Revista Brasileira de Psiquiatria最新文献_第5页

Emergency psychiatric care seeking among individuals who died by suicide in Fortaleza in 2022. 2022 年福塔莱萨自杀死亡者寻求精神科急诊的情况。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.47626/1516-4446-2024-3635

Ana Carolina Parahyba Asfor, Matias Carvalho Aguiar Melo

{"title":"Emergency psychiatric care seeking among individuals who died by suicide in Fortaleza in 2022.","authors":"Ana Carolina Parahyba Asfor, Matias Carvalho Aguiar Melo","doi":"10.47626/1516-4446-2024-3635","DOIUrl":"10.47626/1516-4446-2024-3635","url":null,"abstract":"Objective: Suicide represents 1% of all deaths in the world, and it is more prevalent in developing countries. Because suicide mortality has been growing in recent years in Brazil, we investigated whether patients who committed suicide in 2022 in Fortaleza sought care in the state's only psychiatric emergency service before the act.Methods: This retrospective cross-sectional study used data from electronic psychiatric emergency records and reports from the state department of forensics.Results: A total of 292 deaths (25% women) were identified, representing almost 2% of mortality in Fortaleza that year. Only 2.7% of those who committed suicide during this period requested an emergency psychiatric evaluation in the 3 months prior to death. Of these individuals, 75% mentioned suicidal ideation. Most deaths (70%) were due to hanging.Conclusion: The majority of patients who committed suicide in Fortaleza in 2022 did not seek care from the psychiatric emergency service prior to the event; further studies are needed to investigate the causes of this behavior.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243635"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online narrative therapy intervention improves post-traumatic stress disorder symptoms, perceived stress, anxiety, and depression in nurses: a randomized controlled trial. 在线叙事疗法干预可改善护士的创伤后应激障碍症状、感知压力、焦虑和抑郁：随机对照试验。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2024-09-27 DOI: 10.47626/1516-4446-2024-3740

Mengxin Xue, Ping Yu, Zhie Gu, Yanfei Sun

{"title":"Online narrative therapy intervention improves post-traumatic stress disorder symptoms, perceived stress, anxiety, and depression in nurses: a randomized controlled trial.","authors":"Mengxin Xue, Ping Yu, Zhie Gu, Yanfei Sun","doi":"10.47626/1516-4446-2024-3740","DOIUrl":"10.47626/1516-4446-2024-3740","url":null,"abstract":"Objective: To evaluate the effect of narrative therapy on post-traumatic stress disorder (PTSD) symptoms, perceived stress, anxiety, and depression in nurses.Methods: A total of 92 clinical nurses with positive PTSD symptom screening results were randomly assigned (1:1) to the intervention or control group. The intervention group received narrative therapy and a psychological stress leaflet, while the control group received only a psychological stress leaflet. PTSD, perceived stress, anxiety, and depression were measured before and after the intervention to assess the effect of narrative therapy.Results: After the intervention, the intervention group showed significantly lower PTSD symptom levels (p = 0.025), perceived stress (p = 0.033), anxiety (p = 0.004), and depression (p = 0.015) than the control group. Regarding the dichotomous PTSD, anxiety, and depression outcomes, there was a statistically significant decrease in the number of positive cases of PTSD (p = 0.030) and anxiety (p = 0.002), but no significant change in the number of positive cases of depression (p = 0.060).Conclusion: Narrative therapy is expected to alleviate PTSD symptoms, stress, anxiety, and depression among frontline clinical nurses, and healthcare managers should consider narrative therapy interventions to improve the mental health of their nursing staff.Clinical trial registration: ChiCTR2200058472. Registration date: April 09, 2022. Date of first recruitment: June 1, 2022.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243740"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of suicide in association with major depressive disorder among patients with dementia: a populationbased nested case-control study. 痴呆症患者自杀风险与重度抑郁障碍的关联：基于人群的嵌套病例对照研究》。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2024-09-22 DOI: 10.47626/1516-4446-2024-3605

Jiun-Yi Wang, Yi-Ting Hsu, Chih-Yuan Lin, Chien-Hui Liu, Kun-Chia Chang, Chih-Ching Liu

{"title":"Risk of suicide in association with major depressive disorder among patients with dementia: a populationbased nested case-control study.","authors":"Jiun-Yi Wang, Yi-Ting Hsu, Chih-Yuan Lin, Chien-Hui Liu, Kun-Chia Chang, Chih-Ching Liu","doi":"10.47626/1516-4446-2024-3605","DOIUrl":"10.47626/1516-4446-2024-3605","url":null,"abstract":"Objective: This study aimed to explore the association between major depressive disorder (MDD) and suicide risk in patients with dementia.Methods: A cohort of 625,218 individuals aged = 40 years with dementia was identified from Taiwan's National Health Insurance Research Database (NHIRD) between 2007 and 2018. After excluding prevalent cases in 2007, a nested case-control study enrolling 1,256 suicide cases and 5,022 matched controls was conducted. The frequencies of MDD-related outpatient or inpatient visits over a 7-year period preceding the event dates were calculated and analyzed for association using conditional logistic regression.Results: Dementia comorbid with MDD was associated with increased suicide risk (adjusted OR [AOR]: 2.67), particularly in individuals with = 1.0 MDD episodes per year (AOR: 2.85). A similar association was observed only in individuals aged = 65 years and males, with a pronounced risk of suicide in those experiencing = 1.0 MDD episodes per year (AOR: 3.08 for individuals aged = 65 years; AOR: 3.28 for males). Conversely, the risk increase was evident with > 1.0 MDD episodes per year in those aged < 65 years (AOR: 3.04) and females (AOR: 2.45).Conclusion: MDD is associated with suicide risk in patients with dementia. The strength of this association possibly varies with age and gender.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243605"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short and long-term effects of cognitive behavioral therapy on sleep problems and psychotic symptoms in patients with psychotic disorders: a meta-analysis. 认知行为疗法对精神障碍患者睡眠问题和精神症状的短期和长期影响：一项元分析研究

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2025-01-01 Epub Date: 2024-08-05 DOI: 10.47626/1516-4446-2024-3623

Mustafa Ugurlu, Gorkem Karakas Ugurlu, Esra Kabadayi Sahin, Gulsum Zuhal Kamis, Ali Caykoylu

{"title":"Short and long-term effects of cognitive behavioral therapy on sleep problems and psychotic symptoms in patients with psychotic disorders: a meta-analysis.","authors":"Mustafa Ugurlu, Gorkem Karakas Ugurlu, Esra Kabadayi Sahin, Gulsum Zuhal Kamis, Ali Caykoylu","doi":"10.47626/1516-4446-2024-3623","DOIUrl":"10.47626/1516-4446-2024-3623","url":null,"abstract":"Objective: Sleep problems are common in patients with psychotic disorders, especially schizophrenia. Although pharmacological methods are at the forefront of treatment, they have some drawbacks. Cognitive behavioral therapy for insomnia (CBT-I) is an option for the treatment of individuals with insomnia; in recent years, interest in its use in patients with psychotic disorders has been increasing. This meta-analysis aims to evaluate the effectiveness of CBT-I for sleep problems in patients with psychotic disorders.Methods: A systematic search of the PubMed, Scopus, and EBSCO (MEDLINE) databases was conducted to identify relevant studies. The inclusion criteria were randomized controlled trials (RCTs) and uncontrolled studies that focused on participants diagnosed with schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorders, or unipolar depression with psychotic features, who had had sleep problems for at least 1 month, and who were receiving treatment. The initial search yielded 246 studies, of which eight were ultimately selected for meta-analysis after screening and applying inclusion and exclusion criteria. Statistical analysis was conducted in the R software environment.Results: CBT-I significantly ameliorates insomnia and sleep quality in patients with psychotic disorders in both the short and long term. Additionally, CBT-I leads to significant improvement in psychotic symptoms in the short-term period and contributes significantly to improvement in mental well-being in both short- and long-term follow-up.Conclusions: CBT-I is an effective, valuable method for sleep problems in patients with psychotic disorders. Its widespread use for this purpose is recommended.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243623"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Patterns of Disordered Eating Behaviors in Children and Adolescents from the Brazilian High-Risk Cohort Study for Mental Conditions. 来自巴西精神疾病高危队列研究的儿童和青少年饮食失调行为的纵向模式

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI: 10.47626/1516-4446-2024-3867

Iara Peixoto de Oliveira, Ana C Fernandéz, Giovanni A Salum, Ary Gadelha, Pedro Pan, Eurípedes Constantino Miguel, Daniel C Mograbi, Patricia P Bado

{"title":"Longitudinal Patterns of Disordered Eating Behaviors in Children and Adolescents from the Brazilian High-Risk Cohort Study for Mental Conditions.","authors":"Iara Peixoto de Oliveira, Ana C Fernandéz, Giovanni A Salum, Ary Gadelha, Pedro Pan, Eurípedes Constantino Miguel, Daniel C Mograbi, Patricia P Bado","doi":"10.47626/1516-4446-2024-3867","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3867","url":null,"abstract":"Objective: Disordered Eating Behaviors (DEB) are associated with dysfunctional changes in eating behavior, not meeting diagnostic criteria for eating disorders. DEB affects a significant percentage of individuals, yet it remains under-researched. The current study investigates the developmental trajectory and psychopathological correlates of DEB in children and adolescents in Brazil.Methods: The sample included 1,583 participants from the Brazilian High-Risk Cohort, assessed across three waves between 2010 (age 6-12 years) and 2019 (age 12-21 years). Psychopathology diagnoses were evaluated using the Development and Well-Being Assessment (DAWBA) and DEB was assessed through the DAWBA eating disorders screening. Dimensional psychopathology was measured with the Child Behavior Checklist.Results: Participants were divided into dysfunctional and non-dysfunctional eating groups. DEB showed significant variability, with few maintaining persistent patterns. DEB was strongly linked to higher internalizing symptoms, especially in girls, but less to externalizing behaviors. DEB increased the likelihood of Eating Disorders, Major Depressive Disorder, and higher BMI.Conclusions: This study reveals that DEB are frequent among Brazilian children and adolescents and linked to psychopathology, especially internalizing symptoms, and BMI. Future research should investigate the underlying mechanisms of DEB and develop strategies for early detection and effective interventions.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65. 白质高强度及其在重度抑郁发作中的作用：一项65岁以下成年人的横断面研究。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-28 DOI: 10.47626/1516-4446-2024-3921

Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle

{"title":"White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65.","authors":"Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle","doi":"10.47626/1516-4446-2024-3921","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3921","url":null,"abstract":"Objective: White matter hyperintensities (WMH) are associated with Major Depressive Episodes (MDE) in individuals aged 65 and over. WMH are prevalent in adults under 65, yet the association between their volume and MDE in this population remains uncertain. This study aimed to assess the association between WMH volume and MDE and its severity in patients < 65.Methods: This cross-sectional study included subjects under the age of 65, 69 patients with MDE and 32 healthy controls (HCs). Severity was assessed with the Hamilton Rating Scale and WMH were quantified by 2 experts. Post-hoc mediation analyses were conducted if associations were found between independent variables and WMH.Results: Mean was 34.5 (12.4) years old. There was no difference in WMH between patients and HCs. Higher WMH volume were observed in extremely severe MDE (2170.2 (3767.9) mm3 vs 416.6 (594.9) mm3 (r = 0.21; p < 0.05)), which completely mediated the effect of age on severity.Conclusions: In adults under 65, this study failed to identify higher WMH volume in MDE compared to HCs. However, WMH may act as a mediator of the association between age and MDE severity. This finding suggests that WMH could contribute to more severe depression in late-life.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leme Lopes: the pioneering multiaxial diagnosis and the dilemma of subjectivity. Leme Lopes：开创性的多轴诊断与主体性困境。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-12-27 DOI: 10.47626/1516-4446-2024-3990

Larissa Junkes, Walmor J Piccinini, Antonio E Nardi

引用次数: 0

Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace. 事件影响量表-修订版（IES-R）的项目有效性研究：医院工作人员对工作场所压力反应的自我报告。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-27 DOI: 10.47626/1516-4446-2024-3882

Vitor A Petrilli-Mazon, Marcos O Carvalho-Alves, Eurípedes Constantino Miguel, Felipe Corchs, Mariana Curi, Yuan-Pang Wang

{"title":"Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace.","authors":"Vitor A Petrilli-Mazon, Marcos O Carvalho-Alves, Eurípedes Constantino Miguel, Felipe Corchs, Mariana Curi, Yuan-Pang Wang","doi":"10.47626/1516-4446-2024-3882","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3882","url":null,"abstract":"Objective: Recent studies have revealed a heterogeneous prevalence and presentation of PTSD across countries. It is crucial to assess the methodological and item-level measurement factors that contribute to variations in mental disorder rates across cultures. This study aimed to investigate the traumatic experiences of hospital workers by employing item analysis of the Impact of Event Scale-Revised (IES-R).Methods: Data were collected from 1,000 employees of a large hospital during the COVID-19 pandemic and were further subjected to item response theory (IRT) analysis with respect to the discrimination (a) and difficulty (b) parameters of the item pool.Results: Our results demonstrated that the IES-R items had a good discriminative ability (a) and covered a range of distress severity (b) associated with traumatic experiences. The IES-R was found to be a reliable and informative instrument for assessing individuals with moderate to severe trauma-related distress across the spectrum of traumatic symptoms. In particular, items #10 (\"jumpy or easily startled\") and #6 (\" thought about it when didn't mean to\"), reflecting the PTSD domains of hyperarousal and intrusion, excelled in discriminating between different levels of traumatic distress. Conversely, items related to avoidance and sleep disturbance showed diminished discriminative ability.Conclusions: The item analysis of the IES-R may be used to assess trauma symptoms in the context of a traumatic exposure, thereby identifying the most discriminative and informative items of the PTSD measure in our context. Our findings may refine the IES-R and facilitate the development of a more effective scale with optimized item parameters.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database. FAERS 数据库中奥氮平不良事件的信号挖掘和风险分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-11-17 DOI: 10.47626/1516-4446-2024-3880

Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu

{"title":"Signal Mining and Risk Analysis of Olanzapine Adverse Events in the FAERS Database.","authors":"Aiguo Dong, Lingyi Shi, Zhiqiang Du, Qin Zhou, Ying Jiang, Haohao Zhu, Anqing Zhu","doi":"10.47626/1516-4446-2024-3880","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3880","url":null,"abstract":"Objective: This study aims to assess the safety profile of Olanzapine by analyzing adverse events (AEs) reported in the FAERS database, particularly focusing on newly identified risks.Method: The study involved adverse events (AEs) related to Olanzapine from January 1, 2004, to June 30, 2023. Four signal mining methods were used for a comprehensive analysis of the frequency and strength of AEs, including ROR, PRR, BCPNN, and EBGM.Results: A total of 43,664 reports with Olanzapine as the primary suspect drug were collected. 776 PT signals involving 27 SOCs were identified. The main affected groups were females and the age group of 18 to 45 years. Psychiatric disorders and Nervous system disorders were the most common adverse reactions. Moreover, the analysis revealed some adverse reactions not recorded in the manual, including cardiovascular risks like Pancreatitis, Chylomicron increased, Hyperchylomicronaemia, and Myocardial reperfusion injury, as well as rare but serious adverse reactions like Neuroleptic malignant syndrome and Anosognosia.Conclusion: This study identified new cardiovascular risks associated with Olanzapine, including pancreatitis and myocardial reperfusion injury, which require further investigation.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A randomized, double-blind, placebo-controlled trial of N-acetylcysteine as an adjuvant treatment for alcohol use disorder. N-乙酰半胱氨酸作为酒精使用障碍辅助治疗的随机、双盲、安慰剂对照试验。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-10-09 DOI: 10.47626/1516-4446-2024-3541

Jaqueline B Schuch, Fernanda Hansen, Thiago Hartmann, Daniela Benzano, Henrique M Gomes, José Cláudio F Moreira, Flavio Pechansky, Felix H P Kessler, Fabiana Galland, Daiane Silvello, Anne O Sordi, Lisia von Diemen

{"title":"A randomized, double-blind, placebo-controlled trial of N-acetylcysteine as an adjuvant treatment for alcohol use disorder.","authors":"Jaqueline B Schuch, Fernanda Hansen, Thiago Hartmann, Daniela Benzano, Henrique M Gomes, José Cláudio F Moreira, Flavio Pechansky, Felix H P Kessler, Fabiana Galland, Daiane Silvello, Anne O Sordi, Lisia von Diemen","doi":"10.47626/1516-4446-2024-3541","DOIUrl":"10.47626/1516-4446-2024-3541","url":null,"abstract":"Objective: We aimed to assess the effect of N-acetylcysteine (NAC), as an adjuvant treatment, on treatment adherence (primary outcome), in peripheral biomarkers and clinical improvement (secondary outcomes) in alcohol use disorders (AUD) patients.Methods: A 9-week randomized, double-blind, placebo-controlled trial (RCT) was conducted on 53 (n=25 NAC, n=28 placebo) inpatients with AUD. Neuropeptide Y (NPY), oxidative stress and inflammatory biomarkers, and hepatic parameters were analyzed in three-time moments.Results: Seventeen (60.7%) subjects in placebo and sixteen (64%) in the NAC group completed the RCT. Levels of hepatic biomarkers significantly changed over time (p<0.001). Oxidized glutathione (GSSG) levels at admission were lower in NAC group ((ppairwise=0.043). By the end of the study, both groups had similar GSSG levels (p=0.868), showing a reduction in GSSG levels in the placebo group. In the NAC group, a decrease in superoxide dismutase (SOD) activity and an increase in NPY levels in the end of the intervention were observed. Both groups showed similar mean survival time to relapse, treatment adherence and clinical improvement.Conclusion: Our findings reinforce the alcohol effects on oxidative stress and NPY parameters. However, our sample size may limit the generalizability of the results, especially for clinical outcomes. Future RCTs with less severe alcoholics and longer follow-up may be necessary to test if NAC could be helpful to reduce the mental health burden related to AUD.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0