Reproductive biomedicine online最新文献

{"title":"Donor sperm: only for the rich and straight.","authors":"Guido Pennings","doi":"10.1016/j.rbmo.2024.104434","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104434","url":null,"abstract":"<p><p>Although single women and lesbian couples are given access to donor spermatozoa, all kinds of restrictions limit their actual use of donor insemination. These restrictions are frequently justified by the increase in safety (lowering the genetic risk) or well-being of donor-conceived persons. However, these restrictions directly result in stratified reproduction in which only the rich (those with the necessary financial means) and the straight (those who conform to dominant views of parenthood) are allowed to reproduce.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104434"},"PeriodicalIF":3.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polar body-based PGT-A: not dead yet? A step forward back to the roots of PGT-A.","authors":"Anna Oberle, Michael Feichtinger","doi":"10.1016/j.rbmo.2024.104430","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104430","url":null,"abstract":"<p><p>Trophectoderm-based preimplantation genetic testing for aneuploidies (PGT-A) is used worldwide as a means of selecting embryos with high potential for achieving a live birth. However, trophectoderm analysis may be impaired through embryonic mosaicism, leading to genetically healthy embryos being falsely discarded, and thus even reducing cumulative live birth rates. Polar body biopsy, a technique applied since the early days of preimplantation testing, has been abandoned by most IVF centres. In comparison to trophectoderm analysis, however, polar body biopsy might even have certain advantages over trophectoderm PGT-A. This Countercurrent contribution discusses the newest clinical evidence, as well as ethical and cost-efficiency considerations, and argue that polar body analysis should be reconsidered.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104430"},"PeriodicalIF":3.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures","authors":"Lucie Delaroche ,&nbsp;Lucile Besnard ,&nbsp;Nino Guy Cassuto ,&nbsp;Sébastien Bristeau ,&nbsp;Anne Togola","doi":"10.1016/j.rbmo.2024.104431","DOIUrl":"10.1016/j.rbmo.2024.104431","url":null,"abstract":"<div><h3>Research question</h3><div>Are bisphenols released from disposable devices used in assisted reproductive technology (ART) procedures, and do they accumulate when several disposable devices are used sequentially under routine conditions?</div></div><div><h3>Design</h3><div>A comprehensive assessment of 19 individual disposable devices (31 assessments) and nine combinations of disposable devices replicating the main steps in an ART procedure was undertaken. The extraction of bisphenols followed routine-use conditions (temperature and duration). The concentrations of 10 bisphenols were determined using online solid-phase extraction/liquid chromatography/mass spectrometry methodology.</div></div><div><h3>Results</h3><div>Bisphenol S (BPS) was quantified consistently from 100-mm culture dishes (32 ± 20 pg) and from high security sperm straws (3 ± 1 pg). Also, BPS and bisphenol A (BPA) were quantified consistently from spermicide-free condoms (95 ± 78 and 83 ± 49 pg, respectively). No other bisphenols were detected in disposable devices when tested individually. When disposable devices were used in combination, both BPA and BPS were detected consistently in combinations of 13 disposable devices mimicking sperm collection in a condom and its preparation (46 ± 16 and 43 ± 32 pg, respectively). BPS was quantified consistently in combinations of 14 disposable devices mimicking sperm collection, its preparation and freezing (10 ± 4 pg), and in combinations of 17 disposable devices mimicking oocyte retrieval (37 ± 22 pg).</div></div><div><h3>Conclusions</h3><div>BPA and BPS are released in small quantities from some disposable devices used in routine conditions during ART procedures, but do not appear to accumulate when these disposable devices are used in combination.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104431"},"PeriodicalIF":3.7,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking into the future: a machine learning powered prediction model for oocyte return rates after cryopreservation.","authors":"Yuval Fouks, Pietro Bortoletto, Jeffrey Chang, Alan Penzias, Denis Vaughan, Denny Sakkas","doi":"10.1016/j.rbmo.2024.104432","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104432","url":null,"abstract":"<p><strong>Research question: </strong>Could a predictive model, using data from all US fertility clinics reporting to the Society for Assisted Reproductive Technology, estimate the likelihood of patients using their stored oocytes?</p><p><strong>Design: </strong>Multiple learner algorithms, including penalized regressions, random forests, gradient boosting machine, linear discriminant analysis and bootstrap aggregating decision trees were used. Data were split into training and test datasets. Patient demographics, medical and fertility diagnoses, partner information and geographic locations were analysed.</p><p><strong>Results: </strong>A total of 77,631 oocyte-cryopreservation cycles (2014-2020) were analysed. Patient age averaged 34.5 years. Treatment indications varied: planned (35.6%), gender-related (0.1%), medically indicated (15.5%), oncologic (5.7%) and unknown (42.3%). Infertility diagnoses were less common: unexplained infertility (1.8%), age-related infertility (3.2%), diminished ovarian reserve (9.9%) and endometriosis (1.6%). An ensemble model combining bootstrap aggregation classification and regression trees, stochastic gradient boosting and linear discriminant analysis yielded the highest predictive accuracy on test set (balanced accuracy: 0.83, sensitivity: 0.76, specificity: 0.91), with a receiver operating characteristic curve of 0.90 and precision-recall curve and area under the curve of 0.57. Key factors influencing the likelihood of returning for oocyte use included patient age, presence of a partner, race or ethnicity, the clinic's geographic region and oocyte cryopreservation indication.</p><p><strong>Conclusions: </strong>This model demonstrated significant predictive accuracy, and is a valuable tool for patient counselling on oocyte cryopreservation. It helps to identify patients more likely to use stored oocytes, enhancing healthcare decision-making and the efficiency of gamete storage programmes. The model can be applied to self-financed and insurance-funded cycles.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"104432"},"PeriodicalIF":3.7,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between the ‘October 7th’ events and IVF outcomes in Israel?","authors":"Einav Kadour-Peero ,&nbsp;Chen Shkolnik ,&nbsp;Janan Jadon ,&nbsp;Rabea Bahous ,&nbsp;Yael Gonen ,&nbsp;Michal Silberman ,&nbsp;Ilan Calderon ,&nbsp;Hadar Avraham ,&nbsp;Samer Khoury","doi":"10.1016/j.rbmo.2024.104429","DOIUrl":"10.1016/j.rbmo.2024.104429","url":null,"abstract":"<div><h3>Research question</h3><div>Is there an association between the ‘October 7th’ 2023 events and IVF outcomes in Israel?</div></div><div><h3>Design</h3><div>in this retrospective cohort study the study group was women treated during the 4 weeks after ‘October 7th’, compared with a matched control group treated between 1 January 2021 and 6 October 2023. Each study group participant was matched with three separate control subjects of the same female age at oocyte retrieval, with a matching body mass index (BMI), IVF cycle number and ovarian reserve parameters.</div></div><div><h3>Results</h3><div>The study included 580 patients. The 145 women who underwent oocyte retrieval or frozen embryo transfer after 7 October 2023 were compared with 435 women treated before 7 October. The mean age of the study group was 35.6 ± 5.9 years, and the mean BMI 25.01 ± 5.60 kg/m². Pregnancy rates per embryo transfer were similar between the groups (22.4% versus 30.5%, <em>P = </em>0.28 in fresh cycles; 16.9% versus 27.1%, <em>P = </em>0.12 in frozen embryo transfers). Among women who underwent oocyte retrieval there were no differences in the ovarian stimulation protocols (<em>P = </em>0.95), number of oocytes retrieved (<em>P = </em>0.16) or number of fertilized oocytes (<em>P = </em>0.34). There was no difference in the rate of good-quality embryos between groups (<em>P = </em>0.053). Among women who underwent frozen embryo transfers, during the study period more patients had natural cycles (52.5% versus 24%, <em>P &lt;</em> 0.001), and there was no difference in maximal endometrial thickness before embryo transfer (<em>P = </em>0.33).</div></div><div><h3>Conclusions</h3><div>It appears that there is no association between the ‘October 7’ events and IVF outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104429"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/j.rbmo.2024.104387","DOIUrl":"10.1016/j.rbmo.2024.104387","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104387"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005765/pdfft?md5=92461ed509df46050cfb6d2566ea8249&pid=1-s2.0-S1472648324005765-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/j.rbmo.2024.104390","DOIUrl":"10.1016/j.rbmo.2024.104390","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104390"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005790/pdfft?md5=94dc6b2f0b555f4990c4a9aa564698fb&pid=1-s2.0-S1472648324005790-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/j.rbmo.2024.104388","DOIUrl":"10.1016/j.rbmo.2024.104388","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 3","pages":"Article 104388"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005777/pdfft?md5=023dec1cb9ac34d95dee21652856b1d8&pid=1-s2.0-S1472648324005777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture media with antioxidants improved preimplantation embryo development and clinical outcomes of patients of advanced age.","authors":"Shigetoshi Mizumoto, Yozo Nagao, Hitomi Watanabe, Keiko Tanaka, Takeshi Kuramoto","doi":"10.1016/j.rbmo.2024.104415","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104415","url":null,"abstract":"<p><strong>Research question: </strong>What are the clinical effects of using culture media supplemented with antioxidants (AOX) throughout the IVF process?</p><p><strong>Design: </strong>Prospective randomized single-centre study. Cumulus-oocyte complexes and semen samples collected from 127 treatment cycles were divided evenly between the study arm (culture media with AOX) and the control arm (culture media without AOX). The primary endpoint was the good-quality blastocyst (GQB) rate on day 5-6 per metaphase II (MII) oocyte.</p><p><strong>Results: </strong>Fertilization rate and day 5-6 blastocyst rate per MII oocyte differed significantly in favour of the study arm, whereas GQB rate did not. A subgroup analysis, stratified by maternal age, revealed significant improvements in the study arm for day 3 embryo development rate, day 5-6 blastocyst rate, GQB rate and blastocyst utilization rate for patients aged 35-40 years, while the impacts on these endpoints were much smaller in patients aged <35 years. Ninety-four single vitrified blastocyst transfers (SVBT) were performed in each arm. The blastocysts derived from the study arm showed better results of SVBT for patients aged 35-40 years, defined by embryo implantation rate, fetal heartbeat rate and live birth rate, whereas these variables did not differ significantly between the two arms when assessing the results for patients of all ages and patients aged <35 years.</p><p><strong>Conclusions: </strong>Embryo development and SVBT outcomes of treatment cycles of patients aged 35-40 years improved significantly when using AOX-supplemented culture media throughout the IVF process.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"104415"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted reproductive technologies in Latin America: the Latin American Registry, 2021.","authors":"Fernando Zegers-Hochschild, Javier A Crosby, Carolina Musri, Fanny Petermann-Rocha, Gustavo Martinez, Hitomi Nakagawa, Carlos Morente, Armando Roque, Ana Palma-Govea","doi":"10.1016/j.rbmo.2024.104413","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104413","url":null,"abstract":"<p><strong>Research question: </strong>What are the trends and impact of new technologies on the effectiveness and safety of assisted reproductive technology (ART) performed in Latin America during 2021?</p><p><strong>Design: </strong>This was a retrospective collection of cycle-based multinational data obtained from ART procedures performed by 204 accredited institutions in 16 countries.</p><p><strong>Results: </strong>In total 127,351initiated cycles resulted in 20,032 deliveries and 22,708 births. ART utilization showed great variability, from 623.5 cycles/million inhabitants in Uruguay to fewer than 35 in Guatemala and El Salvador. The proportion of women aged ≥40 years increased to 35.8%, while that of women ≤34 years dropped to 23.9%. Nonetheless, the proportion of single-embryo transfers (SET) increased from 11.9% in the previous decade to 42.4% in 2021. Of 22,708 babies born, 76.8% were singletons, 22.3% twins and 1.0% triplets or more. Intracytoplasmic sperm injection represented 84.5% of fertilization techniques, and blastocyst transfer increased from 49.6% in 2016 to 79.3% in 2021. The delivery rate after fresh blastocyst elective SET was significantly higher than after the transfer of one frozen embryo from a freeze-all cycle (P < 0.0001). The number of aspirations leading to preimplantation genetic testing has increased 2.8 times in 5 years and significantly increased delivery rates/transfer at all ages, including in oocyte donation (P ≤ 0.002), and reduced miscarriage in women ≥35 years old. In oocyte donation, delivery rates after the fresh transfer of embryos from vitrified-warmed oocyte cycles generated similar outcomes to frozen embryo transfer. Perinatal mortality increased from 7.7‰ in singletons to 21.3‰ in twins.</p><p><strong>Conclusion: </strong>The systematic collection of cycle-based multinational data contributes to cooperative sustained development and helps implement evidence-based reproductive decisions.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104413"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}