Revista Brasileira de Psiquiatria最新文献_第6页

Effect of home-based transcranial direct current stimulation combined with nutritional counseling therapy on binge eating disorder symptoms: a randomized pilot trial. 家庭经颅直流电刺激结合营养咨询疗法对暴食症症状的影响：随机试验

IF 2.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI: 10.47626/1516-4446-2024-3776

Jessica Lorenzzi Elkfury, Luciana C Antunes, Betina Franceschini Tocchetto, Lizia Nardi Menegassi, Paulo Sanches, Danton Pereira, Liciane Fernandes Medeiros, Tiago M Cardinal, Iraci L S Torres, Felipe Fregni, Wolnei Caumo

{"title":"Effect of home-based transcranial direct current stimulation combined with nutritional counseling therapy on binge eating disorder symptoms: a randomized pilot trial.","authors":"Jessica Lorenzzi Elkfury, Luciana C Antunes, Betina Franceschini Tocchetto, Lizia Nardi Menegassi, Paulo Sanches, Danton Pereira, Liciane Fernandes Medeiros, Tiago M Cardinal, Iraci L S Torres, Felipe Fregni, Wolnei Caumo","doi":"10.47626/1516-4446-2024-3776","DOIUrl":"10.47626/1516-4446-2024-3776","url":null,"abstract":"Objective: To examine the effect of nutritional counseling therapy (NCT) combined with transcranial direct current stimulation (tDCS) on binge eating disorder (BED) symptoms.Methods: Forty women with BED were randomly allocated (2:2:2 ratio) to one of the following groups: active tDCS (a-tDCS), NCT, sham tDCS (s-tDCS) with NCT, and a-tDCS with NCT. Home-based tDCS was applied to the dorsolateral prefrontal cortex for 28 sessions.Results: A mixed analysis of variance (ANOVA) showed no main effect between groups nor a time × group interaction. However, a significant main effect was found for time on the primary outcome Binge Eating Scale (BES) (p = 0.001; eta2p = 0.325), which tended to decrease during treatment and follow-up. A significant main effect was found for the secondary outcome short-interval intracortical inhibition (SICI) (p = 0.02; eta2p = 0.112), a measure of inhibitory function, which increased from baseline to the final period in the a-tDCS group, without significant differences between groups.Conclusion: Combined NCT and tDCS did not have a synergistic effect on BED symptoms. Nevertheless, the data from this pilot study should help plan future larger-scale studies investigating the effects of tDCS and behavioral interventions in the promising area of BED treatment.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243776"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and future directions of Transcranial Direct Current Stimulation for Depression: insights from a systematic review and meta-analysis. 经颅直流电刺激治疗抑郁症的挑战和未来方向：来自系统回顾和荟萃分析的见解。

IF 2.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-03-16 DOI: 10.47626/1516-4446-2024-3989

Pedro Henrique Rodrigues da Silva, Marie-Anne Vanderhasselt, Giuseppina Pilloni, Leigh Charvet, Frank Padberg, Marom Bikson, André R Brunoni, Lais B Razza

{"title":"Challenges and future directions of Transcranial Direct Current Stimulation for Depression: insights from a systematic review and meta-analysis.","authors":"Pedro Henrique Rodrigues da Silva, Marie-Anne Vanderhasselt, Giuseppina Pilloni, Leigh Charvet, Frank Padberg, Marom Bikson, André R Brunoni, Lais B Razza","doi":"10.47626/1516-4446-2024-3989","DOIUrl":"10.47626/1516-4446-2024-3989","url":null,"abstract":"Objective: Depression is a common and debilitating disorder affecting millions of people. First-line treatments fail to achieve remission in approximately one-third of patients, highlighting a critical need for treatment. Transcranial direct current stimulation (tDCS) has emerged as a novel treatment for depression. Therefore, the aim of this review was to provide a comprehensive overview of the last decade of tDCS trials for depression and to suggest future research directions.Methods: To synthesize studies from the past decade, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) of tDCS for depression.Results: A total of 21 RCTs were included, showing a moderate effect of active tDCS compared to placebo. We also provided a description of study designs, stimulation parameters, and patient characteristics. We then proposed possible strategies to improve clinical efficacy and reduce outcome variability, including 1) optimization/personalization of tDCS through spatial and temporal target localization, 2) optimized methodological strategies, including home-based, accelerated tDCS protocols and novel study designs, and 3) investigation of the patient profile to identify characteristics that may predict treatment response.Conclusion: tDCS shows promise as a treatment for depression, but variability in study parameters and outcomes underscores the need for further optimization. Refinement and standardization of protocols may improve its efficacy.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243989"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65. 白质高强度及其在重度抑郁发作中的作用：一项65岁以下成年人的横断面研究。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI: 10.47626/1516-4446-2024-3921

Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle

{"title":"White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65.","authors":"Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle","doi":"10.47626/1516-4446-2024-3921","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3921","url":null,"abstract":"Objective: White matter hyperintensities (WMH) are associated with Major Depressive Episodes (MDE) in individuals aged 65 and over. WMH are prevalent in adults under 65, yet the association between their volume and MDE in this population remains uncertain. This study aimed to assess the association between WMH volume and MDE and its severity in patients < 65.Methods: This cross-sectional study included subjects under the age of 65, 69 patients with MDE and 32 healthy controls (HCs). Severity was assessed with the Hamilton Rating Scale and WMH were quantified by 2 experts. Post-hoc mediation analyses were conducted if associations were found between independent variables and WMH.Results: Mean was 34.5 (12.4) years old. There was no difference in WMH between patients and HCs. Higher WMH volume were observed in extremely severe MDE (2170.2 (3767.9) mm3 vs 416.6 (594.9) mm3 (r = 0.21; p < 0.05)), which completely mediated the effect of age on severity.Conclusions: In adults under 65, this study failed to identify higher WMH volume in MDE compared to HCs. However, WMH may act as a mediator of the association between age and MDE severity. This finding suggests that WMH could contribute to more severe depression in late-life.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database. FAERS 数据库中奥氮平不良事件的信号挖掘和风险分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-17 DOI: 10.47626/1516-4446-2024-3880

Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu

{"title":"Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database.","authors":"Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu","doi":"10.47626/1516-4446-2024-3880","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3880","url":null,"abstract":"Objective: This study aims to assess the safety profile of Olanzapine by analyzing adverse events (AEs) reported in the FAERS database, particularly focusing on newly identified risks.Method: The study involved adverse events (AEs) related to Olanzapine from January 1, 2004, to June 30, 2023. Four signal mining methods were used for a comprehensive analysis of the frequency and strength of AEs, including ROR, PRR, BCPNN, and EBGM.Results: A total of 43,664 reports with Olanzapine as the primary suspect drug were collected. 776 PT signals involving 27 SOCs were identified. The main affected groups were females and the age group of 18 to 45 years. Psychiatric disorders and Nervous system disorders were the most common adverse reactions. Moreover, the analysis revealed some adverse reactions not recorded in the manual, including cardiovascular risks like Pancreatitis, Chylomicron increased, Hyperchylomicronaemia, and Myocardial reperfusion injury, as well as rare but serious adverse reactions like Neuroleptic malignant syndrome and Anosognosia.Conclusion: This study identified new cardiovascular risks associated with Olanzapine, including pancreatitis and myocardial reperfusion injury, which require further investigation.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Download to Heal: Navigating the Pixelated Path of Digital Therapeutics in Psychiatric Care. 下载《治愈：探索精神病治疗中数字疗法的像素之路》（Digital Therapeutics in Psychiatric Care）。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-09-27 DOI: 10.47626/1516-4446-2024-3802

Jai Ahuja, Sanobar Jaka, Sikandar Saeed, Sasidhar Gunturu

{"title":"Download to Heal: Navigating the Pixelated Path of Digital Therapeutics in Psychiatric Care.","authors":"Jai Ahuja, Sanobar Jaka, Sikandar Saeed, Sasidhar Gunturu","doi":"10.47626/1516-4446-2024-3802","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3802","url":null,"abstract":"Digital therapeutics have evolved rapidly with technological advances in healthcare. Despite their increasing use, gaps remain in understanding their regulatory frameworks, integration, and efficacy for conditions like substance use disorder, insomnia, attention deficit hyperactivity disorder, and post-traumatic stress disorder. This study evaluates FDA-approved digital therapeutics and explores their potential to revolutionize psychiatric treatments amid ongoing technological and regulatory changes. We conducted a comprehensive review of major databases, focusing on articles published up to January 2024 on FDA-approved digital therapeutics. We excluded non-English articles and those lacking empirical data or focusing on non-FDA-approved therapeutics. Our analysis covered regulatory compliance, clinical outcomes, and integration with traditional treatments. The review of nine FDA-cleared digital therapeutics revealed benefits like improved treatment accessibility and potential reductions in healthcare costs. For example, Somryst, a cognitive-behavioral therapy-based treatment for insomnia, showed that over 40 percent of users overcame chronic insomnia, and 60 percent experienced improvements without adverse effects. However, challenges remain, including low provider adoption, inadequate insurance coverage, and high user dropout rates. While digital therapeutics enhance accessibility, they face regulatory challenges, reimbursement issues, and the need for robust clinical evidence. Success depends on collaboration among stakeholders to demonstrate value, ensure safety, and integrate them into existing healthcare systems.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Gut Microbiota Composition During Perinatal period in Women with Different Intensities of Depressive Symptoms. 不同抑郁症状强度妇女围产期的纵向肠道微生物群组成

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-09-21 DOI: 10.47626/1516-4446-2024-3721

Amanda S Mota, Luiz Gustavo Sparvoli, Pedro Augusto R Vanzele, Nathalia F Naspolini, Eric de Castro Tobaruela, Carlos T Yoshizaki, Rossana Pulcineli Vieira Francisco, Ana Maria S S Oliveira, Marco Aurélio Knippel Galletta, Vera Lucia C Tess, Carla R Taddei

{"title":"Longitudinal Gut Microbiota Composition During Perinatal period in Women with Different Intensities of Depressive Symptoms.","authors":"Amanda S Mota, Luiz Gustavo Sparvoli, Pedro Augusto R Vanzele, Nathalia F Naspolini, Eric de Castro Tobaruela, Carlos T Yoshizaki, Rossana Pulcineli Vieira Francisco, Ana Maria S S Oliveira, Marco Aurélio Knippel Galletta, Vera Lucia C Tess, Carla R Taddei","doi":"10.47626/1516-4446-2024-3721","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3721","url":null,"abstract":"Background: Depressive symptoms during perinatal significantly impact mothers and infants. Emerging evidence suggests a connection between gut microbiota and mood regulation. This study investigated whether depressive symptoms are associated with changes in the gut microbiota of women during the perinatal period.Method: A total of 34 pregnant women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS) and categorized based on symptom severity. Stool samples were collected during the third trimester and at two postpartum timepoints. All samples underwent 16S rRNA gene sequencing and Quantification of Short-Chain Fatty Acids (SCFA) using a gas chromatograph-mass spectrometer (GC-MS).Results: No differences in SCFA concentrations were observed between groups (p>0.05). However, postpartum women with moderate to severe symptoms (MG group) had a significant increase in Enterobacteriaceae abundance compared to the mild and absent group (AL group) (p<0.05). The Bifidobacterium genus increased significantly in both groups over time (p<0.05). The MG group showed a reduction in depressive symptoms during psychiatric treatment (p<0.05).Conclusion: These findings suggest a link between gut microbiota and perinatal depressive symptoms. Further research is needed to understand the broader implications for maternal health through microbiome-targeted approaches.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of online group cognitive behavioral therapy for adolescents with obsessive-compulsive disorder: a pilot study. 在线认知行为疗法对强迫症青少年的疗效：一项试点研究。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI: 10.47626/1516-4446-2023-3376

Cristiane Flores Bortoncello, Nicolas de Oliveira Cardoso, Sophia Ronchetti Martins Xavier, Ygor Arzeno Ferrão

{"title":"Effectiveness of online group cognitive behavioral therapy for adolescents with obsessive-compulsive disorder: a pilot study.","authors":"Cristiane Flores Bortoncello, Nicolas de Oliveira Cardoso, Sophia Ronchetti Martins Xavier, Ygor Arzeno Ferrão","doi":"10.47626/1516-4446-2023-3376","DOIUrl":"10.47626/1516-4446-2023-3376","url":null,"abstract":"Objective: To evaluate the effectiveness of online group cognitive behavioral therapy (CBT) based on the CAMALEO TOC manual in the treatment of adolescents with obsessive-compulsive disorder (OCD).Methods: This is a quasi-experimental study with a single-group pretest-posttest intervention. Over a 12-week period, 11 adolescents aged 11 to 17 years with OCD participated in weekly online group CBT sessions based on the CAMALEO TOC manual. We used several assessment tools, including the Children's Yale-Brown Obsessive-Compulsive Scale to assess the severity of OCD symptoms, the Family Accommodation Scale for Obsessive-Compulsive Disorder-Interviewer-Rated to measure family accommodation, the Children's Depression Inventory to assess depression symptoms, the Revised Children's Manifest Anxiety Scale to assess anxiety, and the Multidimensional Students' Life Satisfaction Scale to measure satisfaction with life.Results: OCD symptoms decreased significantly (d = -1.55) after online group CBT, and a strong effect size (d = -1.03) was found for family accommodation. After controlling for variables (e.g., engagement in psychotherapeutic treatment, medication use, or psychiatric comorbidities), no significant differences were found for OCD symptoms and family accommodation scores. In addition, there was insufficient evidence to support the effectiveness of online group CBT in reducing symptoms of depression or anxiety or improving overall quality of life.Conclusion: Our study demonstrates the feasibility of short-term online group CBT as an effective therapeutic approach for adolescents with OCD.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233376"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of adult ADHD symptoms with binge eating spectrum conditions, psychiatric and somatic comorbidity, and healthcare utilization. 巴西某大都市成人多动症症状与暴饮暴食谱系疾病、精神病和躯体疾病合并症以及医疗保健利用率之间的关系。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.47626/1516-4446-2024-3728

Jose Carlos Appolinario, Carlos Eduardo F de Moraes, Rosely Sichieri, Phillipa Hay, Stephen V Faraone, Paulo Mattos

{"title":"Associations of adult ADHD symptoms with binge eating spectrum conditions, psychiatric and somatic comorbidity, and healthcare utilization.","authors":"Jose Carlos Appolinario, Carlos Eduardo F de Moraes, Rosely Sichieri, Phillipa Hay, Stephen V Faraone, Paulo Mattos","doi":"10.47626/1516-4446-2024-3728","DOIUrl":"10.47626/1516-4446-2024-3728","url":null,"abstract":"Objective: To investigate the associations of symptoms of attention deficit hyperactivity disorder (ADHD) with binge eating spectrum conditions (BESC) (binge eating disorder [BED], bulimia nervosa [BN], and recurrent binge eating [RBE]), psychiatric and somatic comorbidity, and healthcare utilization in a representative sample of a Brazilian city.Methods: A household survey of 2,297 adult residents of the city of Rio de Janeiro was conducted. The Adult Self-Rating Scale Screener (ASRS-6) was used to assess ADHD symptoms. BESC was assessed using the Questionnaire on Eating and Weight Patterns-5 (QEWP-5) and confirmed by telephone interview. Standardized questionnaires were used to assess psychiatric comorbidity. Closed-ended questions investigated somatic comorbidity and healthcare utilization.Results: ADHD symptoms were highly associated with BESC (BED: OR = 13.2, 95%CI 4.3-40.6; BN: OR = 27.5, 95%CI 5.9-128.7; RBE: OR = 5.8, 95%CI 2.9-11.4). However, with further adjustment for psychiatric comorbidity (depression, anxiety, alcohol use, and impulsivity), the ORs were no longer significant. Healthcare resource utilization was significantly higher in participants with ADHD and BESC but lost significance after controlling for psychiatric comorbidity.Conclusion: ADHD was associated with an increased prevalence of BESC and greater healthcare utilization. Nonetheless, there was an essential interplay among psychiatric comorbidity in the associations of ADHD and BESC.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243728"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental choroid plexus papilloma in a forensic psychiatric inpatient: a case report. 一名法医精神病住院患者的偶然性脉络丛乳头状瘤：病例报告。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-03-18 DOI: 10.47626/1516-4446-2024-3537

Pınar Celikkiran Erdem, Gamze Onar, Ahmet Türkcan

引用次数: 0

Patient Health Questionnaire-9: A clinimetric analysis. 患者健康问卷-9：临床分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-28 DOI: 10.47626/1516-4446-2023-3449

Fiammetta Cosci, Kaj Sparle Christensen, Sara Ceccatelli, Chiara Patierno, Danilo Carrozzino

{"title":"Patient Health Questionnaire-9: A clinimetric analysis.","authors":"Fiammetta Cosci, Kaj Sparle Christensen, Sara Ceccatelli, Chiara Patierno, Danilo Carrozzino","doi":"10.47626/1516-4446-2023-3449","DOIUrl":"10.47626/1516-4446-2023-3449","url":null,"abstract":"Objective: The Patient Health Questionnaire-9 (PHQ-9) is a widely used self-report measure of depression whose psychometric properties were found to be merely acceptable. Insufficient attention has been devoted to its clinimetric validity, while its clinical utility is still debated, particularly for assessing depression severity. This is the first study to test the PHQ-9 construct validity and clinical utility based on clinimetric principles.Methods: An online survey of 3,398 participants was conducted. Item response theory models (Rasch and Mokken analyses) were used to assess the PHQ-9 validity and determine its clinical utility.Results: Fit to the Rasch model was achieved after adjusting the sample size. Items 2, 4, 6, and 9 over-discriminated, while items 1, 5, and 7 under-discriminated. Local dependency between items 2 and 6 was indicated. The PHQ-9 was not unidimensional. A Loevinger's coefficient of 0.49 was found, indicating an acceptable level of scalability.Conclusion: The PHQ-9 is an instrument with potential clinical utility as an overall index of depression, mainly for screening purposes. Substantial revision, particularly in the wording of over- and under-discriminating items, is needed.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233449"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0