Saudi Medical Journal最新文献

Assessing outcomes of acute myocarditis in Saudi Arabia: A retrospective tertiary center experience. 评估沙特阿拉伯急性心肌炎的预后：回顾性三级中心经验。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240705

Abdullah M Bin Abdu, Mohammed S Assiri, Abdullah N Altasan, Yousef I Alghamdi, Abdullah S Alshalawi, Faisal N Alqahtani, Abdulmajeed A Aljabr, Osamah A Alnahdi, Abdullah I Alhamzani, Saud N Alghamdi, Raed J Alzahrani, Bandar M Alshahrani, Mohammed A Alzahrani, May S Alshalawi

{"title":"Assessing outcomes of acute myocarditis in Saudi Arabia: A retrospective tertiary center experience.","authors":"Abdullah M Bin Abdu, Mohammed S Assiri, Abdullah N Altasan, Yousef I Alghamdi, Abdullah S Alshalawi, Faisal N Alqahtani, Abdulmajeed A Aljabr, Osamah A Alnahdi, Abdullah I Alhamzani, Saud N Alghamdi, Raed J Alzahrani, Bandar M Alshahrani, Mohammed A Alzahrani, May S Alshalawi","doi":"10.15537/smj.2025.46.1.20240705","DOIUrl":"10.15537/smj.2025.46.1.20240705","url":null,"abstract":"Objectives: To assess the clinical course and long-term outcomes of complicated and uncomplicated AM in Saudi Arabia. Acute myocarditis (AM) can have different presentations and outcomes based on different factors, one of which is left ventricular ejection fraction (LVEF).Methods: Data from 382 patients with suspected AM, admitted between January 2016 and October 2023, were reviewed. Clinical course, in-hospital complications, and all-cause mortality were evaluated in both the acute and follow-up phases. Outcomes were compared between 2 groups: LVEF <50% (n=43); and normal LVEF (≥50% [n=41]) at presentation.Results: Data from 84 patients (mean [±SD] age, 33.5±10.2 years; 26.2% female) who fulfilled the inclusion criteria were analyzed. The most common symptom was chest pain (83.3%) and 11 (13.1%) patients had fulminant presentation. ST-T changes were found on electrocardiography in 45.2% of patients. The mean LVEF was 46±12.4% at presentation. Patients in the LVEF <50% group were significantly more likely to experience a first-time cardiac-related adverse event (CRAE) (hazard ratio 2.6 [95% confidence interval 1.1-6.2]; p=0.031) with a mean time of 38.8±3.8. The all-cause in-hospital and follow-up mortality rates in the LVEF <50% group were 4.7% (one-half cardiac-related) (p=0.494) and 4.7% (all cardiac-related) (p=0.494), respectively.Conclusion: Of 84 patients diagnosed with AM, those with LVEF <50% were more likely to experience first-time CRAEs and exhibited low short- and long-term mortality rates.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"71-77"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body shape concerns, sexual satisfaction, and associated factors among patients with polycystic ovarian syndrome: A cross-sectional study in Western Saudi Arabia. 多囊卵巢综合征患者的体型、性满意度和相关因素：沙特阿拉伯西部的一项横断面研究

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240797

Aseel A Alsaidan, Ashokkumar Thirunavukkarasu, Hani H Alsulami

{"title":"Body shape concerns, sexual satisfaction, and associated factors among patients with polycystic ovarian syndrome: A cross-sectional study in Western Saudi Arabia.","authors":"Aseel A Alsaidan, Ashokkumar Thirunavukkarasu, Hani H Alsulami","doi":"10.15537/smj.2025.46.1.20240797","DOIUrl":"10.15537/smj.2025.46.1.20240797","url":null,"abstract":"Objectives: To determine body shape concerns (BSCs), sexual satisfaction, and associated factors in patients with polycystic ovarian syndrome (PCOS).Methods: Using a structured and validated questionnaire, a cross-sectional survey was carried out at the Maternity and Children's Hospital in Makkah, Saudi Arabia. Data were collected between August 2023 and June 2024. We included adult patients with PCOS who had completed at least one follow-up visit. We used multivariate analysis to determine the factors associated with BSC and sexual function. Spearman's correlation analysis was executed to assess the correlation concerning these 2 aspects.Results: Of the 432 patients studied, nearly half (50.9%) had some degree of BSC and sexual dysfunction (50.5%). Body shape concern exhibited a significant association with age (p=0.001), education (p=0.017), occupation (p=0.005), and follow-up status (p=0.005). Sexual function and satisfaction were significantly associated with education (p=0.001), body mass index (p=0.001), and the existence of other comorbidities (p=0.011). Additionally, the study revealed a negative relationship between sexual function assessment and BSC (Spearman's rho= -0.567; p=0.001).Conclusion: This study encourages healthcare providers to proactively query sexual apprehension among these patients. These findings may guide health caregivers, policymakers, and scholars in developing measures to improve the quality of life of women with PCOS.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"94-101"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatobiliary manifestations of inflammatory bowel disease in Saudi Arabia: A retrospective analysis. 沙特阿拉伯炎症性肠病的肝胆表现：回顾性分析

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240758

Murad M Aljiffry, Bayan M Dahal, Razana S Baeisa, Amal A Alzahrani, Taif A Alshahrany, Sumiah B Hijji, Majid A Alsahafi, Abdulaziz M Saleem, Waleed S Alghamdi, Mahmoud H Mosli

{"title":"Hepatobiliary manifestations of inflammatory bowel disease in Saudi Arabia: A retrospective analysis.","authors":"Murad M Aljiffry, Bayan M Dahal, Razana S Baeisa, Amal A Alzahrani, Taif A Alshahrany, Sumiah B Hijji, Majid A Alsahafi, Abdulaziz M Saleem, Waleed S Alghamdi, Mahmoud H Mosli","doi":"10.15537/smj.2025.46.1.20240758","DOIUrl":"10.15537/smj.2025.46.1.20240758","url":null,"abstract":"Objectives: To evaluate the features and frequency of hepatobiliary diseases in individuals with Inflammatory bowel disease (IBD).Methods: This retrospective study included all IBD patients at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The primary focus was on the prevalence of hepatobiliary diseases, such as primary sclerosing cholangitis (PSC), non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis (AIH), and others. The secondary focus was identifying predictors of these hepatobiliary manifestations in IBD patients. Associations were analyzed using simple and multiple logistic regression analyses.Results: Among a total of 885 patients with IBD patients, 4.3% presented with hepatobiliary manifestations. Of these cases, 31.6% were linked to Crohn's disease (CD). While 65.8% were associated with ulcerative colitis (UC). Primary sclerosing cholangitis (PSC) was most prevalent, especially in females. PSC was linked to specific IBD sites 39.3% of UC patients have the left-sided disease and 10.7% of patients with ileocolonic CD had PSC. The absence of comorbidities was associated with lower odds of developing PSC, while UC diagnosis, adalimumab use, and infliximab use were associated with higher odds of developing PSC.Conclusion: A small percentage of IBD patients experience hepatobiliary complications, with PSC being the most prevalent. The study emphasizes the importance of closely monitoring IBD patients, especially those undergoing anti-TNF therapy.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"52-58"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of personalized medicine in Saudi Arabia: Opportunities and challenges. 沙特阿拉伯个性化医疗的未来：机遇与挑战。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240700

Wedad A Mawkili

{"title":"The future of personalized medicine in Saudi Arabia: Opportunities and challenges.","authors":"Wedad A Mawkili","doi":"10.15537/smj.2025.46.1.20240700","DOIUrl":"10.15537/smj.2025.46.1.20240700","url":null,"abstract":"Personalized medicine is a healthcare approach that designs treatment plans of each patient, considering genetic, environmental, and lifestyle factors. This model leverages genomic information, advanced diagnostics, and data analytics to predict disease risk, optimize prevention strategies, and provide customized treatments. In Saudi Arabia, personalized medicine is gaining momentum, driven by the country's Vision 2030 initiative, which aims to transform the healthcare sector by integrating advanced medical technologies and improving healthcare delivery. The Kingdom has made significant strides in genomics and bioinformatics, with initiatives such as the Saudi Human Genome Program and advancements in institutions i.e., King Faisal Specialist Hospital and Research Centre. Continued investment in research, education, and technology, alongside international collaborations, will be crucial in overcoming these challenges and realizing the full potential of personalized medicine. This review explores the current state, challenges, and future prospects of personalized medicine in Saudi Arabia, highlighting its transformative impact on healthcare delivery and patient outcomes.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"19-25"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can drinking coffee or tea help prevent head and neck cancer? 喝咖啡或茶有助于预防头颈癌吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01

引用次数: 0

Comment on: Post surgical hypoparathyroidism. 评论：术后甲状旁腺功能减退。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20241114

引用次数: 0

The relationship between mothers with careers in higher education and child development in Indonesia. 印度尼西亚从事高等教育的母亲与儿童发展之间的关系。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240838

Zakiyah Yasin, Ahmad Nawawi, Shrimarti R Devy, Siti R Nadhiroh

{"title":"The relationship between mothers with careers in higher education and child development in Indonesia.","authors":"Zakiyah Yasin, Ahmad Nawawi, Shrimarti R Devy, Siti R Nadhiroh","doi":"10.15537/smj.2025.46.1.20240838","DOIUrl":"10.15537/smj.2025.46.1.20240838","url":null,"abstract":"Objectives: To identify the association of mothers with a career in higher educati--on and their children's growth and development.Methods: This was an analytical study with a cross-sectional design carried out at Wiraraja University, Sumenep, Indonesia, from March to August 2023. The samples were female lecturers at Wiraraja University. A total of 107 mothers were selected using total sampling. The mother's career was identified using a questionnaire and their child's growth and development were measured using child development pre-screening questionnaire. This study used Spearman's test data analysis.Results: The correlation coefficient was 0.512 indicating a moderately strong relationship between working mothers and their child's growth and development. The findings suggest that time mothers' work-life balance, time allocation, and other support for caring child significantly impact developmental milestones.Conclusion: There is a strong correlation between the time spent with children and the child's growth and development. For working mothers in academia, creating a supportive family or childcare environment and creating dedicated, quality time for interaction with their children are essential. Working mothers are encouraged to manage their time effectively to balance professional and parenting responsibilities and to engage in activities that enhance their children's physical, mental, and emotional development.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"86-93"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ajwa date extract (Phoenix dactylifera L.): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study. Ajwa枣提取物（Phoenix dactylifera L.）：植物化学分析，对单纯疱疹病毒- 1和柯萨奇B4病毒的抗病毒活性，并进行了硅片研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240780

Ahmad K Aljohani, Nader A Maghrabi, Osama M Alrehili, Abdulaziz S Alharbi, Rawad S Alsihli, Abdulrahman M Alharthe, Rayan S Albladi, Khalid A Alosaimi, Bader M Albadrani, Samar F Miski, Hossein M Elbadawy, Bandar D Alrehaili, Fahd A Abdelkarem, Modather F Hussein

{"title":"Ajwa date extract (Phoenix dactylifera L.): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study.","authors":"Ahmad K Aljohani, Nader A Maghrabi, Osama M Alrehili, Abdulaziz S Alharbi, Rawad S Alsihli, Abdulrahman M Alharthe, Rayan S Albladi, Khalid A Alosaimi, Bader M Albadrani, Samar F Miski, Hossein M Elbadawy, Bandar D Alrehaili, Fahd A Abdelkarem, Modather F Hussein","doi":"10.15537/smj.2025.46.1.20240780","DOIUrl":"10.15537/smj.2025.46.1.20240780","url":null,"abstract":"Objectives: To investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action.Methods: High perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical profile of Ajwa date extract. The antiviral activity was assessed using the MTT colorimetric assay against herpes simplex virus type I (HSV-I) and coxsackievirus B4 (CVB-4). Assessment of the mechanism of action against HSV-I was carried out using 3 protocols. Molecular docking and quantum chemical calculations were carried out to predict the binding affinities of the identified compounds to viral glycoprotein D.Results: A total of 17 metabolites belonging to different classes of metabolites, mainly flavonoids, phenolic acid derivatives, fatty acids, and sugar derivatives. Ajwa extract exhibited antiviral activity against HSV-I with an IC: 50 of 113.99±4.67 μg/mL, whereas it showed limited activity against CVB-4. The antiviral activity of Ajwa extract was mainly attributed to its cell protectant activity by preventing adherence of viral to host cell with an IC: 50 equal to 57.82±1.37μg/mL. Molecular docking studies indicated that chlorogenic acid had the strongest binding affinity to viral glycoprotein D, which suggests its potential role in inhibiting viral entry into host cells.Conclusion: The Ajwa date extract demonstrated promising antiviral activity, especially against HSV-I. Integrating in vitro and in silico analyses provided valuable insights into the mechanisms of action.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"26-35"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence (AI) in medical publications pros and cons. 人工智能（AI）在医学出版物中的利弊。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1

引用次数: 0

Oncological surgical outcomes for colorectal cancer surgery with loco-regional anesthesia: A feasibility study. 结直肠癌局部区域麻醉手术的肿瘤手术效果：可行性研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240470

Hüseyin Fahri Martlı, Eda Şahingöz, Emre Şimşek, Ayça Tuba Özcan, Efnan Aşık, Sadettin Er, Erdinç Çetinkaya

{"title":"Oncological surgical outcomes for colorectal cancer surgery with loco-regional anesthesia: A feasibility study.","authors":"Hüseyin Fahri Martlı, Eda Şahingöz, Emre Şimşek, Ayça Tuba Özcan, Efnan Aşık, Sadettin Er, Erdinç Çetinkaya","doi":"10.15537/smj.2025.46.1.20240470","DOIUrl":"10.15537/smj.2025.46.1.20240470","url":null,"abstract":"Objectives: To evaluate the pathological outcomes of colorectal cancer (CRC) patients who were unsuitable for general anesthesia and underwent regional anesthesia in terms of their suitability for oncological surgery.Methods: A total of 53 patients who underwent mesocolicormesorectal surgery under regional anesthesia at Ankara Bilkent City Hospital, Ankara, Turkey, between May 2019 and May 2023 were retrospectively examined. The negative margins of the proximal, distal, and circumferential margins of specimens, as well as the number of lymph nodes removed, were analyzed.Results: All the patients had clear proximal, distal, and circumferential surgical margins. The median number of lymph nodes removed was 23.45 (min-max: 3-97). When patients (n=24) who received neoadjuvant therapy were excluded, an insufficient number (<12) of lymph nodes were removed in 3 (7.69%) patients. A total of 3 patients died postsurgery, resulting in a 30-day mortality rate of 5.6%.Conclusion: For elderly and comorbid individuals with CRC, regional anesthesia can be used to carry out surgery with oncological principles.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"59-64"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0