蛇头草提取物对稳定型COPD肌肉萎缩患者TNF-Α、TGF-Β1、IL-17、SuPAR水平、肺一氧化碳弥散能力及健康相关生活质量的影响

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Susanthy Djajalaksana, Muktiati Nunuk S., Teguh R. Sartono, Vitri Iriani, Ratih Renata, Sasongko Adhi, H. Rasyid
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引用次数: 0

摘要

目的——本研究旨在评估条纹蛇头草提取物对伴有肌肉萎缩的稳定期COPD患者的身体成分、TNF-α、TGF-β1、IL-17、suPAR和中性粒细胞水平、肺部一氧化碳扩散能力(DLCO)和健康相关生活质量(HRQoL)的影响。方法——根据2016年全球慢性阻塞性肺病倡议(GOLD)和生物电阻抗分析(BIA)测量(FFM<14.6 kg/m;BMI<18.5 kg/m2),对来自马朗Saiful Anwar综合医院肺科门诊的32名患有肌肉萎缩的稳定型COPD患者进行临床前后准实验研究。在每天3000 mg纹状体提取物营养干预12周前后,测量COPD引起的生活质量的以下健康相关参数:TNF-α、TGF-β1、IL-17和suPAR水平(通过ELISA)、中性粒细胞(通过血液测试)、DLCO(通过体积描记术)和CAT评分。结果——给予纹状体提取物12周后,TNF-α(p=0.002)、IL-17(p=0.275)、中性粒细胞(p=0.619)和suPAR(p=0.674)水平无显著降低,DLCO(p=0.369)增加。然而,TGF-β1水平显著下降(p=0.022),随后CAT评分显示生活质量增加(p=0.000)。炎性细胞因子与DLCO和CAT评分之间没有显著相关性。结论——研究结果表明,口服营养补充剂在COPD伴肌肉萎缩患者的治疗中具有潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Extract Of Ophiocephalus Striatus Affect Levels Of TNF-Α, TGF-Β1, IL-17 And SuPAR, Pulmonary Diffusing Capacity For Carbon Monoxide, And Health-Related Quality Of Life In Stable COPD Patients With Muscle Wasting
Objective — This study aimed to evaluate the effect of Ophiocephalus striatus extract on body composition, levels of TNF-α, TGF-β1, IL-17, suPAR and neutrophils, diffusing capacity of the lungs for carbon monoxide (DLCO) and health-related quality of life (HRQoL) in stable COPD patients with muscle wasting. Methods — Clinical pre- and post- quasi-experimental study of 32 stable COPD patients with muscle wasting from the Pulmonary Outpatient Clinic of Saiful Anwar General Hospital Malang, determined in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 and bioelectrical impedance analysis (BIA) measurements (FFM <14.6 kg/m; BMI <18.5 kg/m2). Measurements of the following health-related parameters for the QoL due to COPD were performed before and after the nutritional intervention of 3,000 mg of O. striatus extract daily for 12 weeks: TNF-α, TGF-β1, IL-17 and suPAR levels (by ELISA), neutrophils (by blood test), DLCO (by body plethysmography), and CAT score. Results — A non-significant reduction of TNF-α (p=0.302), IL-17 (p=0.275), neutrophil (p=0.619), and suPAR (p=0.674) levels, along with an increase in DLCO (p=0.369), occurred after 12 weeks of O. striatus extract administration. However, the level of TGF-β1 declined significantly (p=0.022), followed by an increase in QoL as assessed by the CAT score (p=0.000). There was no significant correlation between inflammatory cytokines and DLCO, nor with the CAT score. Conclusion — The study results demonstrated a potential role of oral nutritional supplementation in the management of COPD patients with muscle wasting.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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