冠状动脉搭桥术后2型糖尿病及Visfatin水平的预后价值

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
A. Garganeeva, E. A. Kuzheleva, O. Tukish, S. Andreev, O. Ogurkova, S. Popov
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引用次数: 0

摘要

目的:探讨冠状动脉旁路移植术(CABG)患者2型糖尿病(DM)及visfatin水平的预后价值。方法:我们的研究纳入103例慢性心力衰竭和稳定型冠状动脉疾病患者。分析CABG术后12个月的临床结果和不良心血管事件。结果-患者被分为两组:1组(未登记复合终点,n=71)和2组(已发展复合终点的患者,n=32)。组1中诊断为DM的患者占22.5%,组2中为31.2% (p=0.346)。Kaplan-Meier估计表明,与无糖尿病或糖尿病持续时间小于5年的患者相比,糖尿病持续时间超过5年的患者在冠脉搭桥后发生的心血管不良事件明显更早、更频繁。CABG前visfatin水平在两组间无差异(p=0.416),而CABG后10 d, visfatin水平在2组较高。计算CABG前后visfatin水平差异与2型DM病程的相关性(r=0.54, p=0.041)。结论:在冠脉搭桥后的患者中,糖尿病的持续时间对心血管事件的发生有负面影响。糖尿病持续时间超过5年,不良事件发生风险显著增加。CABG术后10天内visfatin水平升高与患者糖尿病持续时间和不良心血管事件的发生有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic Value Of Type 2 Diabetes Mellitus And Visfatin Level In Patients After Coronary Artery Bypass Grafting
Objective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG). Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinical outcomes and adverse cardiovascular events were analyzed 12 months after the CABG. Results — The patients were distributed between two groups: Group 1 (without registration of composite endpoints, n=71) and Group 2 (patients with the development of composite endpoints, n=32). In Group 1, 22.5% of patients were diagnosed with DM vs. 31.2% in Group 2 (p=0.346). Kaplan-Meier estimator demonstrated that patients with duration of DM over 5 years experienced significantly earlier and more frequent adverse cardiovascular events after CABG vs. patients without DM or with duration of DM less than 5 years. The visfatin level before CABG did not differ between the groups (p=0.416), whereas 10 days after CABG it was higher in Group 2. Correlation between the difference in visfatin levels before and after CABG and duration of type 2 DM was calculated (r=0.54, p=0.041). Conclusion — In patients after CABG, the duration of DM had a negative impact on the development of cardiovascular events. With a duration of DM exceeding 5 years, the risk of adverse events increased significantly. An increase in visfatin level 10 days after CABG was associated with the duration of DM and the development of adverse cardiovascular events in patients.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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