Revista Brasileira de Psiquiatria最新文献

{"title":"Addressing the elephant in the screening room: an item response theory analysis of the Prodromal Questionnaire for at-risk symptoms of psychosis.","authors":"Christophe Gauld, Pierre Fourneret, Ben Alderson-Day, Emma Palmer-Cooper, Clément Dondé","doi":"10.47626/1516-4446-2024-3614","DOIUrl":"10.47626/1516-4446-2024-3614","url":null,"abstract":"<p><strong>Objective: </strong>Patients at risk of psychosis present a variety of symptoms, and identifying the most discriminative symptoms is essential for efficient detection and treatment.</p><p><strong>Methods: </strong>This cross-sectional online study analyzed individuals from the general population to better assess their risk of symptoms classified as clinical high risk (CHR) for psychosis. The 16-item Prodromal Questionnaire was applied as a self-report screening tool. Item response theory with a graded response model was used to assess the discrimination and difficulty of the questionnaire's criteria.</p><p><strong>Results: </strong>The analysis included 936 participants (mean age: 21.5 years; 71.9% women). \"Déjà vu\" stood out for its high discriminative power, while the \"voices or whispers\" and \"seeing things\" items had greater precision than the other CHR-related symptoms. Conversely, the \"smell or taste\" and \"changing faces\" items were associated with the most severe cases.</p><p><strong>Conclusion: </strong>This study identified the most indicative CHR-related symptoms for accurate assessment of psychosis severity, which can be used to guide targeted preventative interventions.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243614"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood family adversity and recurrent depression in adulthood: the findings of three ELSA-Brasil follow-up visits.","authors":"Maíra Barroso Léo, Sandhi Maria Barreto, Rosane Harter Griep, Ana Luísa Patrão, Lidyane do Valle Camelo, Maria Carmen Viana, Luana Giatti","doi":"10.47626/1516-4446-2024-3914","DOIUrl":"10.47626/1516-4446-2024-3914","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the association between childhood family adversity and depression in a cohort of Brazilian adults over three visits.</p><p><strong>Methods: </strong>A total of 12,636 participants from the Longitudinal Study of Adult Health (ELSA-Brasil), baseline (2008-2010) and followed up in 2012-2014 and 2017-2019, were included. Five types of family dysfunction and the childhood family dysfunction score (0, 1, and = 2 dysfunctions) were used. The Clinical Interview Schedule-Revised was used to assess depression in visits 1 and 2 or 3. Multinomial logistic regression models estimated crude and adjusted OR and 95%CI.</p><p><strong>Results: </strong>The mean age of the sample was 59.6 (SD, 8.8) years, 7.4% presented depression in one visit, and 2.2% presented it in two or three visits. After adjustment, compared to no family dysfunction, mental disorder (OR = 3.91; 95%%CI 2.94-5.21), substance abuse (OR = 2.14; 95%CI 1.65-2.77), and parental separation/divorce (OR = 1.55; 95%CI 1.12-2.15) increased the odds of depression in two or three visits. Exposure to = 2 types of family dysfunction increased the odds of depression in one, and two or three visits in a dose-response gradient.</p><p><strong>Conclusion: </strong>Exposure to childhood family dysfunction contributes to the occurrence and recurrence of depression in adults. Interventions to prevent dysfunctional family environments and their repercussions on children can reduce the burden of depression.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243914"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Item-wise validity study of the Impact of Event Scale-Revised: self-reported reactions of hospital personnel exposed to a stressful workplace.","authors":"Vitor A Petrilli-Mazon, Marcos O Carvalho-Alves, Eurípedes Constantino Miguel, Felipe Corchs, Mariana Curi, Yuan-Pang Wang","doi":"10.47626/1516-4446-2024-3882","DOIUrl":"10.47626/1516-4446-2024-3882","url":null,"abstract":"<p><strong>Objective: </strong>Recent studies have revealed a heterogeneous prevalence and presentation of post-traumatic stress disorder across countries. It is crucial to assess the methodological and item-level measurement factors that contribute to variations in mental disorder rates across cultures. This study aimed to investigate the traumatic experiences of hospital workers by employing item analysis of the Impact of Event Scale-Revised.</p><p><strong>Methods: </strong>Data were collected from 1,000 employees of a large hospital during the coronavirus disease 2019 pandemic and were analyzed according to item response theory analysis regarding item pool discrimination (a) and difficulty (b) parameters.</p><p><strong>Results: </strong>The Impact of Event Scale-Revised items had good discriminative ability (a) and covered a range of distress severity (b) associated with traumatic experiences. According to our results, the Impact of Event Scale-Revised is a reliable and informative instrument for assessing individuals with moderate to severe trauma-related distress across the spectrum of trauma symptoms. In particular, items 10 (\"jumpy or easily startled\") and 6 (\"I thought about it when I didn't mean to\") reflected the post-traumatic stress disorder domains of hyperarousal and intrusion and excelled in discriminating between different levels of post-traumatic distress. Conversely, items related to avoidance and sleep disturbance showed lower discriminative ability.</p><p><strong>Conclusions: </strong>Item analysis of the Impact of Event Scale-Revised may be used to assess trauma symptoms in the context of a trauma exposure, identifying the most discriminative and informative items for measuring post-traumatic stress disorder in our context. Our findings may help refine the Impact of Event Scale-Revised and facilitate the development of a more effective scale with optimized item parameters.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243882"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfactory levels of functionality and quality of life in caregivers of patients with bipolar disorder: is this possible?","authors":"Mariana Troesch, Sarah Prates, Stella Sarmento, Thiago Cerqueira-Silva, Gabriela Léda-Rêgo, Caroline Dallalana, Juliana S Casqueiro, Paula Studart-Bottó, Ângela Miranda-Scippa","doi":"10.47626/1516-4446-2024-3866","DOIUrl":"10.47626/1516-4446-2024-3866","url":null,"abstract":"<p><strong>Objective: </strong>Functionality and quality of life levels were measured in caregivers of patients with bipolar disorder, investigating the associations between them and with clinical and sociodemographic data.</p><p><strong>Method: </strong>A cross-sectional study was conducted between 2020 and 2022 with caregivers of patients with bipolar disorder treated in a university hospital's outpatient clinic. The following instruments were applied: a clinical and sociodemographic questionnaire, the World Health Organization Disability Assessment Schedule 2.0, the 36-Item Short Form Health Survey, the Mini International Neuropsychiatric Interview Plus, and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders.</p><p><strong>Results: </strong>The median World Health Organization Disability Assessment Schedule 2.0 score was < 20, and the median score on the 36-Item Short Form Health Survey domains was > 60. Caregivers with greater functional impairment had lower quality of life. Being younger, being a parent, having non-psychiatric clinical conditions, and having mental disorders were associated with lower quality of life and functionality.</p><p><strong>Conclusion: </strong>These results indicate less functional impairment and better perceived quality of life than what has been reported in the literature, demonstrating that there is a subgroup of caregivers who perform their role without significant compromise to these health aspects. Exploring other factors associated with functionality and quality of life, such as resilience, psychological support, etc., may allow for more targeted public health interventions, optimizing comprehensive bidirectional care for patients and caregivers.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243866"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internalizing problems can differ in boys and girls since early childhood: findings from the Child Behavioral Checklist 1.5-5.","authors":"Adriana Maldonado-Martinez, Sheila C Caetano, Marcos V Ribeiro, Alexandra Restrepo-Henao, Paola M Okuda, Thiago M Fidalgo, Pamela J Surkan, Luis Manuel Silva, Silvia S Martins","doi":"10.47626/1516-4446-2024-3616","DOIUrl":"10.47626/1516-4446-2024-3616","url":null,"abstract":"<p><strong>Objective: </strong>Internalizing problems disproportionately affect females in adolescence and adulthood, but research at earlier ages is limited due to a focus on disruptive behaviors. Our study addresses this gap by exploring the structure of internalizing problems and gender differences in Brazilian preschoolers.</p><p><strong>Methods: </strong>We analyzed data from the Child Behavioral Checklist 1.5-5 (CBCL 1.5-5) as administered in the Preschool Mental Health Study (PreK Survey), involving 1,292 children aged 4 to 5 in Embu das Artes, state of São Paulo, Brazil. Confirmatory factor analysis and comparisons of means explored internalizing problems and gender variations.</p><p><strong>Results: </strong>A two-factor model best fit both internalizing and externalizing problems. A hierarchical model with four factors (emotionally reactive, anxiety/depression, somatic complaints, and withdrawn) best fit internalizing problems, achieving partial invariance between boys and girls. Boys scored higher in the withdrawn syndrome, while girls scored higher in the somatic complaint syndrome.</p><p><strong>Conclusions: </strong>Preschoolers' internalizing problems warrant attention beyond their link to externalizing problems. While the overall construct is similar in boys and girls, divergent syndrome scores indicate potential distinct risk patterns requiring further exploration.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243616"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, double-blind, placebo-controlled trial of N-acetylcysteine as an adjuvant treatment for alcohol use disorder.","authors":"Leonardo Baldaçara, Thales Marcon Almeida, Diogo Cesar Dos Santos, Ana Beatriz Paschoal, Aldo Felipe Pinto, Luiz Antonio Vesco Gaiotto, Diogo de Lacerda Veiga, Fabiano Franca Loureiro, Leandro Fernandes Malloy-Diniz, Roseli Lage de Oliveira, Quirino Cordeiro, Marsal Sanches, Antonio E Nardi, Antônio Geraldo da Silva, Ricardo R Uchida","doi":"10.47626/1516-4446-2024-3878","DOIUrl":"10.47626/1516-4446-2024-3878","url":null,"abstract":"<p><strong>Objective: </strong>We assessed the effect of N-acetylcysteine, as an adjuvant treatment, on treatment adherence (primary outcome) according to peripheral biomarkers and clinical improvement (secondary outcomes) in patients with alcohol use disorder.</p><p><strong>Methods: </strong>A 9-week randomized, double-blind, placebo-controlled clinical trial was conducted on 53 (n = 25 N-acetylcysteine, n = 28 placebo) inpatients with alcohol use disorder. Neuropeptide Y, oxidative stress and inflammatory biomarkers, and hepatic parameters were analyzed at 3 time points.</p><p><strong>Results: </strong>Seventeen (60.7%) patients in the placebo group and 16 (64%) patients in the N-acetylcysteine group completed the trial. Hepatic biomarker levels changed significantly over time (p < 0.001). Oxidized glutathione levels at admission were lower in the N-acetylcysteine group (ppairwise = 0.043). By the end of the study, both groups had similar oxidized glutathione levels (p = 0.868), and oxidized glutathione levels were lower in the placebo group. At the end of the intervention, superoxide dismutase activity had decreased and neuropeptide Y levels had increased in the N-acetylcysteine group. Both groups showed similar mean time to relapse, treatment adherence, and clinical improvement.</p><p><strong>Conclusion: </strong>Our findings reinforce the effects of alcohol on oxidative stress and neuropeptide Y parameters. However, our sample size may limit the generalizability of the results, especially for clinical outcomes. Future randomized clinical trials including patients with less severe alcohol use disorder and longer follow-up may be needed to determine whether N-acetylcysteine could help reduce the mental health burden of this disorder.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243878"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leme Lopes: pioneering multiaxial diagnosis and the dilemma of subjectivity.","authors":"Larissa Junkes, Walmor J Piccinini, Antonio E Nardi","doi":"10.47626/1516-4446-2024-3990","DOIUrl":"10.47626/1516-4446-2024-3990","url":null,"abstract":"","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243990"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort.","authors":"Marco Antonio Sanabrais-Jiménez, Beatriz Camarena, Alejandro Aguilar-García, Alma Delia Genis-Mendoza, José Jaime Martínez-Magaña, Humberto Nicolini, Jorge Ameth Villatoro-Velá, Marycarmen Bustos-Gamiño, María de Lourdes Gutiérrez-López, María Elena Medina-Mora","doi":"10.47626/1516-4446-2024-3859","DOIUrl":"10.47626/1516-4446-2024-3859","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association of 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) with such symptomatology in a Mexican cohort.</p><p><strong>Methods: </strong>The sample included 2,012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort: 198 with AS, 266 with DS, 66 with both anxiety and depressive symptoms (ADS), and 1,482 healthy controls. The Diagnostic Interview for Psychosis and Affective Disorders (DI-PAD) screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 single nucleotide polymorphisms (SNPs) of 75 genes previously associated with AS and DS. The PLINK logistic regression approach was performed to analyze the association between these SNPs and AS, DS, and ADS.</p><p><strong>Results: </strong>The analysis identified significant associations of LAMA SNP rs2437092 (p = 3.89 × 10(-5)) and MYO1H SNP rs11066591 (p = 4.06 × 10(-5)) with anxiety and depressive symptoms. Additionally, MBD5 SNPs rs7578002 and rs1234428 were associated with DS (p = 7.9 × 10(-6) and p = 1.94 × 10(-5), respectively). However, after adjustment for age, sex, and the three genetic principal components, only the associations of rs7578002 and rs1234428 with DS remained (p = 5.85 × 10(-5) and p = 8.15 × 10(-5), respectively).</p><p><strong>Conclusions: </strong>Our study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243859"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short and long-term effects of cognitive behavioral therapy on sleep problems and psychotic symptoms in patients with psychotic disorders: a meta-analysis.","authors":"Mustafa Ugurlu, Gorkem Karakas Ugurlu, Esra Kabadayi Sahin, Gulsum Zuhal Kamis, Ali Caykoylu","doi":"10.47626/1516-4446-2024-3623","DOIUrl":"10.47626/1516-4446-2024-3623","url":null,"abstract":"<p><strong>Objective: </strong>Sleep problems are common in patients with psychotic disorders, especially schizophrenia. Although pharmacological methods are at the forefront of treatment, they have some drawbacks. Cognitive behavioral therapy for insomnia (CBT-I) is an option for the treatment of individuals with insomnia; in recent years, interest in its use in patients with psychotic disorders has been increasing. This meta-analysis aims to evaluate the effectiveness of CBT-I for sleep problems in patients with psychotic disorders.</p><p><strong>Methods: </strong>A systematic search of the PubMed, Scopus, and EBSCO (MEDLINE) databases was conducted to identify relevant studies. The inclusion criteria were randomized controlled trials (RCTs) and uncontrolled studies that focused on participants diagnosed with schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorders, or unipolar depression with psychotic features, who had had sleep problems for at least 1 month, and who were receiving treatment. The initial search yielded 246 studies, of which eight were ultimately selected for meta-analysis after screening and applying inclusion and exclusion criteria. Statistical analysis was conducted in the R software environment.</p><p><strong>Results: </strong>CBT-I significantly ameliorates insomnia and sleep quality in patients with psychotic disorders in both the short and long term. Additionally, CBT-I leads to significant improvement in psychotic symptoms in the short-term period and contributes significantly to improvement in mental well-being in both short- and long-term follow-up.</p><p><strong>Conclusions: </strong>CBT-I is an effective, valuable method for sleep problems in patients with psychotic disorders. Its widespread use for this purpose is recommended.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243623"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal depressive symptoms trajectories and harsh parenting: the mediating role of maternal quality of life in the 2004 Pelotas Birth Cohort.","authors":"Alicia Matijasevich, Jessica Mayumi Maruyama, Luciana Tovo-Rodrigues, Iná S Santos","doi":"10.47626/1516-4446-2024-3652","DOIUrl":"10.47626/1516-4446-2024-3652","url":null,"abstract":"<p><strong>Objective: </strong>To study the impacts of maternal depressive symptoms trajectories and harsh parenting and explore if the maternal quality of life (QoL) mediates this association.</p><p><strong>Methods: </strong>We used data from the 2004 Pelotas Birth Cohort, a population-based longitudinal study from Pelotas, Brazil (n=3,285 mothers, complete cases analysis). We used the Edinburgh Postnatal Depression Scale (EPDS) to assess maternal depressive symptoms and calculated their trajectories from 3 months until the 11-year follow-up using a group-based modeling approach. Psychological and physical aggression were measured using the Parent-Child Conflict Tactics Scale (CTSPC). Maternal QoL was measured by the question \"How is your quality of life?\" Data were analyzed using path models in Mplus.</p><p><strong>Results: </strong>All maternal depressive symptoms trajectories increased the frequency of psychological and physical aggression at early adolescence when compared to the reference group. Mediation analysis indicated that maternal depressive symptoms led to low levels of perceived maternal QoL, which in turn was associated with increased use of harsh parenting. The proportion of total effect explained by maternal QoL ranged from 4.04% (0.00-5.58%) to 16.31% (10.88-19.10%).</p><p><strong>Conclusion: </strong>Our findings, within a longitudinal framework from a middle-income country, support existing evidence that maternal depressive symptoms are associated with harsh parenting. Our results also suggest that one mechanism underlying this association is lower perceived maternal QoL.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243652"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}