Saudi Medical Journal最新文献_第9页

WHO calls for action to uphold right to health amidst inaction, injustice and crises. 世卫组织呼吁采取行动，在不作为、不公正和危机中维护健康权。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01

引用次数: 0

Correlation between immunohistochemical staining and clinicopathological findings in endometrial carcinoma. 子宫内膜癌免疫组化染色与临床病理结果的相关性。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20230962

Samah N Saharti, Fadwa J Altaf

{"title":"Correlation between immunohistochemical staining and clinicopathological findings in endometrial carcinoma.","authors":"Samah N Saharti, Fadwa J Altaf","doi":"10.15537/smj.2024.45.6.20230962","DOIUrl":"10.15537/smj.2024.45.6.20230962","url":null,"abstract":"Objectives: To analyze the immunohistochemical staining pattern of mismatch repair (MMR) proteins and p53 in endometrial carcinoma cases, including different subtypes and stages, to gain insights into their role in the pathogenesis and clinical behaviour of this malignancy.Methods: In this study, we investigate the association between MMR deficiency, p53 mutational status, and clinical outcomes in various subtypes of endometrial carcinoma. The immunohistochemical staining pattern of MMR proteins in 96 cases of endometrial carcinoma have been analyzed, including 72 endometrioid, 14 papillary serous, 5 clear cell, and 5 mixed Müllerian tumor.Results: The results showed that 36 cases were MMR deficient, with the majority being of endometrioid subtype. The p53 immunostain showed a mutational pattern in a subset of cases, with a documented dismal prognosis. However, aforementioned stains failed to predict synchronous or metachronous cancers in 5 patients.Conclusion: These findings highlight the importance of MMR and p53 immunohistochemical staining in the classification, and prognosis of endometrial carcinoma.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the post-operative outcomes between different surgical techniques for inferior turbinate reduction surgery: A cross sectional study. 下鼻甲缩小手术中不同手术技术的术后效果比较：一项横断面研究。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20230977

Sultan A Al Sumairi, Shmokh Al Salamah, Mohammed Asiri, Mohammed J Al Mahdi, Abdulrahman Al Fayez, Riyadh Al Hedaithy

{"title":"Comparison of the post-operative outcomes between different surgical techniques for inferior turbinate reduction surgery: A cross sectional study.","authors":"Sultan A Al Sumairi, Shmokh Al Salamah, Mohammed Asiri, Mohammed J Al Mahdi, Abdulrahman Al Fayez, Riyadh Al Hedaithy","doi":"10.15537/smj.2024.45.6.20230977","DOIUrl":"10.15537/smj.2024.45.6.20230977","url":null,"abstract":"Objectives: To compare and measure post-operative outcomes among various surgical techniques for reducing inferior turbinate hypertrophy (ITH), and to identify the factors associated with the clinical outcomes of turbinoplasty in patients with this condition.Methods: A cross-sectional study was carried out from January 2021 to December 2022 at the Otorhinolaryngology Department of King Abdulaziz Medical City in Riyadh, Saudi Arabia. A total of 301 adult patients with ITH were included and were divided into different groups. Postoperative follow-up assessments were completed after one week, one month, and 6 months to evaluate outcomes and complications associated with each surgical technique; descriptive analysis, cross-tabulation, and exact logistic regression were utilized as data analysis methods.Results: Most patients in both groups experienced partial or complete improvement after surgery, with 92% showing positive outcomes. Common clinical signs included deviated nasal septum deviation and external nasal deformity, while nasal obstruction was most frequently reported as the primary symptom. Post-surgery bleeding occurred in 3.7% of cases; no adhesions were noted. Microdebrider, medial flap, out-fracture, and submucosal diathermy techniques all demonstrated significantly higher improvement rates than others.Conclusion: The identified techniques with higher improvement rates offer evidence-based guidance for selecting optimal surgical approaches, while the study's limitations warrant further prospective research to validate these findings. Ultimately, it contributes valuable knowledge to the field of otorhinolaryngology, aiming to enhance patient outcomes and improve the management of ITH worldwide.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foodborne botulism outbreak with potential new management options. 食源性肉毒杆菌爆发，可能出现新的管理方案。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20240419

Ali H Altalag, Mohammed A Badawee, Sahar A Hassan, Nahla A Habiballa, Naif M Alotaibi, Ehab A Ahmed, Mohammed N Aljuaid, Muhammad A Almalki, Ahmed A Alahmari, Adulrahman A Alshehri

{"title":"Foodborne botulism outbreak with potential new management options.","authors":"Ali H Altalag, Mohammed A Badawee, Sahar A Hassan, Nahla A Habiballa, Naif M Alotaibi, Ehab A Ahmed, Mohammed N Aljuaid, Muhammad A Almalki, Ahmed A Alahmari, Adulrahman A Alshehri","doi":"10.15537/smj.2024.45.6.20240419","DOIUrl":"10.15537/smj.2024.45.6.20240419","url":null,"abstract":"Objectives: To shed some light on a potential therapeutic modality that may facilitate resolution of botulism symptoms, namely 3,4-diaminopyridine (3,4-DAP).Methods: In Riyadh, Saudi Arabia, we recently encountered a foodborne botulism outbreak that, luckily, was discovered early. In Prince Sultan Military Medical city, we admitted, during a period of approximately 3 weeks, 15 probable cases, 2 of which were excluded due to more likely alternative diagnoses. We report in this case series 13 highly suspected cases of botulism that we encountered during the outbreak.Results: A total of 12 out of 13 patients required intensive care unit (ICU) admission, one of which required intubation. Symptoms included cranial nerve palsies, gastrointestinal symptoms, limb and respiratory muscle weakness. Patients showed clinical improvement when received botulinum antitoxin and 3,4-DAP if given early in the course of the disease.Conclusion: Early admisntration of 3,4-DAP may facilitate recovery and prevent disease progression. Larger prospective trials should be carried out to confirm that.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on: Inappropriate laboratory test utilization in tertiary care. The audit circle needs closure. 评论：三级医疗机构实验室化验使用不当。审计圈需要关闭。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20240418

Ahmed S Mahmoud, Ali S Jawad

引用次数: 0

Incidence, patterns, and management of frontal sinus fractures: A 10-year retrospective study at a tertiary medical center, Saudi Arabia. 额窦骨折的发生率、模式和处理：沙特阿拉伯一家三级医疗中心的十年回顾性研究。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20240167

Abdullah M Alshahrani, Nedal Abu Mostafa, Feras Almoslem, Ayman Alothman, Fares Alrawashdeh

{"title":"Incidence, patterns, and management of frontal sinus fractures: A 10-year retrospective study at a tertiary medical center, Saudi Arabia.","authors":"Abdullah M Alshahrani, Nedal Abu Mostafa, Feras Almoslem, Ayman Alothman, Fares Alrawashdeh","doi":"10.15537/smj.2024.45.6.20240167","DOIUrl":"10.15537/smj.2024.45.6.20240167","url":null,"abstract":"Objectives: To assess the prevalence of various frontal sinus fractures (FSF) and examine the relationships between these fractures, types of treatments, and potential complications.Methods: A retrospective study was carried out in King Saud Medical City, Riyadh, Saudi Arabia. The study analyzed the records of patients who were diagnosed and treated with FSF from 2011-2021. Files with missing documents or incomplete treatment were excluded. The retrieved data includes: patients age, gender, types, locations, treatment, and complications of FSF. Data was analyzed by the statistical Package for the Social Sciences Statistics, version 23.0 using descriptive statistics and Chi-square test.Results: A total of 72 cases were included, 94.4% males and 5.6% females. Road traffic accidents were the common cause of trauma (91%). Frontal sinus fractures were unilateral in 59.7% and associated other injuries in 80.6% of cases. Anterior table fractures were the largest proportion (58.3%), followed by anterior and posterior table (37.5%). The carried out surgical procedures were obliteration (23.9%), cranialization and obliteration (23.9%), and fixation only (52.2%). The post-operative complications were categorized into; neurological (22.2%), ophthalmic (15.3%), infection (2.8%), and deformity (16.7%). Anterior and posterior table had the highest percentage among these categories.Conclusion: Frontal sinus fractures were mostly required surgical treatment (63.9%) and post-operative complications occurred especially the neurological and ophthalmic. We recommend studies on the association of complications and different types of obliteration materials.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of CEA, CA 125, and CA 15-3 serum tumour markers in different regions of Saudi Arabia. 沙特阿拉伯不同地区 CEA、CA 125 和 CA 15-3 血清肿瘤标志物的流行情况。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20230878

Abrar Ashi, Marwan Al-Hajeili, Sarah Almaghrabi, Jaudah Al-Maghrabi, Nora Trabulsi, Shmoukh Alghuraibi, Rawaih Alsiary, Nuha Alrayes

{"title":"Prevalence of CEA, CA 125, and CA 15-3 serum tumour markers in different regions of Saudi Arabia.","authors":"Abrar Ashi, Marwan Al-Hajeili, Sarah Almaghrabi, Jaudah Al-Maghrabi, Nora Trabulsi, Shmoukh Alghuraibi, Rawaih Alsiary, Nuha Alrayes","doi":"10.15537/smj.2024.45.6.20230878","DOIUrl":"10.15537/smj.2024.45.6.20230878","url":null,"abstract":"Objectives: To study the prevalence of tumor marker (TM) carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), and cancer antigen 15-3 (CA 15-3) levels in the Saudi population, based on gender, age, and demographic region, and whether the patients were referred by a hospital or self-referred.Methods: Retrospective analysis was carried out on 7,019 samples gathered from the Western, Northern, Central, Southern, and Eastern regions of Saudi Arabia between 2021-2022. The TMs were categorized into normal and abnormal levels, according to the reference ranges. Statistical analysis was carried out to assess the relations between variants (age groups, gender, and demographic regions) using the Chi-square test, and their correlations were assessed using Spearman's test.Results: Among all patients, CEA, CA 125, and CA 15-3 levels were found to be significantly correlated with age (p=0.0001). The CEA and CA 15-3 levels increased in both males and females with age. The CA 125 was shown to have an abnormally increased level in males with age.Conclusion: Increased levels of CEA, CA 125, and CA 15-3 TMs in the study population were significantly correlated with age. The CEA and CA 15-3 levels were within the normal range, while CA 125 levels were above the normal range in the older male population. These results suggest that the utilization of such TMs is age dependent and would have validity if applied with other parameters.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world treatment patterns and clinical outcomes in patients with prostate cancer.: A single institution experience in Saudi Arabia. 前列腺癌患者的实际治疗模式和临床结果：沙特阿拉伯一家医疗机构的经验。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20240042

Ruba Abu Khizanah, Emad Tashkandi, Mohammad Jaffal, Mohammed Alsaedi, Yazan Al-Ahmdi, Abdulmajeed Almehmadi, Khaled A Elnaghi

{"title":"Real-world treatment patterns and clinical outcomes in patients with prostate cancer.: A single institution experience in Saudi Arabia.","authors":"Ruba Abu Khizanah, Emad Tashkandi, Mohammad Jaffal, Mohammed Alsaedi, Yazan Al-Ahmdi, Abdulmajeed Almehmadi, Khaled A Elnaghi","doi":"10.15537/smj.2024.45.6.20240042","DOIUrl":"10.15537/smj.2024.45.6.20240042","url":null,"abstract":"Objectives: To describe the current real-world treatment landscape, sequence of therapies, and outcomes in patients with prostate cancer (PC).Methods: A retrospective cohort study for PC patients diagnosed at King Abdullah Medical City Cancer Center in Makkah, Saudi Arabia, between January 2011 and December 2021. Data extracted from electronic medical records.Results: A total of 282 patients with PC, with a mean age of 70 years and body mass index of 27. Among them, 274 (99%) had no family history of cancer, while 164 (58%) had hypertension and 125 (44%) had diabetes mellitus. Adenocarcinoma was the most common histology, found in 275 (97%) patients, with 99 (35%) having a Gleason score of 9. Notably, 184 (65%) patients presented with metastatic disease, and 147 (52%) with bone metastasis. While 198 (70%) patients underwent surgery, 184 (65%) did not receive radiotherapy. The most common first-line metastatic therapy was abiraterone in 23 (8%) patients, followed by enzalutamide in 7 (2.5%). During the study period, 167 (59%) patients survived, with an average treatment duration of 2.5 years.Conclusion: This study provides insights into real-world treatment patterns and clinical outcomes in patients with PC. The findings of this study highlight the importance of adhering to treatment standards and making informed clinical decisions.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual reality sessions lessen cancer pain in clinical trial. 在临床试验中，虚拟现实疗程减轻了癌症疼痛。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01

引用次数: 0

Childhood vaccination hesitancy in Saudi Arabia: are we still facing a problem? A narrative review. 沙特阿拉伯儿童疫苗接种犹豫不决：我们是否仍面临问题？叙述性综述。

IF 1.6 4区医学

Saudi Medical Journal Pub Date : 2024-06-01 DOI: 10.15537/smj.2024.45.6.20240116

Abdulrahman A Bin Alamir

引用次数: 0