Saudi Medical Journal最新文献

{"title":"WHO announces first prequalification of a tuberculosis diagnostic test.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"113"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In this issue.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram to predict survival after neoadjuvant chemotherapy in elderly women with triple-negative invasive ductal breast cancer: A SEER population-based study.","authors":"Ying Gao, Jinmiao Wang, Shoujun Wang, Weijie Tao, Ran Duan, Jie Hao, Ming Gao","doi":"10.15537/smj.2025.46.1.20240341","DOIUrl":"10.15537/smj.2025.46.1.20240341","url":null,"abstract":"<p><strong>Objectives: </strong>To construct and verify a nomogram for post-neoadjuvant chemotherapy survival predication in elderly women with triple-negative invasive ductal breast cancer.</p><p><strong>Methods: </strong>Elderly patients diagnosed as triple-negative invasive ductal breast cancer between 2019-2000 were screened from surveillance, epidemiology, and end results database. Depending on the post-neoadjuvant chemotherapy pathological response, they were assigned to the complete or non-complete response group. Inter-group clinicopathological characteristics and disease-specific and overall survivals were compared. Then, they were allocated randomly into the training or validation cohort. A prediction nomogram was developed in the training cohort and verified in the validation cohort.</p><p><strong>Results: </strong>A total of 382 patients were included, with 285 patients in non-response group and 97 patients in response group. After propensity score matching, disease-specific survival showed a significant difference between response and non-response groups (88.7% versus 64.6%, <i>p</i><0.001). The training cohort included 196 patients and the validation cohort included 82 patients. A total of 7 variables (age, race, tumor location, tumor-node-metastasis stage, summary stage, receipt of surgery, and response to neoadjuvant chemotherapy) were integrated to construct a survival prediction nomogram. The C-indexes were 0.756 in the training cohort and 0.791 in the validation cohort. In both cohorts, the predicted survival showed satisfactory coherence with the actual survival in the calibration curve analysis.</p><p><strong>Conclusion: </strong>In elderly women with triple-negative invasive ductal breast cancer, post-neoadjuvant chemotherapy pathological complete response could indicate improved disease-specific survival. A novel survival prediction nomogram was created to have satisfactory performance in these patients.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"43-51"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of laparoscopic intracorporeal reinforcing sutures to prevent anastomotic leakage: A meta-analysis.","authors":"Feng-Bing Wang, Min-Min Song, Nian-Wen Zhang, Wei-Feng, Bin-Liu, Peng-Fei Zhang","doi":"10.15537/smj.2025.46.1.20240422","DOIUrl":"10.15537/smj.2025.46.1.20240422","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effectiveness of reinforcing sutures after surgery for rectal cancer and its associated impact on postoperative recovery. Anastomotic leakage (AL) is a common and serious complication after anteriorrectal resection. It is currently unclear whether laparoscopic intracorporeal reinforcingsutures can effectively reduce the incidence of AL.</p><p><strong>Method: </strong>From inception to 2024, the literature search was conducted using a variety of databases, including PubMed, the Chinese biomedical literature database (CBM), Wanfang, EMBASE, the Cochrane Library, VIP, and China National Knowledge Infrastructure (CNKI), to identify relevant articles. Free-text forms were used to search the literature: \"rectal cancer\", \"rectal neoplasms\", \"reinforcing sutures\", and \"anastomotic leakage\" or AL. The search was undertaken by 2 different reviewers, who independently evaluated the studies.</p><p><strong>Result: </strong>Twelve retrospective studies and 4 RCTs were analyzed in all. A total of 3147 individuals were identified, with 1512 receiving reinforcing sutures and 1635 not. Patients who underwent laparoscopic surgery to get reinforcing sutures had a notably decreased occurrence of anastomotic leakage, according to our data. (OR 0.33; 95% CI 0.21-0.51, <i>p</i><0.00001). It had an earlier anal exhaust time and a shorter hospitalization. The 2 different groups did not differ substantially with regard to intraoperative blood loss or the rate of postoperative intestinal obstruction. However, patients who received reinforced sutures via a laparoscopic approach cost more operative time (MD=16.77, 95% CI 11.31-22.23, <i>p</i><0.00001).</p><p><strong>Conclusion: </strong>The occurrence of AL can be greatly decreased through the use of a laparoscopic approach for anastomotic reinforcement, which may be a better option after radical surgery for rectal patients. However, more RCT studies with large sample sizes are needed.<b>PROSPERO:</b> CRD42024548847.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"9-18"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of urgent care centers on emergency department visits in Al Madina Al Munawara: A pre-post study.","authors":"Ahlam A ALJohani, Jehan M Alhazmi, Osama H Alsaedi, Ahmed F Al-Ahmadi, Noura S Alshammary","doi":"10.15537/smj.2025.46.1.20240537","DOIUrl":"10.15537/smj.2025.46.1.20240537","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of UCCs on reducing non-urgent Emergency Department (ED) visits and improving patient flow, focusing on metrics such as door-to-doctor time, doctor-to-decision time, and overall patient disposition.</p><p><strong>Methods: </strong>This observational cohort pre-post study analyzed data from 198,050 ED visits to King Fahad Hospital, Al Madina Al Munawara between June 2021 and May 2023 and compared visit patterns before and after UCC implementation.</p><p><strong>Results: </strong>Post-UCC implementation, the average door-to-doctor time decreased but was not statistically significant. Significant reductions were observed in doctor-to-decision and door-to-disposition times for CTAS 3 patients. However, overall patient flow improvements were not fully realized, highlighting the need for enhanced public awareness and integration of UCCs with EDs.</p><p><strong>Conclusion: </strong>The study shows that while urgent care centers in Al Madina Al Munawara have improved efficiency for some patient categories, they don't fully achieve expected reductions in waiting times and patient flow. Seasonal variations, limited patient awareness, and data constraints affect outcomes.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"65-70"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milestone: COVID-19 five years ago.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"111-112"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-thyroidectomy hypoparathyroidism: A clinical surgical dilemma.","authors":"Saad M Alqahtani","doi":"10.15537/smj.2024.45.12.20240743","DOIUrl":"10.15537/smj.2024.45.12.20240743","url":null,"abstract":"<p><p>Thyroid dysfunction directly affects human health and overall well-being; various approaches are available for the treatment of thyroid diseases, including conservative measures and surgical interventions. Despite advancements in conservative treatment, surgery remains the preferred option. Hypoparathyroidism is the primary cause of hospitalization after thyroidectomy, leading to cost-related concerns and a detrimental impact on patients' overall quality of life. Postoperative hypoparathyroidism can result in hypocalcemia, and these are challenging conditions that must be identified promptly to prevent immediate and long-term complications. This article focused on the presentation, risk factors, and management of hypoparathyroidism to increase awareness of the risks associated with certain variables, thereby enhancing our ability to predict the risk of this condition. Furthermore, this review highlighted the surgical techniques that may be utilized to prevent hypoparathyroidism. These considerations can help guide preoperative discussions regarding the benefits and potential risks of thyroidectomy.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1305-1311"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In this issue.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1287"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin-induced epistaxis among acne vulgaris patients: A cross sectional study from Saudi Arabia.","authors":"Hanan Ibrahim Almuzaini, Ali Saeed Alamri, Razan Ibrahim Almuzaini","doi":"10.15537/smj.2024.45.12.20240791","DOIUrl":"10.15537/smj.2024.45.12.20240791","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence and risk factors of isotretinoin-related epistaxis, among patients of acne vulgaris.</p><p><strong>Methods: </strong>A retrospective cohort of 230 Saudi patients who received isotretinoin for treatment of acne vulgaris, was included in the study. An online questionnaire was used to collect data regarding demographics and treatment-related adverse events.</p><p><strong>Results: </strong>The prevalence of isotretinoin-induced epistaxis was found to be 45.2%, which was a 5-fold increase in epistaxis, versus baseline. Epistaxis was reported by 90% patients who had a prior history of nasal bleeding. Patients with 'obstructed nose', reported a prevalence of 68.8%. The large majority of patients had a mild form of epistaxis, while nearly one-fourth reported moderate severity. A small subgroup of patients reported severe epistaxis warranting emergency room (ER) visits and blood transfusion. A staggering 93.5% and 61.3% patients were not advised by their dermatologists, regarding the importance of an ear-nose-throat (ENT) specialist consultation and nasal moisturization respectively, while taking isotretinoin.</p><p><strong>Conclusion: </strong>The prevalence of isotretinoin-induced epistaxis is significantly high among Saudi patients; the complication can affect nearly half of the patients receiving this drug. Key risk factors include a prior history of nasal bleeding, nasal obstruction, poor awareness regarding the nasal adverse effects of epistaxis and its preventive measures. Isotretinoin should be prescribed judiciously by dermatologists, in consultation with ENT specialists, and with adequate patient education regarding its potential nasal adverse effects and steps to mitigate the same.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1347-1354"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO adds LC16m8 mpox vaccine to Emergency Use Listing.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"45 12","pages":"1401-1402"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}