评估俄罗斯远东地区呼吸系统疾病居民的短期天气诱导免疫反应

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
L. Veremchuk, T. Vitkina, E. Mineeva, E. V. Kondratyeva
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引用次数: 0

摘要

目的——确定对比符拉迪沃斯托克海洋季风气候中影响支气管肺病理个体免疫反应时间动态的气象变化的标准。方法:我们对178例轻度和中度稳定型慢性阻塞性肺病(COPD)患者、212例控制性支气管哮喘(BA)患者和60名明显健康的志愿者进行了检查。我们评估了适应性免疫系统和先天免疫系统的组成部分对温度、气压和湿度、风速和风向以及相对于患者体检日±2天的降水量的日常变化影响的累积反应。免疫系统的反应是通过积分指标来测量的,积分指标计算为统计显著相关性的总和(p<0.05)与相关性矩阵元素的总和的比率。结果——健康人对天气的短期代偿性严重程度和免疫反应活性(∑D=2.56;∑r=117)几乎是COPD患者(∑D=1.28;∑r=72)或BA患者(∑D%=1.35;∑r=69)类似反应的两倍。与COPD患者的短期反应(±2天)相比,明显健康的受试者在体检当天对特定气象因素作用的免疫反应降低了40%,但差异不显著。在明显健康的患者中,影响气象因素的日常对比标准值降低。结论:海洋性季风气候下的城市人群表现出较弱和中等程度的天气诱导免疫系统反应。风力、湿度和降水对免疫系统有显著影响。在COPD和BA患者中,免疫系统对气候因素影响的最大致病反应在±1天内观察到。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing Short-Term Weather-Induced Immune Response In Russian Far East Residents With Respiratory Diseases
Objective — To identify criteria for contrasting meteorological changes affecting the temporal dynamics of the immune response in individuals with bronchopulmonary pathology in the maritime monsoon climate of Vladivostok. Methods — We examined 178 patients with stable chronic obstructive pulmonary disease (COPD) of mild and moderate severity, 212 patients with controlled bronchial asthma (BA) and 60 apparently healthy volunteers. We assessed the cumulative response of the components of adaptive and innate immune systems to the effects of day-to-day variability in temperature, air pressure and humidity, wind speed and direction, and precipitation relative to the day of the patient’s medical examination ± 2 days. The response of the immune system was measured by an integral indicator calculated as the ratio of the sum of statistically significant correlations (p<0.05) to the total sum of correlation matrix elements. Results — The short-term compensatory severity and activity of the immune response to the weather in healthy people (∑D%=2.56; ∑r=117) was almost twice as high as the similar response in patients with COPD (∑D%=1.28; ∑r=72) or BA (∑D%=1.35; ∑r=69). The immune response of apparently healthy subjects to the action of specific meteorological factors on the day of medical examination was reduced by 40%, compared with the short-term response (±2 days) in patients with COPD, but the difference was not significant. The values of the criteria for the day-to-day contrast of influencing meteorological factors in apparently healthy patients were reduced. Conclusion — The urban population in maritime monsoon climate exhibited weak and moderate weather-induced immune system responses. Wind regime, humidity and precipitation had a pronounced effect on the immune system. In patients with COPD and BA, the maximum pathogenic response of the immune system to the impact of climatic factors was observed within ±1 day.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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