Parameters Of Vascular Tone Regulation And Gene Polymorphism Associated With Cardiovascular Risk In Young Subjects

Abstract

Introduction — The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension (HTN). It is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to vascular tone (VT) dysregulation. Objective — To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young subjects and patients with HTN. Methods — The study involved 2 independent groups: young healthy volunteers and hypertensive patients. The VT regulation was assessed by the active standing test. The polymorphism was identified using DNA pyrosequencing. Results — The C allele of the AGTR1 A1666C A>C variant was associated with lower HR in supine in both groups. The risk allele C of the M268T T>C polymorphism was associated with lower systolic BP and diastolic BP during the 1st minute of upright posture. The C allele of the AGTR1 A1666C A>C variant was associated with earlier onset of HTN. Conclusion — The identification of the AGTR1 A1666C A>C and AGT M268T T>C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of HTN.