L. Veremchuk, T. Vitkina, E. Mineeva, E. V. Kondratyeva
{"title":"评估俄罗斯远东地区呼吸系统疾病居民的短期天气诱导免疫反应","authors":"L. Veremchuk, T. Vitkina, E. Mineeva, E. V. Kondratyeva","doi":"10.15275/rusomj.2023.0203","DOIUrl":null,"url":null,"abstract":"Objective — To identify criteria for contrasting meteorological changes affecting the temporal dynamics of the immune response in individuals with bronchopulmonary pathology in the maritime monsoon climate of Vladivostok. Methods — We examined 178 patients with stable chronic obstructive pulmonary disease (COPD) of mild and moderate severity, 212 patients with controlled bronchial asthma (BA) and 60 apparently healthy volunteers. We assessed the cumulative response of the components of adaptive and innate immune systems to the effects of day-to-day variability in temperature, air pressure and humidity, wind speed and direction, and precipitation relative to the day of the patient’s medical examination ± 2 days. The response of the immune system was measured by an integral indicator calculated as the ratio of the sum of statistically significant correlations (p<0.05) to the total sum of correlation matrix elements. Results — The short-term compensatory severity and activity of the immune response to the weather in healthy people (∑D%=2.56; ∑r=117) was almost twice as high as the similar response in patients with COPD (∑D%=1.28; ∑r=72) or BA (∑D%=1.35; ∑r=69). The immune response of apparently healthy subjects to the action of specific meteorological factors on the day of medical examination was reduced by 40%, compared with the short-term response (±2 days) in patients with COPD, but the difference was not significant. The values of the criteria for the day-to-day contrast of influencing meteorological factors in apparently healthy patients were reduced. Conclusion — The urban population in maritime monsoon climate exhibited weak and moderate weather-induced immune system responses. Wind regime, humidity and precipitation had a pronounced effect on the immune system. In patients with COPD and BA, the maximum pathogenic response of the immune system to the impact of climatic factors was observed within ±1 day.","PeriodicalId":21426,"journal":{"name":"Russian Open Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessing Short-Term Weather-Induced Immune Response In Russian Far East Residents With Respiratory Diseases\",\"authors\":\"L. Veremchuk, T. Vitkina, E. Mineeva, E. V. Kondratyeva\",\"doi\":\"10.15275/rusomj.2023.0203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective — To identify criteria for contrasting meteorological changes affecting the temporal dynamics of the immune response in individuals with bronchopulmonary pathology in the maritime monsoon climate of Vladivostok. Methods — We examined 178 patients with stable chronic obstructive pulmonary disease (COPD) of mild and moderate severity, 212 patients with controlled bronchial asthma (BA) and 60 apparently healthy volunteers. We assessed the cumulative response of the components of adaptive and innate immune systems to the effects of day-to-day variability in temperature, air pressure and humidity, wind speed and direction, and precipitation relative to the day of the patient’s medical examination ± 2 days. The response of the immune system was measured by an integral indicator calculated as the ratio of the sum of statistically significant correlations (p<0.05) to the total sum of correlation matrix elements. Results — The short-term compensatory severity and activity of the immune response to the weather in healthy people (∑D%=2.56; ∑r=117) was almost twice as high as the similar response in patients with COPD (∑D%=1.28; ∑r=72) or BA (∑D%=1.35; ∑r=69). The immune response of apparently healthy subjects to the action of specific meteorological factors on the day of medical examination was reduced by 40%, compared with the short-term response (±2 days) in patients with COPD, but the difference was not significant. The values of the criteria for the day-to-day contrast of influencing meteorological factors in apparently healthy patients were reduced. Conclusion — The urban population in maritime monsoon climate exhibited weak and moderate weather-induced immune system responses. Wind regime, humidity and precipitation had a pronounced effect on the immune system. In patients with COPD and BA, the maximum pathogenic response of the immune system to the impact of climatic factors was observed within ±1 day.\",\"PeriodicalId\":21426,\"journal\":{\"name\":\"Russian Open Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Open Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15275/rusomj.2023.0203\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Open Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15275/rusomj.2023.0203","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Assessing Short-Term Weather-Induced Immune Response In Russian Far East Residents With Respiratory Diseases
Objective — To identify criteria for contrasting meteorological changes affecting the temporal dynamics of the immune response in individuals with bronchopulmonary pathology in the maritime monsoon climate of Vladivostok. Methods — We examined 178 patients with stable chronic obstructive pulmonary disease (COPD) of mild and moderate severity, 212 patients with controlled bronchial asthma (BA) and 60 apparently healthy volunteers. We assessed the cumulative response of the components of adaptive and innate immune systems to the effects of day-to-day variability in temperature, air pressure and humidity, wind speed and direction, and precipitation relative to the day of the patient’s medical examination ± 2 days. The response of the immune system was measured by an integral indicator calculated as the ratio of the sum of statistically significant correlations (p<0.05) to the total sum of correlation matrix elements. Results — The short-term compensatory severity and activity of the immune response to the weather in healthy people (∑D%=2.56; ∑r=117) was almost twice as high as the similar response in patients with COPD (∑D%=1.28; ∑r=72) or BA (∑D%=1.35; ∑r=69). The immune response of apparently healthy subjects to the action of specific meteorological factors on the day of medical examination was reduced by 40%, compared with the short-term response (±2 days) in patients with COPD, but the difference was not significant. The values of the criteria for the day-to-day contrast of influencing meteorological factors in apparently healthy patients were reduced. Conclusion — The urban population in maritime monsoon climate exhibited weak and moderate weather-induced immune system responses. Wind regime, humidity and precipitation had a pronounced effect on the immune system. In patients with COPD and BA, the maximum pathogenic response of the immune system to the impact of climatic factors was observed within ±1 day.
期刊介绍:
Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.