Russian Open Medical Journal最新文献

{"title":"Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry","authors":"T. Safonova, N. P. Kintyukhina","doi":"10.15275/rusomj.2022.0212","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0212","url":null,"abstract":"Objective — To analyze and compare the efficacy of conservative vs. surgical treatment of chronic mixed blepharitis via laser Doppler flowmetry and interferometry. Materials and methods — We enrolled 42 patients (the sample of 84 eyes) with chronic mixed blepharitis in the study. Laser Doppler flowmetry (LDF) was used to assess the microcirculation in the eyelid skin; interferometry was employed to evaluate the lipid layer of the tear film. Patients in the treatment group were treated by meibomian gland probing (MGP) and by artificial tears with a lipid component, introduced 4 times a day for 30 days. Subjects in the control group had their eyelid massaged in addition to administration of artificial tears. Treatment efficacy was monitored at 1 week, 1.5 months and 3 months. Results — MGP demonstrated a statistically significant positive effect, which persisted for 3 months after the procedure: specifically, the restoration of the tear film stability by increasing the thickness of its lipid layer by 0.27-0.5 μm. When comparing the interferoscopy results, an increase in the area of the lipid layer absence was detected in the control group. Analysis of LDF results showed a decrease in neurogenic and myogenic rhythms, as well as in the blood flow coefficient of variation in both groups. The lymph flow coefficient of variation remained stable in the treatment group, while it tended to decrease in the control group. Conclusion — The obtained data analysis on the basis of objective instrumental assessment of the eyelid morphofunctional state by the methods of interferoscopy and LDF suggested that conducting MGP was more effective in chronic mixed blepharitis treatment, compared with performing an eyelid massage.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47126049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Notions On The Role Of 5'-Nucleotidase In Pregnancy","authors":"I. Dovzhikova, I. Andrievskaya","doi":"10.15275/rusomj.2022.0218","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0218","url":null,"abstract":"The review aimed at pooling together available information on 5'-nucleotidase – an enzyme hydrolyzing ribo- and deoxyribonucleoside-5'-monophosphates. The most important product of 5'-nucleotidase activity is adenosine. This enzyme is, in fact, involved in most aspects of normal physiology, along with numerous pathological processes. The article discusses the role of the enzyme in pregnancy, its involvement in early post-implantation development, proliferation, migration/invasion, trophoblast differentiation, decidualization, angiogenesis, vasculogenesis, modulation of cell growth during embryonic development, regulation of hemodynamics, and control of myometrial contractions. A large section of this review is dedicated to the contribution of 5'-nucleotidase to the development of gestational complications, such as preeclampsia. We conducted our study via searching through various databases until October 30, 2021, using the following keywords: 5'-nucleotidase, adenosine, pregnancy, and the combinations of those. All reviewed articles were published in English.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44776854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Of Surgical And N95 Facial Masks On Exercise Tolerance, Heart Rate, Respiratory Rate And Blood Oxygen Saturation","authors":"M. Hassabi, Shahin Salehi, A. A. Yekta, M. Qutbi, A. Hakakzadeh, M. P. Esfahani, S. M. T. Otaghsara, S. S. Shams, J. Parent-Nichols","doi":"10.15275/rusomj.2022.0201","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0201","url":null,"abstract":"Background — Although wearing masks is inevitable these days, the effects of wearing them on physiologic parameters have not been reported. This study aimed to assess the effects of wearing no mask, a three-layer standard surgical mask, and wearing an N95 mask on blood oxygen saturation, aerobic tolerance, and performance during exercise. Methods — Twenty-one participants were enrolled in the study. Each participant was monitored with electrocardiography (ECG) while performing an exercise tolerance test using the Bruce treadmill protocol. Testing was conducted three times on different dates. Participants did not use any mask in the first test but did wear surgical and N95 masks during the second and third tests respectively. Respiratory rate (RR) was assessed for 10 seconds and then multiplied by 6. Heart rate (HR) was monitored by ECG, and oxygen saturation levels were monitored (O2Sat) via digital pulse-oximetry. Assessments were done before warm-up, at the middle and end of each Bruce stage, and as well at 1, 2, and 5 minutes into recovery (masks were worn during recovery). Results — HR, RR, and O2Sat measured data were all significantly different between the three trials at end-stage 3 of Bruce treadmill protocol (p<0.05). Although HR was still higher through the recovery period in the N95 trial in comparison with other trials (p<0.05), RR and O2Sat measured data were not different in the recovery phase. Conclusion — HR, RR, O2Sat and exercise tolerance are significantly affected by wearing surgical and N95 masks.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44278387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Analysis Of Early And Late Radiation Responses In 3D Image-Guided Brachytherapy For Cervical Cancer","authors":"O. Andreyeva, T. Adylkhanov, D. Kaidarova, Isa G. Isayev, Tolegen S. Kurmangaliyev, Z. Khismetova, N. Glushkova","doi":"10.15275/rusomj.2022.0217","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0217","url":null,"abstract":"Rationale – The use of 3D image-guided brachytherapy (3D-IGBT) allows adequately optimizing the dose distribution to bring a target therapeutic dose to clinical target volume (CTV), thereby minimizing an impact on critical organs, while ensuring a decrease in the incidence and severity of radiation-caused complications. Use of 3D-IGBT also allows improving the quality of life in patients with cervical cancer. Objective – To conduct a preliminary analysis of the incidence of early and late radiation responses in 3D-IGBT of locally advanced cervical cancer (LACC). Materials and Methods – The objects of our study were female patients with stages IIB and IIIB of cervical squamous cell carcinoma, without confirmed metastases, preceding chemotherapy (CHT) and/or radiation therapy (RT), and surgical interventions in this localization, who underwent combined chemoradiotherapy during the study. Results – Statistically significant results were obtained when analyzing the incidence of late radiation responses. It is important to point out that when assessing early toxicity in the main group with 3D-IGBT, grade 3 responses were not diagnosed, while in the control group, they were observed in 4 (9.1%) women. For instance, the manifestation of grade 3 delayed radiation injuries in the rectum was diagnosed in 3 (6.8%) women in the control group, while in the main group, they were not detected. Grade 2 cystitis was observed in a smaller number of women in the group with 3D-IGBT, compared with the control group (9.1% vs. 13.6%, p<0.05). Grade 3 delayed radiation responses in the bladder were diagnosed in 4 (9.1%) women in the control group, whereas among the patients of the main group with 3D-IGBT, they were not recorded at all (p <0.05). Grade II reactions in the vaginal mucosa and cervix were diagnosed more often in the control group (16.7% vs. 13.6%, p<0.05). Conclusion – Hence, the method we have used to optimize the treatment of LACC by means of 3D planning in accordance with toxicity criteria exhibited a definite advantage, compared with RT with 2D planning. Based on the results of our research, we concluded that optimization of RT for LACC using 3D-IGBT created clinically favorable conditions for effective therapy: it reduced the risk of displacement of the applicators and decreased an impact on the patient via reducing the total radiation doses and incidence of severe early and late toxic effects, providing good outcomes of local control regardless of tumor size and clinical stage.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47688570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure And Biological Functions Of Milk Caseins","authors":"S. Petrova, S. Khlgatian, O. Emelyanova, L. A. Pishchulina, V. Berzhets","doi":"10.15275/rusomj.2022.0209","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0209","url":null,"abstract":"Caseins, which are contained in milk, play a significant role in the development of clinical symptoms of allergic reactions in adults and children. To date, the properties of caseins have been studied, their primary structure has been identified. However, despite available scientific reviews and original articles, an issue of the structural organization of milk casein micelles and their biological functions is still very controversial. In this regard, the proposed review is relevant, since it most fully reflects current information about various types of caseins, their physicochemical and immunobiological properties, and analyzes in detail the existing theories on the structural organization of casein micelles. Of particular interest in our review are the data on the comparative analysis of the structure and properties of caseins in both human breast milk and cow’s milk, as well as the section dealing with the allergenic activity of cow’s milk caseins and their cross-reactivity with milk proteins of other mammalian species. The objective of this review is to summarize current data on the structure and properties of casein proteins, and to determine their role in the formation of sensitization to dairy products.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48726417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between The BRAF V600E And Tumor Size, Lymph Node, And Distant Metastasis In Papillary Thyroid Carcinoma","authors":"Edmond Rukmana Wikanta, Yan Wisnu Prajoko, Benny Issakh, H. Istiadi, D. Puspasari","doi":"10.15275/rusomj.2022.0216","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0216","url":null,"abstract":"Aim – This study aimed to analyze the association between B-Raf proto-oncogene, serine/threonine kinase (BRAF) V600E and tumor size, lymph node, and distant metastasis (TNM) status on patients with papillary thyroid carcinoma. Material and Methods – This research is a cross-sectional study. A total of 40 samples were papillary thyroid carcinoma tissue paraffin blocks from thyroidectomy surgery at State General Hospital (RSUP) Dr. Kariadi Semarang. Assessment of BRAF V600E mutation protein expression through immunohistochemical methods using antibody BRAF V600E was conducted. Results – The mean age of patients with papillary thyroid carcinoma with a positive BRAF V600E mutation was 49 years. The highest incidence was 71.4% in women. A significant difference between BRAF V600E and tumor size (p=0.03) was observed with as many as 53.2% more cases at size > 4 cm. A significant difference in the expression of BRAF V600E with enlargement of the lymph node (p=0.011) by 60.7% was observed compared to those without enlarged lymph nodes. On the other hand, no significant relationship between BRAF V600E expression and distant metastasis (p=0.652) was observed. The prevalence ratio in the positive BRAF V600E case at tumor size is more than 4 cm, and enlargement of lymph is 9.533 and 7.727. Conclusion – There is a significant relationship between BRAF V600E expression and tumor size and enlarged lymph nodes, while there is no significant relationship between BRAF V600E expression and distant metastases.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43563490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Of Restorative Massage On Regional Blood Flow In Paralympic Athletes","authors":"Victoria V. Kalsina","doi":"10.15275/rusomj.2022.0215","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0215","url":null,"abstract":"Objective — to evaluate an impact of a restorative massage course, integrated into a training session, on the regional blood circulation in Paralympic athletes. Materials and Methods — Athletes with impaired musculoskeletal system (IMSS), shooters and powerlifters (n=23), were subjected to a course of restorative massage in a special preparatory microcycle of the competitive period. In the main group, massage sessions were included in the training session, whereas in the control group, they were conducted at the end of the training session. The evaluation of peripheral circulation in the upper limbs was performed via vascular blood flow test; and the effectiveness of arterial and venous blood flow, vascular tone and elasticity were assessed. Results — The obtained results for the first time allowed describing the effect of restorative massage on the peripheral circulation of Paralympic athletes. After a course of restorative massage was integrated into a training session, changes in peripheral hemodynamics were noted. We revealed an improvement in arterial blood flow due to an increase in the time of rapid blood filling, a decrease in the tone of medium and small vessels, and a reduction in peripheral vascular resistance (PVR). Arterial and venous blood flow at the level of postcapillaries improved in all segments. The blood flow was effectively redistributed between the distal and proximal segments of the upper limbs. Conclusion — The use of massage sessions in the middle of a training session has a positive effect on the state of peripheral circulation in the proximal upper limbs and the tone of large vessels, whereas the use of massage at the end of a workout has a predominant effect on the tone of small vessels and the state of blood circulation in distal segments of the limbs.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46345570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology Of Thermal Hand Injury In Children And Youths In Russia And Abroad","authors":"G. V. Medvedev, M. A. Zhogina, Lubov A. Rodomanova, O.Yu. Timirbaeva, Y. Proshchenko, Anna M. Auglis, L. I. Morozov, S. M. Glukhov, Ilya A. Faryshev, Natalia A. Schneider","doi":"10.15275/rusomj.2022.0219","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0219","url":null,"abstract":": Thermal hand injury (THI) is a severe open damage of superficial and deep hand tissues caused by exposure to high temperatures. THI is characterized by damage of different severity grades to the tissues and hand structures, vascular changes, occurrence of local and multipart inflammatory responses, formation of secondary cicatricial skin changes, as well as of inner tissues, and/or secondary deformation and dysfunction of the hand. Objective — Systematization and update of knowledge about THI occurrence frequency among children and youths. Material and Methods — We analyzed full-text publications originated in Russia and abroad, including: original articles, thematic and systematic reviews, along with Cochrane Reviews. Our search covered the articles published in 2011-2021. We analyzed 368 publications and included 29 studies in our analysis. Results — Mean frequency of THI occurrence among children and youths was as follows: 10.0% in countries of South-East Asia, 12.3% in Mediterranean countries, 23.9% in European countries, 28.4% in Western Pacific countries, 33.0% in African countries, and 36% in countries of the Americas. Mean frequency of THI occurrence among children and adolescents worldwide was 31.3%, and 29.5% in Russia. Conclusion — Mean frequency of THI occurrence, compared with other thermal injuries in children and adolescents, is quite high and makes up for about one-third of all cases (31.3%). Hence, an importance of this interdisciplinary problem in combustiology, as well as in traumatology and plastic surgery, since the long-term consequences of THI in people who experienced it in their childhood or adolescence largely depend on close interaction of physicians representing various specialties.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45904756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Coronary Artery Bypass Grafting Cognitive Decline: Risk Modification And Implications For Screening In Low-Risk Population","authors":"Rada S. Kovaltcova, N. N. Petrova, Sergei F. Zadvorev","doi":"10.15275/rusomj.2022.0204","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0204","url":null,"abstract":"Background — Postoperative cognitive dysfunction (POCD) is an important complication of coronary artery bypass grafting (CABG). Large amount of data points to the problem of POCD in patients with high surgical risk of CABG. Low-risk patients are not safe from these complications either. Assessment of the severity, duration of POCD, degree of recovery and risk factors in off- and on-pump patients with stable coronary artery disease is crucial in minimization of the POCD risk in patients with low surgical risk. Objective — to analyze incidence, severity, reversibility and risk factors of POCD in patients undergoing elective low-risk CABG. Methods and Results — The retrospective cohort study included 79 patients who underwent on-pump (N=44) or off-pump (N=35) elective CABG with low surgical risk (mean EuroSCORE II death risk 1.08±0.71%), with observation period of 6 months. Pre-CABG markers of cognitive impairment were found in 50% of patients, with 44% of patients demonstrating POCD. Patients who underwent off-pump CABG demonstrated more pronounced decline in MoCA score compared to on-pump (-3.9±2.0 vs. -2.2±2.0 at 8 days point, p=0.018), with regress to pre-CABG results after 3 weeks. Baseline MoCA score <25 was found to be a predictor for more pronounced cognitive decline at 8 days point. MMSE demonstrated less predictive value compared to MoCA. Conclusion — POCD risk differs in off-pump and on-pump CABG cohorts, with significantly higher prevalence in the former group, whether assessed using MMSE or MoCA tests. Differences are observed within 3 weeks post-CABG. Pre-CABG MoCA score <25 is associated with more pronounced POCD in low-risk elective CABG cohort.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42761977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features Of Immune Status In COVID-19 Convalescents","authors":"Alina S. Shkaberda, Elena A. Kordovskaya, Diana Y. Bakuta, Lyubov I. Plotnichenko, A. A. Gorbunov, L. Sorokina","doi":"10.15275/rusomj.2022.0206","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0206","url":null,"abstract":"Study objective — assessment of the humoral and cell-mediated immunity features in COVID-19 convalescents three months after their discharge from the hospital. Material and Methods — The study involved 78 COVID-19 convalescents who, depending on the profile of specific IgM and IgG antibodies to SARS-CoV-2, were divided into three groups. The control group consisted of 50 volunteers. Detection of IgM and IgG in blood serum was performed by ELISA. Determination of CRP concentration was conducted using the immunoturbidimetric assay. To determine the levels of IL-6, a sandwich version of the solid-phase ELISA was employed. Immunophenotyping of lymphocytes was performed via flow cytometry. Results — Of 78 COVID-19 convalescents three months after their discharge from the hospital, 30.8% of them had a profile of specific antibodies IgM(+)IgG(+), 37.2% had IgM(-)IgG(+), and 32.0% were characterized by IgM(-)IgG (-). COVID-19 convalescents with an IgM(-)IgG(-) profile had the highest levels of NK cells, T helper cells, B lymphocytes (p<0.001) and were characterized by hyperproduction of proinflammatory IL-6 (p<0.001). COVID-19 convalescents with an IgM(+)IgG(+) specific antibody profile were characterized by the highest levels of cytotoxic T lymphocytes (p<0.001). In a COVID-19 convalescent with an IgM(-)IgG(+) specific antibody profile, we observed an increase in the number of lymphocytes expressing late activation/apoptosis molecules (p<0.001). Conclusion — The collected data is of potential importance in clinical practice for developing a prognosis for epidemiological situation development, as well as for planning preventive measures to COVID-19.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45771194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}