential.","authors":"Maher S Alwethaynani","doi":"10.15537/1658-3175.8836","DOIUrl":"10.15537/1658-3175.8836","url":null,"abstract":"Solid organ transplantation (SOT) is a life-saving procedure for patients with end-stage organ failure; however, lifelong immunosuppressant use is needed to prevent allograft rejection. These drugs increase the risk of non-Hodgkin lymphoma, liver, kidney, and lung cancers, and heighten susceptibility to oncogenic viruses, including hepatitis B and Epstein-Barr virus. The usage of chimeric antigen receptor (CAR) regulatory T (Treg) cells is a promising approach to induce transplant tolerance while minimizing dependence on immunosuppressants. The CAR Tregs offer the potential to enhance graft survival and quality of life by reducing immunosuppressant-related morbidity and mortality. Despite remarkable progress in transplantation tolerance, challenges remain owing to a limited understanding of Treg biology and technical barriers. This review discusses the implications of immunosuppression, CAR and CAR Treg biology, mechanisms of Treg-mediated tolerance, CAR Treg manufacturing, clinical trials, optimization strategies, and existing challenges and future directions for CAR Treg-based therapies in SOT.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1460-1473"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Al-Bahah Paradox: Divergent Patterns of Increased and Decreased Infectious Disease Incidence Relative to National Saudi Rates Over 12 Years of Surveillance. Al-Bahah悖论：在12年的监测中，与沙特国家发病率相比，传染病发病率增加和减少的不同模式。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8840

Mohammed A A Alqumber

{"title":"The Al-Bahah Paradox: Divergent Patterns of Increased and Decreased Infectious Disease Incidence Relative to National Saudi Rates Over 12 Years of Surveillance.","authors":"Mohammed A A Alqumber","doi":"10.15537/1658-3175.8840","DOIUrl":"10.15537/1658-3175.8840","url":null,"abstract":"Objective: To identify statistically significant deviations in notifiable infectious disease incidence between Al-Bahah region and national Saudi averages, and to generate hypotheses that may inform future epidemiological, microbiological, and public health investigations.Methods: In April 2026, a 12-year retrospective ecological study (2013-2024) was conducted using surveillance data from the Saudi Ministry of Health for 37 notifiable infectious diseases across 20 health regions. Cumulative incidence rates, standardized morbidity ratios (SMRs), and Z-tests compared observed cases in Al-Bahah against national estimates.Results: Overall incidence was 15.8% lower in Al-Bahah than nationally (86.42 versus 102.68; incidence rate ratios = 0.842; p = 1.6×10-31), but this aggregate reduction concealed a bidirectional divergence. Reduction anomalies: dengue fever absent; amoebic dysentery reduced by 95%; measles by 76%; malaria by 60%. Excess anomalies: schistosomiasis increased 713%; pneumococcal meningitis 600%; Salmonella food poisoning 232%; brucellosis 73%. A 2021 Salmonella outbreak reached 155.95/100,000 (>20-fold national peak).Conclusion: Al-Bahah exhibited lower incidence of diseases including vector-borne and fecal-oral diseases but higher incidence of several other diseases like zoonotic, foodborne, and freshwater-associated infections relative to national rates. These ecological observations generate hypotheses regarding regional differences in disease transmission, diagnosis, surveillance, and healthcare utilization that warrant further investigation using individual-level data. If confirmed, such findings may have implications for region-specific public health planning, laboratory preparedness, and clinical decision-making.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1495-1505"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental Dysplasia of the Hip in Saudi Arabia and the Gulf Countries: A Genetic Systematic Review Study. 沙特阿拉伯和海湾国家髋关节发育不良：一项遗传系统综述研究。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8834

Naif Z Alrashdi, Ahmed M Almansour, Azfar Jamal

{"title":"Developmental Dysplasia of the Hip in Saudi Arabia and the Gulf Countries: A Genetic Systematic Review Study.","authors":"Naif Z Alrashdi, Ahmed M Almansour, Azfar Jamal","doi":"10.15537/1658-3175.8834","DOIUrl":"10.15537/1658-3175.8834","url":null,"abstract":"Objective: To describe the available research on genetic determinants with special emphasis on the developmental dysplasia of the hip (DDH), in Saudi Arabia and Gulf nations, with reference to the genetic variants, family trend, and environmental factors.Methods: The literature search was conducted in PubMed, Embase, Scopus, Web of Science, and the Saudi Digital Library and Google Scholar through a broad literature search since the beginning of the databases until 2023. Studies that conducted in Saudi Arabia or Gulf countries which evaluated the relationships of genetic factors in DDH were included. Case reports, conference abstracts, and studies that did not evaluate genetic variables and reviews were removed. Due to differences in study design and genetic methods, the data were extracted and summarized qualitatively.Results: The total 473 articles were retrieved from the search data base in which 11 articles were selected for this study. The findings indicated correlations between DDH, and various genes participated in the formation of skeleton and cartilage. Different studies reported rare variants in HSPG2 and ATP2B4, as well as polymorphisms in growth/differentiation factor 5. Several studies also demonstrated a high degree of familial clustering, female dominance, and a potential effect of consanguinity. Genetic susceptibility appears to interact with environmental and cultural factors, such as swaddling practices and delivery-related conditions.Conclusion: The etiology of DDH in Saudi and Gulf populations seems to be multifactorial with both environmental and genetic predisposition factors. There should be bigger genomic studies to further identify population-specific risk factors and aid early detection and prevention measures in the area.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1434-1444"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Translational Medical Research Progress in G20 Countries: 5-Year Study. 探索G20国家转化医学研究进展：5年研究

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8833

Hana A Alhumud, Fars K Alanazi, Edward B DeVol

{"title":"Exploring Translational Medical Research Progress in G20 Countries: 5-Year Study.","authors":"Hana A Alhumud, Fars K Alanazi, Edward B DeVol","doi":"10.15537/1658-3175.8833","DOIUrl":"10.15537/1658-3175.8833","url":null,"abstract":"Objectives: Biomedical research is crucial for advancing medical knowledge and improving public health. However, the research process is often disjointed and lacks seamless progression, leading to delays and missed opportunities. To address this, the concept of translational research has emerged, focusing on the smooth transition of research results to the next stage of inquiry.Methods: This study analyzed approximately 40,000 research publications from the Web of Science database to identify research activities associated with translational research. Publications from Group of 20 (G20) countries over the past 5 years were examined to explore patterns of research focus and progress in this field.Results: There is no universal formula for successful translational research across G20 countries. What works in one country may not yield the same results in another, as factors contributing to success vary significantly among nations. Each country's unique history of success and failure influences its translational research outcomes.Conclusion: The study highlights the importance of collaboration and global research efforts in improving predictability and outcomes in translational research. By drawing on diverse perspectives and experiences, the potential for success in specific research activities is expected to increase. Overall, the study emphasizes the need for a more connected and coordinated approach to biomedical research to enhance its impact on health improvement.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1423-1433"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis on the effect of Tai Chi Chuan on Human Biomechanics and Health from (2021-2025). 2021-2025年太极拳对人体生物力学和健康影响的meta分析

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8835

Bijad S Alqahtani, Husam A Almalki

{"title":"Meta-Analysis on the effect of Tai Chi Chuan on Human Biomechanics and Health from (2021-2025).","authors":"Bijad S Alqahtani, Husam A Almalki","doi":"10.15537/1658-3175.8835","DOIUrl":"10.15537/1658-3175.8835","url":null,"abstract":"Objective: Prior reviews emphasize overall health outcomes of Tai Chi Chuan (TCC) but rarely resolve the biomechanical intermediates (such as Center of Mass (CoM)-Center of Pressure (CoP) control, joint loading) that link practice to clinical function-knowledge that matters for balance, fall risk, and osteoarthritic knee load management. This systematic review and meta-analysis aim to test the null hypothesis that TCC produces no improvement versus comparators in (i) biomechanical stability indices (mediolateral/anterior-posterior CoM-CoP separation; COP Root Mean Square RMS) and (ii) related clinical functions (such as Time up and go (TUG), Berg balance scale (BBS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); alternative hypothesis: TCC improves these outcomes.Methods: Eligible designs were randomized trials, non-randomized interventions (pre-post/controlled before-after), analytical cross-sectional comparisons (including repeated-measures and expert-novice contrasts), and finite-element analyses only when driven by in-study human kinematics/kinetics; timeframe 2021-2025; humans only.Results: Outcomes were continuous; therefore, pooled effects are reported as SMD (95% CI, p). Peak mediolateral CoM-CoP separation: SMD = 0.16 (-1.12 to 1.45), p = 0.80. Peak anteroposterior CoM-CoP separation: SMD = 0.33 (-0.65 to 1.31), p = 0.505. Mediolateral COP RMS in single-leg tasks: SMD = -1.60 (-4.16 to 0.96), p = 0.22.Conclusion: Across the included studies, Tai Chi Chuan demonstrated favourable trends in balance control and joint loading under structured programs, with concurrent reductions in select clinical endpoints.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1445-1459"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Case for Gulf Region-Specific Peripheral Artery Disease Trials: A Comprehensive Literature Review. 海湾地区特异性外周动脉疾病试验案例：综合文献综述

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8837

Hosaam H Nasr, Faisal A Almudaiheem

引用次数: 0

Comparison of the Effects of Spinal Versus General Anesthesia on the Perioperative Intraocular Pressure: A prospective, randomized clinical trial. 脊柱麻醉与全身麻醉对围手术期眼压影响的比较：一项前瞻性、随机临床试验。

IF 2.1 4区医学

Saudi Medical Journal Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.15537/1658-3175.8815

Muzaffer Gencer, Mehmet Yalvaç

{"title":"Comparison of the Effects of Spinal Versus General Anesthesia on the Perioperative Intraocular Pressure: A prospective, randomized clinical trial.","authors":"Muzaffer Gencer, Mehmet Yalvaç","doi":"10.15537/1658-3175.8815","DOIUrl":"10.15537/1658-3175.8815","url":null,"abstract":"Objectives: To evaluate the effects of spinal and general anesthesia on the intraocular pressure (IOP) in patients, who had lumbar spine and lower extremity orthopedic surgeries.Methods: Sixty adult were randomly classified into Group spinal anesthesia (SA) and Group general anesthesia (GA). The IOP, mean systemic arterial pressure, and heart rhythm were measured at 6 pre-determined timepoints (T0: Baseline, T1: Before spinal procedure or anesthesia induction, T2: After injection with intrathecal or anesthesia induction, T3: 5th minutes (min) after spinal procedure or tracheal intubation, T4: 30th min intraoperative, T5: At the end of surgery, T6: 5th min after surgery or tracheal extubation in the operation room.Results: The baseline IOP and IOP1 measurements during were not significantly different between the groups (SA = 14.28 ± 0.8 mmHg; GA = 14.62 ± 0.9 mmHg, p = 0.923; and IOP1: SA = 15.83 ± 0.9 mmHg; GA = 15.88 ± 0.9 mmHg, p = 0.929). The most significant decrease in IOP in both groups was recorded at T2 (SA: 12.37 ± 0.6. GA: 12.24 ± 0.4, p < 0.001). The decrease in IOP2 was more significant in the GA group. The IOP3 was significantly higher in GA group after intubation (GA: 19.82 ± 1.2, SA: 12.86 ± 1.0)(p < 0.05). The IOP4 and IOP5 in the SA group were lower than those in the GA group. The IOP6 in both groups was higher (SA: 15.20 ± 0.8, GA: 16.50 ± 1.0) than the baseline IOP values, albeit not significant (p > 0.05). In prone position, IOP at the T4 and T5 timepoints were significantly higher than the initial values in both the SA and the GA groups; however, the increase in the GA group was more higher than that of the SA group.Conclusion: In intraoperative period, intraocular pressure may increase in both management of anesthesia, but this increase is higher in the general anesthesia group.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 9","pages":"1549-1557"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0