Russian Open Medical Journal最新文献

{"title":"Functional Status And Cytokine Profile Assessment In Patients With Chronic Obstructive Pulmonary Disease And Chronic Heart Failure","authors":"R. Tokmachev, S. Avdeev, Andrey Ya. Kravchenko, A. Budnevsky, E. S. Ovsyannikov","doi":"10.15275/rusomj.2022.0310","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0310","url":null,"abstract":"Objective — to evaluate the effect of chronic obstructive pulmonary disease (COPD) on the level of cytokines and the functional status of patients with chronic heart failure (CHF) with different categories of left ventricular ejection fraction. Methods — The study included 240 patients 40–70 years of age with CHF. All patients were divided into four groups: 69 CHF patients with preserved ejection fraction (CHFpEF), 91 CHF patients with reduced ejection fraction (CHFrEF), 36 COPD patients with CHFpEF and 44 COPD patients with CHFrEF. All participants underwent echocardiography, six-minute walk test (6MWT), the results of which were compared with the predicted six-minute walk distance: 6МWD (i). Additionally, we assessed the levels of NT-terminal fragment of pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), IL-1β, IL-6, TNF-α, suppression of tumorigenicity 2 (ST2) in patient blood samples. Results — Patients with CHFpEF had higher levels of hs-CRP and proinflammatory cytokines as compared with patients with CHFrEF. The levels of NT-proBNP were higher in patients with COPD and CHF, compared with patients with CHF alone. A negative effect of COPD on the functional status of CHF patients with different EF values was established by the lower 6MWT values and 6MWD/6MWD ratio (i). An increase in the level of suppression of tumorigenicity 2 soluble forms (sST2) was noted in patients with COPD and CHF as compared with the isolated course of cardiac pathology patients. Conclusion — We established that unfavorable effect of COPD on patients with CHF was caused by disadvantageous values of NT-proBNP, ST2, 6MWT, and 6MWD/6MWD (i) ratio.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49563115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic And Health-Related Predictors Of Online Information Seeking On Healthcare Providers In Russian Adults","authors":"N. Polukhin, N. Ekkert","doi":"10.15275/rusomj.2022.0308","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0308","url":null,"abstract":"The objective of this study was to examine the factors of online information seeking on healthcare providers in Russian adults. Material and Methods — Our online survey involved 1,319 participants and regarded their sociodemographic and health-related characteristics, along with online information seeking on healthcare providers. The association of factors to online information seeking on healthcare providers was examined via Pearson’s chi-squared test. The odds ratios for determined predictors of online information seeking were obtained from multiple logistic regression model fitted to the data. Results — Majority of Russian adults – 58.6% (95% CI: 55.9%-61.2%) – used the Internet to collect information on healthcare providers. The most rigorous online information seeking on healthcare providers was exhibited by females (OR: 1.951, p<0.001), adults with graduate degrees (OR: 2.870, p=0.036), adults using the Internet more often (OR: 2.623, p<0.001), adults with two or more chronic diseases (OR: 1.699, p=0.005), and those who had 7 or more medical appointments during the last year preceding the survey (OR: 2.438, p=0.002). However, the age of participants was not significantly associated with online information seeking on healthcare providers (p=0.922). No statistical difference was found between those residing in rural, suburban, and urban areas (p=0.518). Conclusion — Sociodemographic and health-related factors affect patients in terms of their online information seeking on healthcare providers. The current demand for online information on healthcare providers existing in various groups highlights the need to increase patient engagement and empower the less active among them.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47193166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features Of Iron Metabolism In Patients With HIV Infection And Pulmonary Dissemination In Tuberculosis And Pneumonia: An Exploratory Case-Control Study","authors":"E. Borodulina, E. Yakovleva","doi":"10.15275/rusomj.2022.0207","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0207","url":null,"abstract":"Background — Differential diagnosis of pneumonia vs. tuberculosis in patients with HIV infection and pulmonary dissemination syndrome is an important problem in contemporary clinical medicine. The goal of our study was to determine the features of iron metabolism in patients with HIV infection and pulmonary dissemination in tuberculosis and pneumonia. Methods — The case-control study was conducted on 42 cases (patients with tuberculosis, hereinafter referred to as Group 1) and 44 control subjects (patients with pneumonia, hereinafter referred to as Group 2). All of them had HIV infection and syndrome of pulmonary dissemination. For subjects in both groups, we analyzed clinical and social characteristics, along with laboratory data. We also examined hepcidin content, iron concentration, and ferritin level in blood serum, and performed statistical data processing. Findings — There were significant differences between cases and controls in terms of iron metabolism. Hepcidin and hemoglobin levels were statistically significantly higher (p <0·001), whereas iron concentration was lower (p=0·0002) in patients with tuberculosis (cases). Furthermore, there were statistically significant differences between groups in CD4+ T-cell count, viral load, and RBC and WBC counts in complete blood count tests; in duration of complaints prior to hospital admission; and in terms of job stability. Conclusion — The quantitative parameters with the greatest statistical significance of the differences between the groups were iron concentration, hepcidin level, RBC count, WBC count, and CD4+ T-cell count.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49312344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors Of Breakfast Consumption Among Iranian Students: Applying Social Cognitive Theory","authors":"Shadi Askari, N. Salimi, E. Bakhshi","doi":"10.15275/rusomj.2022.0208","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0208","url":null,"abstract":"Background — Despite the known significance of regular breakfast consumption, skipping or inadequate consumption of breakfast is common among students. Social cognitive theory (SCT) is one of the most effective theories in predicting nutritional behaviors, especially breakfast-related behaviors Objective — This study aimed to determine the factors related to breakfast consumption based on SCT among students of Islamic Azad University Kermanshah Branch. Methods — In this cross-sectional study, 206 students of Islamic Azad University Kermanshah Branch were selected based on availability sampling. An online questionnaire consisting of demographic information scales, SCT variables and breakfast consumption behavior was sent to student groups. Data were analyzed using descriptive statistical tests, chi-square test, linear regression and correlation analysis in SPSS software version 16. Results — On average, students consume breakfast 4.39 times a week. Overall, 17.6% of students had completely ignored breakfast and 42.4% of them ate breakfast irregularly between one and six times a week. Among the components of social cognitive theory, self-efficacy and observational learning predicted 55.7% of changes in breakfast consumption among students (P<0.001). Conclusions — It seems that social cognitive theory is a useful framework for predicting breakfast consumption behavior among young people, and it is possible to improve breakfast consumption behavior by designing and implementing appropriate educational interventions based on this theory.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48568385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Systems For Targeted Drug Delivery To The Posterior Eye Segment: A Systematic Review","authors":"E. R. Orlova, A. V. Gorobets, D. A. Dorofeev, E. V. Kirilik, I. Kozlova","doi":"10.15275/rusomj.2022.0213","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0213","url":null,"abstract":"Background — Intravitreal implants solve a number of serious problems arising in diseases of the posterior segment of the eyeball. Unlike intravitreal injections, the implant provides a prolonged release of a pharmaceutical drug over time. The review presents the characteristics of existing systems for intravitreal drug delivery: nanosystems, non-biodegradable and biodegradable implants. The review also highlights the main advantages and disadvantages of various implants. Based on the conducted literature review, the following conclusion is formulated: the most promising means of targeted drug delivery of drugs to the posterior segment of the eyeball are biodegradable implants. However, currently existing biodegradable implants do not provide entirely controlled release of the drug (uncontrollable extraction episodes occur at times), which constitutes a serious issue requiring improvement. Objective — to summarize the published data on existing systems for the targeted drug delivery into the vitreous chamber, identifying their major advantages and disadvantages. Material and Methods — Information was searched in such databases as PubMed, Google Scholar and ClinicalTrials.gov, using the keywords in both Russian and English languages: intravitreal implants, intraocular implants, biodegradable implants, non-biodegradable implants, nanosystems, nanoparticles, liposomes, targeted drug delivery, posterior segment of the eye, etc.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48672596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Of Low-Level Laser Therapy On Inflammatory Sequеlae Of Impacted Mandibular Third Molar Surgery: A Single-Blind, Placebo-Controlled, Randomized Clinical Trial","authors":"S. Hamad","doi":"10.15275/rusomj.2022.0220","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0220","url":null,"abstract":"Objective — Postoperative pain, facial swelling, and limitation of mouth opening are common sequеlae of lower third molar surgery. The objective of the study was to evaluate the effect of Low- level laser irradiation in controlling these sequеlae. Material and Methods — This randomized, single-blinded, split-mouth pilot study was carried out at the department of oral and maxillofacial surgery, university affiliated hospital, Erbil, Iraq. The study was conducted on 20 patients (13 males and 7 females), with a mean age of 26.3±7.4 years, who needed surgical removal of symmetrical bilateral impacted lower third molars. In each patient, one side was treated by low level laser and the other side was control. Laser irradiation was performed by postoperative single intraoral application of 940 nm laser beam at four points. Pain, trismus, and facial swelling were evaluated at the first, third, and seventh postoperative days. The data were analyzed using Mann–Whitney U test and unpaired t -test. Results — As compared to the control sides, low- level laser irradiated sides showed a significant reduction in visual analogue pain scales (VAS) during the first three postoperative days (P<0.05). The VAS scores of the laser treated sides were 4.46, 4.00, and 3.35 as compared to 6.58, 5.82, and 5.17 for the control sides. The swelling, and trismus were significantly reduced on the first and third postoperative days in the laser treated sides, as compared to the control sides (P<0.05). The facial measurements during the first and third postoperative days were 108.72 mm and 114.77 mm in the laser sides and 113.57 mm and 118.43 mm in the control sides. The degree of mouth opening during the first and third postoperative days were 33.48 mm and 30.37 mm in the laser sides and 27.93 mm and 25.58 mm in the control sides Conclusions — Single intraoral application of low- level laser is effective in reducing pain, swelling and trismus after mandibular third molar surgery. Therefore, it can be used as an adjuvant in controlling postoperative complications after lower third molar surgery.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45770616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry","authors":"T. Safonova, N. P. Kintyukhina","doi":"10.15275/rusomj.2022.0212","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0212","url":null,"abstract":"Objective — To analyze and compare the efficacy of conservative vs. surgical treatment of chronic mixed blepharitis via laser Doppler flowmetry and interferometry. Materials and methods — We enrolled 42 patients (the sample of 84 eyes) with chronic mixed blepharitis in the study. Laser Doppler flowmetry (LDF) was used to assess the microcirculation in the eyelid skin; interferometry was employed to evaluate the lipid layer of the tear film. Patients in the treatment group were treated by meibomian gland probing (MGP) and by artificial tears with a lipid component, introduced 4 times a day for 30 days. Subjects in the control group had their eyelid massaged in addition to administration of artificial tears. Treatment efficacy was monitored at 1 week, 1.5 months and 3 months. Results — MGP demonstrated a statistically significant positive effect, which persisted for 3 months after the procedure: specifically, the restoration of the tear film stability by increasing the thickness of its lipid layer by 0.27-0.5 μm. When comparing the interferoscopy results, an increase in the area of the lipid layer absence was detected in the control group. Analysis of LDF results showed a decrease in neurogenic and myogenic rhythms, as well as in the blood flow coefficient of variation in both groups. The lymph flow coefficient of variation remained stable in the treatment group, while it tended to decrease in the control group. Conclusion — The obtained data analysis on the basis of objective instrumental assessment of the eyelid morphofunctional state by the methods of interferoscopy and LDF suggested that conducting MGP was more effective in chronic mixed blepharitis treatment, compared with performing an eyelid massage.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47126049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Notions On The Role Of 5'-Nucleotidase In Pregnancy","authors":"I. Dovzhikova, I. Andrievskaya","doi":"10.15275/rusomj.2022.0218","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0218","url":null,"abstract":"The review aimed at pooling together available information on 5'-nucleotidase – an enzyme hydrolyzing ribo- and deoxyribonucleoside-5'-monophosphates. The most important product of 5'-nucleotidase activity is adenosine. This enzyme is, in fact, involved in most aspects of normal physiology, along with numerous pathological processes. The article discusses the role of the enzyme in pregnancy, its involvement in early post-implantation development, proliferation, migration/invasion, trophoblast differentiation, decidualization, angiogenesis, vasculogenesis, modulation of cell growth during embryonic development, regulation of hemodynamics, and control of myometrial contractions. A large section of this review is dedicated to the contribution of 5'-nucleotidase to the development of gestational complications, such as preeclampsia. We conducted our study via searching through various databases until October 30, 2021, using the following keywords: 5'-nucleotidase, adenosine, pregnancy, and the combinations of those. All reviewed articles were published in English.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44776854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Of Surgical And N95 Facial Masks On Exercise Tolerance, Heart Rate, Respiratory Rate And Blood Oxygen Saturation","authors":"M. Hassabi, Shahin Salehi, A. A. Yekta, M. Qutbi, A. Hakakzadeh, M. P. Esfahani, S. M. T. Otaghsara, S. S. Shams, J. Parent-Nichols","doi":"10.15275/rusomj.2022.0201","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0201","url":null,"abstract":"Background — Although wearing masks is inevitable these days, the effects of wearing them on physiologic parameters have not been reported. This study aimed to assess the effects of wearing no mask, a three-layer standard surgical mask, and wearing an N95 mask on blood oxygen saturation, aerobic tolerance, and performance during exercise. Methods — Twenty-one participants were enrolled in the study. Each participant was monitored with electrocardiography (ECG) while performing an exercise tolerance test using the Bruce treadmill protocol. Testing was conducted three times on different dates. Participants did not use any mask in the first test but did wear surgical and N95 masks during the second and third tests respectively. Respiratory rate (RR) was assessed for 10 seconds and then multiplied by 6. Heart rate (HR) was monitored by ECG, and oxygen saturation levels were monitored (O2Sat) via digital pulse-oximetry. Assessments were done before warm-up, at the middle and end of each Bruce stage, and as well at 1, 2, and 5 minutes into recovery (masks were worn during recovery). Results — HR, RR, and O2Sat measured data were all significantly different between the three trials at end-stage 3 of Bruce treadmill protocol (p<0.05). Although HR was still higher through the recovery period in the N95 trial in comparison with other trials (p<0.05), RR and O2Sat measured data were not different in the recovery phase. Conclusion — HR, RR, O2Sat and exercise tolerance are significantly affected by wearing surgical and N95 masks.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44278387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Analysis Of Early And Late Radiation Responses In 3D Image-Guided Brachytherapy For Cervical Cancer","authors":"O. Andreyeva, T. Adylkhanov, D. Kaidarova, Isa G. Isayev, Tolegen S. Kurmangaliyev, Z. Khismetova, N. Glushkova","doi":"10.15275/rusomj.2022.0217","DOIUrl":"https://doi.org/10.15275/rusomj.2022.0217","url":null,"abstract":"Rationale – The use of 3D image-guided brachytherapy (3D-IGBT) allows adequately optimizing the dose distribution to bring a target therapeutic dose to clinical target volume (CTV), thereby minimizing an impact on critical organs, while ensuring a decrease in the incidence and severity of radiation-caused complications. Use of 3D-IGBT also allows improving the quality of life in patients with cervical cancer. Objective – To conduct a preliminary analysis of the incidence of early and late radiation responses in 3D-IGBT of locally advanced cervical cancer (LACC). Materials and Methods – The objects of our study were female patients with stages IIB and IIIB of cervical squamous cell carcinoma, without confirmed metastases, preceding chemotherapy (CHT) and/or radiation therapy (RT), and surgical interventions in this localization, who underwent combined chemoradiotherapy during the study. Results – Statistically significant results were obtained when analyzing the incidence of late radiation responses. It is important to point out that when assessing early toxicity in the main group with 3D-IGBT, grade 3 responses were not diagnosed, while in the control group, they were observed in 4 (9.1%) women. For instance, the manifestation of grade 3 delayed radiation injuries in the rectum was diagnosed in 3 (6.8%) women in the control group, while in the main group, they were not detected. Grade 2 cystitis was observed in a smaller number of women in the group with 3D-IGBT, compared with the control group (9.1% vs. 13.6%, p<0.05). Grade 3 delayed radiation responses in the bladder were diagnosed in 4 (9.1%) women in the control group, whereas among the patients of the main group with 3D-IGBT, they were not recorded at all (p <0.05). Grade II reactions in the vaginal mucosa and cervix were diagnosed more often in the control group (16.7% vs. 13.6%, p<0.05). Conclusion – Hence, the method we have used to optimize the treatment of LACC by means of 3D planning in accordance with toxicity criteria exhibited a definite advantage, compared with RT with 2D planning. Based on the results of our research, we concluded that optimization of RT for LACC using 3D-IGBT created clinically favorable conditions for effective therapy: it reduced the risk of displacement of the applicators and decreased an impact on the patient via reducing the total radiation doses and incidence of severe early and late toxic effects, providing good outcomes of local control regardless of tumor size and clinical stage.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47688570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}