Russian Open Medical Journal最新文献

{"title":"MiR-134 And MiR-106b Are Circulating Biomarkers For Temporal Lobe Epilepsy: Pilot Study Results","authors":"Kristina D. Lysova, Anna A. Usoltseva, Ekaterina A. Domoratskaya, Irina G. Areshkina, Natalia A. Shnayder, Diana V. Dmitrenko","doi":"10.15275/rusomj.2023.0303","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0303","url":null,"abstract":"Temporal lobe epilepsy (TLE) is among the most common forms of focal epilepsy in adults. Currently, scientists search for microRNAs as noninvasive epilepsy biomarkers. MicroRNAs constitute a class of short (or small) non-coding RNAs that control the level of gene expression affecting the stability of mRNA. They are key regulators and therapeutic targets in epilepsy. Considering the role of miRNA-134 and miRNA-106b in the processes of epileptogenesis, the goal of our study was the clinical evaluation of their circulation as novel noninvasive molecular diagnostic markers of TLE. Material and Methods — Our pilot study involved 59 participants. The main group included 33 patients with mesial temporal lobe epilepsy, the control group encompassed 26 healthy volunteers. The ranking of patients was carried out depending on the disease duration, presence of epileptiform activity on the electroencephalogram (EEG) and hippocampal sclerosis on MRI, the number of taken antiepileptic drugs (AEDs), and patient response to the pharmacotherapy of epilepsy. The isolation of circulating microRNAs from blood plasma was accomplished via the sorption method, and the analysis of microRNA expression was performed by real-time PCR. Results — The expression levels of miR-134 and miR-106b in blood plasma in patients with TLE were reduced. Therefore, these microRNAs can be diagnostic biomarkers of patients with TLE, compared with the control group. The results of receiver operating characteristic (ROC) analysis yielded high sensitivity and specificity values of this biomarker for the diagnosis of TLE. Conclusion — Circulating miR-134 and miR-106b concentrations were significantly reduced in patients with mesial TLE (MTLE), compared with healthy controls. At the same time, the level of microRNA expression did not depend on the presence of hippocampal sclerosis and the response to antiepileptic therapy.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135385154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-Derived Exosomes With Anti-Inflammatory Properties As A New Minimally Invasive Intratesticular Therapy For Aflatoxin B1-Associated Chronic Testopathy","authors":"Fatemeh Mansouri Torghabeh, Mona Keivan, Mandana Fakoor, Reza Dadfar, Mahsa Nazarzadeh, Amir Abdolmaleki","doi":"10.15275/rusomj.2023.0301","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0301","url":null,"abstract":"Rationale — Aflatoxin B1 (AB1) is a dangerous toxin causing severe poisoning and even death in human. Testopathy or even infertility is one of the adverse effects of AB1. Exosomes (Ex) with anti-inflammatory action are known as biological substances derived from body fluids. This experimental study aimed to investigate the possible therapeutic effects of blood-derived Ex on orchitis caused by chronic exposure to AB1. Methods — Male rats (n=18) were distributed among three groups: control, AB1 and AB1+Ex. Orchitis was induced with AB1 (45 μL/kg of rat weight) for 40 days (3 times a week). A day later, 10 IU Ex were injected intratesticularly. A week later, testicular tissue and blood serum were sampled. To confirm the therapeutic effects of Ex, inflammatory genes (TNF-α, IL-6 and IL-10), nitric oxide (NO), malondialdehyde (MDA), testosterone (Tes) and sperm quality were fully evaluated. In addition, H&amp;E staining was used to investigate tissue changes, and immunohistochemical (IHC) assessment was employed to detect the inflammatory protein, galectin-3. The results were analyzed using SPSS (v.19). Results and Discussion — Our results confirmed that Ex therapy can significantly (p<0.05) increase normal morphology (25.01±2.23 in the AB1+Ex group vs. 10.1±0.9 in the AB1 group), number (76.12±6.7 in the AB1+Ex group vs. 27.8±3.2 in AB1 group), and vitality (53.4±6.12 in AB1+Ex vs. 41.9±4.6 in AB1) of sperm cells. Blood-derived Ex significantly (p<0.05) reduced the expression of inflammatory genes (6-fold change was observed in AB1+Ex vs. 17-fold in AB1 for TNF-α, 3-fold change was detected in AB1+Ex vs. 6-fold in AB1 for IL-6, and 2-fold change took place in AB1+Ex vs. 6-fold in AB1 for IL-10), NO (23.1±2.6 in AB1+Ex vs. 62.8±8 0.1 in AB1) and MDA (33.2±4.9 in AB1+Ex vs. 68.9±5.46 in AB1), and increased Tes level (7.1±0.5 in AB1+Ex vs. 1.14±0.3 in AB1) in AB1-affected rats. Histopathological evaluations revealed tissue regeneration after Ex injection. Also, the produced sperm cells were of high quality. Conclusion — Intratesticular injection of Ex from the blood can be considered as a novel anti-inflammatory therapy after AB1-induced orchitis.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135420312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choosing Data Clustering Tools For GIS-Based Visualization Of Disease Incidence In The Population","authors":"Roman V. Buzinov, Vladimir N. Fedorov, Aleksandr A. Kovshov, Yuliya A. Novikova, Nadezhda A. Tikhonova, Maxim S. Petrov, Ksenia V. Krutskaya","doi":"10.15275/rusomj.2023.0306","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0306","url":null,"abstract":"Objective — To substantiate the choice of optimal tools for clustering spatially referenced data on disease incidence for GIS-based analysis of their spatial distribution. Material and Methods — We used primary data on the incidence of malignant neoplasms, chronic alcoholism, and asthma in the population of eight administrative areas in Arkhangelsk Oblast as a constituent entity of the Arctic Zone of the Russian Federation. Disease incidence was averaged over a 5-year period from 2016 to 2020. We assessed the methods for visualizing the distribution of spatially referenced indicators using the ArcMap geoinformation system tools. Results — The study yielded differences in the outcomes of automated clustering of spatially referenced data in ArcMap, depending on the normality of the distribution in individual samples and the spread of indicator values, which was visually reflected on the resulting map. The parameter values in the samples directly affected the features of data clustering. Hence, this issue is important to consider for ensuring the correct choice of the appropriate analytical tool. Conclusion — Our study demonstrated that when using tools for automated clustering of spatially referenced incidence data in terms of their visualization in ArcGIS, it is necessary to consider the factors that directly affect the accuracy of their presentation. We consider it most appropriate to use a clustering tool based on the geometric interval method.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135420130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Of Vibroacoustic Therapy In Treatment Of Pneumonia In Children With Bronchopulmonary Dysplasia","authors":"Madina Syzdykova, Marina Morenko, Madina Gatauova, Saule Zhumambayeva, Kseniya Shnaider","doi":"10.15275/rusomj.2023.0307","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0307","url":null,"abstract":"Background — Advances in neonatal intensive care have resulted in high survival rates for infants born with extremely low birth weight. Accordingly, the treatment and rehabilitation of premature neonates with bronchopulmonary dysplasia (BPD) is indisputably an urgent problem. Objective — To evaluate the efficacy of vibroacoustic therapy in patients with BPD in the complex of therapeutic measures. Material and Methods — The study was a prospective, non-randomized open-label controlled clinical trial conducted in 2018-2020 in Astana, Kazakhstan. It included 69 children with BPD hospitalized with a concomitant diagnosis of pneumonia between the ages of 1 and 2 years. The study subjects were distributed among two groups: Group 1 (the main group, n=37) receiving vibroacoustic therapy with the VibroLung apparatus in combination with the main treatment and Group 2 (the control, n=32) receiving solely the main treatment. Results — The inclusion of the vibroacoustic method of treatment in the combination therapy of pneumonia in children with BPD resulted in early leveling of the following clinical symptoms: a reduction in the duration of the high fever by 1.18 days vs. the control group (p<0.05), relief of respiratory failure 1.4 days earlier vs. the control group (p<0.05) and a decrease in the duration of inpatient treatment by 2.9 days, compared with the control group (p<0.05). All of these implied the efficacy of this treatment method. Conclusion — Our results demonstrated that vibroacoustic therapy was a relevant addition to the treatment of pneumonia in children with BPD.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135420973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthovoltage X-Ray Therapy Significantly Reduces Disability Risk In Knee Osteoarthritis Patients: A Decade-Long Cohort Study","authors":"Maria V. Makarova, Mikhail Yu. Valkov, Andrey M. Grjibovski","doi":"10.15275/rusomj.2023.0304","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0304","url":null,"abstract":"Introduction — Osteoarthritis (OA) of the knee and hip joints affects 13% of the adult population in the Russian Federation. While medications can provide some relief from the pain associated with OA, they are often not enough. An alternative treatment option is orthovoltage radiation therapy (OVRT), which not only relieves pain, but can also help prevent disability. However, there is little evidence for the long-term effectiveness of OVRT. Objective — We compared the incidence of disability among patients with OA who received standard treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) in combination with the symptomatic slow-acting drugs for osteoarthritis (SYSADOA), or in combination with OVRT for knee OA in the setting of an open randomized controlled trial with long-term follow-up. Material and Methods — The sampling frame included patients with confirmed OA of the knee sensu Altman (1991), with radiographic grades of OA from 0 to 2 sensu Kellgren-Lawrence. A total of 292 patients were randomly distributed among two groups of equal sizes. The control group received combination therapy with NSAIDs and SYSADOA. In the experimental group, OVRT was additionally performed at a total dose of 4.5 Gy. Relationships between treatment regimen and time to disability were studied using actuarial analysis, Kaplan-Meier plots. Crude and adjusted hazard ratios (HR) with 95% confidence intervals (CI), as well as attributable fraction (AF) and population attributable fraction (PAF) were calculated. Results — The cumulative time at risk for disability was 2,304.9 person-years. In total, 9.5% of patients in the experimental group became disabled during the observation period vs. 17.8% in the control group. In the experimental group, the level of disability was lower (HR=0.49, 95% CI: 0.26-0.95). Differences became more pronounced after adjusting for sex, age, radiographic grade of OA, pain intensity, and duration of OA before treatment (HR=0.24, 95% CI: 0.11-0.48). AF and PAF were 49.9% and 25.8%, respectively. Conclusion — It has been shown that the introduction of OVRT in the treatment regimen can reduce the disability of patients with knee OA by almost 50%. One in four disability cases could be prevented if OVRT were used universally in the treatment of knee OA. Our results indicate that combining OVRT with standard care is a more effective approach to preventing disability in patients with knee OA than standard treatment alone.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135420588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective Dietary Pattern Of Siberian Population","authors":"Darya P. Tsygankova, Evgeny D. Bazdyrev, Alena S. Agienko, Olga V. Nakhratova, Elena V. Indukaeva, Galina V. Artamonova, Olga L. Barbarash","doi":"10.15275/rusomj.2023.0302","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0302","url":null,"abstract":"Background — Analysis of eating habits can help identify cardioprotective dietary patterns. It is necessary to qualitatively study the diet of modern inhabitants of Siberia and identify food stereotypes that contribute to effective cardiac prophylaxis. Objective — to study the diet of the inhabitants of Siberia and to identify the features of cardioprotective nutrition. Methods — A clinical and epidemiological prospective group study of the population permanently residing in Kemerovo Oblast (administrative entity of the Russian Federation) was carried out. The baseline study included 1,124 women (70.3%) and 476 men (29.7%). To identify latent factors (stereotypes of eating behavior), we used factor analysis (method of principal components). Results — Adherence to the fruit-and-vegetable stereotype was associated with an increased risk of obesity according to body mass index (BMI) (OR=1.57, CI: 1.27-1.96), waist circumference (WC) (OR=1.43, CI: 1.1-1.9), and presence of diabetes mellitus (DM) (OR=1.27, CI: 1.2-2.2). Adherence to the protein-and-carbohydrate dietary pattern was connected to a reduced risk of detecting obesity in terms of BMI criteria (OR=0.75, CI: 0.6-0.95, p=0.015), WC (OR=0.52, CI:0.41-0.66), DM (OR=0.66, CI:0.47-0.93), hypercholesterolemia (OR=0.78, CI:0.62-0.98) and hypertriglyceridemia (OR=0.66, CI:0.52-0.83). Prospective observation demonstrated the variability of stereotypes: after three years, the following five stereotypes were identified: vegetable, protein-and-carbohydrate, fruit, dairy, and mixed. Conclusion — In contrast to the protein-and-carbohydrate diet, the fruit-and-vegetable stereotype of nutrition was associated with the development of obesity and DM. Considering the obtained results, it is necessary to study the qualitative characteristics of each stereotype (the content of macro- and microelements, kcal) and the motor activity of the respondents.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135420774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Different Is The Status Of Depression And Anxiety In Patients With Rheumatoid Arthritis Receiving Methotrexate With Sulfasalazine Or Hydroxychloroquine?","authors":"Mansour Babaei, Mehdi Dorparvar, Behnaz Yousef Ghahari, Behzad Heidari, Hemmat Gholinia, Sussan Moudi","doi":"10.15275/rusomj.2023.0305","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0305","url":null,"abstract":"Background — Depression and anxiety are among the most common clinical manifestations in patients with rheumatoid arthritis (RA). Sulfasalazine and hydroxychloroquine are important medications used to treat these patients. Objective — The goal of this study was to compare the occurrence of depression and anxiety in RA patients taking sulfasalazine or hydroxychloroquine for at least six months. Methods — This study included 300 patients with RA referred to inpatient or outpatient departments of a public hospital in northern Iran who were treated with two combination regimens of methotrexate and sulfasalazine or methotrexate and hydroxychloroquine. Participants were assessed on the standard Hospital Anxiety and Depression Scale (HADS) for symptoms of depression and anxiety. Results — The mean HADS depression subscale score was 6.77±3.98 in the hydroxychloroquine group and 3.50±3.53 in the sulfasalazine group (p<0.001). The mean HADS anxiety subscale score was 7.66±4.43 in the hydroxychloroquine group and 5.34±4.35 in the sulfasalazine group (p<0.001). Multiple linear regression analysis revealed a significant difference in the incidence of depression and anxiety between the two treatment groups. Conclusion — A higher prevalence of depression and anxiety was observed in RA patients treated with methotrexate and hydroxychloroquine versus those treated with methotrexate with sulfasalazine.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Extract Of Ophiocephalus Striatus Affect Levels Of TNF-Α, TGF-Β1, IL-17 And SuPAR, Pulmonary Diffusing Capacity For Carbon Monoxide, And Health-Related Quality Of Life In Stable COPD Patients With Muscle Wasting","authors":"Susanthy Djajalaksana, Muktiati Nunuk S., Teguh R. Sartono, Vitri Iriani, Ratih Renata, Sasongko Adhi, H. Rasyid","doi":"10.15275/rusomj.2023.0202","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0202","url":null,"abstract":"Objective — This study aimed to evaluate the effect of Ophiocephalus striatus extract on body composition, levels of TNF-α, TGF-β1, IL-17, suPAR and neutrophils, diffusing capacity of the lungs for carbon monoxide (DLCO) and health-related quality of life (HRQoL) in stable COPD patients with muscle wasting. Methods — Clinical pre- and post- quasi-experimental study of 32 stable COPD patients with muscle wasting from the Pulmonary Outpatient Clinic of Saiful Anwar General Hospital Malang, determined in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 and bioelectrical impedance analysis (BIA) measurements (FFM <14.6 kg/m; BMI <18.5 kg/m2). Measurements of the following health-related parameters for the QoL due to COPD were performed before and after the nutritional intervention of 3,000 mg of O. striatus extract daily for 12 weeks: TNF-α, TGF-β1, IL-17 and suPAR levels (by ELISA), neutrophils (by blood test), DLCO (by body plethysmography), and CAT score. Results — A non-significant reduction of TNF-α (p=0.302), IL-17 (p=0.275), neutrophil (p=0.619), and suPAR (p=0.674) levels, along with an increase in DLCO (p=0.369), occurred after 12 weeks of O. striatus extract administration. However, the level of TGF-β1 declined significantly (p=0.022), followed by an increase in QoL as assessed by the CAT score (p=0.000). There was no significant correlation between inflammatory cytokines and DLCO, nor with the CAT score. Conclusion — The study results demonstrated a potential role of oral nutritional supplementation in the management of COPD patients with muscle wasting.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42339062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value Of Type 2 Diabetes Mellitus And Visfatin Level In Patients After Coronary Artery Bypass Grafting","authors":"A. Garganeeva, E. A. Kuzheleva, O. Tukish, S. Andreev, O. Ogurkova, S. Popov","doi":"10.15275/rusomj.2023.0205","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0205","url":null,"abstract":"Objective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG). Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinical outcomes and adverse cardiovascular events were analyzed 12 months after the CABG. Results — The patients were distributed between two groups: Group 1 (without registration of composite endpoints, n=71) and Group 2 (patients with the development of composite endpoints, n=32). In Group 1, 22.5% of patients were diagnosed with DM vs. 31.2% in Group 2 (p=0.346). Kaplan-Meier estimator demonstrated that patients with duration of DM over 5 years experienced significantly earlier and more frequent adverse cardiovascular events after CABG vs. patients without DM or with duration of DM less than 5 years. The visfatin level before CABG did not differ between the groups (p=0.416), whereas 10 days after CABG it was higher in Group 2. Correlation between the difference in visfatin levels before and after CABG and duration of type 2 DM was calculated (r=0.54, p=0.041). Conclusion — In patients after CABG, the duration of DM had a negative impact on the development of cardiovascular events. With a duration of DM exceeding 5 years, the risk of adverse events increased significantly. An increase in visfatin level 10 days after CABG was associated with the duration of DM and the development of adverse cardiovascular events in patients.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44478442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyunsaturated Fatty Acids And Lipid Mediators Controlling Chronic Inflammation In Asthma","authors":"O. Kytikova, Y. Denisenko, T. Novgorodtseva, I. S. Kovalenko, M. Antonyuk","doi":"10.15275/rusomj.2023.0201","DOIUrl":"https://doi.org/10.15275/rusomj.2023.0201","url":null,"abstract":"Asthma is a common chronic heterogeneous inflammatory respiratory disease with complex pathogenesis. Chronic lung inflammation can be the result of a defect in the resolution of the inflammatory process caused by an imbalance between the synthesis of proinflammatory and pro-resolving lipid mediators. The identification of immunomodulatory effects of eicosanoids, specialized pro-resolving mediators (SPMs), and endocannabinoids synthesized from polyunsaturated fatty acids (PUFAs) allows taking a fresh look at the ways of controlling inflammation rather than solely at its mechanisms. The use of ω-3 PUFA-containing food supplements in combination with standard therapy leads to improved asthma control due to the ability of ω-3 PUFAs to stimulate SPM synthesis and inhibit intracellular signaling pathways of inflammation. Lipid mediators are agonists of peroxisome proliferator-activated receptors (PPARs) and glucocorticoid receptors (GR) that have anti-inflammatory properties. The receptors that are widely expressed in the pulmonary epithelium, endothelium, dendritic cells, eosinophils, fibroblasts, and macrophages play an important role in the regulation of immunometabolic homeostasis in the bronchopulmonary system. Our review systematizes the published data on the properties and mechanism of action of biologically active ω-3 and ω-6 PUFAs involved in the inflammatory process in asthma. Also, this article presents the prospects of using ω-3 PUFAs for the resolution of inflammation in asthma.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43518713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}