Reproductive biomedicine online最新文献

{"title":"Do directed and non-directed oocyte donors differ regarding their motives, ambivalence, satisfaction and openness about donating?","authors":"Emilia Thorup ,&nbsp;Gunilla Sydsjö ,&nbsp;Agneta Skoog Svanberg ,&nbsp;Claudia Lampic","doi":"10.1016/j.rbmo.2024.104455","DOIUrl":"10.1016/j.rbmo.2024.104455","url":null,"abstract":"<div><h3>Research question</h3><div>Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness?</div></div><div><h3>Design</h3><div>The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-year period (2005–2008). The participants of the current study were 16 women who donated oocytes to family members or friends (directed donation) and 123 women who donated to unknown recipients (non-directed donation). Survey data on motivation, ambivalence, post-donation satisfaction and openness were collected at five time points between acceptance as a donor and 14–17 years post-donation. Statistical group comparisons and longitudinal analyses were conducted.</div></div><div><h3>Results</h3><div>In contrast to non-directed donors, who reported general altruism as their main motivation, directed donors were primarily motivated by empathy with the recipients. Pre-donation ambivalence was present in a quarter of donors and did not differ between groups (<em>P</em> = 0.601). Post-donation satisfaction was similar between groups (<em>P</em> = 0.17) and stable over time (<em>P</em> = 0.37). One directed donor reported regretting her donation, and this was attributed to negative relations with the recipients. Donors from both groups were generally open about having donated, but some directed donors felt restricted by the recipients’ wishes.</div></div><div><h3>Conclusions</h3><div>Despite being differently motivated, the current findings suggest that directed oocyte donors are comparable to non-directed oocyte donors in terms of pre-donation ambivalence and post-donation satisfaction and openness. The findings also highlight how directed donation may be associated with specific challenges, which emphasizes the need for pre- and post-donation counselling.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104455"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(25)00017-3","DOIUrl":"10.1016/S1472-6483(25)00017-3","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104810"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision-making in women who considered planned oocyte cryopreservation: decision satisfaction or regret?","authors":"A. Korkidakis ,&nbsp;S. Martinez ,&nbsp;R. Sabbagh ,&nbsp;Q. Heyward ,&nbsp;D. Sakkas ,&nbsp;A. Domar ,&nbsp;T.L. Toth","doi":"10.1016/j.rbmo.2024.103944","DOIUrl":"10.1016/j.rbmo.2024.103944","url":null,"abstract":"<div><h3>Research question</h3><div>Among women who considered planned oocyte cryopreservation, does decision regret differ between those who pursued planned oocyte cryopreservation and those who did not?</div></div><div><h3>Design</h3><div>A survey was e-mailed to all women who presented for an initial consultation for planned oocyte cryopreservation between January 2016 and December 2021 using a secure REDCap platform. The survey comprised questions on demographics, reproductive planning and the validated Decision Regret Scale (DRS). Univariable and multivariable models were fitted to compare decision regret in the group who had proceeded with planned oocyte cryopreservation with the group who had not. A sentiment analysis was employed to characterize the emotional tone of respondents.</div></div><div><h3>Results</h3><div>In total, 338 respondents met the eligibility criteria. Of these, 178 (52.7%) patients had proceeded with planned oocyte cryopreservation and 160 (47.3%) had not. The groups were similar in age, race, ethnicity and education. Respondents who had proceeded with planned oocyte cryopreservation were more likely to be single, to anticipate starting a family at ≥39 years of age, and to consider the use of donor spermatozoa to be an acceptable option. Respondents who had not proceeded with planned oocyte cryopreservation more frequently reported starting attempts at conception since their consultation. A higher proportion of respondents who had not undergone planned oocyte cryopreservation experienced moderate-to-severe regret with their decision compared with respondents who had undergone at least one cycle of planned oocyte cryopreservation (50% versus 13%; <em>P</em> &lt; 0.001). There was a correlation between decreasing number of cryopreserved oocytes and increasing DRS score (<em>R</em> = -0.41, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Women who consider planned oocyte cryopreservation but do not proceed with it experience substantial decision regret. The DRS score was highest among respondents who had not proceeded with planned oocyte cryopreservation, and respondents who had undergone at least one cycle of planned oocyte cryopreservation that resulted in a low number of cryopreserved oocytes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 103944"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation before sterilizing treatment: cryopreservation of both ovaries to restore endocrine and reproductive functions","authors":"Catherine Poirot ,&nbsp;Nicolas Foureur ,&nbsp;Claudine Esper ,&nbsp;Marie-Madeleine Dolmans","doi":"10.1016/j.rbmo.2024.104472","DOIUrl":"10.1016/j.rbmo.2024.104472","url":null,"abstract":"<div><div>Ovarian cortex cryopreservation is now a validated fertility preservation technique. Autotransplantation of this tissue allows restoration of ovarian hormone function in more than 90% of patients, and birth of at least one child in 30% of transplanted women. In the case of very highly gonadotoxic treatments, it is recommended that ovarian cortex be cryopreserved as first-line therapy to safeguard future fertility. However, the ovary left in place runs a very high risk of being significantly altered. This raises the question of harvesting both ovaries, looking to restore fertility as well as endocrine function. Indeed, hormone balance in these cancer survivors may be recovered naturally for their entire lifetime. Autotransplantation could also be performed to restore hormone function in women with no wish to have children, with the sole purpose of improving their quality of life. Ethical and legal challenges exist and are discussed in this paper, but they do not constitute an argument against it. Clinical trials investigating this strategy are clearly needed, but this approach truly offers women the chance of having both endocrine and reproductive functions restored and maintained throughout their entire life.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104472"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oocyte yield and live birth rate after follitropin delta dosing and fresh embryo transfer: an individual patient data meta-analysis","authors":"Rita Lobo ,&nbsp;Ali Falahati ,&nbsp;Kelle Moley ,&nbsp;Anja Pinborg ,&nbsp;Samuel Santos-Ribeiro ,&nbsp;Nick S. Macklon ,&nbsp;Ida E. Jepsen","doi":"10.1016/j.rbmo.2024.104451","DOIUrl":"10.1016/j.rbmo.2024.104451","url":null,"abstract":"<div><h3>Research question</h3><div>What number of retrieved oocytes is associated with the optimum chance of achieving a live birth for women undergoing ovarian stimulation with individualized follitropin delta?</div></div><div><h3>Design</h3><div>An individual patient data meta-analysis was performed on 1772 patients from five randomized controlled trials using individualized follitropin delta for ovarian stimulation with fixed daily dosing based on serum anti-Müllerian hormone (AMH) level and body weight. Live birth rate (LBR) and ovarian hyperstimulation syndrome (OHSS) were evaluated in relation to the number of oocytes retrieved. Predicted LBR was obtained using a logistic regression analysis with fractional polynomials. Subgroup analyses were performed based on number of oocytes retrieved, age and AMH level.</div></div><div><h3>Results</h3><div>The analysis included patients treated with follitropin delta who had at least one oocyte retrieved. The mean number of oocytes retrieved was 10.4, and overall LBR was 32.1%. Predicted LBR increased with the number of oocytes retrieved, reaching &gt;34% for patients with 8-14 oocytes retrieved, and peaking at 34.9% for patients with 11 oocytes retrieved. LBR declined gradually beyond retrieval of 14 oocytes. LBR was 27.8%, 33.6% and 30.9% for patients with 1-7, 8-14, and ≥15 oocytes retrieved, respectively. LBR decreased with increasing age: 32.7%, 30.7% and 23.4% at &lt;35, 35–37 and 38–42 years, respectively. The incidence of OHSS (any grade) was 2.1%, 5.2% and 17.0% for patients with 1-7, 8-14, and ≥15 oocytes retrieved, respectively.</div></div><div><h3>Conclusions</h3><div>After ovarian stimulation with individualized follitropin delta, LBR in fresh transfer cycles was highest for patients with 8-14 oocytes retrieved, and peaked in patients with 11 oocytes retrieved. The results support the appropriateness of the follitropin delta dosing algorithm.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104451"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/S1472-6483(25)00018-5","DOIUrl":"10.1016/S1472-6483(25)00018-5","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104811"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Successful live birth in women with partial 17α-hydroxylase deficiency: report of two cases' [Reproductive BioMedicine Online (2024) Volume 49, Issue 2, 103855].","authors":"Xiaofang Du, Qi Jia, Sheling Wu, Bijun Wang, Yichun Guan","doi":"10.1016/j.rbmo.2024.104780","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104780","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104780"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of vitamin D receptor gene polymorphisms, metabolic features and susceptibility to polycystic ovary syndrome: a preliminary study","authors":"Talida Vulcan,&nbsp;Mihaela Iancu,&nbsp;Lucia Maria Procopciuc,&nbsp;Tudor Sergiu Suciu,&nbsp;Gabriela Adriana Filip","doi":"10.1016/j.rbmo.2024.104447","DOIUrl":"10.1016/j.rbmo.2024.104447","url":null,"abstract":"<div><h3>Research question</h3><div>Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (<em>FokI, ApaI</em> and <em>TaqI</em>) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?</div></div><div><h3>Design</h3><div>This case–control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction–restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.</div></div><div><h3>Results</h3><div>Women in the PCOS group had a larger waist circumference (<em>P</em> = 0.0383) and a higher visceral adiposity index (VAI) (<em>P</em> &lt; 0.0001) compared with controls. Total cholesterol (<em>P</em> &lt; 0.0001), high-density lipoprotein cholesterol (<em>P</em> = 0.00001) and triglyceride (<em>P</em> &lt; 0.0001) concentrations were higher in the PCOS group. The VDR-<em>FokI</em> C/C (F/F) genotype was associated with significantly higher odds of PCOS (adjusted OR 6.27, 95% CI 1.53–25.65). The VDR-<em>ApaI</em> genotype was associated with susceptibility to PCOS in the dominant model; the variant genotypes [A/C + A/A (A/a + a/a)] had higher odds of PCOS than the wild genotype [C/C (A/A)] (adjusted OR 3.15, 95% CI 1.07–9.32). Haplotype analysis revealed that the T-C-T (f-A-T) haplotype was significantly associated with lower odds of PCOS (adjusted OR 0.10, 95% CI 0.01–0.95). Women with PCOS carrying the VDR-<em>FokI</em> T/T (f/f) genotype had lower fasting glucose (<em>P</em> = 0.0469) and higher VAI (<em>P</em> = 0.0406) compared with women with the C/T (Ff) + C/C (F/F) genotype.</div></div><div><h3>Conclusion</h3><div>The present findings suggest an association between <em>FokI</em> and <em>ApaI</em> polymorphisms and PCOS susceptibility. Moreover, the VDR-<em>FokI</em> T/T (f/f) genotype could be a marker for decreased fasting glucose in women with PCOS. No association was found between the <em>TaqI</em> polymorphism and PCOS susceptibility in the study population.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104447"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legal framework and IVF outcomes: a comparative analysis of fresh and frozen embryo transfers in Switzerland","authors":"Janna Pape ,&nbsp;Jérémy Levy ,&nbsp;Sofia Makieva ,&nbsp;Michael von Wolff","doi":"10.1016/j.rbmo.2024.104483","DOIUrl":"10.1016/j.rbmo.2024.104483","url":null,"abstract":"<div><h3>Research question</h3><div>To what extent do legislative measures impact standard reproductive outcome parameters?</div></div><div><h3>Design</h3><div>Retrospective cohort study using data from the Swiss national IVF registry analysing the outcomes of 13,908 women undergoing embryo transfers resulting from their first lifetime oocyte retrieval before (2014–2016) or after (2020–2022) revision of the legislation, allowing extended culture for 12 zygotes. Live birth rates (LBR) and cumulative LBR (cLBR) were compared in fresh and frozen embryo transfer strategies in both periods. Adjusted multivariable mixed model analyses were performed to determine OR and incidence rate ratios (IRR).</div></div><div><h3>Results</h3><div>Before revision of the legislation, LBR was higher for fresh embryo transfers compared with frozen embryo transfers (27.2% versus 22.7%; <em>P</em> = 0.006). After revision of the legislation, LBR was lower for fresh embryo transfers (29.3% versus 36.3%; <em>P</em> &lt; 0.001), and cLBR was higher for the freeze-all embryo transfer strategy (59.0% versus 39.8%; <em>P</em> &lt; 0.001). However, in a multivariable analysis, no difference in the odds of live birth was found between fresh and frozen embryo transfers (OR = 1.08, 95% CI 0.95–1.22), and the freeze-all embryo transfer strategy was not found to be more effective than the fresh embryo transfer strategy (IRR = 1.12, 95% CI 0.98–1.27). In a subgroup analysis, fresh blastocyst embryo transfers showed higher LBR than cleavage stage embryo transfers (OR = 2.01, 95% CI 1.62–2.49).</div></div><div><h3>Conclusion</h3><div>The change in national legislation provided the unique opportunity to evaluate the legal impact on reproductive outcomes. Besides a reduction in the number of multiple births, LBR in frozen embryo transfers improved, resulting in comparable success of fresh and frozen embryo transfer strategies. In addition to technological improvement, the legal framework influences the evolution of clinical practice, thereby contributing to enhanced reproductive outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104483"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(25)00028-8","DOIUrl":"10.1016/S1472-6483(25)00028-8","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104821"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}