Saudi Medical Journal最新文献_第7页

Comparison of pediatric diabetic ketoacidosis in newly diagnosed versus known patients with type 1 diabetes mellitus: A single-center study. 儿童糖尿病酮症酸中毒在新诊断与已知1型糖尿病患者中的比较：一项单中心研究

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240734

Nagham Alsolaimani, Mawadah Kattan, Zahia Algabbani, Ghram Awlia, Yara Alhamdani, Abdulmoien AlAgha

{"title":"Comparison of pediatric diabetic ketoacidosis in newly diagnosed versus known patients with type 1 diabetes mellitus: A single-center study.","authors":"Nagham Alsolaimani, Mawadah Kattan, Zahia Algabbani, Ghram Awlia, Yara Alhamdani, Abdulmoien AlAgha","doi":"10.15537/smj.2024.45.12.20240734","DOIUrl":"10.15537/smj.2024.45.12.20240734","url":null,"abstract":"Objectives: To compare the demographic, clinical, and biochemical characteristics of newly diagnosed versus known patients with type 1 diabetes mellitus (T1DM) presenting with diabetic ketoacidosis (DKA) in a tertiary care center in the Western region of Saudi Arabia.Methods: We retrospectively reviewed 147 children and adolescents diagnosed with T1DM who presented with DKAs between January 2019 and December 2023. Data on age, gender, nationality, economic status, episode severity, presenting symptoms, and biochemical markers were collected and analyzed.Results: The mean patient age was 7.24 years, with known patients being older (mean age: 8.24 years) than newly diagnosed patients (mean age: 6.34 years). Most patients (55.8%) belonged to the middle-childhood age group (6 to 11 years). Among known patients, the most prevalent symptoms included vomiting, reported by 62 (88.6%) individuals, and abdominal pain, which affected 55 (78.6%). In contrast, new patients exhibited a strikingly high incidence of polyuria, with 68 (88.3%) cases, and polydipsia, affecting 65 (84.4%) individuals.Conclusion: The DKA incidence was higher in newly diagnosed patients, particularly in the middle-childhood age group. Economic factors may contribute to disease manifestations, and newly diagnosed patients had longer DKA symptom durations. The higher DKA incidence and severity in newly diagnosed patients, particularly in certain age groups, underscores the importance of increased disease awareness and early diagnosis.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1326-1333"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does work-related stress compromise cardiovascular health? 工作压力会损害心血管健康吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01

引用次数: 0

Assessment of contraceptive methods choice among women during childbearing age in Mosul, Iraq. 伊拉克摩苏尔育龄妇女避孕方法选择评估。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240565

Ruqaya Adnan Salih

{"title":"Assessment of contraceptive methods choice among women during childbearing age in Mosul, Iraq.","authors":"Ruqaya Adnan Salih","doi":"10.15537/smj.2024.45.12.20240565","DOIUrl":"10.15537/smj.2024.45.12.20240565","url":null,"abstract":"Objectives: To assess factors influencing choice of contraceptive methods among women in Mosul, Iraq.Methods: An analytic cross-sectional study was conducted during the period extending from July 2022 to March 2023, and a convenience sample of 100 women at child-bearing age (15-49 years) was collected from those attending the Family Planning Clinic at Al-Khansaa Teaching Hospital in Mosul. A direct interview was used to collect data required by using a special questionnaire form. Data was tabulated and analyzed using Excel 2010 and Statistical Package of the Social Sciences, version 24.0. The frequency and percentage of variables have been calculated. Together with calculating factors influencing choice of contraceptive method by using the Chi-Square test to compare different factors, p-value of <0.05 was considered significant.Results: The commonest method used was coitus interruptus (43%), follow by pills in 21%. The most important factor influenced the choice of the contraceptive method was the safety of method with fewer side effects (p=0.001).Conclusion: Although different modern contraceptive methods are available, coitus interruptus (withdrawal) was found to be the most frequent method used awing to its safety. Adapting a national program to increase women's awareness for other method is needed to be applied in all antenatal care unit in Primary Health Center for pregnant women and encouraging them to decided using these methods after delivery.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1368-1373"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing tele-pharmacy and standard clinic follow-up for newly initiated warfarin anticoagulation therapy: A retrospective study. 比较远程药房和标准临床随访新开始华法林抗凝治疗：一项回顾性研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240672

Sumaiah J Alarfaj, Sara Alsulami, Ebtehaj Alashjaey, Reema Albulayhi, Faisal Alqarni, Abeer Alharbi

{"title":"Comparing tele-pharmacy and standard clinic follow-up for newly initiated warfarin anticoagulation therapy: A retrospective study.","authors":"Sumaiah J Alarfaj, Sara Alsulami, Ebtehaj Alashjaey, Reema Albulayhi, Faisal Alqarni, Abeer Alharbi","doi":"10.15537/smj.2024.45.12.20240672","DOIUrl":"10.15537/smj.2024.45.12.20240672","url":null,"abstract":"Objectives: To compare the effectiveness of providing telepharmacy anticoagulation to on-site clinics in achieving optimal outcomes for patients newly starting warfarin.Methods: This single-center retrospective cohort study included adult patients who started warfarin for the first time and were monitored by clinical pharmacists either on-site or via telepharmacy anticoagulation clinics between January 2017 and March 2024. The primary outcome is to compare the time in therapeutic range (TTR) between the 2 groups. The secondary outcome is the occurrence of anticoagulation therapy-related complications.Results: We included 191 patients, with 77 in the telepharmacy group and 114 in the on-site group. The baseline characteristics were similar for both groups. The primary outcome- time in therapeutic range (TTR)-was not significantly different between thetelepharmacy and the on-site groups (50% versus 53.8%, p=0.455) and remained so after univariable and multivariable adjustments (OR [odd ratio]= 0.63, p=0.14 and OR=0.58, p=0.102). Additionally, there were no significant differences in secondary outcomes, including thromboembolism and bleeding (p=1 for both).Conclusion: This study demonstrates that patients who receive warfarin for the first time at an anticoagulation clinic can use the telepharmacy method without the fear undesirable outcomes. Results of this study support the continued use and expansion of telepharmacy services in Saudi Arabia. However, further research larger sample sizes and multiple centers is needed to confirm these findings.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1374-1382"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study reveals links between many pesticides and prostate cancer. 研究揭示了许多杀虫剂与前列腺癌之间的联系。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01

引用次数: 0

Measles Cases Surge Worldwide, Infecting 10.3 Million People In 2023. 全球麻疹病例激增，2023年感染1030万人。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01

引用次数: 0

Prevalence of hyperlipidemia in psoriatic arthritis patients in Riyadh, Saudi Arabia. 沙特阿拉伯利雅得银屑病关节炎患者高脂血症患病率

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240817

Khalid AlTalhi, Sara Alotaiwi, Mohammed Alotaibi, Hanan A Alhamzi, Seham Alrashedi, Mosaab Makkawy, Fahdah Alokaily

{"title":"Prevalence of hyperlipidemia in psoriatic arthritis patients in Riyadh, Saudi Arabia.","authors":"Khalid AlTalhi, Sara Alotaiwi, Mohammed Alotaibi, Hanan A Alhamzi, Seham Alrashedi, Mosaab Makkawy, Fahdah Alokaily","doi":"10.15537/smj.2024.45.12.20240817","DOIUrl":"10.15537/smj.2024.45.12.20240817","url":null,"abstract":"Objectives: To estimate the prevalence of hyperlipidemia in patients with psoriatic arthritis (PsA) in Riyadh, Saudi Arabia, and to investigate the relationship between PsA and hyperlipidemia.Methods: This retrospective study examined medical records of PsA patients from January 2010 to May 2023 at 2 medical centers in Riyadh. Patients over 18 years old with a lipid profile were included. Hyperlipidemia cases were determined using Adult Treatment Panel III (ATP III) guidelines and European Association of Preventive Cardiology definitions based on lipid profile results.Results: A total of 141 patients were included in the analysis. The prevalence of hyperlipidemia in patients with PsA was 40.7% at diagnosis, and 28.7% at the last visit. The prevalence of hyperlipidemia was significantly higher in males than females (56% versus [vs] 29.4%, p<0.005). While not statistically significant, among patients who received a biologic disease-modifying antirheumatic drugs (bDMARD), 31.6% had hyperlipidemia at the last visit, compared to 20% of those who did not receive it (p=0.317). Among patients who received conventional disease-modifying antirheumatic drugs (cDMARD), 30% had hyperlipidemia at the last visit, compared to 25.8% of those who did not it (p=0.813). The prevalence rates of hyperlipidemia at the first visit and the last visit were found to be statistically significant among patients who have comorbidities other than PsA (7.6 vs. 17.3%, p=0.004).Conclusion: The study results are comparable to those of other studies showing no significant effect of PsA on the lipid profile. The prevalence of hyperlipidemia in PsA patients appears similar to that of the general population in Saudi Arabia, based on indirect comparison.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1340-1346"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and safety of a cable transmission magnetically controlled capsule endoscopy system for examination of the human upper digestive tract. 用于人体上消化道检查的电缆传输磁控胶囊内窥镜系统的可行性和安全性。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240645

Hang Yu, Yuan Tian, Long Rong, Yunlong Cai, Guanyi Liu, Yan He, Xinyue Guo

{"title":"Feasibility and safety of a cable transmission magnetically controlled capsule endoscopy system for examination of the human upper digestive tract.","authors":"Hang Yu, Yuan Tian, Long Rong, Yunlong Cai, Guanyi Liu, Yan He, Xinyue Guo","doi":"10.15537/smj.2024.45.12.20240645","DOIUrl":"10.15537/smj.2024.45.12.20240645","url":null,"abstract":"Objectives: To evaluate the safety and feasibility of the cable-transmitted, magnetically controlled capsule endoscopy (CT-MCCE) system for examining the esophagus and stomach.Methods: A pilot study was carried out at the endoscopy facility of Peking University First Hospital; 30 volunteers were enrolled between September and November 2022. All participants were instructed to swallow the CT-MCCE capsule. An external magnetic robot arm was utilized to manipulate the capsule endoscope with string-facilitated control of the endoscope. This study assessed gastric preparation, safety, maneuverability, and mucosal visualization.Results: The participants exhibited favorable reactions to the gastric preparation and examination, with no reported adverse effects, and the average duration of the gastric examination was 29.5±6.63 minutes. The gastric cavity cleanliness assessment revealed a good rating in 25 participants (83.3%) and a moderate rating in 5 participants (11.8%). TheCT-MCCE demonstrated good maneuverability in all 30 subjects (100%).The analysis of visualization indicated that more than 75% of the gastric mucosa was discerned in 79.4% of the participants (27 individuals), whereas 50% to 75% was visualized in 20.6% of the participants (7 individuals).Conclusion: This study substantiates the feasibility and safety of employing magnetically controlled capsule endoscopy with cable transmission for the evaluation of human stomach and esophagus.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1318-1325"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals. 单纯疱疹病毒1型血清阳性健康人CD56+ T细胞、CD16+ CD56+ T细胞和CD56dim NK细胞水平升高

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240498

Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A Alsuwat, Mustafa Halawi

{"title":"Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals.","authors":"Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A Alsuwat, Mustafa Halawi","doi":"10.15537/smj.2024.45.12.20240498","DOIUrl":"10.15537/smj.2024.45.12.20240498","url":null,"abstract":"Objectives: To investigate the numbers of natural killer (NK) cells, CD56+ T-cells and CD56- T cells, and the levels ofCD16 in healthy individuals seropositive for herpes simplex virus Type 1 (HSV-1). Specifically, it seeks to measure the levels of these cells to learn about the possible immunological significance during HSV-1 seropositive status.Methods: This study employed a cross-sectional research design to examine the levels of CD56+ T-cells and CD16+ among individuals seropositive for herpes simplex virus type 1 (HSV-1) in Taif city. A total of 112 participants were enrolled, with HSV-1 serostatus determined via ELISA, and cellular evaluation conducted using flow cytometry. The study was performed between January 2023 to July 2023.Results: Our study found 36% HSV-1 seropositivity, contrasting with higher rates in Saudi Arabia. No significant age or gender differences were observed. HSV-1 seropositive individuals showed elevated dim CD56 NK cells and CD56+ T-cells, aligning with prior research on lymphocyte infiltration during HSV-1 activation. Further investigation is warranted for CD56- T-cells and bright NK cells.Conclusion: HSV-1 seropositive individuals showed elevated dim CD56 NK cells and CD56+ T-cells, consistent with lymphocyte activities during viral activation. CD16 expression on CD56+ T-cells suggests their involvement in viral defence, emphasizing the need for further investigation into immune responses against HSV-1.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1312-1317"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK2-V617F mutation among blood donors: A meta-analysis. 献血者中JAK2-V617F突变：荟萃分析

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-12-01 DOI: 10.15537/smj.2024.45.12.20240594

Mada H Alsharif, Eman M Mansory, Amjad A Alharazi, Maha A Badawi

{"title":"JAK2-V617F mutation among blood donors: A meta-analysis.","authors":"Mada H Alsharif, Eman M Mansory, Amjad A Alharazi, Maha A Badawi","doi":"10.15537/smj.2024.45.12.20240594","DOIUrl":"10.15537/smj.2024.45.12.20240594","url":null,"abstract":"Objectives: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial. Evidence on managing these donors is limited.Methods: We performed a literature search using EMBASE and MEDLINE from inception until August 2023, including studies on the prevalence of JAK2 mutation or PV among blood donors. Eligible studies examined blood donors in hospital or community settings, had a sample size of at least 20 donors, and reported the prevalence of the JAK2 mutation or PV. We assessed bias, extracted data, and used a random effects model meta-analysis to estimate pooled prevalence and 95% confidence intervals. Subgroup analysis differentiated donors with normal hematocrit from those with polycythemia. Heterogeneity was assessed using I2 statistics.Results: Our review included eleven studies in total. Of those, ten studies examined the presence of a JAK-2 mutation in 1,999 blood donors. The overall proportion of JAK2 mutations was 3% (95% CI 0.60 - 6.9, I2 90.21%). Subgroup analysis revealed a prevalence of 4.7% (95% CI 2.1 - 8.0, I2 0.00%) among repeat donors with polycythemia and 2.3% (95% CI 0.0 - 7.7, I2 0.00%) among healthy ones. Only 3 (309 donors) studies reported PV prevalence, precluding a meta-analysis.Conclusion: The prevalence of the JAK2 mutation among blood donors is similar to the general population's but slightly higher among repeat donors with elevated hematocrit. Further research is necessary to establish definitive upper hemoglobin limits for donor deferral.PROSPERO No.: CRD42023456878.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1289-1304"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0