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Let's not abandon programmed frozen embryo transfers yet: a countercurrent perspective 先不要放弃程序化冷冻胚胎移植 (FET):逆流观点
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-06 DOI: 10.1016/j.rbmo.2024.104365
Paul Pirtea , James P. Toner , Richard T. Scott Jr , Dominique de Ziegler
{"title":"Let's not abandon programmed frozen embryo transfers yet: a countercurrent perspective","authors":"Paul Pirtea ,&nbsp;James P. Toner ,&nbsp;Richard T. Scott Jr ,&nbsp;Dominique de Ziegler","doi":"10.1016/j.rbmo.2024.104365","DOIUrl":"10.1016/j.rbmo.2024.104365","url":null,"abstract":"<div><p>The countercurrent opinion given in this paper is that the optimal management of frozen embryo transfers (FET) is not a one-size-fits-all matter, but rather one that should be decided after considering all the various parameters and options. This choice should notably encompass patients’ individual characteristics – including variable risks of obstetric complications – and weigh out the respective advantages of each FET option in each case. While there may be real advantages for natural-cycle FET in many cases, these need to be balanced against both practical and clinical issues. Contrary to several prevailing, sometimes loudly expressed suggestions, there is not a one single effective approach when it comes to choosing a mode of scheduling FET.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are you aware of your citations? A cross-sectional survey on improper citations of retracted articles in assisted reproduction 您完全了解您的引文吗?关于医学辅助生殖领域撤稿文章引用不当的横断面调查研究
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-06 DOI: 10.1016/j.rbmo.2024.104366
Sabrina Minetto , Domenico Pisaturo , Greta Chiara Cermisoni , Valeria Stella Vanni , Luca Pagliardini , Enrico Papaleo , Vincenzo Berghella , Ben W. Mol , Alessandra Alteri
{"title":"Are you aware of your citations? A cross-sectional survey on improper citations of retracted articles in assisted reproduction","authors":"Sabrina Minetto ,&nbsp;Domenico Pisaturo ,&nbsp;Greta Chiara Cermisoni ,&nbsp;Valeria Stella Vanni ,&nbsp;Luca Pagliardini ,&nbsp;Enrico Papaleo ,&nbsp;Vincenzo Berghella ,&nbsp;Ben W. Mol ,&nbsp;Alessandra Alteri","doi":"10.1016/j.rbmo.2024.104366","DOIUrl":"10.1016/j.rbmo.2024.104366","url":null,"abstract":"<div><h3>Research question</h3><p>Are authors aware when they have cited a retracted paper in their manuscripts in the medically assisted reproduction (MAR) field?</p></div><div><h3>Design</h3><p>A cross-sectional study based on an online survey was conducted to acquire information on the citation pattern from corresponding authors who had cited a retracted article. A dataset of retracted articles in the MAR field was collected from PubMed and Retraction Watch. A complete list of published articles that cited each retracted article was retrieved. The survey was distributed via e-mail to corresponding authors who had cited a retracted paper in their study.</p></div><div><h3>Results</h3><p>The survey revealed a significant lack of awareness among authors, with 78.7% unaware that they had cited retracted articles. This lack of awareness was attributed to insufficient notification mechanisms within research databases and journals, alongside a reliance on previously stored copies of manuscripts. A notable finding was that reference checks were typically performed by a single author, with no instances of retraction concerns raised during the peer-review process. Only a small fraction (17.8%) of respondents reported verifying retraction notices on both journal websites and scientific databases.</p></div><div><h3>Conclusions</h3><p>Correcting publications that contain references which are subsequently retracted is significant for systematic reviews, meta-analyses and guidelines. Citations of retracted articles perpetuate erroneous scientific data, but assessing the accuracy of citations requires considerable effort. Proper notification of retraction status and cross-checking of citations can help to prevent errors.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assisted reproductive technologies in Africa: The African Network and Registry for ART, 2020 非洲的辅助生殖技术:非洲 ART 网络和登记处,2020 年
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104353
Paversan Archary , Liezel Potgieter , Frissiano Honwana , Eman Elgindy , Rudolph Kantum Adageba , Founzégué Amadou Coulibaly , Faye Iketubosin , Gamal Serour , Silke Dyer , African Network and Registry for Assisted Reproductive Technology
{"title":"Assisted reproductive technologies in Africa: The African Network and Registry for ART, 2020","authors":"Paversan Archary ,&nbsp;Liezel Potgieter ,&nbsp;Frissiano Honwana ,&nbsp;Eman Elgindy ,&nbsp;Rudolph Kantum Adageba ,&nbsp;Founzégué Amadou Coulibaly ,&nbsp;Faye Iketubosin ,&nbsp;Gamal Serour ,&nbsp;Silke Dyer ,&nbsp;African Network and Registry for Assisted Reproductive Technology","doi":"10.1016/j.rbmo.2024.104353","DOIUrl":"10.1016/j.rbmo.2024.104353","url":null,"abstract":"<div><h3>Research question</h3><p>What were the utilization, effectiveness and safety of assisted reproductive technology (ART) in Africa during 2020?</p></div><div><h3>Design</h3><p>Cross-sectional, cycle-based and retrospective summary data were collected from voluntarily participating ART centres.</p></div><div><h3>Results</h3><p>During 2020, 37,063 ART procedures were reported by 67 centres in 15 countries. Autologous fresh transfers were predominant at 65.0%, whereas autologous frozen embryo transfers (FET) represented 26.2% and oocyte donation cycles remained less than 10%. Women undergoing autologous fresh embryo transfer had a mean age of 34.9 years and received a mean number of 2.4 embryos per transfer. The clinical pregnancy rate (CPR) per embryo transfer was 37.3% after fresh embryo transfer and 37.8% after frozen embryo transfer. The cumulative CPR per aspiration was 41.9% in autologous cycles.</p><p>Most ART procedures resulted in a multiple delivery rate above 20%. After autologous ART, multiples were predominantly born preterm (twin and triplet deliveries 59.5% versus singleton 21.9% born before 37 weeks), with a substantially increased perinatal mortality compared with ART singletons (59.0‰ versus 22.2‰). Cycle-based data documented that elective single embryo transfer (eSET) provides the optimal balance of effectiveness (eSET CPR per embryo transfer 36.7%) and safety.</p></div><div><h3>Conclusion</h3><p>This fourth report of the African Network and Registry for ART provides real-world evidence of ART utilization, practices and outcomes in Africa, which is relevant to many stakeholders. It critically informs and represents regional ART development based on national, regional and global cooperation.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147264832400542X/pdfft?md5=eb73b8d7389e213bcd31a909509a74c4&pid=1-s2.0-S147264832400542X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periconceptional maternal and paternal alcohol consumption and embryonic and fetal development: the Rotterdam periconception cohort 围孕期母亲和父亲饮酒与胚胎和胎儿发育:鹿特丹围孕期队列
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104351
M. van der Windt, E.W. Tobi, I. Chidi, S. Schoenmakers, L. van Rossem, R.P.M. Steegers-Theunissen, M. Rousian
{"title":"Periconceptional maternal and paternal alcohol consumption and embryonic and fetal development: the Rotterdam periconception cohort","authors":"M. van der Windt,&nbsp;E.W. Tobi,&nbsp;I. Chidi,&nbsp;S. Schoenmakers,&nbsp;L. van Rossem,&nbsp;R.P.M. Steegers-Theunissen,&nbsp;M. Rousian","doi":"10.1016/j.rbmo.2024.104351","DOIUrl":"10.1016/j.rbmo.2024.104351","url":null,"abstract":"<div><h3>Research question</h3><p>What is the impact of maternal and paternal alcohol consumption in the periconception period on embryonic and fetal development assessed using three-dimensional ultrasound and virtual reality techniques?</p></div><div><h3>Design</h3><p>This prospective observational study was embedded in the Rotterdam periconception cohort (Predict study). Participating women received longitudinal three-dimensional transvaginal ultrasound examinations from week 7 to week 12 of gestation to measure crown–rump length and embryonic volume. Mid-pregnancy fetal size parameters and birth weight were retrieved from medical files. Participants completed a periconception exposure questionnaire and a validated food frequency questionnaire. Linear mixed models were used to analyse the association between parental alcohol consumption, and embryonic and fetal developmental parameters.</p></div><div><h3>Results</h3><p>In total, 1141 female and 987 male participants were included in the analyses. Moderate maternal alcohol consumption in the periconception period resulted in a smaller head circumference (β = -1.85, SE = 0.84, <em>P</em> = 0.03), abdominal circumference (β = -2.65, SE = 0.93, <em>P</em> = 0.004), femur length (β = -0.56, SE = 0.22, <em>P</em> = 0.01) and estimated fetal weight (β = -9.36, SE = 4.35, <em>P</em> = 0.03) at 20 weeks of gestation. Paternal alcohol consumption showed significant positive associations, mainly with fetal size parameters (abdominal circumference: β = 0.033, SE = 0.01, <em>P</em> = 0.008; estimated fetal weight: β = 0.131, SE = 0.06, <em>P</em> = 0.03).</p></div><div><h3>Conclusions</h3><p>Moderate maternal alcohol consumption is negatively associated with fetal growth parameters. Moreover, alcohol is proven to be a strong teratogen, and its consumption before and during pregnancy should be discouraged in both women and men as it affects several parameters of embryonic and fetal development.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005406/pdfft?md5=31f97ddc7ce72a48ad6e765c28db2ed3&pid=1-s2.0-S1472648324005406-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering endometrial dysfunction in patients with uterine myoma using endometrial organoids: a pilot study 利用子宫内膜器官组织解密子宫肌瘤患者的子宫内膜功能障碍:一项试点研究
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104355
Yu Zhang , Minghui Lu , Yanli Han , Boyang Liu , Rusong Zhao , Peishu Liu , Han Zhao
{"title":"Deciphering endometrial dysfunction in patients with uterine myoma using endometrial organoids: a pilot study","authors":"Yu Zhang ,&nbsp;Minghui Lu ,&nbsp;Yanli Han ,&nbsp;Boyang Liu ,&nbsp;Rusong Zhao ,&nbsp;Peishu Liu ,&nbsp;Han Zhao","doi":"10.1016/j.rbmo.2024.104355","DOIUrl":"10.1016/j.rbmo.2024.104355","url":null,"abstract":"<div><h3>Research question</h3><p>What influence does an intramural myoma have on the endometrium, and how is this mediated?</p></div><div><h3>Design</h3><p>Endometrium was collected from 13 patients with non-cavity-distorting intramural myomas (diameter ≤4 cm; International Federation of Gynecology and Obstetrics type 4) and 13 patients without myomas undergoing hysterectomy for benign cervical diseases with a similar clinical baseline. Endometrial organoids were established <em>in vitro</em> and induced to reach the secretory phase by oestrogen and progesterone. Transcriptome sequencing was conducted on endometrial organoids in both untreated and secretory stages from three individuals with myomas and three control participants. Immunofluorescence and real-time quantitative PCR (RT-qPCR) were performed on endometrial organoids from another 10 myoma patients and 10 control patients for validation.</p></div><div><h3>Results</h3><p>The data revealed abnormally increased hormone receptor (<em>PGR</em>) levels in the untreated endometrial organoids with myomas, resulting in potentially abnormal glandular and vascular development. The aberrant responses to oestrogen and progestogen prompted further investigation into the secretory phase. The secretory endometrial organoids with myomas exhibited greater changes in acetyl-α-tubulin, <em>ODF2</em> and <em>TPPP</em>, demonstrating likely decreased cilia, and <em>COL6A1</em>, used as a marker for increased extracellular matrix (ECM) modelling. Both untreated and secretory endometrial organoids with myoma showed an up-regulation of genes and pathways related to ECM mechanotransduction. The expression pattern of receptivity-related genes was disturbed in endometrial organoids with myoma.</p></div><div><h3>Conclusions</h3><p>This study is the first to reveal that intramural myomas create an abnormal hormonal and mechanical environment in the untreated and secretory endometrial organoids. The intramural myomas negatively impacted gene expression relating to endometrial glands, blood vessels, cilia and ECM, indicating that intramural myomas impair endometrial decidualization and receptivity.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005443/pdfft?md5=fdd5786b0971c58eca2f3690e3570225&pid=1-s2.0-S1472648324005443-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of aneuploidy for patients of different ages treated with progestin-primed ovarian stimulation or GnRH antagonist protocols 采用孕激素刺激卵巢或 GnRH 拮抗剂方案治疗的不同年龄患者植入前非整倍体基因检测结果的比较
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104349
Lili Wan , Furui Chen , Dongsheng Xiong , Shiqi Chen , Jiexiu Chen , Juan Qin , Jesse Li-Ling , Taiqing Zhong , Xueyan Wang , Yan Gong
{"title":"Comparison of aneuploidy for patients of different ages treated with progestin-primed ovarian stimulation or GnRH antagonist protocols","authors":"Lili Wan ,&nbsp;Furui Chen ,&nbsp;Dongsheng Xiong ,&nbsp;Shiqi Chen ,&nbsp;Jiexiu Chen ,&nbsp;Juan Qin ,&nbsp;Jesse Li-Ling ,&nbsp;Taiqing Zhong ,&nbsp;Xueyan Wang ,&nbsp;Yan Gong","doi":"10.1016/j.rbmo.2024.104349","DOIUrl":"10.1016/j.rbmo.2024.104349","url":null,"abstract":"<div><h3>Research question</h3><p>Does euploidy status differ among patients of different ages treated with progestin-primed ovarian stimulation (PPOS) or gonadotrophin releasing hormone antagonist (GnRH-a) protocols?</p></div><div><h3>Design</h3><p>Patients undergoing PGT-A (<em>n</em> = 418; 440 cycles) were enrolled and grouped according to female age (&lt;35 years and ≥35 years). Protocols were as follows: PPOS: &lt;35 years (<em>n</em> = 131; 137 cycles); ≥35 years (<em>n</em> = 72; 80 cycles); GnRH-a: &lt;35 years (<em>n</em> = 149; 152 cycles); ≥35 years (<em>n</em> = 66; 71 cycles).</p></div><div><h3>Results</h3><p>For cycles treated with PPOS in the older group, rates of euploid blastocyst per metaphase Ⅱ oocyte (15.48% versus 10.47%) and per biopsied blastocyst (54.94% versus 40.88%) were significantly higher than those treated with GnRH-a (<em>P</em> &lt; 0.05). The mosaic rate per biopsied blastocyst was significantly lower for cycles treated with PPOS than cycles treated with GnRH-a (8.64% versus 23.36%) (<em>P</em> &lt; 0.001). In the younger group, no significant difference was found between treatments (<em>P</em> &gt; 0.05). In older and younger groups, the drug to inhibit LH surge was cheaper for cycles treated with PPOS compared with GnRH-a (<em>P</em> &lt; 0.001). Generalized estimation equations based on binomial distribution female age and euploidy rate was significantly negatively correlated for all participants (β –0.109, 95% CI –0.183 to –0.035, <em>P</em> = 0.004), and between GnRH-a protocol (reference: PPOS) and the euploidy rate in the older group (β –0.126, 95% CI –0.248 to –0.004, <em>P</em> = 0.042). Multiple logistic regression indicated that ovarian stimulation protocol was not associated with ongoing pregnancy rate (OR 0.652, 95% CI 0.358 to 1.177; <em>P</em> = 0.14).</p></div><div><h3>Conclusions</h3><p>PPOS is suitable for patients undergoing PGT-A, particularly older patients for the higher euploid blastocyst rate attained by PPOS protocol.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing risks for genetic conditions in donor sperm treatment: current practices in Belgian fertility clinics 管理捐精治疗中的遗传病风险:比利时生育诊所的现行做法
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104352
Dorian Accoe , Guido Pennings , Kelly Tilleman , Frauke Vanden Meerschaut , Sandra Janssens , Heidi Mertes
{"title":"Managing risks for genetic conditions in donor sperm treatment: current practices in Belgian fertility clinics","authors":"Dorian Accoe ,&nbsp;Guido Pennings ,&nbsp;Kelly Tilleman ,&nbsp;Frauke Vanden Meerschaut ,&nbsp;Sandra Janssens ,&nbsp;Heidi Mertes","doi":"10.1016/j.rbmo.2024.104352","DOIUrl":"10.1016/j.rbmo.2024.104352","url":null,"abstract":"<div><h3>Research question</h3><p>How do fertility clinics in Belgium manage risks for genetic conditions in donor sperm treatment?</p></div><div><h3>Design</h3><p>An electronic questionnaire was distributed to all fertility clinics in Belgium in June 2023, focusing on treatments with anonymous sperm donors from 2018 to 2022. Responses from 15 clinics were analysed anonymously using IBM SPSS statistics.</p></div><div><h3>Results</h3><p>All clinics assessed donor risks, including a personal and family history, conventional karyotyping and (for 83.3% of the clinics) carrier screening for common autosomal recessive conditions. For recipients, 58.3% of the clinics relied only on a personal and family history. Despite efforts, the suspicion or detection of genetic conditions in donor sperm treatment was prevalent, with 9.4 adverse events reported per 100 children born. When adverse events occurred, most clinics (58.3%) would not inform the donor if no additional genetic testing was needed. Around 1 in 4 (26.7%) clinics always informed recipients about an adverse event possibly related to their donor. An equal number (26.7%) categorically ruled out the use of spermatozoa from a donor after an adverse event was traced back to his DNA, and 53.3% would not consider using the donor when the adverse event was not genetically confirmed. For the other clinics, deciding when to disclose new genetic risk information or when to allow the use of a donor linked to an adverse event was a complex matter involving different considerations.</p></div><div><h3>Conclusion</h3><p>Although suspected or detected genetic conditions linked to donor treatments were common, there was wide variation in how Belgian clinics prevented and managed these situations.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis affects natural and ART fertility in different ways: let's look at the whole patient and not at the single lesion 子宫内膜异位症对自然受孕和人工受孕的影响是不同的:让我们关注整个患者,而不是单个病灶
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-03 DOI: 10.1016/j.rbmo.2024.104354
Sofia Gambigliani Zoccoli, Antonio La Marca
{"title":"Endometriosis affects natural and ART fertility in different ways: let's look at the whole patient and not at the single lesion","authors":"Sofia Gambigliani Zoccoli,&nbsp;Antonio La Marca","doi":"10.1016/j.rbmo.2024.104354","DOIUrl":"10.1016/j.rbmo.2024.104354","url":null,"abstract":"<div><p>When considering the typical lesions associated with endometriosis, such as endometriomas, and pelvic adherences involving the tubes, it is very clear how this pathology may impair both natural and assisted reproductive technology (ART) fertility. It may be more difficult for clinicians to recognize that endometriosis can reduce female fertility potential through other mechanisms which may be independent of direct damage to ovarian reserve and tubal function. The most recent clinical studies have shown that endometriosis is associated with increased risk of infertility, independent of the type of endometriosis (ovarian, peritoneal and deep endometriosis). In the IVF setting, the cumulative live birth rate in women with endometriosis has been reported to be significantly lower compared with women without endometriosis. Endometriosis is a complex, multifactorial condition that encompasses not only the presence of endometriotic lesions, but also involves women's sexuality, uterine and ovarian compartment. Endometriosis should always be considered a severe risk factor for infertility and ART failure.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progesterone-modified natural cycle preparation for frozen embryo transfer 用于冷冻胚胎移植的黄体酮改良自然周期制备法
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-02 DOI: 10.1016/j.rbmo.2024.104350
Nikolay Kornilov , Alex Polyakov , Anastasiya Mungalova , Lubov Yakovleva , Pavel Yakovlev
{"title":"Progesterone-modified natural cycle preparation for frozen embryo transfer","authors":"Nikolay Kornilov ,&nbsp;Alex Polyakov ,&nbsp;Anastasiya Mungalova ,&nbsp;Lubov Yakovleva ,&nbsp;Pavel Yakovlev","doi":"10.1016/j.rbmo.2024.104350","DOIUrl":"10.1016/j.rbmo.2024.104350","url":null,"abstract":"<div><h3>Research question</h3><p>Is there any difference in clinical outcomes between the progesterone-modified natural cycle (P4mNC) and hormone replacement therapy (HRT) endometrial preparation protocols after single euploid blastocyst frozen embryo transfer (FET) cycles?</p></div><div><h3>Design</h3><p>A retrospective cohort study was performed at a single, private, high-volume fertility centre. Patients who underwent single euploid blastocyst FET between January 2017 and December 2019 were included. A total of 1933 FET cycles were reviewed, and 723 FET cycles from 548 patients met the inclusion criteria. Two groups were compared according to endometrial preparation: 327 P4mNC-FET and 396 HRT-FET cycles. The primary outcome was the live birth rate. The secondary outcomes included the clinical pregnancy rate and the miscarriage rate.</p></div><div><h3>Results</h3><p>There were no differences in the clinical pregnancy rate (50.2% versus 47.0%, <em>P</em> = 0.688), miscarriage rate (9.8% versus 14.5%, <em>P</em> = 0.115) and live birth rate (45.0% versus 39.6%, <em>P</em> = 0.331) between the P4mNC-FET and HRT-FET groups after covariate adjustments.</p></div><div><h3>Conclusions</h3><p>There were no differences in the clinical outcomes between the P4mNC-FET and HRT-FET cycles. These results indicate that P4mNC-FET cycles produce clinical outcomes comparable to those of more traditional HRT-FET while allowing greater flexibility in the timing of embryo transfer.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147264832400539X/pdfft?md5=d299876a20a489f69c453f9bb5907010&pid=1-s2.0-S147264832400539X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is HyFosy the new gold standard for assessing tubal patency? A systematic review and meta-analysis HyFosy 是评估输卵管通畅性的新黄金标准吗?系统回顾和荟萃分析
IF 3.7 2区 医学
Reproductive biomedicine online Pub Date : 2024-07-01 DOI: 10.1016/j.rbmo.2024.104380
Elisabeth Gerard Cassiman, Sophie Harter, Romane Mougel, Cécile Mezan De Malartic, C. Bertholdt, Olivier Morel, Mikaël Agopiantz
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引用次数: 0
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