年轻受试者血管张力调节参数和基因多态性与心血管风险相关

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Natalya S. Akimova, Anastasiya Yu. Elkina, Olga N. Dzhioeva, Ivan M. Sokolov, Anton R. Kiselev, Oxana M. Drapkina, Yury G. Shvarts
{"title":"年轻受试者血管张力调节参数和基因多态性与心血管风险相关","authors":"Natalya S. Akimova, Anastasiya Yu. Elkina, Olga N. Dzhioeva, Ivan M. Sokolov, Anton R. Kiselev, Oxana M. Drapkina, Yury G. Shvarts","doi":"10.15275/rusomj.2023.0204","DOIUrl":null,"url":null,"abstract":"Introduction — The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension (HTN). It is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to vascular tone (VT) dysregulation. Objective — To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young subjects and patients with HTN. Methods — The study involved 2 independent groups: young healthy volunteers and hypertensive patients. The VT regulation was assessed by the active standing test. The polymorphism was identified using DNA pyrosequencing. Results — The C allele of the AGTR1 A1666C A>C variant was associated with lower HR in supine in both groups. The risk allele C of the M268T T>C polymorphism was associated with lower systolic BP and diastolic BP during the 1st minute of upright posture. The C allele of the AGTR1 A1666C A>C variant was associated with earlier onset of HTN. Conclusion — The identification of the AGTR1 A1666C A>C and AGT M268T T>C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of HTN.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Parameters Of Vascular Tone Regulation And Gene Polymorphism Associated With Cardiovascular Risk In Young Subjects\",\"authors\":\"Natalya S. Akimova, Anastasiya Yu. Elkina, Olga N. Dzhioeva, Ivan M. Sokolov, Anton R. Kiselev, Oxana M. Drapkina, Yury G. Shvarts\",\"doi\":\"10.15275/rusomj.2023.0204\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction — The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension (HTN). It is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to vascular tone (VT) dysregulation. Objective — To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young subjects and patients with HTN. Methods — The study involved 2 independent groups: young healthy volunteers and hypertensive patients. The VT regulation was assessed by the active standing test. The polymorphism was identified using DNA pyrosequencing. Results — The C allele of the AGTR1 A1666C A>C variant was associated with lower HR in supine in both groups. The risk allele C of the M268T T>C polymorphism was associated with lower systolic BP and diastolic BP during the 1st minute of upright posture. The C allele of the AGTR1 A1666C A>C variant was associated with earlier onset of HTN. Conclusion — The identification of the AGTR1 A1666C A>C and AGT M268T T>C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of HTN.\",\"PeriodicalId\":21426,\"journal\":{\"name\":\"Russian Open Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Open Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15275/rusomj.2023.0204\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Open Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15275/rusomj.2023.0204","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

血管病理临床前阶段的识别是预防高血压(HTN)最有希望的方法。研究参与血压(BP)调节和血管张力(VT)失调易感性的终产物基因多态性具有重要意义。目的:探讨年轻受试者和HTN患者中与心血管风险增加相关的AGT和AGTR1多态性变异的临床和预后意义。方法:本研究分为两组:年轻健康志愿者和高血压患者。通过主动站立试验对VT调节进行评价。利用DNA焦磷酸测序鉴定其多态性。结果- AGTR1 A1666C A>C变异的C等位基因与两组仰卧者较低的HR相关。m268tt>C多态性的风险等位基因C与直立姿势第1分钟的收缩压和舒张压降低有关。AGTR1 A1666C A>C变异的C等位基因与HTN的早期发病有关。结论- AGTR1 A1666C A>C和AGT M268T T>C变异的鉴定可以在年轻受试者检查时阐明HTN的风险,以及HTN早发的概率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parameters Of Vascular Tone Regulation And Gene Polymorphism Associated With Cardiovascular Risk In Young Subjects
Introduction — The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension (HTN). It is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to vascular tone (VT) dysregulation. Objective — To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young subjects and patients with HTN. Methods — The study involved 2 independent groups: young healthy volunteers and hypertensive patients. The VT regulation was assessed by the active standing test. The polymorphism was identified using DNA pyrosequencing. Results — The C allele of the AGTR1 A1666C A>C variant was associated with lower HR in supine in both groups. The risk allele C of the M268T T>C polymorphism was associated with lower systolic BP and diastolic BP during the 1st minute of upright posture. The C allele of the AGTR1 A1666C A>C variant was associated with earlier onset of HTN. Conclusion — The identification of the AGTR1 A1666C A>C and AGT M268T T>C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of HTN.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信