Reproductive biomedicine online最新文献

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(24)00963-5","DOIUrl":"10.1016/S1472-6483(24)00963-5","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104774"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Lugano Workshop on the role of adenomyosis in ART","authors":"Mauro Cozzolino ,&nbsp;Serdar Bulun ,&nbsp;Dominique De Ziegler ,&nbsp;Caterina Exacoustos ,&nbsp;Human Fatemi ,&nbsp;Juan Antonio Garcia-Velasco ,&nbsp;Andrew Horne ,&nbsp;Felice Petraglia ,&nbsp;Pietro Santulli ,&nbsp;Edgardo Somigliana ,&nbsp;Kim Soorin ,&nbsp;Thierry Van den Bosch ,&nbsp;Paola Viganò ,&nbsp;Peter Humaidan","doi":"10.1016/j.rbmo.2024.104444","DOIUrl":"10.1016/j.rbmo.2024.104444","url":null,"abstract":"<div><div>Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical knowledge on the impact of adenomyosis on ART outcomes, the First Lugano Adenomyosis Workshop was a symposium involving experts in the field of adenomyosis, covering basic research, imaging, surgery and infertility to highlight current advances and future research areas over a wide range of topics related to adenomyosis. Adenomyosis is characterized by altered oestrogen and progesterone signalling pathways. Although the criteria of the Morphological Uterus Sonographic Assessment (MUSA) Consortium apply to patients with infertility, the presence of direct signs and localization in the different myometrial layers, particularly the inner myometrium, need more focus. In addition to the MUSA criteria, clinical symptoms and the magnitude of uterine enlargement should also be considered. Whilst pre-treatment with gonadotrophin-releasing hormone agonist with or without an aromatase inhibitor in frozen embryo transfer cycles seems promising, many issues related to therapy remain unanswered. During the Workshop, therapeutic progress over the past decades as well as novel insights were presented and discussed. The role of this opinion paper is to stimulate discussion and spark further interest in adenomyosis and the role of adenomyosis in infertility.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104444"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cairo Consensus on Accreditation as the Basis for Future-Proofing the ART Laboratory","authors":"Cairo Consensus Group 2023,&nbsp;Alpha Scientists in Reproductive Medicine","doi":"10.1016/j.rbmo.2024.104106","DOIUrl":"10.1016/j.rbmo.2024.104106","url":null,"abstract":"<div><div>An international consensus meeting was convened to discuss globally applicable strategies for ‘future-proofing’ ART laboratories. The central theme was how the application of the foundational principles of laboratory accreditation enables any centre to create an ethos and framework that will support future-proofing in all regards. Discussions focussed on ART laboratory services from egg retrieval and semen specimen receipt to embryo transfer, as well as pertinent cryobanking activities. Issues related to whether ART treatment should be considered an essential service, overall clinic operations, general patient care, and the provision of clinical treatment, were not included as they fall under the purview of physicians and public health authorities. This report details the 16 core consensus points reached, which are supported by extensive practical recommendations that cover the gamut of ART laboratory operations.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104106"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture media with antioxidants improved preimplantation embryo development and clinical outcomes of patients of advanced age","authors":"Shigetoshi Mizumoto,&nbsp;Yozo Nagao,&nbsp;Hitomi Watanabe,&nbsp;Keiko Tanaka,&nbsp;Takeshi Kuramoto","doi":"10.1016/j.rbmo.2024.104415","DOIUrl":"10.1016/j.rbmo.2024.104415","url":null,"abstract":"<div><h3>Research question</h3><div>What are the clinical effects of using culture media supplemented with antioxidants (AOX) throughout the IVF process?</div></div><div><h3>Design</h3><div>Prospective randomized single-centre study. Cumulus–oocyte complexes and semen samples collected from 127 treatment cycles were divided evenly between the study arm (culture media with AOX) and the control arm (culture media without AOX). The primary endpoint was the good-quality blastocyst (GQB) rate on day 5–6 per metaphase II (MII) oocyte.</div></div><div><h3>Results</h3><div>Fertilization rate and day 5–6 blastocyst rate per MII oocyte differed significantly in favour of the study arm, whereas GQB rate did not. A subgroup analysis, stratified by maternal age, revealed significant improvements in the study arm for day 3 embryo development rate, day 5–6 blastocyst rate, GQB rate and blastocyst utilization rate for patients aged 35–40 years, while the impacts on these endpoints were much smaller in patients aged &lt;35 years. Ninety-four single vitrified blastocyst transfers (SVBT) were performed in each arm. The blastocysts derived from the study arm showed better results of SVBT for patients aged 35–40 years, defined by embryo implantation rate, fetal heartbeat rate and live birth rate, whereas these variables did not differ significantly between the two arms when assessing the results for patients of all ages and patients aged &lt;35 years.</div></div><div><h3>Conclusions</h3><div>Embryo development and SVBT outcomes of treatment cycles of patients aged 35–40 years improved significantly when using AOX-supplemented culture media throughout the IVF process.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104415"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the shortened warming protocol on human blastocyst viability: an in-vitro experimental study","authors":"Kenji Ezoe,&nbsp;Tetsuya Miki,&nbsp;Nanoha Fujiwara,&nbsp;Keiichi Kato","doi":"10.1016/j.rbmo.2024.104454","DOIUrl":"10.1016/j.rbmo.2024.104454","url":null,"abstract":"<div><h3>Research question</h3><div>Does the shortened warming protocol impact the cell viability and outgrowth competence of human vitrified blastocysts warmed with or without fatty acids?</div></div><div><h3>Design</h3><div>In this study, 326 discarded vitrified human blastocysts donated for research by consenting couples were used. The blastocysts were randomly allocated to five groups depending on the warming solutions, protocols and recovery culture media: the control-conventional, control-shortened, FA-conventional, FA-shortened, and FA-shortened/recovery culture with fatty acid (FA-shortened/RF) groups. The blastocysts were warmed with or without fatty acids following the manufacturer's instruction (conventional method) or using the shortened method, in which blastocysts were immersed in a thawing solution for 1 min and then cultured in the recovery medium for 2 h. The embryo volume recovery, cell viability, intracytoplasmic lipid droplets and outgrowth competence were evaluated.</div></div><div><h3>Results</h3><div>The degree of blastocyst volume recovery was significantly higher after shortened warming than after conventional warming (<em>P</em> = 0.0130–0.0278). Cell membrane collapse was observed during the shortened warming. The blastocyst survival rate and expansion status after the recovery culture were comparable among the five groups. However, the proportion of necrotic cells was increased in the control-shortened, FA-shortened and FA-shortened/RF groups (<em>P</em> = 0.0160–0.0498). The adhesion rates were comparable among all the groups; however, the outgrowth area was significantly higher in the FA-conventional group than in the other groups at 96 h (<em>P</em> = 0.0026–0.0487).</div></div><div><h3>Conclusions</h3><div>The efficacy of the shortened warming protocol depends on the warming solutions used. The shortened protocol effectively improves the daily workflow; however, to prioritize clinical outcomes, each laboratory should thoroughly examine its impact before introducing it.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104454"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm recovery and ICSI outcomes in non-obstructive azoospermia with cryptorchidism treated by orchiopexy: a systematic review and meta-analysis","authors":"ZiHan Qin ,&nbsp;QiaoHua Xiong ,&nbsp;MingHan Lu ,&nbsp;ShuHua Li ,&nbsp;YuJun Chen ,&nbsp;WenHan Ma ,&nbsp;Ling Ma ,&nbsp;Chun Zhou ,&nbsp;Quanfei Zhu ,&nbsp;YuanZhen Zhang ,&nbsp;Ming Zhang ,&nbsp;JunHao Lei","doi":"10.1016/j.rbmo.2024.104392","DOIUrl":"10.1016/j.rbmo.2024.104392","url":null,"abstract":"<div><div>The aim of this meta-analysis was to quantify the available data concerning sperm retrieval rate (SRR) subsequent to testicular sperm extraction (TESE) and the clinical pregnancy rate (CPR) and live birth rate (LBR) subsequent to TESE and intracytoplasmic sperm injection (ICSI) in patients with non-obstructive azoospermia with cryptorchidism treated by orchidopexy. Furthermore, the aim was to explore the potential predictors of SRR, CPR and LBR within this population. Extensive searches were conducted in <em>PubMed, Embase, Cochrane</em> and <em>Web of Science</em> databases, and 23 articles were included in the study, with 1496 patients. The overall SRR per TESE cycle in the total evaluated trials was 60.9% (55.7–66.2%). Factors such as age at TESE, age at orchidopexy, testicular volume, and FSH, LH and testosterone levels did not affect final SRR. Meta-analyses were conducted on 13 studies each for CPR and LBR, including 913 and 799 ICSI cycles, respectively. The overall CPR per ICSI cycle was 37.6% (29.1–46.1%), and the overall LBR per ICSI cycle was 32.6% (24.9–40.4%). Factors as mentioned above, and the age of women undergoing ICSI, did not affect CPR or LBR per ICSI cycle. Although this meta-analysis extensively investigated outcomes of TESE and potential predictors of SRR, CPR and LBR for patients with non-obstructive azoospermia with cryptorchidism treated by orchidopexy, no effective predictors of outcomes were identified.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104392"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor sperm: only for the rich and straight","authors":"Guido Pennings","doi":"10.1016/j.rbmo.2024.104434","DOIUrl":"10.1016/j.rbmo.2024.104434","url":null,"abstract":"<div><div>Although single women and lesbian couples are given access to donor spermatozoa, all kinds of restrictions limit their actual use of donor insemination. These restrictions are frequently justified by the increase in safety (lowering the genetic risk) or well-being of donor-conceived persons. However, these restrictions directly result in stratified reproduction in which only the rich (those with the necessary financial means) and the straight (those who conform to dominant views of parenthood) are allowed to reproduce.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104434"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(24)00960-X","DOIUrl":"10.1016/S1472-6483(24)00960-X","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104771"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen cryopreservation for an oncological reason: a retrospective study","authors":"Ana Santana-Plata ,&nbsp;Rocio Rivera-Egea ,&nbsp;Nicolás Garrido","doi":"10.1016/j.rbmo.2024.103898","DOIUrl":"10.1016/j.rbmo.2024.103898","url":null,"abstract":"<div><h3>Research question</h3><div>How do cancer type and treatment affect semen quality before and after treatment, and what effect does it have in their clinical management of infertility? Also, what is the rate of patients using cryopreserved semen samples after treatment?</div></div><div><h3>Design</h3><div>Patients who cryopreserved spermatozoa for oncological reasons between 2000 and 2022 in IVI clinics in Spain were retrospectively reviewed. Semen parameters were analysed before and after treatment, and utilization and destruction rates were calculated. Total motile sperm count (TMSC) was used for assisted reproductive technology (ART) counselling.</div></div><div><h3>Results</h3><div>A total of 724 patients cryopreserved their semen during the study period. The semen parameters of the cancer patients' semen before and after treatment were heterogeneous, with significant differences between cancer type and semen parameters. The utilization rate was relatively low (0.4%), whereas the destruction rate was 23.1%.</div></div><div><h3>Conclusion</h3><div><span>Cancer and antineoplastic treatment affect everyone differently. Therefore, sperm </span>cryopreservation should be offered to all patients before starting treatment to ensure their reproductive future. Furthermore, in addition to considering the semen parameters defined by the World Health Organization, it is important to use TMSC in the diagnosis of men to choose appropriate ART according to type of cancer.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 103898"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective co-parenting with someone already known versus someone met online: implications for parent and child psychological functioning.","authors":"Sarah Foley, Vasanti Jadva, Susan Golombok","doi":"10.1016/j.rbmo.2024.104747","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104747","url":null,"abstract":"<p><strong>Research question: </strong>What are the psychological outcomes for parents and children in elective co-parenting families, and do these differ based on whether or not the co-parents met online?</p><p><strong>Design: </strong>This cross-sectional study provides novel descriptive quantitative data on the wellbeing of parents and children within 23 elective co-parenting families, defined as two or more parents deciding to have and raise children together outside of a romantic partnership or conjugal couple relationship. Standardized questionnaires were administered to assess parent and child psychological adjustment. Bayesian independent t-tests were conducted to compare the parent and child outcomes in 13 families who met online via a connection website with 10 families who were co-parenting with someone known to them previously.</p><p><strong>Results: </strong>Elective co-parent scores for depression, anxiety, parenting stress, resilience, perceived social support and couple relationship satisfaction were within the normal range. Children's average competencies, and behavioural and emotional problem scores were low risk when compared with population norms. Bayes factors suggest no support for the alternative hypothesis that there were differences in parent or child wellbeing between families with co-parents who met via connection sites compared with families with co-parents who already knew each other.</p><p><strong>Conclusions: </strong>Parents and children in elective co-parenting families are functioning well regardless of how they were formed, but individuals may require tailored professional advice or support for this growing new route to parenthood. Future longitudinal work with larger samples is required to replicate these findings, and explore children's perspectives of their families, as well as the support needs of co-parents and their children throughout their parenting journey.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104747"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}