Reproductive biomedicine online最新文献

{"title":"Is there an association between the ‘October 7th’ events and IVF outcomes in Israel?","authors":"Einav Kadour-Peero ,&nbsp;Chen Shkolnik ,&nbsp;Janan Jadon ,&nbsp;Rabea Bahous ,&nbsp;Yael Gonen ,&nbsp;Michal Silberman ,&nbsp;Ilan Calderon ,&nbsp;Hadar Avraham ,&nbsp;Samer Khoury","doi":"10.1016/j.rbmo.2024.104429","DOIUrl":"10.1016/j.rbmo.2024.104429","url":null,"abstract":"<div><h3>Research question</h3><div>Is there an association between the ‘October 7th’ 2023 events and IVF outcomes in Israel?</div></div><div><h3>Design</h3><div>in this retrospective cohort study the study group was women treated during the 4 weeks after ‘October 7th’, compared with a matched control group treated between 1 January 2021 and 6 October 2023. Each study group participant was matched with three separate control subjects of the same female age at oocyte retrieval, with a matching body mass index (BMI), IVF cycle number and ovarian reserve parameters.</div></div><div><h3>Results</h3><div>The study included 580 patients. The 145 women who underwent oocyte retrieval or frozen embryo transfer after 7 October 2023 were compared with 435 women treated before 7 October. The mean age of the study group was 35.6 ± 5.9 years, and the mean BMI 25.01 ± 5.60 kg/m². Pregnancy rates per embryo transfer were similar between the groups (22.4% versus 30.5%, <em>P = </em>0.28 in fresh cycles; 16.9% versus 27.1%, <em>P = </em>0.12 in frozen embryo transfers). Among women who underwent oocyte retrieval there were no differences in the ovarian stimulation protocols (<em>P = </em>0.95), number of oocytes retrieved (<em>P = </em>0.16) or number of fertilized oocytes (<em>P = </em>0.34). There was no difference in the rate of good-quality embryos between groups (<em>P = </em>0.053). Among women who underwent frozen embryo transfers, during the study period more patients had natural cycles (52.5% versus 24%, <em>P &lt;</em> 0.001), and there was no difference in maximal endometrial thickness before embryo transfer (<em>P = </em>0.33).</div></div><div><h3>Conclusions</h3><div>It appears that there is no association between the ‘October 7’ events and IVF outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104429"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/j.rbmo.2024.104387","DOIUrl":"10.1016/j.rbmo.2024.104387","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104387"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005765/pdfft?md5=92461ed509df46050cfb6d2566ea8249&pid=1-s2.0-S1472648324005765-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/j.rbmo.2024.104390","DOIUrl":"10.1016/j.rbmo.2024.104390","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104390"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005790/pdfft?md5=94dc6b2f0b555f4990c4a9aa564698fb&pid=1-s2.0-S1472648324005790-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/j.rbmo.2024.104388","DOIUrl":"10.1016/j.rbmo.2024.104388","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104388"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005777/pdfft?md5=023dec1cb9ac34d95dee21652856b1d8&pid=1-s2.0-S1472648324005777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted reproductive technologies in Latin America: the Latin American Registry, 2021.","authors":"Fernando Zegers-Hochschild, Javier A Crosby, Carolina Musri, Fanny Petermann-Rocha, Gustavo Martinez, Hitomi Nakagawa, Carlos Morente, Armando Roque, Ana Palma-Govea","doi":"10.1016/j.rbmo.2024.104413","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104413","url":null,"abstract":"<p><strong>Research question: </strong>What are the trends and impact of new technologies on the effectiveness and safety of assisted reproductive technology (ART) performed in Latin America during 2021?</p><p><strong>Design: </strong>This was a retrospective collection of cycle-based multinational data obtained from ART procedures performed by 204 accredited institutions in 16 countries.</p><p><strong>Results: </strong>In total 127,351initiated cycles resulted in 20,032 deliveries and 22,708 births. ART utilization showed great variability, from 623.5 cycles/million inhabitants in Uruguay to fewer than 35 in Guatemala and El Salvador. The proportion of women aged ≥40 years increased to 35.8%, while that of women ≤34 years dropped to 23.9%. Nonetheless, the proportion of single-embryo transfers (SET) increased from 11.9% in the previous decade to 42.4% in 2021. Of 22,708 babies born, 76.8% were singletons, 22.3% twins and 1.0% triplets or more. Intracytoplasmic sperm injection represented 84.5% of fertilization techniques, and blastocyst transfer increased from 49.6% in 2016 to 79.3% in 2021. The delivery rate after fresh blastocyst elective SET was significantly higher than after the transfer of one frozen embryo from a freeze-all cycle (P < 0.0001). The number of aspirations leading to preimplantation genetic testing has increased 2.8 times in 5 years and significantly increased delivery rates/transfer at all ages, including in oocyte donation (P ≤ 0.002), and reduced miscarriage in women ≥35 years old. In oocyte donation, delivery rates after the fresh transfer of embryos from vitrified-warmed oocyte cycles generated similar outcomes to frozen embryo transfer. Perinatal mortality increased from 7.7‰ in singletons to 21.3‰ in twins.</p><p><strong>Conclusion: </strong>The systematic collection of cycle-based multinational data contributes to cooperative sustained development and helps implement evidence-based reproductive decisions.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104413"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adenomyosis on placenta-related obstetric complications","authors":"Ran Matot ,&nbsp;Uval Bar-Peled ,&nbsp;Yossi Geron ,&nbsp;Shir Danieli-Gruber ,&nbsp;Yinon Gilboa ,&nbsp;Lior Drukker ,&nbsp;Haim Krissi ,&nbsp;Adi Borovich ,&nbsp;Sharon Perlman","doi":"10.1016/j.rbmo.2024.104414","DOIUrl":"10.1016/j.rbmo.2024.104414","url":null,"abstract":"<div><h3>Research question</h3><div>What is the relationship between sonographic diagnosis of isolated adenomyosis and placenta-associated obstetric outcomes?</div></div><div><h3>Design</h3><div>In this 12-year retrospective cohort study (2010–2022), patients presenting with adenomyosis-related symptoms were assessed via ultrasound. The study included 59 women diagnosed with adenomyosis and 62 controls, leading to 203 births (90 in the adenomyosis group and 113 in the control group). Patients with endometriosis, uterine fibroids and anomalies, and those using assisted reproductive technology were excluded. The primary outcome focused on a composite of placenta-associated adverse outcomes, including preterm birth, small-for-gestational-age fetuses, hypertensive disorders of pregnancy, placental abruption and post-partum haemorrhage.</div></div><div><h3>Results</h3><div>No clinically significant differences in demographic characteristics were noted between the two groups. However, the adenomyosis group showed a significantly higher rate of adverse placental function outcomes (27%) compared with the control group (11%, <em>P</em> = 0.005). Adjusted analyses for maternal age, parity and aspirin usage revealed increased risk of hypertensive disorders (adjusted OR 5.91, 95% CI 1.50–30.0; <em>P</em> = 0.017) and adverse placental function outcomes (adjusted OR 3.44, 95% CI 1.53–8.09; <em>P</em> = 0.003) in the adenomyosis group.</div></div><div><h3>Conclusion</h3><div>Adenomyosis is significantly associated with increased risk of adverse placental function outcomes and hypertensive disorders of pregnancy. These findings suggest that adenomyosis may have a distinct impact on pregnancy, underscoring the need for further research to elucidate specific sonographic characteristics of adenomyosis and their effects on placental function.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104414"},"PeriodicalIF":3.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailor-made embryo transfer considering embryonic developmental speed to overcome the dilemma of personalized embryo transfer.","authors":"Yasuhiro Ohara, Hidehiko Matsubayashi, Shimpei Mizuta, Masakazu Doshida, Takumi Takeuchi, Tomomoto Ishikawa, Mika Handa, Tatsuya Miyake, Tsuyoshi Takiuchi, Tadashi Kimura","doi":"10.1016/j.rbmo.2024.104405","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104405","url":null,"abstract":"<p><strong>Research question: </strong>Does tailor-made embryo transfer (TmET), timed with respect to embryonic developmental speed, affect pregnancy outcomes in patients with recurrent implantation failure?</p><p><strong>Design: </strong>Among 741 patients identified as receptive through endometrial receptivity testing, the clinical pregnancy rates and live birth rates were retrospectively compared between those who underwent standard personalized embryo transfer and those who underwent TmET in hormone replacement therapy cycles. Personalized embryo transfer was performed according to endometrial receptivity test results (standard personalized embryo transfer group) or considering embryonic developmental speed (TmET group). For TmET, the expansion grade of warmed blastocysts was estimated based on each patient's previous embryonic developmental pattern. The embryo transfer days were set so that estimated blastocyst grades 3, 4, 5 and 6 were transferred on days P+5, P+5.5, P+6.0 and P+6.5, respectively.</p><p><strong>Results: </strong>In a propensity score matching analysis, the clinical pregnancy rate was significantly higher in the TmET group than the standard personalized embryo transfer group (P = 0.014), whereas the live birth rates were similar between the two groups (P = 0.65). In a subgroup analysis with euploid embryo transfers, the clinical pregnancy rate was significantly higher in the TmET group than the standard personalized embryo transfer group, although there was no difference in live birth rate between the two groups (P = 0.045 and P = 0.057, respectively).</p><p><strong>Conclusions: </strong>For patients experiencing recurrent implantation failure and identified as receptive through endometrial receptivity testing, subsequent TmET strategies may further enhance pregnancy outcomes.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104405"},"PeriodicalIF":3.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study examining the value of three-dimensional transvaginal ultrasonography during the diagnosis and evaluation of Asherman syndrome","authors":"Rui Huang ,&nbsp;Sijing Li ,&nbsp;Yuting Zhao ,&nbsp;YingTao Li ,&nbsp;Mingyang Ge ,&nbsp;Sotirios Saravelos ,&nbsp;Xiaodan Lv ,&nbsp;Qi Cheng ,&nbsp;Xiaowu Huang ,&nbsp;Enlan Xia ,&nbsp;Tin-Chiu Li","doi":"10.1016/j.rbmo.2024.104404","DOIUrl":"10.1016/j.rbmo.2024.104404","url":null,"abstract":"<div><h3>Research question</h3><div>What is the value of three-dimensional (3D) transvaginal ultrasonography (TVS) in the diagnosis and assessment of Asherman syndrome?</div></div><div><h3>Design</h3><div>This was a prospective study conducted at a hysteroscopy centre.</div></div><div><h3>Results</h3><div>A total of 685 participants were recruited, 65 dropped out and 620 were finally enrolled and analysed. The overall sensitivity, specificity and accuracy of 3D-TVS in the diagnosis of Asherman syndrome were 95.7%, 80.7% and 93.5%, respectively, and the sensitivity and accuracy were significantly higher than those of two-dimensional (2D) TVS (<em>P</em> &lt; 0.001). The likelihood of 2D-TVS missing a case of mild intrauterine adhesions (IUA) was 43.7%, compared with only 6.2% for 3D-TVS. The frequency of involvement of each anatomical area by adhesions in decreasing order was right and left uterine side walls (both 80%), central or mid-cavity (31%), right cornual region (26%), left cornual region (23%), fundal wall (15%) and isthmus (4.5%). The correlation between 3D-TVS and hysteroscopy in each of the seven anatomical areas was analysed separately. The results showed good agreement with regard to the three uterine walls (fundus, left lateral and right lateral), with kappa values of 0.678–0.811. The likelihood of the IUA being severe in nature when there were five or more areas, three or four areas, or one or two areas was 82%, 37.1% and 6.3%, respectively (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The diagnostic value of 3D-TVS is higher than that of 2D-TVS. In clinical practice, 3D-TVS should whenever possible replace 2D-TVS as the initial method of assessment to decide if hysteroscopy is necessary and to help with planning surgery.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104404"},"PeriodicalIF":3.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced endometrial glycolysis concomitant with increased lesional fibrosis in patients with adenomyosis who complained of heavy menstrual bleeding.","authors":"Chenyu Mao, Xishi Liu, Sun-Wei Guo","doi":"10.1016/j.rbmo.2024.104406","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104406","url":null,"abstract":"<p><strong>Research question: </strong>What role, if any, does the extent of lesional fibrosis play in impaired glycolysis leading to adenomyosis-associated heavy menstrual bleeding (ADM-HMB)?</p><p><strong>Design: </strong>Forty-eight patients with ADM-HMB were recruited, among them 25 reported moderate to heavy bleeding (MHB), and the remaining 23, excessive bleeding (EXB). The full-thickness uterine tissue columns were processed for Masson trichrome staining and immunohistochemistry analyses. The expression levels of HIF-1α, GLUT1, HK2, PFKFB3 and PKM2 proteins that are critically involved in glycolysis in endometrial epithelial cells cultured on substrates of different stiffness, and the levels of glycolysis were quantitated. A mouse experiment with induced adenomyosis and simulated menstrual bleeding was conducted to assess the effect of adenomyosis on immunoexpression of proteins involved in glycolysis and inflammation as well as on endometrial repair and bleeding.</p><p><strong>Results: </strong>The endometrial staining of HIF-1α, GLUT1, HK2, PFKFB3 and PKM2 was significantly lower in the EXB group as compared with MHB patients, concomitant with higher extent of fibrosis. The expression of HIF-1α, GLUT1, HK2, PFKFB3 and PKM2 was significantly reduced when endometrial epithelial cells were cultured in stiff substrate, concomitant with reduced glycolysis. Mice with induced adenomyosis had reduced immunoexpression of Hif-1α, as well as those proteins each of which plays a vital, rate-limiting role in different steps of the glycolysis pathway, such as Glut1, Hk2, Pfkfb3 and Pkm2, and elevated fibrosis in endometrium, concomitant with disrupted endometrial repair and more bleeding.</p><p><strong>Conclusions: </strong>Lesional fibrosis results in reduced endometrial glycolysis in eutopic endometrium and subsequent imbalance in pro-inflammatory and anti-inflammatory response, leading to ADM-HMB.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104406"},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of hypertensive disorders of pregnancy in electively induced or expectantly managed full-term IVF pregnancies","authors":"Stylianos Vagios ,&nbsp;Charles L. Bormann ,&nbsp;Irene Souter ,&nbsp;Michael D. House ,&nbsp;Irene Dimitriadis","doi":"10.1016/j.rbmo.2024.104408","DOIUrl":"10.1016/j.rbmo.2024.104408","url":null,"abstract":"<div><h3>Research question</h3><div>Are there differences in the rates of hypertensive disorders of pregnancy among IVF patients who underwent induction of labour at 39 weeks compared with those who were managed expectantly?</div></div><div><h3>Design</h3><div>This was a retrospective cohort study of 1176 low-risk singleton pregnancies conceived via IVF with no contraindications to vaginal delivery. Two groups were constructed: elective induction of labour from 39 weeks 0 days to 39 weeks 6 days (<em>n</em> = 234); and expectant management (<em>n</em> = 942). The main outcome measure was the incidence of hypertensive disorders of pregnancy. The secondary outcome was the rate of caesarean delivery. Subanalyses were performed within fresh and frozen embryo transfer groups.</div></div><div><h3>Results</h3><div>Hypertensive disorders of pregnancy developed in 8.1% of patients in the induction of labour group and in 12.4% of patients in the expectant management group (<em>P</em> = 0.06). This difference was attenuated after controlling for potential confounders (<em>P</em> = 0.28). For frozen embryo transfers, the unadjusted odds of hypertensive disorders of pregnancy were significantly lower for the induction of labour group compared with the expectant management group (<em>P</em> = 0.02), and after adjusting for confounders, the OR lost significance (<em>P</em> = 0.09). For fresh embryo transfers, there was no difference in the odds of hypertensive disorders of pregnancy between the two groups. The odds of delivering via caesarean section were higher in the induction of labour group, in the total population (<em>P</em> &lt; 0.001) and in subanalyses (<em>P</em> ≤ 0.03).</div></div><div><h3>Conclusion</h3><div>Overall, in IVF-conceived pregnancies, induction of labour was not associated with lower incidence of hypertensive disorders of pregnancy compared with expectant management. However, induction of labour was associated with a higher rate of caesarean delivery.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104408"},"PeriodicalIF":3.7,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}