Russian Open Medical Journal最新文献

{"title":"How Different Is The Status Of Depression And Anxiety In Patients With Rheumatoid Arthritis Receiving Methotrexate With Sulfasalazine Or Hydroxychloroquine?","authors":"Mansour Babaei, Mehdi Dorparvar, Behnaz Yousef Ghahari, Behzad Heidari, Hemmat Gholinia, Sussan Moudi","doi":"10.15275/rusomj.2023.0305","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0305","url":null,"abstract":"Background — Depression and anxiety are among the most common clinical manifestations in patients with rheumatoid arthritis (RA). Sulfasalazine and hydroxychloroquine are important medications used to treat these patients. Objective — The goal of this study was to compare the occurrence of depression and anxiety in RA patients taking sulfasalazine or hydroxychloroquine for at least six months. Methods — This study included 300 patients with RA referred to inpatient or outpatient departments of a public hospital in northern Iran who were treated with two combination regimens of methotrexate and sulfasalazine or methotrexate and hydroxychloroquine. Participants were assessed on the standard Hospital Anxiety and Depression Scale (HADS) for symptoms of depression and anxiety. Results — The mean HADS depression subscale score was 6.77±3.98 in the hydroxychloroquine group and 3.50±3.53 in the sulfasalazine group (p<0.001). The mean HADS anxiety subscale score was 7.66±4.43 in the hydroxychloroquine group and 5.34±4.35 in the sulfasalazine group (p<0.001). Multiple linear regression analysis revealed a significant difference in the incidence of depression and anxiety between the two treatment groups. Conclusion — A higher prevalence of depression and anxiety was observed in RA patients treated with methotrexate and hydroxychloroquine versus those treated with methotrexate with sulfasalazine.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value Of Type 2 Diabetes Mellitus And Visfatin Level In Patients After Coronary Artery Bypass Grafting","authors":"A. Garganeeva, E. A. Kuzheleva, O. Tukish, S. Andreev, O. Ogurkova, S. Popov","doi":"10.15275/rusomj.2023.0205","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0205","url":null,"abstract":"Objective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG). Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinical outcomes and adverse cardiovascular events were analyzed 12 months after the CABG. Results — The patients were distributed between two groups: Group 1 (without registration of composite endpoints, n=71) and Group 2 (patients with the development of composite endpoints, n=32). In Group 1, 22.5% of patients were diagnosed with DM vs. 31.2% in Group 2 (p=0.346). Kaplan-Meier estimator demonstrated that patients with duration of DM over 5 years experienced significantly earlier and more frequent adverse cardiovascular events after CABG vs. patients without DM or with duration of DM less than 5 years. The visfatin level before CABG did not differ between the groups (p=0.416), whereas 10 days after CABG it was higher in Group 2. Correlation between the difference in visfatin levels before and after CABG and duration of type 2 DM was calculated (r=0.54, p=0.041). Conclusion — In patients after CABG, the duration of DM had a negative impact on the development of cardiovascular events. With a duration of DM exceeding 5 years, the risk of adverse events increased significantly. An increase in visfatin level 10 days after CABG was associated with the duration of DM and the development of adverse cardiovascular events in patients.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44478442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Extract Of Ophiocephalus Striatus Affect Levels Of TNF-Α, TGF-Β1, IL-17 And SuPAR, Pulmonary Diffusing Capacity For Carbon Monoxide, And Health-Related Quality Of Life In Stable COPD Patients With Muscle Wasting","authors":"Susanthy Djajalaksana, Muktiati Nunuk S., Teguh R. Sartono, Vitri Iriani, Ratih Renata, Sasongko Adhi, H. Rasyid","doi":"10.15275/rusomj.2023.0202","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0202","url":null,"abstract":"Objective — This study aimed to evaluate the effect of Ophiocephalus striatus extract on body composition, levels of TNF-α, TGF-β1, IL-17, suPAR and neutrophils, diffusing capacity of the lungs for carbon monoxide (DLCO) and health-related quality of life (HRQoL) in stable COPD patients with muscle wasting. Methods — Clinical pre- and post- quasi-experimental study of 32 stable COPD patients with muscle wasting from the Pulmonary Outpatient Clinic of Saiful Anwar General Hospital Malang, determined in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 and bioelectrical impedance analysis (BIA) measurements (FFM <14.6 kg/m; BMI <18.5 kg/m2). Measurements of the following health-related parameters for the QoL due to COPD were performed before and after the nutritional intervention of 3,000 mg of O. striatus extract daily for 12 weeks: TNF-α, TGF-β1, IL-17 and suPAR levels (by ELISA), neutrophils (by blood test), DLCO (by body plethysmography), and CAT score. Results — A non-significant reduction of TNF-α (p=0.302), IL-17 (p=0.275), neutrophil (p=0.619), and suPAR (p=0.674) levels, along with an increase in DLCO (p=0.369), occurred after 12 weeks of O. striatus extract administration. However, the level of TGF-β1 declined significantly (p=0.022), followed by an increase in QoL as assessed by the CAT score (p=0.000). There was no significant correlation between inflammatory cytokines and DLCO, nor with the CAT score. Conclusion — The study results demonstrated a potential role of oral nutritional supplementation in the management of COPD patients with muscle wasting.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42339062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyunsaturated Fatty Acids And Lipid Mediators Controlling Chronic Inflammation In Asthma","authors":"O. Kytikova, Y. Denisenko, T. Novgorodtseva, I. S. Kovalenko, M. Antonyuk","doi":"10.15275/rusomj.2023.0201","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0201","url":null,"abstract":"Asthma is a common chronic heterogeneous inflammatory respiratory disease with complex pathogenesis. Chronic lung inflammation can be the result of a defect in the resolution of the inflammatory process caused by an imbalance between the synthesis of proinflammatory and pro-resolving lipid mediators. The identification of immunomodulatory effects of eicosanoids, specialized pro-resolving mediators (SPMs), and endocannabinoids synthesized from polyunsaturated fatty acids (PUFAs) allows taking a fresh look at the ways of controlling inflammation rather than solely at its mechanisms. The use of ω-3 PUFA-containing food supplements in combination with standard therapy leads to improved asthma control due to the ability of ω-3 PUFAs to stimulate SPM synthesis and inhibit intracellular signaling pathways of inflammation. Lipid mediators are agonists of peroxisome proliferator-activated receptors (PPARs) and glucocorticoid receptors (GR) that have anti-inflammatory properties. The receptors that are widely expressed in the pulmonary epithelium, endothelium, dendritic cells, eosinophils, fibroblasts, and macrophages play an important role in the regulation of immunometabolic homeostasis in the bronchopulmonary system. Our review systematizes the published data on the properties and mechanism of action of biologically active ω-3 and ω-6 PUFAs involved in the inflammatory process in asthma. Also, this article presents the prospects of using ω-3 PUFAs for the resolution of inflammation in asthma.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43518713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Short-Term Weather-Induced Immune Response In Russian Far East Residents With Respiratory Diseases","authors":"L. Veremchuk, T. Vitkina, E. Mineeva, E. V. Kondratyeva","doi":"10.15275/rusomj.2023.0203","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0203","url":null,"abstract":"Objective — To identify criteria for contrasting meteorological changes affecting the temporal dynamics of the immune response in individuals with bronchopulmonary pathology in the maritime monsoon climate of Vladivostok. Methods — We examined 178 patients with stable chronic obstructive pulmonary disease (COPD) of mild and moderate severity, 212 patients with controlled bronchial asthma (BA) and 60 apparently healthy volunteers. We assessed the cumulative response of the components of adaptive and innate immune systems to the effects of day-to-day variability in temperature, air pressure and humidity, wind speed and direction, and precipitation relative to the day of the patient’s medical examination ± 2 days. The response of the immune system was measured by an integral indicator calculated as the ratio of the sum of statistically significant correlations (p<0.05) to the total sum of correlation matrix elements. Results — The short-term compensatory severity and activity of the immune response to the weather in healthy people (∑D%=2.56; ∑r=117) was almost twice as high as the similar response in patients with COPD (∑D%=1.28; ∑r=72) or BA (∑D%=1.35; ∑r=69). The immune response of apparently healthy subjects to the action of specific meteorological factors on the day of medical examination was reduced by 40%, compared with the short-term response (±2 days) in patients with COPD, but the difference was not significant. The values of the criteria for the day-to-day contrast of influencing meteorological factors in apparently healthy patients were reduced. Conclusion — The urban population in maritime monsoon climate exhibited weak and moderate weather-induced immune system responses. Wind regime, humidity and precipitation had a pronounced effect on the immune system. In patients with COPD and BA, the maximum pathogenic response of the immune system to the impact of climatic factors was observed within ±1 day.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45165029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parameters Of Vascular Tone Regulation And Gene Polymorphism Associated With Cardiovascular Risk In Young Subjects","authors":"Natalya S. Akimova, Anastasiya Yu. Elkina, Olga N. Dzhioeva, Ivan M. Sokolov, Anton R. Kiselev, Oxana M. Drapkina, Yury G. Shvarts","doi":"10.15275/rusomj.2023.0204","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0204","url":null,"abstract":"Introduction — The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension (HTN). It is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to vascular tone (VT) dysregulation. Objective — To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young subjects and patients with HTN. Methods — The study involved 2 independent groups: young healthy volunteers and hypertensive patients. The VT regulation was assessed by the active standing test. The polymorphism was identified using DNA pyrosequencing. Results — The C allele of the AGTR1 A1666C A&gt;C variant was associated with lower HR in supine in both groups. The risk allele C of the M268T T&gt;C polymorphism was associated with lower systolic BP and diastolic BP during the 1st minute of upright posture. The C allele of the AGTR1 A1666C A&gt;C variant was associated with earlier onset of HTN. Conclusion — The identification of the AGTR1 A1666C A&gt;C and AGT M268T T&gt;C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of HTN.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135503204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Segmental Strain Based On Speckle Tracking Echocardiography Versus Indications Of Immune Inflammation In Patients After COVID-19 Pneumonia","authors":"N. Shirokov, E. Yaroslavskaya, D. Krinochkin, N. A. Osokina, N. Musikhina, T. I. Petelina","doi":"10.15275/rusomj.2023.0206","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0206","url":null,"abstract":"Background — The significance of cytokine activation and immune inflammation in subclinical damage to cardiomyocytes and resulting development of the congestive heart failure (CHF) is frequently discussed in published studies, as well as whether there are cardiac lesions in COVID-19 survivors identified by the speckle tracking echocardiography (STE). Objective — To examine the association of echocardiographic parameters with indications of immune inflammation in patients recovered from COVID-19 pneumonia depending on segmental longitudinal strain (LS) of the left ventricle (LV) identified by STE. Methods — Our study encompassed 216 patients (51.1% men, mean age of 50.1±11.1 years) distributed among two groups: Group I (n=108) included study subjects with segmental LS (≥3 LV segments) revealed by the STE; Group II (n=108) comprised patients without visually detectable LV lesions. All patients were examined three months after COVID-19 pneumonia. Results — Groups did not differ statistically significantly in terms of LV ejection fraction (68.7±4.3% in Group I vs. 68.6±4.3% in Group II; p=0.916). Global LS was significantly lower in the Group I than in the Group II at the time of the control follow-up visit three months later (-18.2 [-16.7; -19.4] % vs. -20.6 [-19.5; -22.1] %, respectively; p<0.001). When analyzing laboratory indications of immune inflammation in groups, we revealed statistically significantly higher values in Group I vs. Group II in the concentrations of interleukin 6 (3.1 [2.4;3.9] pg/mL vs. 2.5 [3.8;4.7] pg/mL; p=0.009), C-reactive protein (4.7 [2.9;8.3] mg/L vs. 3.0 [1.5; 5.3] mg/L; p<0.001), and tumor necrosis factor α (6.0 [4.8;4.1] pg/ml vs. 5.0 [4.0;6.4] pg/ml; p=0.001). In Group I, we detected diffuse lesion of LS (≥4 segments of the same LV level; 38.0% of patients) and regional lesion of LS (≥3 segments corresponding to the blood supply pools of the anterior, circumflex, or right coronary arteries; 62.0% of patients). According to logistic regression, the LS of the basal LV level (OR 3.028; 95% CI 1.909-4.802; р<0.001) in combination with LS of the apical LV level (OR 1.287; 95% CI 1.099-1.507; р=0.002) and LV lateral wall annular velocity assessed by tissue Doppler imaging, peak e’ (OR 0.774; 95% CI 0.657-0.911; р=0.002) had an independent relationship with each of diffuse and regional LS lesions. Conclusion — Based on STE data, we have identified a relationship of diffuse and regional LV lesions with features of systolic and diastolic LV dysfunction and markers of immune inflammation in patients three months after COVID-19 pneumonia.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44778158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 And The Role Of Estrogen In The Immune Response","authors":"I. Dovzhikova, I. Andrievskaya","doi":"10.15275/rusomj.2023.0207","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0207","url":null,"abstract":"We conducted a study using the keyword search (estrogens and COVID-19) in various databases through June 2022. All articles were published in English. In the context of the COVID-19 pandemic, gender differences were found in the course and outcomes of the disease. The goal of this review was to summarize the knowledge of the mechanisms underlying gender-based differences in COVID-19, with a focus on the role of estrogens. The article discusses the involvement of estrogen in the implementation of the immune response to viral infection. Separate sections of the review are dedicated to the effect of estrogens on innate and adaptive varieties of immunity. We concluded that there is great potential for future research on deciphering the effect of hormones on human physiology and immune responses to explain the heterogeneity of human pathogenic responses.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44451728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment Of Fluid Retention In Patients With Paroxysmal And Long-Standing Persistent Types Of Atrial Fibrillation","authors":"Garganeeva Alla A., V. V. Kirillova, E. Kuzheleva, R. Batalov, A. Smorgon, S. Mayanskaya","doi":"10.15275/rusomj.2023.0105","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0105","url":null,"abstract":"Determining fluid retention in circulatory system currently remains a challenge. The objective of our study was to determine the sensitivity of individual symptoms and signs of chronic heart failure (CHF) and echocardiographic criteria for detecting fluid retention in patients with atrial fibrillation and invasively measured elevated atrial pressure. Methods — We conducted a prospective study of adult patients with a history of cardiovascular disease (coronary artery disease or/and arterial hypertension in combination with atrial fibrillation [AF]) hospitalized for radiofrequency catheter ablation. All patients underwent expert ultrasound examination of the heart using Philips HD 15 and Philips iE33 devices, as well as invasive measurement of pressure in the left and right atria at rest (n=20). Results — The sensitivity of dyspnea in patients with paroxysmal AF and long-standing persistent AF was 44.4% and 90.9%, respectively. The sensitivity of the mean E/e' ratio in patients with paroxysmal AF and long-standing persistent AF was 22.2% and 18.1%, correspondingly. According to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) algorithm, only one patient (11.1%) in the group with paroxysmal AF and 54.5% of subjects in the group with a long-standing persistent AF type had two positive criteria. The sensitivity of lower limb edema was 0% in patients with paroxysmal AF and 57.1% in those with long-standing persistent AF. The sensitivity of IVC diameter >22 mm was 80% in patients with paroxysmal AF and 57.1% in the group with long-standing persistent AF. At the same time, the sensitivity of the IVC inspiratory collapse ≤50% was significantly lower in both groups: 60% in patients with paroxysmal AF and 42.9% in subjects with long-standing persistent AF. Conclusion — Clinical symptoms and signs of chronic heart failure (CHF), as well as echocardiographic parameters reflecting an increase in the filling pressure of the heart chambers, are characterized by extremely low sensitivity in a cohort of patients with paroxysmal AF. The use of more stringent criteria for diagnosing congestion in this group of patients leads to a significant underdiagnosis of elevated filling pressure in the left chambers of the heart, which, in turn, increases the likelihood of insufficient prescription of diuretic therapy when it is objectively necessary.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44318473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment Of Antibody Levels In A Population Vaccinated With Sputnik V","authors":"D. Gonzalez, Federico Fortuna, A. Fritzler, Juan J. Jamardo, E. Duarte, C. Ibar, D. Jacobsen, M. Estevez, J. Aguirre, Belky B. Garzón, R. Absi, E. Repetto, Gelos Diego Sanchez, Damian Zopatti, B. Fabre","doi":"10.15275/rusomj.2023.0102","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0102","url":null,"abstract":"Objectives — The objective of our study was to assess humoral response in a population of health workers after vaccination with the first and second doses of Sputnik V. Methods — SARS-CoV-2 total antibodies (IgG and IgM) were measured, using the Centaur XPT autoanalyzer, Siemens®, in 530 serum samples taken from health workers in Buenos Aires vaccinated with Sputnik V. Results — After 21 days of the first dose application, 10 individuals (1.9%) presented antibody levels <1.0 (non-reactive), while 520 subjects (98.1%) responded with antibody values >1.0 (reactive). The results, obtained 21 days after the second dose, show that only 2 individuals (0.38%) had antibody levels <1.0 (non-reactive) and 528 (99.6%) responded with antibody values >1.0 (reactive). Conclusion — This study results implied that two doses of Sputnik V vaccine generated a proper antibody response in virtually the entire studied population.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43376588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}