Saudi Medical Journal最新文献_第9页

WHO issues its first-ever reports on tests and treatments for fungal infections. 世卫组织首次发布关于真菌感染检测和治疗的报告。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

Does cancer treatment affect connections in the brain? 癌症治疗会影响大脑的连接吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01

引用次数: 0

The risk factors for cardiovascular disease and chronic kidney disease in patients with nonalcoholic fatty liver disease in Saudi Arabia. 沙特阿拉伯非酒精性脂肪肝患者心血管疾病和慢性肾脏疾病的危险因素

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240901

Walaa Mohammedsaeed, Abdullah Al Malki, Salma Alsayed

{"title":"The risk factors for cardiovascular disease and chronic kidney disease in patients with nonalcoholic fatty liver disease in Saudi Arabia.","authors":"Walaa Mohammedsaeed, Abdullah Al Malki, Salma Alsayed","doi":"10.15537/smj.2025.46.5.20240901","DOIUrl":"10.15537/smj.2025.46.5.20240901","url":null,"abstract":"Objectives: To identify potential risk factors for chronic kidney disease (CKD) and cardiovascular disease (CVD) in Saudi Arabian patients with non-alcoholic fatty liver disease (NAFLD).Methods: A 6-year prospective cohort study was carried out from January 2018 to January 2023, enrolling 1,500 patients. Data were initially collected between January 2018-2019, and follow-up assessments were carried out annually from 2020-2023. Patients were evaluated using biomarker analyses, and medical records were reviewed to assess the incidence of CVD and CKD. Biomarker levels, including blood creatinine, urine albumin, glomerular filtration rate (GFR), atherogenic index of plasma (AIP), and other key parameters, were monitored throughout the study.Results: Of the 1500 patients, 735 (49%) were diagnosed with NAFLD in 2018, while 765 (51%) did not have the condition. Compared to non-NAFLD patients, those with NAFLD exhibited elevated blood creatinine levels, lower GFR, and higher urine albumin, a key marker of kidney damage that is strongly linked to accelerated CKD progression and increased cardiovascular risk. Furthermore, NAFLD patients had a significantly higher AIP. Over the 4-year follow-up, these individuals showed a notable rise in the incidence of CKD and CVD.Conclusion: Non-alcoholic fatty liver disease is associated with alterations in lipid profiles, elevated high-sensitivity C-reactive protein (hs-CRP), and elevated aspartate aminotransferase (AST), all of which may contribute to early CKD and CVD development. Older, obese individuals with NAFLD, high triglyceride, AST, and hs-CRP levels are at an elevated risk for these diseases.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"478-490"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia. 沙特阿拉伯吉赞省最近和过去登革热感染的血液学参数

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240879

Abdulrahim Hakami, Ryhanh Tomehi, Ahmad A Irekeola, Gasim Dobie, Sultan Alasmari, Mohammed Makkawi, Yahya Matari, Ahmed Mohammed, Ahmad A Alshehri

{"title":"Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia.","authors":"Abdulrahim Hakami, Ryhanh Tomehi, Ahmad A Irekeola, Gasim Dobie, Sultan Alasmari, Mohammed Makkawi, Yahya Matari, Ahmed Mohammed, Ahmad A Alshehri","doi":"10.15537/smj.2025.46.5.20240879","DOIUrl":"10.15537/smj.2025.46.5.20240879","url":null,"abstract":"Objectives: To analyze hematological parameters for potential predictive markers of dengue.Methods: Blood samples were obtained from 146 individuals suspected of having dengue at 2 hospitals in Jazan, Saudi Arabia. Control samples were concurrently collected from healthy adults (n=59). Samples were screened for anti-dengue antibodies by employing enzyme-linked immunosorbent assay. Hematological parameters, such as hemoglobin (HGB), white blood cells, hematocrit (HCT), platelets count, and red blood cells (RBCs) levels were determined for the dengue positive samples and all the controls.Results: Of the patients examined, 15% were dengue immunoglobulin M positive and 25% were immunoglobulin G positive. Dengue-infected patients showed lower values of the tested hematological parameters than controls, and significantly lower values were observed for RBCs (p=0.0022), HGB (p=0.0002), and HCT (p<0.0001). Average HGB (12.47g/dl) and HCT (39.03%) values of dengue patients were abnormally low. The average HCT levels were significantly lower in patients with recent dengue infection (41.41% vs. 45.91%, p=0.0230) and past dengue infection (38.63% vs. 45.91%, p<0.0001) compared to controls. However, RBCs and HGB levels were only significantly lower in patients with past and not recent infections.Conclusion: The results of this study suggest that prior dengue infections could result in abnormal hematological values, although further research is needed.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"515-521"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia: Trends and demographic patterns (2017-2023). 沙特阿拉伯食源性疾病暴发的纵向分析：趋势和人口模式（2017-2023）。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20241010

Hissah A Alzahrani

{"title":"Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia: Trends and demographic patterns (2017-2023).","authors":"Hissah A Alzahrani","doi":"10.15537/smj.2025.46.5.20241010","DOIUrl":"10.15537/smj.2025.46.5.20241010","url":null,"abstract":"Objectives: To explore the long-term patterns of foodborne disease outbreaks (FBDOs) in Saudi Arabia between 2017-2023 using longitudinal data analysis models.Methods: A 7-year longitudinal study was carried out on FBDO data from all 13 regions of Saudi Arabia. This study examined 5 outcomes: the number of FBDOs, FBDO cases, and FBDO cases classified by gender, nationality, and age groups. The analysis used generalized estimating equations and generalized linear mixed models based on a negative binomial distribution.Results: The findings revealed a significant decrease in FBDO counts and cases from 2017-2020, followed by an increase until 2023. Public sources consistently reported higher numbers of FBDOs and cases than home sources. No substantial difference was observed in FBDO cases between men and women. Saudi nationals had higher FBDO case counts than non-Saudi residents. The age groups 5-19 years and 20-49 years exhibited the highest FBDO case numbers.Conclusion: The observed patterns, particularly the decline toward 2020 and the subsequent increase, underscore the necessity for adaptable public health strategies to mitigate the heightened incidence following the COVID-19 pandemic in Saudi Arabia and may inform future prevention and control measures.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"507-514"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological stress and its association with bronchial asthma in Saudi Arabia: A cross-sectional study. 沙特阿拉伯的心理压力及其与支气管哮喘的关系：一项横断面研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20250028

Alaa A Bugis, Faisal A Turkestani, Mohammed E Ahmed, Mohammed M Alqahtani, Abdullah K Alnafisi, Bassam O Alamri, Alhasan M Algobayshi

{"title":"Psychological stress and its association with bronchial asthma in Saudi Arabia: A cross-sectional study.","authors":"Alaa A Bugis, Faisal A Turkestani, Mohammed E Ahmed, Mohammed M Alqahtani, Abdullah K Alnafisi, Bassam O Alamri, Alhasan M Algobayshi","doi":"10.15537/smj.2025.46.5.20250028","DOIUrl":"10.15537/smj.2025.46.5.20250028","url":null,"abstract":"Objectives: To investigate the psychological stress and its association with bronchial asthma in Saudi Arabia, focusing on the mechanisms by which stress affects asthma.Methods: This cross-sectional study included 733 adults with asthma aged ≥18 years and was carried out between October 2022 and May 2023 in Saudi Arabia. Data were obtained using an online questionnaire assessing asthma severity and stress levels.Results: Cronbach's alpha indicated that the reliability of the stress scale was 0.728 and the reliability of the asthma control tool was 0.819. Of the participants, 52% were women and 48% were men, with 48.7% aged 18-26 years. Asthma severity was classified as low (20.3%) or high (54.6%) and 85.4% of the respondents reported elevated stress levels. A statistically significant correlation was noted between asthma control and sterss (r= -0.22, p<0.05), indicating that higher stress levels hinder the management of asthma.Conclusion: There is a strong association between psychological stress and exacerbation of bronchial asthma. Stress impacts immune responses, thereby contributing to the pathogenesis of asthma. Therefore, effective stress management is essential in improving the control of asthma and the alleviation of its symptoms.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"560-566"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience of pediatric liver disease at a university hospital in Western Saudi Arabia. 在沙特阿拉伯西部一所大学医院的儿科肝病的经验。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20240854

Nawal H Almohammad, Rana Y Bokhary

{"title":"Experience of pediatric liver disease at a university hospital in Western Saudi Arabia.","authors":"Nawal H Almohammad, Rana Y Bokhary","doi":"10.15537/smj.2025.46.5.20240854","DOIUrl":"10.15537/smj.2025.46.5.20240854","url":null,"abstract":"Objectives: To describe the diverse spectrum presented by pediatric liver diseases and prevalence of histopathological patterns and assess the role of histopathological findings in predicting prognosis.Methods: We carried out a retrospective cohort study of 158 pediatric patients who underwent liver biopsy or resection for liver disease at King Abdulaziz University Hospital, Jeddah, Saudi Arabia (2014-2023). Demographic data, clinical data, and histopathological findings were analyzed using counts and percentages.Results: The majority of the patients were infants (n=83; 52.5%), with male predominance (n=97; 61.4%). Biopsies were the most common specimen type (n=137; 86.7%). Cholestatic/bile duct disorders were the most prevalent pathological pattern (n=92; 58.2%), with extrahepatic biliary atresia being the most common subtype (n=32; 34.8%). Inflammatory/infectious disorders accounted for 13.3% (n=21) of cases, with chronic active hepatitis-not otherwise specified (n=10; 47.6%) being the most frequent. Metabolic disorders represented 12.0% of cases, with glycogen storage disorders and non-alcoholic fatty liver disease both at 31.6% (n=6). Neoplastic disorders were found in 7.6% (n=12) of cases, evenly distributed between benign and malignant tumors.Conclusion: This study provides a comprehensive overview of histopathological patterns in pediatric liver diseases, highlighting the predominance of cholestatic disorders and the significance of early diagnosis.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"567-570"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of asthma control levels in a tertiary hospital: A cross-sectional study. 某三级医院哮喘控制水平评估：一项横断面研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20241038

Entisar S Alsafwani, Ayed M Alenazi, Mansour M Alqwaiee, Khaled A BaQais, Adel S Alharbi, Abdullah S Al-Shamrani

{"title":"Assessment of asthma control levels in a tertiary hospital: A cross-sectional study.","authors":"Entisar S Alsafwani, Ayed M Alenazi, Mansour M Alqwaiee, Khaled A BaQais, Adel S Alharbi, Abdullah S Al-Shamrani","doi":"10.15537/smj.2025.46.5.20241038","DOIUrl":"10.15537/smj.2025.46.5.20241038","url":null,"abstract":"Objectives: To assess asthma control levels in pediatric patients under 12 years of age attending a tertiary hospital, utilizing the childhood asthma control test (C-ACT) and the test for respiratory and asthma control in kids (TRACK).Methods: The study involved 384 children. Data were collected from December 2023 to July 2024 from outpatient clinics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. A total of 2 tools, C-ACT and TRACK, were employed to measure asthma control.Results: The results showed that 51.2% of children under 5 years of age exhibited uncontrolled asthma. Among children aged 5-12, 34.5% showed uncontrolled. A statistically significant association was found between uncontrolled asthma and emergency room visits in both age groups (p<0.001), with 39.7% of younger children and 45.6% of older children with uncontrolled asthma seeking emergency care in the previous 4 weeks.Conclusion: The result underscore the importance of regular asthma monitoring and the use of validated tools such as C-ACT and TRACK to improve asthma management and reduce emergency room visits.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"552-559"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying individuals at risk of post-stroke depression: Development and validation of a predictive model. 识别有卒中后抑郁风险的个体：预测模型的开发和验证。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20250080

Saeed A Alqahtani

{"title":"Identifying individuals at risk of post-stroke depression: Development and validation of a predictive model.","authors":"Saeed A Alqahtani","doi":"10.15537/smj.2025.46.5.20250080","DOIUrl":"10.15537/smj.2025.46.5.20250080","url":null,"abstract":"Objectives: To identify the factors associated with post-stroke depression (PSD) and develop a machine learning predictive model using a large dataset, considering sociodemographic, lifestyle, and clinical factors.Methods: Our 2025 study used data from the 2023 Behavioral Risk Factor Surveillance System, released in September 2024. Data processing was carried out using Google Colab and Python. We carried out descriptive statistics, logistic regression, and feature importance analyses (mutual information and adjusted mutual information). A total of 4 machine-learning models were trained and evaluated: random forest, decision tree, gradient boosting, and logistic regression. Model performance was assessed using the accuracy, precision, recall, harmonic mean of precision and recall (F1-score), and area under the curve - receiver operating characteristic (AUC-ROC). The best-performing model was fine-tuned using GridSearchCV with 5-fold cross-validation.Results: Increasing age, male gender, being married, higher income, and physical activity were associated with lower odds of PSD. Obesity, smoking, diabetes, and high cholesterol are associated with increased odds of PSD. Age and gender were the most informative features for predicting the PSD. Random forest demonstrated the best performance for predicting PSD (accuracy=0.73, precision=0.71, recall=0.77, F1-score=0.74, and AUC-ROC=0.81), which was further improved by hyperparameter optimization.Conclusion: Post-stroke depression's complex etiology involves sociodemographic, lifestyle, and clinical factors, notably age and gender. A random forest model effectively predicts PSD, highlighting the need for comprehensive assessment, early intervention, and management of modifiable risks (obesity, smoking, and inactivity) to improve stroke survivors' outcomes.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"497-506"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring communication challenges with children and parents among pharmacists in Saudi Arabia: A cross-sectional study. 探索与儿童和家长的沟通挑战在沙特阿拉伯药剂师：一个横断面研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-05-01 DOI: 10.15537/smj.2025.46.5.20250048

Mustafa A Malki, Rahaf A Alnemary, Sarah K Alabbasi, Dania M Almanea

{"title":"Exploring communication challenges with children and parents among pharmacists in Saudi Arabia: A cross-sectional study.","authors":"Mustafa A Malki, Rahaf A Alnemary, Sarah K Alabbasi, Dania M Almanea","doi":"10.15537/smj.2025.46.5.20250048","DOIUrl":"10.15537/smj.2025.46.5.20250048","url":null,"abstract":"Objectives: To identify trends and challenges in pharmacists' communication with pediatric patients in Saudi Arabia. It also studies the potential factors affecting their overall performance.Methods: A cross-sectional survey of 170 pharmacists working in different healthcare settings in Saudi Arabia was carried out. A novel comprehensive 38-item survey questionnaire was utilized. The questionnaire comprised 2 main sections: demographic data and potential influencing factors and communication skills with children. The communication domain assessed the degree to which the pharmacist could communicate with a child in 7 main areas. Comparisons of communication performance were carried out by Chi-square tests, and associations with 24 factors were determined by logistic regression analyses.Results: Approximately 76% of pharmacists demonstrated unsatisfactory communication with children (p=8.47×10-10). Approximately 91% of pharmacists depended on speaking to parents rather than directly talking to children, even when present (p=7.791×10-26). In addition, although 88.23% of pharmacists expressed high confidence in their communication skills (p=9.899×10-24), their actual performance with children in different age groups showed that 63.52% performed poorly, while only 36.46% demonstrated good performance (p=4.2×10-4). Factors which might be associated with pharmacists' performance were identified.Conclusion: Pharmacists in Saudi Arabia face significant challenges in communicating with pediatric patients. Targeted training is needed to improve communication skills, medication adherence, and children's health outcomes.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 5","pages":"529-544"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0