White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65.

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI:10.47626/1516-4446-2024-3921

Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle

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引用次数: 0

Abstract

Objective: White matter hyperintensities (WMH) are associated with Major Depressive Episodes (MDE) in individuals aged 65 and over. WMH are prevalent in adults under 65, yet the association between their volume and MDE in this population remains uncertain. This study aimed to assess the association between WMH volume and MDE and its severity in patients < 65.

Methods: This cross-sectional study included subjects under the age of 65, 69 patients with MDE and 32 healthy controls (HCs). Severity was assessed with the Hamilton Rating Scale and WMH were quantified by 2 experts. Post-hoc mediation analyses were conducted if associations were found between independent variables and WMH.

Results: Mean was 34.5 (12.4) years old. There was no difference in WMH between patients and HCs. Higher WMH volume were observed in extremely severe MDE (2170.2 (3767.9) mm3 vs 416.6 (594.9) mm3 (r = 0.21; p < 0.05)), which completely mediated the effect of age on severity.

Conclusions: In adults under 65, this study failed to identify higher WMH volume in MDE compared to HCs. However, WMH may act as a mediator of the association between age and MDE severity. This finding suggests that WMH could contribute to more severe depression in late-life.

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白质高强度及其在重度抑郁发作中的作用：一项65岁以下成年人的横断面研究。

目的：白质高强度（WMH）与65岁及以上人群重度抑郁发作（MDE）相关。WMH在65岁以下的成年人中普遍存在，但其数量与该人群MDE之间的关系仍不确定。本研究旨在评估65岁以下患者WMH体积与MDE及其严重程度之间的关系。方法：本横断面研究包括65岁以下的受试者，69例MDE患者和32例健康对照（hc）。严重度采用Hamilton评定量表，WMH由2位专家量化。如果发现自变量与WMH之间存在关联，则进行事后中介分析。结果：平均年龄34.5岁（12.4岁）。患者和hc患者的WMH无差异。极严重MDE患者WMH体积较高(2170.2 (3767.9)mm3 vs 416.6 (594.9) mm3) (r = 0.21；P < 0.05))，完全介导了年龄对严重程度的影响。结论：在65岁以下的成年人中，本研究未能确定MDE患者的WMH体积高于hc患者。然而，WMH可能在年龄和MDE严重程度之间起中介作用。这一发现表明，WMH可能会导致晚年更严重的抑郁症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.