Saudi Medical Journal最新文献_第2页

Rate of glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia at a private tertiary centre. 一家私立三级医疗中心新生儿间接高胆红素血症中葡萄糖-6-磷酸脱氢酶缺乏症的发病率。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01 DOI: 10.15537/smj.2024.45.10.20240524

Hussain M Alhiwaishil, Mohammed A Alghareeb, Ammar S Alkhars, Taha H Abdalla, Abdulhadi A Almohsen, Abbas Al Mutair

{"title":"Rate of glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia at a private tertiary centre.","authors":"Hussain M Alhiwaishil, Mohammed A Alghareeb, Ammar S Alkhars, Taha H Abdalla, Abdulhadi A Almohsen, Abbas Al Mutair","doi":"10.15537/smj.2024.45.10.20240524","DOIUrl":"10.15537/smj.2024.45.10.20240524","url":null,"abstract":"Objectives: To investigate the rate of hospitalized neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency presented with indirect hyperbilirubinemia at a private tertiary center in Al-Ahsa, Saudi Arabia, over 4 years and to compare the characteristics of G6PD-deficient and normal neonates admitted for indirect hyperbilirubinemia.Methods: The retrospective case control study was carried out at Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia. Data were collected from Yassasi Medical System from 2018-2021 and finalized in 2024. The study included 2 groups: G6PD-normal and G6PD-deficient neonates with indirect hyperbilirubinemia not having recognizable triggers of hemolysis. The analysis focused on serum bilirubin levels, direct bilirubin levels, hematocrit levels, hemoglobin levels, reticulocyte percentage, G6PD levels, duration of phototherapy, and the need for exchange transfusion.Results: The study enrolled 3200 neonates with hyperbilirubinemia, of whom 274 met inclusion criteria. A total of 103 (37.6%) neonates were G6PD-deficient, with 77 (74.8%) being male and 26 (25.2%) female. Glucose-6-phosphate dehydrogenase-deficient neonates exhibited significantly higher initial total bilirubin levels and earlier sampling times. There was no significant correlation between G6PD deficiency and hematocrit or hemoglobin levels in hyperbilirubinemic neonates, but 4 neonates required exchange transfusion, demonstrating statistical significance (p=0.009).Conclusion: High rate of G6PD deficiency in neonates with indirect hyperbilirubinemia, requiring close monitoring to prevent exchange transfusions, with no significant differences in hematocrit or hemoglobin levels.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fourteen African countries, key partners unite to provide critical resources for health in WHO's first-ever investment round. 十四个非洲国家和主要合作伙伴联合起来，在世卫组织有史以来的第一轮投资中为卫生事业提供重要资源。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01

引用次数: 0

Global strategic preparedness and response plan launched by WHO to contain mpox outbreak. 世卫组织启动全球战略准备和应对计划，遏制麻风疫情爆发。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01

引用次数: 0

CAR T-cell therapy in acute myeloid leukemia. 急性髓性白血病的 CAR T 细胞疗法。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01 DOI: 10.15537/smj.2024.45.10.20240330

Alhomidi Almotiri

引用次数: 0

Impact of high-order repeat cesarean deliveries on early maternal complications among major placenta previa patients in Southern Saudi Arabia. 沙特阿拉伯南部重大前置胎盘患者高位重复剖宫产对早期产妇并发症的影响。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01 DOI: 10.15537/smj.2024.45.10.20240329

Ayman H Shaamash, Mehad H AlQasem, Ahmed A Mahfouz, Deama S Al Ghamdi, Norah I Almanie, Mamdoh A Eskandar

{"title":"Impact of high-order repeat cesarean deliveries on early maternal complications among major placenta previa patients in Southern Saudi Arabia.","authors":"Ayman H Shaamash, Mehad H AlQasem, Ahmed A Mahfouz, Deama S Al Ghamdi, Norah I Almanie, Mamdoh A Eskandar","doi":"10.15537/smj.2024.45.10.20240329","DOIUrl":"10.15537/smj.2024.45.10.20240329","url":null,"abstract":"Objectives: To investigate the rates and odds ratios (ORs) of early maternal complications among patients with major placenta previa (PP) who have undergone high-order repeat cesarean deliveries (HOR-CDs) in comparison to those with low-order repeat cesarean deliveries (LOR-CDs).Methods: We carried out a retrospective review of all major PP patients (n=184) who delivered through second or subsequent repeat CDs, from January 2012 to December 2021 (Abha Maternity and Children's Hospital, Abha, Saudi Arabia). The patients were categorized into 2 groups: the LOR-CDs group (n=100), comprising individuals with their second and third CDs (CD2-CD3) and the HOR-CDs group (n=84), consisting of those undergoing their fourth to seventh CDs (CD4-CD7).Results: In comparison to the LOR-CDs, the HOR-CDs group with major PP exhibited significantly higher rates and ORs of early maternal complications, including MRI-diagnosed placenta accreta spectrum (PAS, OR=2.67), transfusions of packed red blood cells (OR=2.71), moderate to severe intra-operative bleeding (OR=1.80), emergency hysterectomy (OR=2.96), urological injuries (OR=3.17), and length of post-operative hospital stay (OR=3.91). The major PP subgroup undergoing CD6-CD7 showed the highest rates and ORs for PAS diagnosis at 84.6% (OR=3.98) and emergency hysterectomy at 28.6% (OR=4.04).Conclusion: Among patients with major PP, undergoing more than 3 CDs is associated with a notable increase in both the rates and ORs of various early maternal complications. This trend of increasing many complications correlates directly with an ascending number of CDs.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances. 随着 O 型血和年龄的增长，ABO 血型抗原分泌表型的表达增加。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01 DOI: 10.15537/smj.2024.45.10.20240308

Jamil M Obaid, Sultan A Saghir, Amir M Al-Hroob, Shaima A Mohammed, Ola'a A Melhi, Ashgan A Alhomamy, Elham A Al-Qodaimi

{"title":"Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances.","authors":"Jamil M Obaid, Sultan A Saghir, Amir M Al-Hroob, Shaima A Mohammed, Ola'a A Melhi, Ashgan A Alhomamy, Elham A Al-Qodaimi","doi":"10.15537/smj.2024.45.10.20240308","DOIUrl":"10.15537/smj.2024.45.10.20240308","url":null,"abstract":"Objectives: To ascertain the prevalence of ABH antigen secretors and non-secretors among Yemenis. In addition to explore the factors that may affect the expression of the secretion phenotype.Methods: This cross-sectional study was carried out between May and September 2022 on 215 healthy Yemeni individuals at the International Malaysian University, Ibb, Yemen. The participants were tested for blood group antigen on their blood samples using standard test tube method using the suitable ABH antisera. Saliva was collected and tested for secretion using hemagglutination inhibition test with suitable A, B, and H antisera. Before collecting the blood samples, informed consent was obtained from each participant and complete data and history questionnaire were collected by the research team.Results: In general, 78.1% of Yemini participants were found to be secretor (80% men and 73.3% females). This percentage increased within O blood group (95%) and decreased within AB blood group (54%) individuals. Both O and AB blood groups showed statistically significant association with secretor trait. Also, it was noticed that age advance increases the expression of Se gene. In addition, the secretor state increased among Rh-negative people.Conclusion: The frequency of ABH secretors was 78.1% among Ibb province population in Yemen. Blood group O revealed the greatest frequency (95%), whereas blood group AB showed the lowest secretor frequency (54%). The secretor phenotype was highly expressed gradually with advance age then decline.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of liver fibrosis and chronic kidney disease in patients with metabolic associated fatty liver disease: A cross-sectional study. 代谢相关性脂肪肝患者肝纤维化与慢性肾病的关系：横断面研究

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-10-01 DOI: 10.15537/smj.2024.45.10.20240393

Rehab Badawi, Naglaa Samy Fahmy Abou Taira, Sara Essam Hasby, Walaa Elkhalawany, Waleed Elrefaey, Nahla Ahmed Khalf, Hanaa Ibrahim Okda

{"title":"The association of liver fibrosis and chronic kidney disease in patients with metabolic associated fatty liver disease: A cross-sectional study.","authors":"Rehab Badawi, Naglaa Samy Fahmy Abou Taira, Sara Essam Hasby, Walaa Elkhalawany, Waleed Elrefaey, Nahla Ahmed Khalf, Hanaa Ibrahim Okda","doi":"10.15537/smj.2024.45.10.20240393","DOIUrl":"10.15537/smj.2024.45.10.20240393","url":null,"abstract":"Objectives: To examine the relation between liver fibrosis and chronic kidney disease (CKD) in metabolic-associated fatty liver disease (MAFLD) patients and its risk factors.Methods: The current study was carried out at Tanta University Hospital, Tanta, Egypt, from May 2021 to January 2023 and included 84 MAFLD patients with CKD and 80 MAFLD patients without CKD. All participants had been examined by abdominal ultrasonography and transient elastography with controlled attenuation parameter.Results: Chronic kidney disease patients exhibited a greater incidence of fibrosis compared to patients without CKD (75.6% vs. 24.4%). Logistic analysis demonstrated that the presence of multiple health conditions, such as MAFLD, diabetes mellitus, hypertension, and cardiovascular disease, were individually linked to CKD. Gender and body mass index were not independent factors related to CKD. Additionally, factors such as age, hyperuricemia, hypertriglyceridemia, hypercholesterolemia, hypoalbuminemia, hyperbilirubinemia, and viral hepatitis, apart from MAFLD comorbidities, were independently linked to CKD.Conclusion: Chronic kidney disease may represent a potential risk influence for liver fibrosis development in MAFLD patients.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of effective diagnostic genes and immune cell infiltration characteristics in small cell lung cancer by integrating bioinformatics analysis and machine learning algorithms. 通过整合生物信息学分析和机器学习算法，识别小细胞肺癌的有效诊断基因和免疫细胞浸润特征。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.8.20240170

Yinyi Chen, Kexin Han, Yanzhao Liu, Qunxia Wang, Yang Wu, Simei Chen, Jianlin Yu, Yi Luo, Liming Tan

{"title":"Identification of effective diagnostic genes and immune cell infiltration characteristics in small cell lung cancer by integrating bioinformatics analysis and machine learning algorithms.","authors":"Yinyi Chen, Kexin Han, Yanzhao Liu, Qunxia Wang, Yang Wu, Simei Chen, Jianlin Yu, Yi Luo, Liming Tan","doi":"10.15537/smj.2024.45.8.20240170","DOIUrl":"10.15537/smj.2024.45.8.20240170","url":null,"abstract":"Objectives: To identify potential diagnostic markers for small cell lung cancer (SCLC) and investigate the correlation with immune cell infiltration.Methods: GSE149507 and GSE6044 were used as the training group, while GSE108055 served as validation group A and GSE73160 served as validation group B. Differentially expressed genes (DEGs) were identified and analyzed for functional enrichment. Machine learning (ML) was used to identify candidate diagnostic genes for SCLC. The area under the receiver operating characteristic curves was applied to assess diagnostic efficacy. Immune cell infiltration analyses were carried out.Results: There were 181 DEGs identified. The gene ontology analysis showed that DEGs were enriched in 455 functional annotations, some of which were associated with immunity. The kyoto encyclopedia of genes and genomes analysis revealed that there were 9 signaling pathways enriched. The disease ontology analysis indicated that DEGs were related to 116 diseases. The gene set enrichment analysis results displayed multiple items closely related to immunity. ZWINT and NRCAM were screened using ML and further validated as diagnostic genes. Significant differences were observed in SCLC with normal lung tissue samples among immune cell infiltration characteristics. Strong associations were found between the diagnostic genes and immune cell infiltration.Conclusion: This study identified 2 diagnostic genes, ZWINT and NRCAM, that were related to immune cell infiltration by integrating bioinformatics analysis and ML algorithms. These genes could serve as potential diagnostic biomarkers and provide possible molecular targets for immunotherapy in SCLC.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombocytopenia following iron repletion with ferrous gluconate. 葡萄糖酸亚铁补铁后血小板减少。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.8.20231003

Aljoharah A Al Saud, Muneerah R AlRomaizan, Muath A Alkhunizan

引用次数: 0

Electronic device usage among preschool children and its association with mental health status in Saudi Arabian kindergartens. 沙特阿拉伯幼儿园学龄前儿童使用电子设备的情况及其与心理健康状况的关系。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.9.20240354

Siham O Al-Mehmadi, Abdulrahman T Halawani, Mrnan T Sulaimani, Tamim O Al-Mehmadi

{"title":"Electronic device usage among preschool children and its association with mental health status in Saudi Arabian kindergartens.","authors":"Siham O Al-Mehmadi, Abdulrahman T Halawani, Mrnan T Sulaimani, Tamim O Al-Mehmadi","doi":"10.15537/smj.2024.45.9.20240354","DOIUrl":"10.15537/smj.2024.45.9.20240354","url":null,"abstract":"Objectives: To estimate the prevalence of electronic device usage and its association with mental health status among preschool children aged 3-6 years.Methods: A cross-sectional study was conducted among preschool children aged 3-6 years in kindergartens in Makkah city in 2023-2024, using an electronic questionnaire. An Arabic version of the Strengths and Difficulties Questionnaire was used to assess mental health.Results: We recruited a total of 399 children. The prevalence of electronic device usage was 91.5%. The number of hours spent using electronic devices ranged from 0 to 12 hour (h)/day, with a mean of 3.1 h/day. We found a significant positive correlation between the number of hours spent using electronic devices and emotional problems (r=0.200, p<0.001), conduct problems (r=0.149, p=0.003), hyperactivity (r=0.279, p<0.001), peer problems (r=0.104, p=0.038), and total difficulty scores (r=0.263, p<0.001). We also found a significant negative correlation between the number of hours spent using electronic devices and the prosocial score (r= -0.128, p=0.011), and most of the included children had scores within the \"close to average\" category across all scales of mental health status.Conclusion: There was a high prevalence of electronic device usage among preschool children, which exceeded the recommended time limit. A significant correlation was observed between electronic device use and mental health scores. Further longitudinal studies are required to understand the nature of this association and its implications for child development.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0