Reproductive biomedicine online最新文献_第3页

Response: Would surgical retrieval of product of conception for the purpose of genetic analysis increase the risk of intra uterine adhesions? 答复：为进行基因分析而手术取出受孕产物是否会增加宫腔内粘连的风险？

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-12 DOI: 10.1016/j.rbmo.2024.104446

William H. Kutteh, Melissa Maisenbacher, Elias M. Dahdouh

引用次数: 0

The First Lugano Workshop on the role of adenomyosis in ART.

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-12 DOI: 10.1016/j.rbmo.2024.104444

Mauro Cozzolino, Serdar Bulun, Dominique De Ziegler, Caterina Exacoustos, Human Fatemi, Juan Antonio Garcia-Velasco, Andrew Horne, Felice Petraglia, Pietro Santulli, Edgardo Somigliana, Kim Soorin, Thierry Van den Bosch, Paola Viganò, Peter Humaidan

{"title":"The First Lugano Workshop on the role of adenomyosis in ART.","authors":"Mauro Cozzolino, Serdar Bulun, Dominique De Ziegler, Caterina Exacoustos, Human Fatemi, Juan Antonio Garcia-Velasco, Andrew Horne, Felice Petraglia, Pietro Santulli, Edgardo Somigliana, Kim Soorin, Thierry Van den Bosch, Paola Viganò, Peter Humaidan","doi":"10.1016/j.rbmo.2024.104444","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104444","url":null,"abstract":"<p><p>Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical knowledge on the impact of adenomyosis on ART outcomes, the First Lugano Adenomyosis Workshop was a symposium involving experts in the field of adenomyosis, covering basic research, imaging, surgery and infertility to highlight current advances and future research areas over a wide range of topics related to adenomyosis. Adenomyosis is characterized by altered oestrogen and progesterone signalling pathways. Although the criteria of the Morphological Uterus Sonographic Assessment (MUSA) Consortium apply to patients with infertility, the presence of direct signs and localization in the different myometrial layers, particularly the inner myometrium, need more focus. In addition to the MUSA criteria, clinical symptoms and the magnitude of uterine enlargement should also be considered. Whilst pre-treatment with gonadotrophin-releasing hormone agonist with or without an aromatase inhibitor in frozen embryo transfer cycles seems promising, many issues related to therapy remain unanswered. During the Workshop, therapeutic progress over the past decades as well as novel insights were presented and discussed. The role of this opinion paper is to stimulate discussion and spark further interest in adenomyosis and the role of adenomyosis in infertility.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"104444"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover - Editorial Board 封底外页 - 编辑委员会

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-12 DOI: 10.1016/S1472-6483(24)00616-3

引用次数: 0

Inside Front Cover - Affiliations and First page of TOC 封面内页 - 隶属机构和目录首页

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-12 DOI: 10.1016/S1472-6483(24)00606-0

引用次数: 0

Would surgical retrieval of product of conception for the purpose of genetic analysis increase the risk of intrauterine adhesions? 为进行基因分析而手术取出受孕产物是否会增加宫内粘连的风险？

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-11 DOI: 10.1016/j.rbmo.2024.104445

Lionel Reyftmann

引用次数: 0

A biomimetic sperm selection device for routine sperm selection.

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-11 DOI: 10.1016/j.rbmo.2024.104433

Steven A Vasilescu, Dale M Goss, Kathryn H Gurner, Rebecca L Kelley, Maria Mazi, Fabrice K De Bond, Jennifer Lorimer, Fabrizzio Horta, Farin Y Parast, David K Gardner, Reza Nosrati, Majid E Warkiani

{"title":"A biomimetic sperm selection device for routine sperm selection.","authors":"Steven A Vasilescu, Dale M Goss, Kathryn H Gurner, Rebecca L Kelley, Maria Mazi, Fabrice K De Bond, Jennifer Lorimer, Fabrizzio Horta, Farin Y Parast, David K Gardner, Reza Nosrati, Majid E Warkiani","doi":"10.1016/j.rbmo.2024.104433","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104433","url":null,"abstract":"<p><strong>Research question: </strong>Can a biomimetic microfluidic sperm sorter isolate motile sperm while minimizing DNA damage in comparison with density gradient centrifugation (DGC)?</p><p><strong>Design: </strong>This was a two-phase study of 61 men, consisting of a proof-of-concept study with 21 donated semen samples in a university research laboratory, followed by a diagnostic andrology study with 40 consenting patients who presented at a fertility clinic for semen diagnostics. Each sample was split to perform DGC and microfluidic sperm selection (one-step sperm selection with 15 min of incubation) side-by-side. Outcomes evaluated included concentration, progressive motility, and DNA fragmentation index (DFI) of raw semen, and sperm isolated using DGC and the microfluidic device. Results were analysed using Friedman's test for non-parametric data (significant when P < 0.05). DFI values were assessed by sperm chromatin dispersion assay.</p><p><strong>Results: </strong>Sperm isolated using DGC and the microfluidic device showed improved DFI values and motility compared with the raw semen sample in both cohorts. However, the microfluidic device was significantly better than DGC at reducing DFI values in both the proof-of-concept study (P = 0.012) and the diagnostic andrology study (P < 0.001). Progressive motility was significantly higher for sperm isolated using the microfluidic device in the proof-of-concept study (P = 0.0061) but not the diagnostic andrology study. Sperm concentration was significantly lower for samples isolated using the microfluidic device compared with DGC for both cohorts (P < 0.001).</p><p><strong>Conclusions: </strong>Channel-based biomimetic sperm selection can passively select motile sperm with low DNA fragmentation. When compared with DGC, this method isolates fewer sperm but with a higher proportion of progressively motile cells and greater DNA integrity.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"104433"},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Vitamin D receptor gene polymorphisms (FokI, ApaI, TaqI), metabolic features and susceptibility to polycystic ovary syndrome: a preliminary single center case-control study 维生素 D 受体基因多态性（FokI、ApaI、TaqI）、代谢特征与多囊卵巢综合征易感性的关系：一项初步的单中心病例对照研究

IF 4 2区医学

Reproductive biomedicine online Pub Date : 2024-09-08 DOI: 10.1016/j.rbmo.2024.104447

Talida Vulcan, Iancu Mihaela, Lucia Maria Procopciuc, Tudor Sergiu Suciu, Gabriela Adriana Filip

{"title":"Association of Vitamin D receptor gene polymorphisms (FokI, ApaI, TaqI), metabolic features and susceptibility to polycystic ovary syndrome: a preliminary single center case-control study","authors":"Talida Vulcan, Iancu Mihaela, Lucia Maria Procopciuc, Tudor Sergiu Suciu, Gabriela Adriana Filip","doi":"10.1016/j.rbmo.2024.104447","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104447","url":null,"abstract":"Are the combined genotypes and haplotypes of VDR gene polymorphisms () associated with PCOS susceptibility and metabolic features of the disease? We performed a case-control study, including 46 women with PCOS and 48 controls. Genotypes of VDR genes were determined using the PCR-RFLP (restriction fragment length polymorphism) method. In all women, the waist circumference, parameters of lipid and glucose metabolism were evaluated. PCOS group presented higher waist circumference and visceral adiposity index (VAI) levels compared to controls. Total cholesterol, LDL-C and triglycerides had higher values in PCOS women. VDR- C/C (F/F) genotype had significantly higher odds of PCOS (adjusted OR = 6.27, 95% CI: 1.53-25.65). VDR- was associated with susceptibility to PCOS in the dominant model, the variant genotype (A/C-A/A) (A/a- a/a) had higher odds of PCOS than the wild genotype C/C (A/A) (adjusted OR = 3.15, 95% CI: 1.07-9.32). Haplotype analysis revealed that T-C- T (f-A-T) haplotype was statistically associated with lower odds of PCOS (adjusted OR = 0.10, 95% CI: 0.01-0.95). PCOS women with VDR-Fokl T/T (f/f) genotype had lower fasting glucose and higher VAI levels compared to C/T (Ff) or C/C (F/F) genotype. The present findings suggest the association between and polymorphisms and PCOS susceptibility. Moreover, T/T (f/f) genotype of VDR- could be a marker of decreased fasting glucose in PCOS. polymorphism did not reveal a relationship with PCOS susceptibility in our study population.","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"8 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian tissue cryopreservation in breast cancer patients: glass half empty or glass half full? 乳腺癌患者的卵巢组织冷冻：半杯空还是半杯满？

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-06 DOI: 10.1016/j.rbmo.2024.104442

Claus Y. Andersen , Jacques Donnez , Erik Ernst , Debbie Gook , Antonio Pellicer , Michael Von Wolff , Nao Suzuki , Christophe Roux , Marie-Madeleine Dolmans

引用次数: 0

Machine learning tool for predicting mature oocyte yield and trigger day from start of stimulation: towards personalized treatment.

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-04 DOI: 10.1016/j.rbmo.2024.104441

Akhil Garg, Jose Bellver, Ernesto Bosch, José Alejandro Remohí, Antonio Pellicer, Marcos Meseguer

{"title":"Machine learning tool for predicting mature oocyte yield and trigger day from start of stimulation: towards personalized treatment.","authors":"Akhil Garg, Jose Bellver, Ernesto Bosch, José Alejandro Remohí, Antonio Pellicer, Marcos Meseguer","doi":"10.1016/j.rbmo.2024.104441","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104441","url":null,"abstract":"<p><strong>Research question: </strong>Can machine learning tools predict the number of metaphase II (MII) oocytes and trigger day at the start of the ovarian stimulation cycle?</p><p><strong>Design: </strong>A multicentre, retrospective study including 56,490 ovarian stimulation cycles (primary dataset) was carried out between 2020 and 2022 for analysis and feature selection. Of these, 13,090 were used to develop machine learning models for trigger day and the number of MII prediction, and another 5103 ovarian stimulation cycles (clinical validation dataset) from 2023 for clinical validation. Machine learning algorithms using deep learning were developed using optimal features from the primary dataset based on correlation.</p><p><strong>Results: </strong>A tool with two novel progressive machine learning algorithms using deep learning was able to predict the trigger day and number of MII oocytes: mean absolute error 1.60 (95% CI 1.56 to 1.64) and 3.75 (95% CI 3.65 to 3.86), respectively. The R<sup>2</sup> value for the algorithm to predict the number of MII in the interquartile (Q3-Q1/P75-P25) range was 0.88; the entire dataset was 0.70 after removing the outliers at the planning phase of the stimulation cycle, which shows high accuracy. The interquartile root mean square error was 1.10 and 0.66 for the trigger day and the number of oocytes algorithm, respectively.</p><p><strong>Conclusion: </strong>The tool using deep learning algorithms has high prediction power for trigger day and number of MII outcomes, and can be retrieved from patients at the start of the ovarian stimulation cycle; however, inclusion of more data and validation from different clinics are needed.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"104441"},"PeriodicalIF":3.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive outcomes of high-intensity focused ultrasound ablation and myomectomy for uterine fibroids: a systematic review and meta-analysis

IF 3.7 2区医学

Reproductive biomedicine online Pub Date : 2024-09-03 DOI: 10.1016/j.rbmo.2024.104436

Yishan Chen , Jingsong Yi , Shunhe Lin , Xi Xie , Xishi Liu , Sun-Wei Guo

{"title":"Reproductive outcomes of high-intensity focused ultrasound ablation and myomectomy for uterine fibroids: a systematic review and meta-analysis","authors":"Yishan Chen , Jingsong Yi , Shunhe Lin , Xi Xie , Xishi Liu , Sun-Wei Guo","doi":"10.1016/j.rbmo.2024.104436","DOIUrl":"10.1016/j.rbmo.2024.104436","url":null,"abstract":"<div><h3>Research question</h3><div>Does high-intensity focused ultrasound (HIFU) ablation have comparable reproductive outcomes to myomectomy for patients with uterine fibroids?</div></div><div><h3>Design</h3><div>A systematic review and a meta-analysis of data extracted from published studies up to March 2024.</div></div><div><h3>Results</h3><div>Through a more structured analysis, HIFU treatment yielded a pooled pregnancy rate of 23.3% (95% CI 11.5 to 37.6%) and a pooled live birth rate (LBR) of 17.3% (95% CI 7.8 to 29.3%), significantly lower than those after myomectomy, which had a pooled pregnancy rate of 56.9% (95% CI 45.6 to 67.9%) and a pooled LBR of 44.1% (95% CI 34.9 to 53.4%) (<em>P</em> = 0.0001 and <em>P</em> = 0.0003, respectively). After controlling for patient age, ultrasound-guided HIFU studies reported significantly lower pregnancy rate and LBR compared with myomectomy. Moreover, studies enrolling younger patients and explicitly recruiting those desiring to conceive reported better reproductive outcomes.</div></div><div><h3>Conclusions</h3><div>Patients with uterine fibroids undergoing HIFU treatment and desiring to preserve their uteri resulted in poorer reproductive outcomes compared with myomectomy. Although uterine fibroids are now the number one disease that receives HIFU treatment worldwide, the overall quality in design and execution of HIFU studies on reproductive outcomes for women with uterine fibroids leaves much room for improvement. Above all, comparative trials against the standard of care are badly needed.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104436"},"PeriodicalIF":3.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0