Saudi Medical Journal最新文献

In this issue. 在本期中。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

Exploring hypothyroidism's effects on lipid profiles: Evidence of metabolic consequences in subclinical disease. 探索甲状腺功能减退对脂质谱的影响：亚临床疾病代谢后果的证据

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20241147

Haifa M Alnahdi

{"title":"Exploring hypothyroidism's effects on lipid profiles: Evidence of metabolic consequences in subclinical disease.","authors":"Haifa M Alnahdi","doi":"10.15537/smj.2025.46.5.20241147","DOIUrl":"10.15537/smj.2025.46.5.20241147","url":null,"abstract":"Objectives: To investigate the association between thyroid-stimulating hormone (TSH) levels and lipid profiles in patients with subclinical hypothyroidism (SCH) to assess the metabolic risks.Methods: This retrospective study included patients diagnosed with SCH between January 2023 and August 2024. Thyroid function markers (TSH, free triiodothyronine, and free thyroxine levels) and lipid profiles (total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglyceride levels) were assessed in 137 patients.Results: The mean age of patients was 44.6±13.6 years, with 86.1% being female and 92.7% having dyslipidemia. Thyroid-stimulating hormone levels were correlated with serum creatinine levels (r=0.27, p=0.001) and showed a non-significant trend toward higher cholesterol levels (r=0.15, p=0.09). Free thyroxine were significantly lower in women (p=0.035) and in patients with hypertriglyceridemia (n=32; p=0.005), showing an inverse correlation (r= -0.2; p=0.02). Free triiodothyronine were lower in patients with obesity (p=0.003) and inversely associated with body mass index (BMI, r= -0.2, p=0.019). Serum creatinine levels independently predict TSH levels, whereas triglyceride levels inversely predict free thyroxine levels.Conclusion: Subclinical hypothyroidism impairs lipid metabolism, particularly in females with high BMI. Triglycerides suppress free thyroxine levels, whereas elevated TSH levels correlate with increased creatinine levels. Our findings suggest a potential relationship between SCH and lipid alterations, warranting further investigation into targeted lipid management in these patients.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"491-496"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pocket-creation method versus conventional method of endoscopic submucosal dissection for early gastric cancer: A systematic review and meta-analysis. 早期胃癌的内镜下粘膜下剥离术与造袋法：一项系统综述和荟萃分析。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20250045

Min-Min Song, Feng-Bing Wang, Jian-Lin Yang, Hai-Yan Zhang, Tai-Ping Wang

{"title":"Pocket-creation method versus conventional method of endoscopic submucosal dissection for early gastric cancer: A systematic review and meta-analysis.","authors":"Min-Min Song, Feng-Bing Wang, Jian-Lin Yang, Hai-Yan Zhang, Tai-Ping Wang","doi":"10.15537/smj.2025.46.5.20250045","DOIUrl":"10.15537/smj.2025.46.5.20250045","url":null,"abstract":"Objectives: To compare the efficacy and safety between 2 endoscopic surgical approaches for early gastric cancer: pocket creation method of endoscopic submucosal dissection (PCM-ESD) and conventional ESD (CM-ESD).Methods: A comprehensive literature search was carried out in PubMed, China National Knowledge Infrastructure, and the Cochrane Library from their inception to July 2024 using medical subject headings and free-text terms, which were \"pocket-creation method\", \"gastric cancer\", \"gastric neoplasms\", and \"endoscopic submucosal dissection\" or \"ESD\". Two independent reviewers carried out the search, screened studies, and extracted data.Results: A total of 578 cases were included in our study, which sourced from 2 randomized controlled trials and 5 retrospective cohort studies. Among them, 258 cases were in the intervention group that received PCM-ESD, and 320 cases were in the control group that received CM-ESD. The PCM-ESD demonstrated a significantly faster dissection speed (mean difference=5.57 mm²/min; 95% confidence interval: [4.24-6.91]; p<0.00001) and shorter procedure time compared to CM-ESD. The incidence of intraoperative perforation in the PCM-ESD group was notably lower than that in the CM-ESD group. In terms of complete resection, R0 resection, or delayed bleeding, the 2 groups had no significant differences.Conclusion: For endoscopists, the use of PCM in early gastric cancer seems to be superior to CM-ESD in terms of dissection speed and the procedure time, and got a lower incidence of perforation. Moreover, there was no discernible difference between the 2 groups' rates of en bloc and R0 resection, and the use of PCM-ESD did not increase the chance of delayed bleeding.PROSPERO No. ID: CRD42024564118.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"450-458"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful management of human parainfluenza virus-3 outbreak in a tertiary neonatal intensive care unit. 在新生儿三级重症监护室成功管理人副流感病毒3型暴发。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240864

Nabiha A Bouafia, Mohammed F Qureshi, Reham Q Alwetishi, Naoufel M Kaabia, Dalal Bukhari, Maechel Joy L Santiago, Mohammed A Althomali, Souad M Alateah, Fawaz T Kashlan, Hania M Farhan, Ziyad H Alhaje, Abdurahman N Al Odayani

{"title":"Successful management of human parainfluenza virus-3 outbreak in a tertiary neonatal intensive care unit.","authors":"Nabiha A Bouafia, Mohammed F Qureshi, Reham Q Alwetishi, Naoufel M Kaabia, Dalal Bukhari, Maechel Joy L Santiago, Mohammed A Althomali, Souad M Alateah, Fawaz T Kashlan, Hania M Farhan, Ziyad H Alhaje, Abdurahman N Al Odayani","doi":"10.15537/smj.2025.46.5.20240864","DOIUrl":"10.15537/smj.2025.46.5.20240864","url":null,"abstract":"Objectives: To describe the role of infection control measures in controlling human parainfluenza virus type 3 (HPIV-3) outbreaks in the neonatal intensive care unit of a tertiary military hospital in Riyadh, Saudi Arabia.Methods: This single center, retrospective study collected clinical and diagnostic data from date to date. We collected nasopharyngeal swabs from symptomatic patients and processed using multiplex real-time polymerase chain reaction assays to detect HPIV-3.Results: The HPIV-3 outbreak occurred between December 2022 and January 2023, and affected 22 patients (mean age: 13 months), among whom 18 had underlying chronic medical conditions. Most patients (n=18) presented with lower respiratory tract infections, 16 of whom required oxygen therapy. Almost all cases improved clinically except for one baby who died of holoprosencephaly. Among the symptomatic healthcare workers (n=21), only one nurse tested positive for HPIV-3. Early screening for HPIV-3, proper cohorting under isolation precautions, and the restriction of admissions and visitors, along with additional infection control measures, have been progressively implemented during the outbreak period.Conclusion: Strict implementation of infection control approaches can contribute to limiting the spread of HPIV-3.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"571-575"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do disasters delay early cancer diagnoses? 灾难会延迟早期癌症诊断吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit: A descriptive-analytical study. 影响冠状动脉重症监护病房患者舒适度和舒适度的因素：一项描述性分析研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240702

Esin S Dogan, Cansu K Sahin, Meral Besli, Ozlem E Yildirim

{"title":"The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit: A descriptive-analytical study.","authors":"Esin S Dogan, Cansu K Sahin, Meral Besli, Ozlem E Yildirim","doi":"10.15537/smj.2025.46.5.20240702","DOIUrl":"10.15537/smj.2025.46.5.20240702","url":null,"abstract":"Objectives: To determine comfort levels and the factors affecting the comfort of patients hospitalized in the coronary intensive care unit (CICU).Methods: This descriptive, analytical study was carried out between May 2023 and May 2024 in a university hospital in Manisa, Turkey. The sample consisted of 275 patients. Data were collected using the Patient Information Form and General Comfort (GC) questionnaire.Results: The mean patient overall comfort score was 2.09±0.23. The GC levels were higher in males, those who lived alone, were retired, were hospitalized in intensive care due to myocardial infarction or dysrhythmia, and those hospitalized due to a cardivascular disease for the first time (p<0.05). Regression analysis results showed that the reason for previous hospitalization was related to GC.Conclusion: Patients hospitalized in the CICU have modearate general comfort levels. Previous hospitalization affects their GC levels. Their condition during their stay in the CICU worsened due to worry and fear of death, and frequent invasive procedures also had a negative effect on the GC levels.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"522-528"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged flight exposure and its effects on sinonasal health among aircrew members. 长时间飞行暴露及其对机组人员鼻部健康的影响。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20241032

Mohammad H Al-Bar

{"title":"Prolonged flight exposure and its effects on sinonasal health among aircrew members.","authors":"Mohammad H Al-Bar","doi":"10.15537/smj.2025.46.5.20241032","DOIUrl":"10.15537/smj.2025.46.5.20241032","url":null,"abstract":"Objectives: To investigate the effects of prolonged air travel on sinonasal symptoms among aircrew members.Methods: This study was carried out among airline aircrew members over 4 months, between May 2023 and August 2023. The collected data encompassed demographic and clinical characteristics, including age, gender, and a history of sinus, nasal, or ear surgery. A validated sino-nasal outcome test-22 data collection sheet to measure the presence of sinonasal symptoms was carried out.Results: Of the 184 aircrew members, 81% were male and 34.8% were aged 20-30 years. Sinonasal symptoms after the flights were reported by 68.5% of participants. Symptom prevalence varied significantly based on factors such as being a flight attendant, experiencing symptoms during flights, symptoms affecting job performance, altering trips due to recurring symptoms, long flight durations, use of medications, and a history of sinus, nasal, or ear surgery. Multivariate regression analysis identified post-flight or in-flight nasal, sinus, or ear problems, symptoms affecting job performance, and previous sinus, nasal, or ear surgery as significant independent predictors of sinonasal symptoms.Conclusion: Over two-thirds of airline crew members may experience sinonasal symptoms after prolonged air travel. Flight attendants with a history of nasal, or ear surgery and those with longer flight durations were more likely to experience sinonasal symptoms. Larger observational studies are required to further clarify the prevalence and contributing factors of sinonasal symptoms among aircrew members.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"545-551"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WHO issues its first-ever reports on tests and treatments for fungal infections. 世卫组织首次发布关于真菌感染检测和治疗的报告。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

Does cancer treatment affect connections in the brain? 癌症治疗会影响大脑的连接吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

The risk factors for cardiovascular disease and chronic kidney disease in patients with nonalcoholic fatty liver disease in Saudi Arabia. 沙特阿拉伯非酒精性脂肪肝患者心血管疾病和慢性肾脏疾病的危险因素

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240901

Walaa Mohammedsaeed, Abdullah Al Malki, Salma Alsayed

{"title":"The risk factors for cardiovascular disease and chronic kidney disease in patients with nonalcoholic fatty liver disease in Saudi Arabia.","authors":"Walaa Mohammedsaeed, Abdullah Al Malki, Salma Alsayed","doi":"10.15537/smj.2025.46.5.20240901","DOIUrl":"10.15537/smj.2025.46.5.20240901","url":null,"abstract":"Objectives: To identify potential risk factors for chronic kidney disease (CKD) and cardiovascular disease (CVD) in Saudi Arabian patients with non-alcoholic fatty liver disease (NAFLD).Methods: A 6-year prospective cohort study was carried out from January 2018 to January 2023, enrolling 1,500 patients. Data were initially collected between January 2018-2019, and follow-up assessments were carried out annually from 2020-2023. Patients were evaluated using biomarker analyses, and medical records were reviewed to assess the incidence of CVD and CKD. Biomarker levels, including blood creatinine, urine albumin, glomerular filtration rate (GFR), atherogenic index of plasma (AIP), and other key parameters, were monitored throughout the study.Results: Of the 1500 patients, 735 (49%) were diagnosed with NAFLD in 2018, while 765 (51%) did not have the condition. Compared to non-NAFLD patients, those with NAFLD exhibited elevated blood creatinine levels, lower GFR, and higher urine albumin, a key marker of kidney damage that is strongly linked to accelerated CKD progression and increased cardiovascular risk. Furthermore, NAFLD patients had a significantly higher AIP. Over the 4-year follow-up, these individuals showed a notable rise in the incidence of CKD and CVD.Conclusion: Non-alcoholic fatty liver disease is associated with alterations in lipid profiles, elevated high-sensitivity C-reactive protein (hs-CRP), and elevated aspartate aminotransferase (AST), all of which may contribute to early CKD and CVD development. Older, obese individuals with NAFLD, high triglyceride, AST, and hs-CRP levels are at an elevated risk for these diseases.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"478-490"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0