Saudi Medical Journal最新文献_第8页

Assessing the accuracy and efficiency of Chat GPT-4 Omni (GPT-4o) in biomedical statistics: Comparative study with traditional tools. 评估Chat GPT-4 Omni （gpt - 40）在生物医学统计学中的准确性和效率：与传统工具的比较研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240454

Anusha S Meo, Narmeen Shaikh, Sultan A Meo

{"title":"Assessing the accuracy and efficiency of Chat GPT-4 Omni (GPT-4o) in biomedical statistics: Comparative study with traditional tools.","authors":"Anusha S Meo, Narmeen Shaikh, Sultan A Meo","doi":"10.15537/smj.2024.45.12.20240454","DOIUrl":"10.15537/smj.2024.45.12.20240454","url":null,"abstract":"Objectives: To assess the accuracy of ChatGPT-4 Omni (GPT-4o) in biomedical statistics. The recent novel inauguration of Artificial Intelligence ChatGPT-Omni (GPT-4o), has emerged with the potential to analyze sophisticated and extensive data sets, challenging the expertise of statisticians using traditional statistical tools for data analysis.Methods: This study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, in May 2024. Three datasets in a raw Excel file format were imported onto Statistical Package for the Social Sciences (SPSS) version 29 for data analysis. Based on this analysis, a script of 9 questions was prepared to command GPT-4 Omni, which was used for data analysis for all 3 datasets on Omni. The score and the time were recorded for each result and verified after being compared to the original analysis results performed on SPSS.Results: GPT-4 Omni scored 73 (85.88%) out of 85 points for all 3 datasets. All datasets took a total of 38.43 minutes to be fully analyzed. Individually, Omni scored 21/25 (84%) for the small dataset in 487.4 seconds, 20/25 (80%) for the middle dataset in 747.02 seconds and 32/35 (91.42%) for the large dataset in 1071 seconds. GPT-4 Omni produced accurate graphs and charts.Conclusion: ChatGPT-4 Omni scored better over 80% in all 3 statistical datasets in a short period. GPT-4 Omni also produced accurate graphs and charts as commanded however it required explicit commands with clear instructions to avoid errors and omission of results to achieve appropriate results in biomedical data analysis.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1383-1390"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent reactivation of Varicella Zoster virus in hemodialysis patients.: A management dilemma. 水痘带状疱疹病毒在血液透析患者中的沉默再激活。管理困境。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240553

Bandar A Suliman, Hassan T Alhazmi, Hamzah A Alamri, Ahmed A Aljuhani, Mohammed S Younis, Khalid H Mahallawi, Fayez H Alsehli, Ibrahim T Alomani, Bashayer A Almoutairi, Yasser S Asar, Mohammed A Alkhaily, Walaa A Momena, Waleed H Mahallawi

{"title":"Silent reactivation of Varicella Zoster virus in hemodialysis patients.: A management dilemma.","authors":"Bandar A Suliman, Hassan T Alhazmi, Hamzah A Alamri, Ahmed A Aljuhani, Mohammed S Younis, Khalid H Mahallawi, Fayez H Alsehli, Ibrahim T Alomani, Bashayer A Almoutairi, Yasser S Asar, Mohammed A Alkhaily, Walaa A Momena, Waleed H Mahallawi","doi":"10.15537/smj.2024.45.12.20240553","DOIUrl":"10.15537/smj.2024.45.12.20240553","url":null,"abstract":"Objectives: To determine the seroprevalence of Varicella Zoster virus (VZV) immunoglobulin (Ig)G and IgM antibodies among hemodialysis patients (HDP). Additionally, the presence of VZV viral DNA has been investigated for possible reactivation status.Methods: Sera from 265 individuals were collected and tested. The study was carried out from November 2023 to February 2024. Enzyme linked immunosorbent assay was accomplished to determine the VZV IgG and IgM antibody levels. The viral DNA was tested by qPCR.Results: We found a significantly higher proportion of Host defense peptides (HDP) have positive antibody levels compared to healthy controls (HC) (92.0% of HDP have positive immune responses compared to 79.1% of HC, p=0.005). Patients with both hypertension and diabetes showed lower VZV seropositivity (25.6%) than those without (74.4%). Only 3 HDP had positive IgG and IgM levels (1.9%, n=3), while 14 patients (100%) had negative IgG and IgM levels. Additionally, all IgM-positive patients appeared to have detectable viral DNA of the VZV.Conclusion: In conclusion, significantly higher VZV seroprevalence and antibody levels in HDP indicate greater viral exposure than HC. Screening of hemodialysis (HD) to VZV serologically or at the molecular level is most important to avoid the consequences of viral reactivation, especially in those with asymptomatic HDP.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1391-1395"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiating mycosis fungoides lesions from their mimickers clinically and histologically: A single tertiary center retrospective analysis in Saudi Arabia. 鉴别蕈样真菌病病变从他们的模拟临床和组织学：一个单一三级中心回顾性分析在沙特阿拉伯。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240796

Fatimah M Budair, Ahmed A Alsayyah, Omar M Alakloby

{"title":"Differentiating mycosis fungoides lesions from their mimickers clinically and histologically: A single tertiary center retrospective analysis in Saudi Arabia.","authors":"Fatimah M Budair, Ahmed A Alsayyah, Omar M Alakloby","doi":"10.15537/smj.2024.45.12.20240796","DOIUrl":"10.15537/smj.2024.45.12.20240796","url":null,"abstract":"Objectives: To identify the clinical and histological features of MF that can assist in distinguishing MF from MF-mimicking cases. Although mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma, clinicopathological correlations are required to establish an accurate diagnosis, which are currently lacking.Methods: This retrospective observational study evaluated the clinical presentations, characteristics, and histological features of 56 patients with suspected MF who presented to our clinic between January 2018 and August 2022. Immunohistochemistry was performed, and the loss of CD5 and CD7 T-cells and T-cell receptor rearrangement was evaluated.Results: Overall, 34 patients were diagnosed with MF, whereas 22 were not. Clinical erythroderma, poikiloderma, and nodular presentations were more commonly associated with a histological diagnosis of MF than macular presentations. Erythema and pruritus were significantly more common in MF cases than in MF-mimicking cases (p<0.05). Epidermotropism and parakeratosis were the key histological features for diagnosing MF. Additionally, Pautrier's microabscesses correlated with the clinical presentation of plaques in MF. Loss of CD7 expression on the T-cell surface was observed even in early-stage MF cases.Conclusion: Our proposed diagnostic features are statistically valid and, along with those previously reported, can aid in identifying and distinguishing MF cases from MF-mimicking cases.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1355-1367"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rising epidemiological trends in prevalence and mortality of mpox: Global insights and analysis. m痘患病率和死亡率上升的流行病学趋势：全球见解和分析。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240720

Muhammad Os Meo, Muhammad Zs Meo, Isra M Khan, Muhammad As Butt, Adnan M Usmani, Sultan A Meo

{"title":"Rising epidemiological trends in prevalence and mortality of mpox: Global insights and analysis.","authors":"Muhammad Os Meo, Muhammad Zs Meo, Isra M Khan, Muhammad As Butt, Adnan M Usmani, Sultan A Meo","doi":"10.15537/smj.2024.45.12.20240720","DOIUrl":"10.15537/smj.2024.45.12.20240720","url":null,"abstract":"Objectives: To explore the global epidemiological trends in the prevalence and mortality due to mpox in various regions worldwide.Methods: In this cross-sectional study the data about mpox outbreak were recorded by the \"World Health Organization, Centers for Disease Control and Prevention, and GSAID\" from August 2023 to August 2024, analyzing the epidemiological trends from different countries worldwide.Results: The total number of mpox cases has reached 99,518 (95,196 cases from 115 countries that have not historically reported mpox; and 4,322 cases from 07 states that have traditionally reported mpox), from a total of 122 countries. The top 10 countries with the greatest number of mpox cases include the United States (33,435) followed by Brazil (11212), Spain (8084), France (4272), Colombia (4249), Mexico (4124), United Kingdom (3952), Peru (3875), Germany (3857), and Democratic Republic of Congo (3104). America has the highest number of cases (63,145) accounting for 63% of total cases globally, followed by Europe (27,194). Democratic Republic of Congo faces the highest increase in cases within a single year, with the infectious rate in the region up by 160%, alongside a higher risk of mortality.Conclusion: Mpox cases have rapidly spread worldwide, reaching 99,518 cases across 122 countries, and being declared a \"Public Health Emergency of International Concern\" by the WHO. Healthcare authorities must take timely measures to control this outbreak since the world cannot afford the global burden of it being another potential pandemic.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1334-1339"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In this issue. 本期内容

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01

引用次数: 0

Can coping with a cancer diagnosis contribute to psychological and cardiovascular problems in family members? 应对癌症诊断会导致家庭成员出现心理和心血管问题吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01

引用次数: 0

Do cancer and cancer-related treatments increase cardiovascular disease risk in older cancer survivors? 癌症和癌症相关治疗是否会增加老年癌症幸存者患心血管疾病的风险？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01

引用次数: 0

The clinical value of integrated pulmonary index monitoring during an endobronchial ultrasound-guided transbronchial needle aspiration procedure under sedoanalgesia: A prospective study. 在镇静镇痛下进行支气管内超声引导下经支气管针吸术期间综合肺指数监测的临床价值：一项前瞻性研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01 DOI: 10.15537/smj.2024.45.11.20240621

Hulya Y Ak, Kubra Taskin, Merve B Yediyildiz, Irem Durmus, Gulten Arslan, Sevda S Comert, Baris Sandal, Kemal T Saracoglu

{"title":"The clinical value of integrated pulmonary index monitoring during an endobronchial ultrasound-guided transbronchial needle aspiration procedure under sedoanalgesia: A prospective study.","authors":"Hulya Y Ak, Kubra Taskin, Merve B Yediyildiz, Irem Durmus, Gulten Arslan, Sevda S Comert, Baris Sandal, Kemal T Saracoglu","doi":"10.15537/smj.2024.45.11.20240621","DOIUrl":"10.15537/smj.2024.45.11.20240621","url":null,"abstract":"Objectives: To evaluate the clinical relevance of Integrated Pulmonary Index (IPI) monitoring during transbronchial needle aspiration (EBUS-TBNA) under sedation and determine whether it reduces hypoxic events compared to standard monitoring.Methods: This prospective observational research was carried out at Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey, between July 2022 and July 2023. A total of 50 patients, aged 18-80 years with American Society of Anesthesiologists scores of I-III, undergoing EBUS-TBNA with deep sedation for diagnostic purposes were included. The IPI values were measured at 6 time points: baseline, induction, 3, 5, 10 minutes, and at the end of the procedure. Patients were categorized based on whether their IPI scores were above 7 (group 1) or below 7 (group 2).Results: A total of 43 patients completed the study. Group 1 had higher end-tidal carbon dioxide and respiratory rate at multiple time points, including induction and at 3, 5, and 10 minutes post-induction (p<0.05). Group 2 experienced a higher rate of apnea at these times (p<0.05). Those with lower IPI scores (namely, IPI=3 and IPI=4) showed significantly higher apnea rates, while those with higher scores (namely, IPI=7 and IPI=8) were less likely to have apneic episodes.Conclusion: The IPI monitoring during EBUS-TBNA under sedation demonstrated improved detection of apnea episodes and enhanced respiratory safety compared to standard monitoring techniques. Additional research involving more varied populations is necessary to confirm these results.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 11","pages":"1223-1227"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WHO approves first mpox diagnostic test for emergency use, boosting global access. 世卫组织批准首个用于紧急用途的麻风病诊断测试，促进全球普及。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01

引用次数: 0

BOLA family genes are the drivers and potential biomarkers of survival in kidney renal clear cell carcinoma patients. BOLA家族基因是肾透明细胞癌患者生存的驱动因素和潜在生物标志物。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-11-01 DOI: 10.15537/smj.2024.45.11.20240604

Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi, Mohammed A Alshehri, Meshari A Alsuwat, Mamdouh Allahyani, Ali G Alkhathami

{"title":"BOLA family genes are the drivers and potential biomarkers of survival in kidney renal clear cell carcinoma patients.","authors":"Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi, Mohammed A Alshehri, Meshari A Alsuwat, Mamdouh Allahyani, Ali G Alkhathami","doi":"10.15537/smj.2024.45.11.20240604","DOIUrl":"10.15537/smj.2024.45.11.20240604","url":null,"abstract":"Objectives: To analyze the diagnostic and prognostic potential of the BOLA gene family in kidney renal clear cell carcinoma (KIRC).Methods: This study is an observational study. The whole study was carried out at Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia from January to November 2023. As it involves in silico and in vitro methods, ethical consent was not required. Various in silico and molecular experimental techniques were employed in this study.Results: Significant up-regulation and hypomethylation of BOLA1, BOLA2, and BOLA3 were observed across 12 KIRC cell lines. Retrospective analysis of the cancer genome atlas program (TCGA)-KIRC cohorts confirmed hypomethylation of these genes in KIRC tissues. The cBioPortal analysis showed minimal genetic alterations, with amplification being the most common. Kaplan-Meier plotter data revealed that high BOLA1, BOLA2, and BOLA3 expression correlated with shorter overall survival and relapse-free survival in KIRC. Tumor-immune system interactions database analysis linked BOLA1 expression to immune and molecular subtypes. Gene silencing of BOLA1, BOLA2, and BOLA3 in 786-0 cells reduced cell growth and proliferation, enhancing wound healing capacity.Conclusion: BOLA genes may serve as diagnostic and prognostic markers in KIRC, offering insights into therapeutic targets and disease progression.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 11","pages":"1207-1218"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0