Saudi Medical Journal最新文献

{"title":"Comparison of the Predictive Value of CRP/Albumin, CRP/Prealbumin, and the Clinical Frailty Scale for Mortality in Geriatric Intensive Care Patients.","authors":"Natali T Aksoy, Bülent B Güven, Sümeyya M Soyalan, Dilek Metin Yamaç, Tuna Ertürk, Süheyla Abitağaoğlu","doi":"10.15537/1658-3175.8769","DOIUrl":"10.15537/1658-3175.8769","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the relationship between C-reactive protein (CRP)/prealbumin and CRP/albumin ratios, Clinical Frailty Scale (CFS) scores, and short-term (first 3 days) and long-term (28 days) mortality in geriatric patients hospitalized in the intensive care unit.</p><p><strong>Methods: </strong>After obtaining ethical approval and informed consent, 213 patients aged 65 years and older were included. Patients discharged within 24 hours, those discharged and readmitted during the study period, those receiving routine albumin replacement, and patients with cirrhosis or undergoing chronic dialysis were excluded. Demographic characteristics, admission diagnoses, chronic comorbidities, frailty scores at admission, and laboratory values, including albumin, prealbumin, and CRP levels measured within the first 24 hours were recorded.</p><p><strong>Results: </strong>The study population comprised 97 (45.5%) female and 116 (54.5%) male patients, with a mean age of 78.8 years. The most common diagnosis was septicemia (56.33%), and the most prevalent comorbidities were hypertension (65.25%), malignancy (35.6%) and diabetes (34.7%). Both CRP/prealbumin and CRP/albumin ratios were higher in patients who experienced early and late mortality. Frailty scores did not differ in cases of early mortality; however, patients with higher frailty scores were more likely to experience long-term mortality. Additionally, the length of intensive care unit stay was longer in patients with a frailty score ≥7 compared to those with a score ≤6.</p><p><strong>Conclusion: </strong>The CFS, CRP/prealbumin, and CRP/albumin ratios are valuable predictors of long-term mortality in older patients receiving intensive care.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"852-858"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"The Association between Inflammatory Bowel Disease and Ischemic Heart Disease: A Retrospective Cohort Study\" [Saudi Medical Journal 2025 Oct; 46(10):1174-1181].","authors":"Mahmoud H Mosli, Dima M Alsulami, Yara K Alghamdi, Abdullah S Badahdah, Asmaa H Alhibshi, Thamer M Alamri, Maan S Alkhattabi, Khames T Alzahrani, Hadeel A Alsufyani, Omar I Saadah","doi":"10.15537/1658-3175.8776","DOIUrl":"https://doi.org/10.15537/1658-3175.8776","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.15537/smj.2025.46.10.20250181.].</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"970"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Clinical Outcome of Mushroom Poisonings with and without Specific Treatment: <i>A 5-year Retrospective Analysis</i>.","authors":"Kamil Deveci, Necmi Baykan, Baycan Kus, Fatma Ünlü, Ömer Salt, Serhat Koyuncu","doi":"10.15537/1658-3175.8771","DOIUrl":"10.15537/1658-3175.8771","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the demographic and clinical characteristics, potential specific antidote treatments, clinical outcomes, and organ failure (morbidity) rates of patients with mushroom poisoning admitted to our center.</p><p><strong>Methods: </strong>We included 425 patients admitted to the emergency department of Kayseri City Hospital complaining of mushroom poisoning, between May 2018 and December 2023, who met the study criteria.</p><p><strong>Results: </strong>The median age of the 425 patients admitted was 51 years (34-63); 49.5% were female (n = 211), and 75% (n = 319) were admitted by ambulance. According to the Poisoning Severity Score, 70.3% (n = 299) of cases were mild, 21.9% (n = 93) moderate, 7.3% (n = 31) severe, and 0.5% (n = 2) fatal. Patients who received specific antidote treatment had a statistically significantly higher morbidity rate than those who did not (48.6% vs. 22.9%, <i>p</i> < 0.01). In the subgroup analysis, hepatotoxicity was more common (35.8% vs. 8.8%, <i>p</i> < 0.01), whereas there was no significant difference in other organ failure.</p><p><strong>Conclusion: </strong>Mushroom poisoning is an uncommon type of poisoning that varies seasonally. The integrity of treatment may have been lost because of intermittent visits. We recommend careful evaluation of the patients and rapid initiation of specific possible antidote therapies, in addition to basic supportive treatment (fluid resuscitation, activated charcoal, and so on).</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"869-876"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Delta Neutrophil Index in Determining the Severity of Intrahepatic Cholestasis of Pregnancy.","authors":"Selçuk Atalay, Melike Çaltekin, Nihal Çallıoğlu, Fırat Ersan, Verda Alpay, Yasin Anasız, Ipek Geyikoğlu","doi":"10.15537/1658-3175.8763","DOIUrl":"10.15537/1658-3175.8763","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the clinical utility of the delta neutrophil index (DNI) in distinguishing patients with intrahepatic cholestasis of pregnancy (ICP) from healthy pregnant women, and to assess its potential role in evaluating disease severity.</p><p><strong>Methods: </strong>This retrospective analysis included data from 249 pregnant women. Among them, 131 were identified with ICP, based on clinical symptoms and total bile acid levels ≥10 μmol/L. The remaining 118 participants served as healthy controls. The ICP cases were categorized into mild (TBA 10-39 μmol/L; n = 90) and severe (TBA ≥ 40 μmol/L; n = 41) subgroups. Demographic data, routine blood parameters, and DNI values were evaluated across the groups.</p><p><strong>Results: </strong>The ICP group demonstrated significantly elevated white blood cell (WBC) counts, neutrophil counts, immature granulocyte (IG) levels, DNI values, and neutrophil-to-lymphocyte ratio (NLR) compared to controls (<i>p</i> < 0.05 for all). Both mild and severe ICP subgroups exhibited higher IG, DNI, and NLR than controls. Furthermore, DNI and IG values significantly differed between mild and severe ICP cases. Receiver operating characteristic (ROC) analysis revealed high diagnostic performance for both DNI (cut-off: 0.65; sensitivity: 82.4%; specificity: 78%) and IG (cut-off: 0.06; sensitivity: 77.1%; specificity: 82.2%).</p><p><strong>Conclusion: </strong>The DNI levels were markedly elevated in ICP and varied with disease severity, suggesting its potential as a noninvasive marker for both diagnosis and risk stratification.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"801-807"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Arabic Version of the NOSE-Perf Scale.","authors":"Rayan M Alfallaj, Abdullah I BinGhaith, Mohammed Y Alyoussef, Ahmed S Alsaleh, Saad A Alsaleh, Abdulaziz A AlQahtani, Ahmad S Alroqi","doi":"10.15537/1658-3175.8765","DOIUrl":"10.15537/1658-3175.8765","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the psychometric validity of the Arabic adaptation of the nasal obstruction symptom evaluation-perforation (NOSE-Perf) scale. To assess how reliable and valid the Arabic adaptation of the NOSE-Perf questionnaire is. Patients with septal perforations, particularly Arabic speakers, lack validated self-assessment tools for subjective symptom evaluation.</p><p><strong>Methods: </strong>Conducted between May 2024 and June 2025, the study included 100 participants-20 patients with septal perforation and 80 controls. Participants filled out a questionnaire consisting of demographic data as well as the Arabic forms of the Sino-Nasal Outcome Test-22 (SNOT-22), NOSE, and NOSE-Perf scales. Cronbach's alpha was applied to determine internal consistency, and the intraclass correlation coefficient (ICC) was utilized to verify test-retest reliability. Discriminative validity was evaluated by comparing score differences, while concurrent validity was analyzed through correlations with the NOSE and SNOT-22 scales.</p><p><strong>Results: </strong>Strong correlations were observed between the NOSE-Perf and the established NOSE (r = 0.920, <i>p</i> < 0.001) and SNOT-22 (r = 0.885, <i>p</i> < 0.001) measures, confirming the scale's concurrent validity. Discriminative validity was evident: NOSE-Perf scores were significantly higher in cases (29.8 ± 9.48) than controls (5.76 ± 8.10, <i>p</i> < 0.001; AUC = 0.856). NOSE scores also differed (cases: 68.1 ± 26.1; controls: 9.44 ± 21.9; <i>p</i> < 0.001; AUC = 0.931). SNOT-22 scores were 57.1 ± 24.2 in cases and 18.0 ± 18.4 in controls (<i>p</i> < 0.001; AUC = 0.32).</p><p><strong>Conclusion: </strong>The Arabic adaptation of the NOSE-Perf questionnaire exhibited reliability and validity as a tool for assessing subjective symptoms among individuals experiencing septal perforation.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"817-825"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health in Relation to Parental Absence: <i>A Systematic Review</i>.","authors":"Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh","doi":"10.15537/1658-3175.8759","DOIUrl":"10.15537/1658-3175.8759","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the literature based on the relationship between orphaned children and mental health, compared to non-orphaned children. Mental well-being of orphaned children is a profound intricate topic that connects with broader concerns of childcare. This systematic review aims to evaluate the literature regarding the relationship between mental health and parental absence.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, MEDLINE, and Science Direct in October 2025, with 1017 screened studies. Six studies met the inclusion criteria. Independent reviewers performed quality assessments using the Newcastle-Ottawa scale (NOS). Subsequently, a meta-analysis was performed when possible.</p><p><strong>Results: </strong>Findings indicate that orphaned children demonstrated higher levels of aggressive behavior (1 study: <i>p</i> = 0.05), depression (2 studies: <i>p</i><0.001 and <i>p</i><0.001), and PTSD symptoms (1 study: <i>p</i><0.001). Anxiety was also higher among orphans (3 studies: <i>p</i> = 0.038, <i>p</i> = 0.006 and <i>p</i><0.001). Orphans also had poorer psychological well-being (1 study: <i>p</i><0.001), greater somatic symptoms (1 study: <i>p</i><0.001), and higher social dysfunction (1 study: <i>p</i><0.001). There were no statistically significant differences in resilience (1 study: <i>p</i> = 0.16), self-efficacy (1 study: <i>p</i> = 0.58), or internalizing and externalizing problems (1 study: <i>p</i> = 0.64). Meta-analysis of studies evaluating depression yielded non-significant increased standardized mean differences (SMD) of 0.77 (<i>p</i> = 0.10). While the meta-analysis of studies evaluating anxiety showed a significant increased SMD of 0.68 (<i>p</i> = 0.02) among children with parental absence.</p><p><strong>Conclusion: </strong>Orphaned children may exhibit elevated levels of depression, anxiety, aggression, and poorer psychological well-being compared to their non-orphaned peers. However, they also possess internal strengths such as resilience and self-efficacy. These findings should be interpreted with caution due to the limited number of studies and the high degree of heterogeneity across studies and cultural contexts.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"760-768"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Unmasking Iron Deficiency and Iron Deficiency Anemia in Saudi Arabia\" [Saudi Medical Journal 2025; 46(9):1000-1007].","authors":"Osman O Radhwi, Omar M Raslan, Eman M Mansory","doi":"10.15537/1658-3175.8775","DOIUrl":"https://doi.org/10.15537/1658-3175.8775","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.15537/smj.2025.46.9.20240970.].</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"969"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Rheumatology in the Middle East: MRC 2025 Abstracts.","authors":"Martin Lee, Ahmed Zayat, Beena Hameed, Elsadeg Sharif, Fahda Al Okaily, Fehaid Alanazi, Francis Kynaston-Pearson, Khalid A Alnaqbi, Mahmood Hachim, Mayam Al Nesf, Mira Mirashli, Mohammed Tariq, Ravi Gutta, Reem Abdwani, Saadeya Naji, Shamma Lootah, Tareq Al Araimi, Waleed Hafiz, Suad Hannawi","doi":"10.15537/1658-3175.1055","DOIUrl":"https://doi.org/10.15537/1658-3175.1055","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"920-968"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Appendectomy in Patients Undergoing Surgery for Gynecological Malignancies: <i>A Retrospective Analysis from a Tertiary Referral Center</i>.","authors":"Gazi Güner, Can Tercan, Emrah Dağdeviren, Ali Selçuk Yeniocak, Ceylin Elbistanli, Sure Nur Erdoğmuş, Ayşe Hazirbulan, Yiğit Mert Bayrak, Neçirvan Çağdaş Çaltek, Gözde Şahin, Ergun Tercan, Figen Efe Çamili, Nazlı Aylin Vural, Hüseyin Karatay, Saniye Merve Gül Kara, İlkbal Temel Yüksel","doi":"10.15537/1658-3175.8766","DOIUrl":"10.15537/1658-3175.8766","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate appendectomy specimen findings and their association with tumor type and stage. Concurrent appendectomy is frequently performed during gynecologic oncology surgery to prevent postoperative appendicitis and detect occult pathology, yet its value remains debated.</p><p><strong>Methods: </strong>In this study, we reviewed the medical records of 300 women who underwent gynecologic oncologic surgery accompanied by appendectomy at Başakşehir Çam and Sakura City Hospital (Istanbul, Türkiye) over the period from July 2020 to April 2025. Clinical, surgical, andhistopathologic data were collected. Appendiceal pathologies were categorized as reactive hyperplasia, chronic inflammation, benign neoplasms, metastatic tumors, or primary. Statistical analyses included chi-square, t-test, and ANOVA.</p><p><strong>Results: </strong>Participants had an average age of 55.6 ± 13.4 years, and 61.7% of them were postmenopausal. Among ovarian tumors, malignant epithelial lesions represented 54.7% of cases, while borderline tumors accounted for 17.7% and benign tumors for 17%. Histopathology revealed chronic inflammation in 40.7%, reactive changes in 34.3%, metastatic disease in 23.3%, benign neoplasms in 1.3%, and primary malignancy in 0.3%. Metastases occurred only in malignant ovarian tumors (35.7%), predominantly high-grade serous carcinomas <i>(p</i> < 0.001). Borderline and benign tumors were mainly associated with reactive findings, and no metastatic involvement was detected.</p><p><strong>Conclusion: </strong>Concurrent appendectomy during gynecologic oncology surgery is safe and frequently reveals clinically relevant pathology. Appendectomy should be encouraged during cytoreduction, while its role in benign and early-stage cases warrants further investigation.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 5","pages":"826-832"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application Effect of Modified Pressure-Reducing Fixation Protective Nasal Strip in the Nursing Care of Patients Receiving High-Flow Nasal Cannula Therapy.","authors":"Ying Zhou, Xuting He, Jianying Sang","doi":"10.15537/1658-3175.1069","DOIUrl":"10.15537/1658-3175.1069","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of a modified pressure-reducing fixation protective nasal strip in preventing device-related pressure injuries and improving nursing outcomes in patients undergoing high-flow nasal cannula (HFNC) therapy.</p><p><strong>Methods: </strong>This study included 60 patients receiving HFNC therapy from January 2024 to September 2024. Participants were randomly divided into an observation group (n = 30), which used the modified decompression fixation protective nasal strip, and a control group (n = 30), which underwent standard care with hydrocolloid dressing protection. The study compared general demographic data, the interval between fixation strap changes, frequency of catheter position adjustments, skin management effectiveness (Braden score), number of ineffective oxygenation attempts, incidence of adverse events, and patient comfort scores.</p><p><strong>Results: </strong>The 2groups were comparable in baseline characteristics (<i>p</i> > 0.05). The observation group showed longer intervals between fixation strap changes, fewer catheter position adjustments, fewer ineffective oxygenation attempts, and a lower incidence of adverse events relative to the control group (<i>p</i> < 0.05). Furthermore, the observation group had significantly higher Braden scores and comfort levels than those in the control group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The modified pressure-reducing fixation protective nasal strip is effective in reducing device-related complications and enhancing patient comfort during HFNC therapy.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"47 4","pages":"718-725"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}