Risk of Suicide in Association with Major Depressive Disorder among Patients with Dementia: A Population-based Nested Case-Control Study.

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2024-09-22 DOI:10.47626/1516-4446-2024-3605

Jiun-Yi Wang, Yi-Ting Hsu, Chih-Yuan Lin, Chien-Hui Liu, Kun-Chia Chang, Chih-Ching Liu

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引用次数: 0

Abstract

Objective: This study aimed to explore the association between major depressive disorder (MDD) and suicide risk in dementia patients.

Methods: A cohort of 625,218 individuals aged ≥40 years with dementia between 2007 and 2018 was identified from Taiwan's National Health Insurance Research Database. After excluding prevalent cases in 2007. Subsequently, a nested case-control study enrolled 1,256 suicide cases and 5,022 matched controls was conducted. The frequencies of MDD-related outpatient or inpatient visits over a 7-year period preceding the event dates were calculated and analyzed for association using conditional logistic regression.

Results: Dementia comorbid with MDD was associated with increased suicide risk (adjusted odds ratio [AOR]: 2.67), particularly in individuals with ≤1.0 MDD episodes per year (AOR: 2.85). Similar association was observed only in individuals aged ≥65 years and males, with a pronounced risk of suicide in those ≤1.0 MDD episodes per year (AOR: 3.08 for individuals aged ≥65 years; AOR: 3.28 for males). Conversely, the risk increase was evident with >1.0 MDD episodes per year in those aged <65 years (AOR: 3.04) and females (AOR: 2.45).

Conclusions: MDD is associated with suicide risk in dementia patients, with the strength of this association possibly varying by age and gender.

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痴呆症患者自杀风险与重度抑郁障碍的关联：基于人群的嵌套病例对照研究》。

研究目的本研究旨在探讨重性抑郁障碍（MDD）与痴呆症患者自杀风险之间的关联：从台湾 "国民健康保险研究数据库 "中筛选出2007年至2018年期间年龄≥40岁的625218名痴呆症患者。在排除了 2007 年的流行病例后。随后，进行了一项巢式病例对照研究，纳入了 1,256 例自杀病例和 5,022 例匹配对照。研究人员计算了事件发生日期前 7 年内与痴呆症相关的门诊或住院就诊频率，并利用条件逻辑回归分析了两者之间的关联：结果：合并 MDD 的痴呆症与自杀风险增加有关（调整赔率比 [AOR]：2.67），尤其是每年 MDD 发作次数≤1.0 次的患者（AOR：2.85）。仅在年龄≥65 岁的人和男性中观察到类似的关联，每年 MDD 发作次数≤1.0 次的人有明显的自杀风险（年龄≥65 岁的人的 AOR：3.08；男性的 AOR：3.28）。相反，在结论年龄组中，每年 MDD 发作次数大于 1.0 次的风险明显增加：多发性抑郁与痴呆症患者的自杀风险有关，这种关联的强度可能因年龄和性别而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.