Saudi Medical Journal最新文献_第4页

Biological studies of the activity of Manuka honey against Carbapenem-resistant Enterobacterales (CRE) bacteria. 麦卢卡蜂蜜对耐碳青霉烯类肠杆菌（CRE）活性的生物学研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.9.20240153

Mamdouh A Bukhari, Razaz A Qamash, Rasha A Bulkhi, Jehad A Bifari, Omar S Bakhsh, Khalid O Hawsawi, Ehab Y Matuure, Kamil A Sulaimani, Ashwaq T Hakim, Maher S Mujahid

{"title":"Biological studies of the activity of Manuka honey against Carbapenem-resistant Enterobacterales (CRE) bacteria.","authors":"Mamdouh A Bukhari, Razaz A Qamash, Rasha A Bulkhi, Jehad A Bifari, Omar S Bakhsh, Khalid O Hawsawi, Ehab Y Matuure, Kamil A Sulaimani, Ashwaq T Hakim, Maher S Mujahid","doi":"10.15537/smj.2024.45.9.20240153","DOIUrl":"10.15537/smj.2024.45.9.20240153","url":null,"abstract":"Objectives: To evaluate the potency of Manuka honey UMF +15 against Carbapenem-resistant Enterobacterales (CRE). Bacterial resistance is a worldwide problem that is increasing year by year, especially Carbapenem resistance. Alternatives to antibiotics are needed to both reduce costs, and to reduce the spread of antibiotic resistance, with the ultimate goal of saving lives.Methods: The efficacy of Manuka honey UMF +15 was tested by 2 methods; Well diffusion assay and minimum bactericidal concentration (MBC) against twenty Carbapenem-resistant isolates which collected from Makkah city hospitals during three months of study from 1st of September 2023 up to 1st of December 2023.Results: The growth of all isolates of Carbapenem-resistant Enterobacterales (CRE) was severely inhibited by low concentrations of Manuka honey, affecting 25% of isolates at 15% and 75% of isolates at 18% of Manuka honey. In addition, using the honey at different concentrations in a well diffusion assay resulted, as expected, in a variable zone diameter, ranging from large zones(14mm) to small zones (2 mm) according to the concentration of the honey.Conclusion: This study shows the remarkable antibacterial activity of Manuka honey and suggests that this natural remedy might be used in the future as an alternative treatment option against Carbapenem-resistant Enterobacterales (CRE); however, further clinical trials should be performed to corroborate our initial findings.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nearly 1.8 billion adults at risk of disease from not doing enough physical activity. 近 18 亿成年人因缺乏足够的体育锻炼而面临患病风险。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01

引用次数: 0

Is postoperative adjuvant radiotherapy necessary for patients with esophageal cancer after neoadjuvant chemoradiotherapy? An analysis based on the SEER database. 新辅助化放疗后的食管癌患者是否需要术后辅助放疗？基于 SEER 数据库的分析。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.9.20240045

Qiuying An, Yuhao Su, Yajing Wang, Chanjun Zhen, Wenwen Bai, Liyuan Fu, Yibing Liu, Ping Zhang, Zhiguo Zhou

{"title":"Is postoperative adjuvant radiotherapy necessary for patients with esophageal cancer after neoadjuvant chemoradiotherapy? An analysis based on the SEER database.","authors":"Qiuying An, Yuhao Su, Yajing Wang, Chanjun Zhen, Wenwen Bai, Liyuan Fu, Yibing Liu, Ping Zhang, Zhiguo Zhou","doi":"10.15537/smj.2024.45.9.20240045","DOIUrl":"10.15537/smj.2024.45.9.20240045","url":null,"abstract":"Objectives: To evaluate the outcomes of adjuvant radiotherapy in patients with esophageal cancer (EC) who underwent esophagectomy following neoadjuvant chemoradiotherapy (NCRT).Methods: The data of EC patients who received adjuvant therapy after NCRT between 2004 to 2019 was retrieved from the SEER database. The patients were split into the adjuvant radiotherapy with or without chemotherapy (RT±CT) and the adjuvant chemotherapy (CT) groups. The process of propensity score matching (PSM) was employed.Results: Following PSM, 157 patients in total were recruited in each treatment group. There were no significant variations in either overall survival (OS) or cancer-specific survival (CSS) between the RT±CT and CT groups (median OS: 28 months versus. 51 months, p=0.063; median CSS: 31 months versus. 52 months, p=0.16). Within the CT group, patients with ypI/II or cI/II tumor stage, positive lymph node ratio (LNR) ≤0.1, and tumor size ≥50 mm (p<0.05) had higher OS compared to the RT±CT groups. Among patients with cT3-4 tumors in N-stage downstaging group, the OS and CSS were significantly greater for those underwent RT±CT as opposed to the CT group (5-year OS:56.6% versus 19.4%, p=0.042; 5-year CSS:67.9% versus. 19.4%, p=0.023). Multivariate Cox regression analysis identified the tumor histology grade as an independent prognostic factor of OS and CSS.Conclusion: Radiotherapy-based adjuvant therapy does not significantly improve the prognosis of EC patients after NCRT, although it may provide a survival benefit for patients with cT3-4 tumors in N-stage downstaging.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newborn hearing screening in Eastern Saudi Arabia: A tertiary hospital experience. 沙特阿拉伯东部的新生儿听力筛查：一家三级医院的经验。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.9.20240365

Amal A Al-Shaikh Sulaiman

{"title":"Newborn hearing screening in Eastern Saudi Arabia: A tertiary hospital experience.","authors":"Amal A Al-Shaikh Sulaiman","doi":"10.15537/smj.2024.45.9.20240365","DOIUrl":"10.15537/smj.2024.45.9.20240365","url":null,"abstract":"Objectives: To analyze the performance of a leading institution in implementing newborn hearing screening and address two key areas: the knowledge gap in screening practice and the prevalence of permanent sensorineural hearing loss in Saudi Arabia.Methods: We analyzed the prevalence of hearing impairment in all live births at King Fahad Hospital of the University, Al Khobar, Saudi Arabia, from September 2018 to June 2022. Automated auditory brainstem response was used for both initial screening and rescreening. Newborns who failed the rescreening underwent a diagnostic evaluation. We assessed the coverage of initial screening, the rate of lost follow-up, referrals for rescreening and diagnostic evaluation, and the prevalence of hearing impairment.Results: A total of 5,986 newborns were born. Of these, 96.5% were screened. The passing rate for the initial screening and rescreening was 71.8%. However, 27.5% of newborns were lost to follow-up. Only 0.7% required referral for a diagnostic evaluation. The overall prevalence of hearing impairment was 2.6 per 1,000 newborns.Conclusion: Early identification of hearing loss through newborn screening improves the lives of affected individuals. Our program currently meets the World Health Organization's 1-3-6 benchmark goals. However, the underestimation of permanent hearing loss due to the 30% lost-to-follow-up rate is a limitation. Emphasizing the importance of the screening program is crucial to raising awareness and improving the accuracy of prevalence rates.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Middle East Immunology Summit of the Gulf Cooperation Council Association of Immunology and Rheumatology (GCC AIR), 2023 Dubai, United Arab Emirate. Scientific abstracts and case reports. 海湾合作委员会免疫学和风湿病学协会中东免疫学峰会，2023 年，阿拉伯联合酋长国迪拜。科学摘要和病例报告。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01

Ahmed S Zayat, Sadeya Naji, Omar Syed, Adeeba Al Herz, Ahmed Elasareeri, Mira Merashli, Mahdi Abusalameh, Waleed Hafiz, Elsadeg Sharif, Martin Lee, Fahdah Alokaily, Suad Hannawi

引用次数: 0

Does air pollution affect lupus risk? 空气污染会影响狼疮风险吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01

引用次数: 0

Effect of the prone position on mechanical power in elective surgical patients under general anesthesia: A prospective observational study. 俯卧位对全身麻醉下择期手术患者机械力的影响：前瞻性观察研究。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.8.20240242

Berrak S Aydın, Eren Açıkgöz

{"title":"Effect of the prone position on mechanical power in elective surgical patients under general anesthesia: A prospective observational study.","authors":"Berrak S Aydın, Eren Açıkgöz","doi":"10.15537/smj.2024.45.8.20240242","DOIUrl":"10.15537/smj.2024.45.8.20240242","url":null,"abstract":"Objectives: To evaluate how the prone position influences mechanical power (MP) during elective surgical procedures.Methods: In this prospective study carried out at Karadeniz Ereğli Government Hospital, Zonguldak, Turkey, from January 2024 to February 2024, 76 patients under general anesthesia were evaluated at different time points during the surgical procedure. Hemodynamic, laboratory, and mechanical ventilation data were also recorded.Results: The MP increased in the prone position at the beginning of surgery. Transitioning to the supine position at the end of surgery led to a decrease in MP. At the end of surgery, the mean MP in supine and prone positions was found to be higher compared to those measured in the first hour of surgery. Mechanical power and body mass index (BMI) exhibited a significant positive correlation.Conclusion: Position changes influence MP. Returning to the prone position increases MP. An increase in BMI is associated with an increase in MP.ANZCTR Reg. No.: ACTRN12623001281684.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum levels of zinc, folate, and vitamin B12 in healthy children aged 3-12 months: Is routine screening necessary? 3-12 个月健康儿童血清中的锌、叶酸和维生素 B12 含量：是否有必要进行常规筛查？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.8.20240248

Furkan Kalayci, Metin Yigit

{"title":"Serum levels of zinc, folate, and vitamin B12 in healthy children aged 3-12 months: Is routine screening necessary?","authors":"Furkan Kalayci, Metin Yigit","doi":"10.15537/smj.2024.45.8.20240248","DOIUrl":"10.15537/smj.2024.45.8.20240248","url":null,"abstract":"Objectives: To retrospectively assess the serum levels of zinc, folate, and vitamin B12 in healthy children aged between 3-12 months.Methods: This study includes healthy children aged between 3-12 months who presented to the pediatric outpatient clinics of Ankara Bilkent City Hospital, Ankara, Turkey, between January 2020 and July 2022. The levels of serum zinc, folate, and vitamin B12 were evaluated retrospectively.Results: Of the 495 patients enrolled in our study, 248 (50.1%) were female. The median age of the patients was 10 (range: 7-12) months. Zinc deficiency was detected in 24 (4.8%) patients, and vitamin B12 deficiency was found in 49 (9.8%) patients. No folate deficiency was observed in any patient. There was no significant correlation between the patients' height and weight percentiles and their serum levels of zinc, folate, and vitamin B12 (p>0.05 for each).Conclusion: In conclusion, we do not recommend routine screening for zinc, folate, and vitamin B12 levels in children under 12 months of age without active issues or chronic diseases due to the associated costs. We propose that evaluating serum levels of zinc, folate, and vitamin B12 is a more appropriate clinical approach in children at risk for micronutrient deficiencies and in selected patient groups.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protagonist of contemporary and emerging nanotechnology-based theranostics and therapeutic approaches in reshaping intensive care unit. 以纳米技术为基础的当代和新兴疗法和治疗方法是重塑重症监护室的主角。

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01 DOI: 10.15537/smj.2024.45.8.20240069

Ling Xie, Yun Chen

{"title":"The protagonist of contemporary and emerging nanotechnology-based theranostics and therapeutic approaches in reshaping intensive care unit.","authors":"Ling Xie, Yun Chen","doi":"10.15537/smj.2024.45.8.20240069","DOIUrl":"10.15537/smj.2024.45.8.20240069","url":null,"abstract":"To maintain a clean and hygienic environment in the intensive care unit (ICU) is crucial for ensuring patient safety, preventing infections, and reducing healthcare-associated complications. With the increasing prevalence of infections and the emergence of viral and bacterial resistance to standard antiseptics, there is a pressing need for innovative antiseptic solutions. Nanotechnology is increasingly being employed in medicine, particularly focusing on mitigating the activities of various pathogens, including those associated with hospital-acquired infections. This paper explores the current impact of nanotechnology, with a particular focus on bacterial infections and SARS-CoV-2, which significantly strain healthcare systems, and then discusses how nanotechnology can enhance existing treatment methodologies. We highlight the effectiveness of the nanotechnology-based bactericide Bio-Kil in reducing bacterial counts in an ICU. The aim is to educate healthcare professionals on the existing role and prospects of nanotechnology in addressing prevalent infectious diseases.","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could Botox make walking easier in children with cerebral palsy? 肉毒杆菌素能让脑瘫儿童更容易行走吗？

IF 1.7 4区医学

Saudi Medical Journal Pub Date : 2024-08-01

引用次数: 0