Reproductive biomedicine online最新文献

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(26)00197-5","DOIUrl":"10.1016/S1472-6483(26)00197-5","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105656"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive medicine and human embryo research: rethinking risk through the lens of Aristotle’s phronesis","authors":"Maxime Chaillot ,&nbsp;Maxence Gaillard ,&nbsp;Laurent David ,&nbsp;Thomas Freour","doi":"10.1016/j.rbmo.2025.105287","DOIUrl":"10.1016/j.rbmo.2025.105287","url":null,"abstract":"<div><div>In the field of assisted reproductive technology (ART) and human embryo research, clinicians and scientists regularly face decisions that blend scientific uncertainty with profound ethical complexity. As innovation accelerates in these fast-moving fields, ethical navigation can be challenging. Guidelines, regulations and protocols generally provide structure, yet often fall short of offering sufficient moral clarity. In this complex and evolving landscape, we propose that Aristotle’s famous concept of <em>phronesis</em> – practical wisdom, i.e. the ability to make morally sound decisions in complex, real-life situations by balancing knowledge, experience and ethical judgement – can offer an essential tool for navigating choices in ART and/or human embryo research where evidence, ethics and lived human experiences intersect.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105287"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of transfer of blastocyst and embryo vitrification on birth weight: a retrospective cohort study","authors":"Ming Li ,&nbsp;Qingqing Tao ,&nbsp;Zhengyang Zhao ,&nbsp;Jin Huang ,&nbsp;Ying Lian ,&nbsp;Ping Liu ,&nbsp;Qin Li ,&nbsp;Rong Li ,&nbsp;Jie Qiao","doi":"10.1016/j.rbmo.2025.105340","DOIUrl":"10.1016/j.rbmo.2025.105340","url":null,"abstract":"<div><h3>Research question</h3><div>Does the synergistic interaction between blastocyst-stage embryo transfer and vitrification in assisted reproductive technology increase the risk of adverse neonatal outcomes, specifically elevated birth weight z-scores and a higher incidence of clinically concerning large for gestational age (LGA) or macrosomia in offspring?</div></div><div><h3>Design</h3><div>In this cohort study, multivariable regression analyses were conducted to examine the association between embryo transfer strategies (fresh versus frozen; cleavage versus blastocyst stage) and the birth weight z-score of singletons, as well as the incidence of LGA and macrosomia among 42,190 singleton live births from the Center for Reproductive Medicine at Peking University Third Hospital between 2012 and 2022.</div></div><div><h3>Results</h3><div>Compared with cleavage-stage embryo transfer, newborns resulting from blastocyst-stage transfers had significantly higher birth weight z-scores (<em>P</em> &lt; 0.001), LGA (<em>P</em> &lt; 0.001) and macrosomia (<em>P</em> = 0.013). Frozen embryo transfer (only vitrified–warmed) was associated with increased birth weight z-scores (<em>P</em> = 0.001), LGA (<em>P</em> = 0.004) and macrosomia (<em>P</em> = 0.007), compared with fresh embryo transfers. A significant synergetic effect of blastocyst transfer and vitrified–warmed transfer concerning the LGA was found (relative excess risks due to interaction = 0.24; 95% CI 0.06 to 0.42; <em>P</em> = 0.022 for multiplicative interaction term) on the additive and multiplicative scales.</div></div><div><h3>Conclusions</h3><div>Blastocyst stage and embryo vitrification were associated with elevated birth weight z-scores and an increased likelihood of LGA, with evidence of a synergistic effect. These findings support the importance of personalized clinical decision-making in the use of vitrified–warmed cleavage-stage transfer, particularly in the absence of clear medical indications.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105340"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single motherhood by choice in Sweden: survey of unanticipated support needs and financial challenges","authors":"Ylva Af Sandeberg ,&nbsp;Claudia Lampic ,&nbsp;Agneta Skoog Svanberg ,&nbsp;Camilla Stenfelt ,&nbsp;Anna-Karin Lind ,&nbsp;Gunilla Sydsjö ,&nbsp;Evangelia Elenis","doi":"10.1016/j.rbmo.2025.105241","DOIUrl":"10.1016/j.rbmo.2025.105241","url":null,"abstract":"<div><h3>Research question</h3><div>What are the backgrounds, treatment motives, experiences of mandatory psychosocial evaluation, support needs, post-birth financial circumstances, and reflections on motherhood among single mothers by choice who received publicly or privately funded treatment in Sweden?</div></div><div><h3>Design</h3><div>A cross-sectional, anonymous, web-based survey was conducted in 2022 and completed by 256 single mothers by choice with children under five years conceived through assisted reproduction with donated gametes. Outcomes were analyzed by funding source.</div></div><div><h3>Results</h3><div>Participants were aged 28–48 years; 53.9% had received publicly funded treatment. Most (87.1%) held a university, master's, or PhD degree, with a median salary of €3,600. At treatment, 47.7% had been single for more than four years, and 25.4% chose single motherhood for reasons beyond partner absence, such as a desire for sole custody. Obstetric complications were reported by 48.8%. Substantial proportions were dissatisfied with practical support from family or friends (23% and 42%, respectively). After childbirth, 35.5% reduced employment, and 22.7% reported worse-than-expected finances due to unforeseen expenses or instability. Despite these challenges, 98.8% expressed no regret, and 45.3% planned additional children. Findings were largely similar across funding groups. Exceptions included privately funded women, who were older and more likely to report plans to remain voluntarily single, express dissatisfaction with workplace and healthcare support and question the psychosocial evaluation.</div></div><div><h3>Conclusions</h3><div>Single mothers by choice in Sweden are generally well educated and financially stable at treatment initiation but often face greater-than-expected challenges after childbirth, including medical complications, reduced income, and limited support. Nevertheless, most remain confident in their decision, reflecting long-term planning and strong reproductive agency. Funding source had minimal impact on post-birth financial hardship.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105241"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital twins in fertility, assisted reproductive technology and pregnancy: a systematic review","authors":"Alexandre Vallée ,&nbsp;Gaby Moawad ,&nbsp;Anis Feki ,&nbsp;Jean-Marc Ayoubi","doi":"10.1016/j.rbmo.2025.105281","DOIUrl":"10.1016/j.rbmo.2025.105281","url":null,"abstract":"<div><div>Digital twins – the term for virtual representations of biological systems – are emerging as promising tools in reproductive medicine. They offer personalized simulations for optimizing fertility, assisted reproductive technology (ART) and pregnancy outcomes. However, their use remains limited and fragmented across diverse applications. A systematic search was conducted in PubMed, EMBASE, Scopus and IEEE Xplore up to July 2025 for this review of the current evidence on digital twins in fertility, ART and pregnancy, identifying applications, outcomes, challenges and future prospects. Original studies that applied digital twins to fertility, ART or pregnancy in human or in-silico models were included in this review. Eight original studies were included, complemented by nine mechanistic or conceptual works. Applications encompassed embryo selection, IVF procedure modelling, placental physiology, pregnancy pharmacokinetics, and intrapartum monitoring. Most studies were predictive or descriptive in nature, static or batch-coupled, and at early stages of validation. Risk of bias ranged from moderate to high due to study design and external validity concerns. Only two studies fulfilled strict digital twin criteria, and the exclusion of borderline studies did not change the overall conclusions. Digital twins hold substantial promise for personalized reproductive care. However, their clinical utility remains largely theoretical. Future work must improve modelling accuracy, data integration and ethical implementation to unlock their full potential.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105281"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of one-step and conventional warming in sibling donor oocytes: a proof-of-concept study","authors":"Ana Cobo ,&nbsp;Aila Coello ,&nbsp;Lucía Murria ,&nbsp;Yolanda Garijo ,&nbsp;María José de los Santos ,&nbsp;Juan A García-Velasco ,&nbsp;Fernando Bronet","doi":"10.1016/j.rbmo.2025.105339","DOIUrl":"10.1016/j.rbmo.2025.105339","url":null,"abstract":"<div><h3>Research question</h3><div>Are there differences in survival, embryo development and clinical outcomes between sibling oocytes warmed using one-step and conventional protocols?</div></div><div><h3>Design</h3><div>A prospective, randomized, proof-of-concept trial using sibling donor oocytes to evaluate a one-step warming procedure. A total of 352 metaphase II oocytes (<em>n</em> = 30 donors) that had been previously vitrified using the conventional procedure were included. Just before warming, the oocytes were randomized into two groups: one-step warming (<em>n</em> = 179) and conventional warming (<em>n</em> = 173). The conventional warming protocol takes 10 min and involves three steps, using decreasing concentrations of trehalose. One-step warming only requires 1 min in 1.0 M trehalose solution. The main outcome was the survival rate. Fertilization rates, embryo quality, clinical results and oocyte developmental competence were also analysed.</div></div><div><h3>Results</h3><div>The survival rate was 96.1% in the one-step warming group and 94.2% in the conventional-warming group, with no statistically significant difference. No differences were found when comparing the usable blastocyst rate (55.3% versus 52.1%) or good-quality blastocyst rate (46.1% versus 43.6%) of the one-step and conventional warming protocols, respectively. Similarly, no significant differences were found between implantation rates (69.2% versus 58.8%, respectively) and ongoing pregnancy rate per embryo transfer (53.8% versus 41.2%). The logistic regression analysis showed that the warming protocol did not correlate with ongoing pregnancy rate.</div></div><div><h3>Conclusion</h3><div>One-step warming can be safely applied to donor metaphase II oocytes, providing similar survival rates and clinical outcomes compared with conventional warming.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105339"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oocyte quality in women with diminished ovarian reserve: not as poor as assumed","authors":"En-Qi Yan ,&nbsp;Hong-Xia Chen ,&nbsp;Yuan-Li Li ,&nbsp;Lei Jin ,&nbsp;Bing-Xin Ma","doi":"10.1016/j.rbmo.2025.105354","DOIUrl":"10.1016/j.rbmo.2025.105354","url":null,"abstract":"<div><h3>Research question</h3><div>How does diminished ovarian reserve (DOR) affect euploid blastocyst rates, and how many embryos need to be biopsied for women with or without DOR to achieve one euploid embryo?</div></div><div><h3>Design</h3><div>A retrospective study was conducted at a single reproductive centre, involving 694 women (126 with and 568 without DOR) undergoing 803 preimplantation genetic testing for aneuploidies (PGT-A) cycles from 2016 to 2024. DOR was defined as a concentration of anti-Müllerian hormone below 1.1 ng/ml and/or an antral follicle count of less than 7. Participants were stratified by age into three groups: &lt;35, 35–39 and &gt;39 years. Euploidy rates and pregnancy outcomes were compared between the DOR and non-DOR groups. Cumulative euploid embryo acquisition was analysed.</div></div><div><h3>Results</h3><div>DOR patients showed comparable euploidy rates to their non-DOR counterparts. The number of embryos required to obtain a euploid embryo was a: for age &lt;35 years, a mean of 1.6 embryos for the DOR group and 1.7 for the non-DOR group; for age 35–39 years, a mean of 1.9 and 2.3 embryos, respectively; and for age &gt;39 years, a mean of 7.2 and 4.2 embryos, respectively. In women over aged 39 years, the mean number of euploid embryos obtained remained low even after two retrievals for both groups. Pregnancy outcomes after euploid embryo transfer were similar between the two groups.</div></div><div><h3>Conclusions</h3><div>Participants with DOR had similar euploidy rates and pregnancy outcomes to non-DOR patients. Limited embryo quantity, rather than inferior oocyte quality, thus remains the predominant challenge for individuals with DOR.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105354"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double embryo transfer with mosaic embryos: experience from a large academic fertility centre","authors":"Amelia G. Kelly ,&nbsp;Zoey McFarland ,&nbsp;Andria Besser ,&nbsp;James A. Grifo ,&nbsp;Jennifer K. Blakemore","doi":"10.1016/j.rbmo.2025.105358","DOIUrl":"10.1016/j.rbmo.2025.105358","url":null,"abstract":"<div><h3>Research question</h3><div>What are the overall, singleton and twin live birth rates (LBR) after a double embryo transfer (DET) involving mosaic embryos?</div></div><div><h3>Design</h3><div>This was a retrospective cohort study of DET with at least one mosaic embryo between 1 December 2016 and 1 December 2024. Each DET was assigned a prognostic score (A–F) based on the ploidy of both embryos. The primary outcome was the overall, singleton and twin LBR of good-prognosis (A and B), moderate-prognosis (C and D) and poor-prognosis (E and F) DET. Secondary outcomes were the LBR for mosaic/mosaic compared with euploid/mosaic transfers. Comparisons were also made with previously published data on euploid/euploid transfers.</div></div><div><h3>Results</h3><div>In total, there were 38 DET: 22 mosaic/mosaic and 16 euploid/mosaic. Twenty-nine (76.3%) patients had prior failed euploid transfers, and 19 (86.4%) mosaic/mosaic patients did not have any euploid embryos. The differences in overall LBR between the prognostic groups did not reach significance [65.0% (13/20) good-prognosis group versus 71.4% (5/7) moderate-prognosis group versus 45.5% (5/11) poor-prognosis group; <em>P</em> = 0.5]. The twin LBR was higher in the good-prognosis group (46.2%) compared with the moderate- and poor-prognosis groups (0% for both; <em>P</em> = 0.04).</div><div>Overall [72.7% (16/22) versus 43.8% (7/16); <em>P</em> = 0.07], singleton [54.5% (12/22) versus 31.3% (5/11); <em>P</em> = 0.20] and twin [18.2% (4/22) versus 12.5% (2/16); <em>P</em> = 0.6] LBR were similar between mosaic/mosaic and euploid/mosaic DET. While the multiple LBR was high in both groups, it was lower for mosaic/mosaic and euploid/mosaic DET compared with euploid/euploid DET [26.1% (6/23) versus 49.8% (113/227, previously published data); <em>P</em> = 0.04].</div></div><div><h3>Conclusions</h3><div>Caution must be exercised with mosaic embryos as they can behave like euploid embryos, and DET can result in twins. DET with moderate- or poor-prognosis mosaic embryos had lower twin rates and may be reasonably considered. Larger studies are needed.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105358"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘The inhibition of WIP1 phosphatase accelerates the depletion of primordial follicles’Reproductive BioMedicine Online 43 (2021) 161-171","authors":"Su Zhou,&nbsp;Yueyue Xi,&nbsp;Yingying Chen,&nbsp;Tong Wu,&nbsp;Wei Yan,&nbsp;Milu Li,&nbsp;Meng Wu,&nbsp;Aiyue Luo,&nbsp;Wei Shen,&nbsp;Tao Xiang,&nbsp;Shixuan Wang","doi":"10.1016/j.rbmo.2025.105444","DOIUrl":"10.1016/j.rbmo.2025.105444","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105444"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation and family-building in transgender and non-binary patients: 14 years at a UK centre","authors":"Ellen Davenport-Pleasance,&nbsp;Mimi Arian-Schad,&nbsp;Rukma Bhattacharya,&nbsp;Mona Rahmati,&nbsp;Elena Linara-Demakakou,&nbsp;Nick Macklon,&nbsp;Kaj Rydman,&nbsp;Jemma Garratt,&nbsp;Kamal K Ahuja","doi":"10.1016/j.rbmo.2025.105361","DOIUrl":"10.1016/j.rbmo.2025.105361","url":null,"abstract":"<div><h3>Research question</h3><div>How is assisted reproductive technology used by trans and/or non-binary (TNB) individuals and their partners at London Women's Clinic?</div></div><div><h3>Design</h3><div>This retrospective observational study examined treatments undertaken by TNB people at London Women's Clinic between 2011 and 2025. Demographic information on patients' age, body mass index, anti-Mullerian hormone, antral follicle count and history of gender-affirming hormone therapy/surgery was analysed. Outcomes included the types of treatment pursued, ongoing pregnancies, and live births.</div></div><div><h3>Results</h3><div>Sixty-four individuals who identified as TNB (<em>n</em> = 42) or had a TNB partner (<em>n</em> = 22) attended the clinic. Treatments included egg freezing (22 cycles), intrauterine insemination (IUI; 17 cycles) and IVF (25 cycles). A minority of IVF cycles involved intra-partner donation (reciprocal IVF; 2/25) or donor eggs (2/25). Three couples' journeys involved surrogacy arrangements. Most TNB individuals attended the clinic with a partner (<em>n</em> = 30), with the exception of those undertaking egg freezing. Of the individuals/couples attempting pregnancy (<em>n</em> =24), most (<em>n</em> =20) were using donor spermatozoa, with the exception of four couples (two involving transgender women who had frozen spermatozoa, and two involving cisgender men). Thirteen live births were achieved and four individuals were discharged from the clinic with ongoing pregnancies.</div></div><div><h3>Conclusions</h3><div>TNB individuals in the UK are successfully using the spectrum of assisted reproduction options, often with donor gametes and occasionally surrogacy, to build families. In this study, IVF out-performed IUI, underscoring that with inclusive, legally informed care pathways, family formation for TNB patients is both feasible and effective.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 3","pages":"Article 105361"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}