Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort.

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2025-01-09 DOI:10.47626/1516-4446-2024-3859

Marco Antonio Sanabrais-Jiménez, Beatriz Camarena, Alejandro Aguilar-García, Alma Delia Genis-Mendoza, José Jaime Martínez-Magaña, Humberto Nicolini, Jorge Ameth Villatoro-Velá, Marycarmen Bustos-Gamiño, María de Lourdes Gutiérrez-López, María Elena Medina-Mora

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引用次数: 0

Abstract

Objective: To explore the association between 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) in a Mexican cohort.

Methods: The sample included 2012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort, 198 showed AS, 266 DS, 66 anxiety and depressive symptoms (ADS), and 1482 healthy controls. The DI-PAD screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 SNPs of 75 genes previously associated with AS and DS. PLINK's logistic regression approach was performed.

Results: The analysis showed association between the rs2437092 (p=3.89x10-5) of LAMA and rs11066591 (p=4.06x10-5) of MYO1H with anxiety and depressive symptomatology. Additionally, rs7578002 (p=7.9x10-6) and rs1234428 (p=1.94x10-5) of MBD5 found association with DS. However, after adjustment for age, sex, and the three genetic principal components, only the association of rs7578002 (p=5.85x10-5) and rs1234428 (p=8.15x10-5) of MBD5 with DS remained.

Conclusions: Our study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population.

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甲基- cpg结合结构域蛋白5基因与墨西哥人群抑郁症状的关系：来自MxGDAR/Encodat队列的结果

目的：探讨先前在墨西哥队列中报道的焦虑症状（AS）和抑郁症状（DS）受试者中的75个候选基因之间的关系。方法：样本包括来自墨西哥成瘾研究基因组数据库（MxGDAR/Encodat）队列的2012例个体，其中AS 198例，DS 266例，焦虑和抑郁症状（ADS） 66例，健康对照1482例。采用DI-PAD筛查问卷评估终生AS和DS。样品用商用微阵列PsychArray头芯片进行基因分型。我们鉴定了75个先前与AS和DS相关的基因的707个snp。采用PLINK逻辑回归方法。结果：分析显示LAMA基因rs2437092 （p=3.89x10-5）和MYO1H基因rs11066591 （p=4.06x10-5）与焦虑、抑郁症状相关。此外，MBD5的rs7578002 （p=7.9x10-6）和rs1234428 （p=1.94x10-5）与DS存在关联。然而，在调整了年龄、性别和三个遗传主成分后，MBD5的rs7578002 （p=5.85x10-5）和rs1234428 （p=8.15x10-5）与DS的相关性仍然存在。结论：我们的研究重复了MBD5和DS之间的关联。MBD5蛋白参与基因沉默，这表明它在墨西哥人群中DS的发展中具有潜在的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.