Saudi Medical Journal最新文献_第5页

Ajwa date extract (Phoenix dactylifera L.): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study. Ajwa枣提取物（Phoenix dactylifera L.）：植物化学分析，对单纯疱疹病毒- 1和柯萨奇B4病毒的抗病毒活性，并进行了硅片研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240780

Ahmad K Aljohani, Nader A Maghrabi, Osama M Alrehili, Abdulaziz S Alharbi, Rawad S Alsihli, Abdulrahman M Alharthe, Rayan S Albladi, Khalid A Alosaimi, Bader M Albadrani, Samar F Miski, Hossein M Elbadawy, Bandar D Alrehaili, Fahd A Abdelkarem, Modather F Hussein

{"title":"Ajwa date extract (Phoenix dactylifera L.): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study.","authors":"Ahmad K Aljohani, Nader A Maghrabi, Osama M Alrehili, Abdulaziz S Alharbi, Rawad S Alsihli, Abdulrahman M Alharthe, Rayan S Albladi, Khalid A Alosaimi, Bader M Albadrani, Samar F Miski, Hossein M Elbadawy, Bandar D Alrehaili, Fahd A Abdelkarem, Modather F Hussein","doi":"10.15537/smj.2025.46.1.20240780","DOIUrl":"10.15537/smj.2025.46.1.20240780","url":null,"abstract":"Objectives: To investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action.Methods: High perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical profile of Ajwa date extract. The antiviral activity was assessed using the MTT colorimetric assay against herpes simplex virus type I (HSV-I) and coxsackievirus B4 (CVB-4). Assessment of the mechanism of action against HSV-I was carried out using 3 protocols. Molecular docking and quantum chemical calculations were carried out to predict the binding affinities of the identified compounds to viral glycoprotein D.Results: A total of 17 metabolites belonging to different classes of metabolites, mainly flavonoids, phenolic acid derivatives, fatty acids, and sugar derivatives. Ajwa extract exhibited antiviral activity against HSV-I with an IC: 50 of 113.99±4.67 μg/mL, whereas it showed limited activity against CVB-4. The antiviral activity of Ajwa extract was mainly attributed to its cell protectant activity by preventing adherence of viral to host cell with an IC: 50 equal to 57.82±1.37μg/mL. Molecular docking studies indicated that chlorogenic acid had the strongest binding affinity to viral glycoprotein D, which suggests its potential role in inhibiting viral entry into host cells.Conclusion: The Ajwa date extract demonstrated promising antiviral activity, especially against HSV-I. Integrating in vitro and in silico analyses provided valuable insights into the mechanisms of action.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"26-35"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between mothers with careers in higher education and child development in Indonesia. 印度尼西亚从事高等教育的母亲与儿童发展之间的关系。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240838

Zakiyah Yasin, Ahmad Nawawi, Shrimarti R Devy, Siti R Nadhiroh

{"title":"The relationship between mothers with careers in higher education and child development in Indonesia.","authors":"Zakiyah Yasin, Ahmad Nawawi, Shrimarti R Devy, Siti R Nadhiroh","doi":"10.15537/smj.2025.46.1.20240838","DOIUrl":"10.15537/smj.2025.46.1.20240838","url":null,"abstract":"Objectives: To identify the association of mothers with a career in higher educati--on and their children's growth and development.Methods: This was an analytical study with a cross-sectional design carried out at Wiraraja University, Sumenep, Indonesia, from March to August 2023. The samples were female lecturers at Wiraraja University. A total of 107 mothers were selected using total sampling. The mother's career was identified using a questionnaire and their child's growth and development were measured using child development pre-screening questionnaire. This study used Spearman's test data analysis.Results: The correlation coefficient was 0.512 indicating a moderately strong relationship between working mothers and their child's growth and development. The findings suggest that time mothers' work-life balance, time allocation, and other support for caring child significantly impact developmental milestones.Conclusion: There is a strong correlation between the time spent with children and the child's growth and development. For working mothers in academia, creating a supportive family or childcare environment and creating dedicated, quality time for interaction with their children are essential. Working mothers are encouraged to manage their time effectively to balance professional and parenting responsibilities and to engage in activities that enhance their children's physical, mental, and emotional development.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"86-93"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can drinking coffee or tea help prevent head and neck cancer? 喝咖啡或茶有助于预防头颈癌吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01

引用次数: 0

Comment on: Post surgical hypoparathyroidism. 评论：术后甲状旁腺功能减退。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20241114

引用次数: 0

Artificial intelligence (AI) in medical publications pros and cons. 人工智能（AI）在医学出版物中的利弊。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1

引用次数: 0

Oncological surgical outcomes for colorectal cancer surgery with loco-regional anesthesia: A feasibility study. 结直肠癌局部区域麻醉手术的肿瘤手术效果：可行性研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240470

Hüseyin Fahri Martlı, Eda Şahingöz, Emre Şimşek, Ayça Tuba Özcan, Efnan Aşık, Sadettin Er, Erdinç Çetinkaya

{"title":"Oncological surgical outcomes for colorectal cancer surgery with loco-regional anesthesia: A feasibility study.","authors":"Hüseyin Fahri Martlı, Eda Şahingöz, Emre Şimşek, Ayça Tuba Özcan, Efnan Aşık, Sadettin Er, Erdinç Çetinkaya","doi":"10.15537/smj.2025.46.1.20240470","DOIUrl":"10.15537/smj.2025.46.1.20240470","url":null,"abstract":"Objectives: To evaluate the pathological outcomes of colorectal cancer (CRC) patients who were unsuitable for general anesthesia and underwent regional anesthesia in terms of their suitability for oncological surgery.Methods: A total of 53 patients who underwent mesocolicormesorectal surgery under regional anesthesia at Ankara Bilkent City Hospital, Ankara, Turkey, between May 2019 and May 2023 were retrospectively examined. The negative margins of the proximal, distal, and circumferential margins of specimens, as well as the number of lymph nodes removed, were analyzed.Results: All the patients had clear proximal, distal, and circumferential surgical margins. The median number of lymph nodes removed was 23.45 (min-max: 3-97). When patients (n=24) who received neoadjuvant therapy were excluded, an insufficient number (<12) of lymph nodes were removed in 3 (7.69%) patients. A total of 3 patients died postsurgery, resulting in a 30-day mortality rate of 5.6%.Conclusion: For elderly and comorbid individuals with CRC, regional anesthesia can be used to carry out surgery with oncological principles.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"59-64"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the long-term effect of extracorporeal shockwave therapy and therapeutic ultrasound in treating trigger finger: A prospective cohort study. 比较体外冲击波治疗和超声治疗扳机指的长期疗效：一项前瞻性队列研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240612

Reem M Alfaifi, Alaa A Juraybi, Abdulrahman M Alrashed, Abdullah M Alghidani, Hana M Alfaifi

{"title":"Comparing the long-term effect of extracorporeal shockwave therapy and therapeutic ultrasound in treating trigger finger: A prospective cohort study.","authors":"Reem M Alfaifi, Alaa A Juraybi, Abdulrahman M Alrashed, Abdullah M Alghidani, Hana M Alfaifi","doi":"10.15537/smj.2025.46.1.20240612","DOIUrl":"10.15537/smj.2025.46.1.20240612","url":null,"abstract":"Objectives: To investigate the long-term effects of Extracorporeal shockwave therapy (ESWT) and ultrasound (US) in treating the trigger finger. Trigger finger, also known as stenosing tenosynovitis, is a common type of tenosynovitis affecting the flexor sheath of any finger. Extracorporeal shockwave therapy and therapeutic US are conservative treatments that use waves of varied frequency to target damaged regions and improve function.Methods: This cohort study was carried out in Saudi Arabia, using samples obtain from the files of patients with trigger fingers who visited the orthopedic department at Al-Rass General Hospital between May and June 2023. Of the 38 people with trigger fingers who were initially included, 24 satisfied the requirements for inclusion (11 underwent US, and 13 received ESWT). Assessments were conducted in September 2023, two months later. A goniometer was used to measure the range of motion (ROM), an electrical dynamometer was used to test grip strength, a numerical pain rating scale was used to quantify discomfort, and QuickDASH was used to measure general functional capacity.Results: Extracorporeal shockwave therapy and US significantly affected all outcomes, including pain severity, ROM, hand strength, and general functional capability (p<0.005). In the immediate period, the US outperformed ESWT in enhancing general functional capability. Over time, ESWT was more essential for reducing pain (p=0.001).Conclusion: This study provides preliminary evidence that ESWT and US have similar effects in treating trigger fingers.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"36-42"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does having more chronic conditions increase older adults' risk of declining kidney function? 有更多的慢性疾病会增加老年人肾功能下降的风险吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01

引用次数: 0

Predictors of hypocalcemia among children admitted in the Emergency Pediatric Unit of the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria. 尼日利亚迈杜古里大学教学医院儿科急诊科住院儿童低钙血症的预测因素

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240679

Ruqayyatu A Imam, Hassan A Elechi, Hauwa Y Musa, Adamu I Rabasa, Habiba B Bakari

{"title":"Predictors of hypocalcemia among children admitted in the Emergency Pediatric Unit of the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.","authors":"Ruqayyatu A Imam, Hassan A Elechi, Hauwa Y Musa, Adamu I Rabasa, Habiba B Bakari","doi":"10.15537/smj.2025.46.1.20240679","DOIUrl":"10.15537/smj.2025.46.1.20240679","url":null,"abstract":"Objectives: To determine the prevalence and pattern of hypoglycemia among children admitted to the Emergency Pediatric Unit (EPU) at the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.Methods: A cross-sectional study was conducted between February and September 2020. Blood glucose, along with other relevant laboratory investigations, was measured for each patient upon admission to the EPU using a point-of-care test glucometer (ACCU-CHEK with strips).Results: Of the 340 children recruited for the study, 54 patients had hypoglycemia (<2.2 mmol/L), giving a prevalence rate of 15.9%. Thirty-six (66.7%) of the children with hypoglycemia were under the age of 5 years (odds ratio [OR]: 6.218 [1.077-35.912], p=0.041) and 26 (48.1%) were severely underweight (OR: 3.692 [1.266-10.971], p=0.017). Factors such as not having eaten for at least 16 h, weakness, and coma at presentation all independently predicted hypoglycemia (OR: 5.696 [1.768-18.352], 6.556 [1.730-24.850], 9.479 [3.092-29.059], p=0.004, 0.006 and <0.001) respectively. Severe malaria was also independently related to hypoglycemia (OR: 2.720 [0.554-13.365], p=0.021).Conclusion: Hypoglycemia is a common occurrence among children admitted to the EPU. Factors such as being under five years old, in a coma, weakness, severe malaria, and prolonged fasting were all identified as independent predictors of hypoglycemia. Therefore, routine blood glucose monitoring of children admitted to the EPU, specifically those at higher risk, is recommended.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 1","pages":"78-85"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of a horseshoe kidney with a single left-sided ureter presented with recurrent urinary tract infection. 一个罕见的马蹄肾与单一左侧输尿管表现为反复尿路感染的病例。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2025-01-01 DOI: 10.15537/smj.2025.46.1.20240826

Abdullah Ayed, Raed I Alwadai, Assad A Rezigalla

引用次数: 0