Reproductive biomedicine online最新文献

Front Matter - Continued TOC 正面物质-继续TOC

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-05-01 Epub Date: 2026-04-30 DOI: 10.1016/S1472-6483(26)00248-8

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Inside Front Cover - Affiliations and First page of TOC 内部封面-附属机构和第一页的TOC

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-05-01 Epub Date: 2026-04-30 DOI: 10.1016/S1472-6483(26)00247-6

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Outside Back Cover - Editorial Board 封底外-编辑委员会

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-05-01 Epub Date: 2026-04-30 DOI: 10.1016/S1472-6483(26)00252-X

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AI-driven paradigm shift in follicle ultrasound monitoring: from automated segmentation to clinical decision support 人工智能驱动的卵泡超声监测范式转变：从自动分割到临床决策支持。

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.1016/j.rbmo.2025.105440

Chenke Kuang , Zichao Liu , Yiyang Huang , Yaocheng Xiao , Meng Du , Zhiyi Chen

{"title":"AI-driven paradigm shift in follicle ultrasound monitoring: from automated segmentation to clinical decision support","authors":"Chenke Kuang , Zichao Liu , Yiyang Huang , Yaocheng Xiao , Meng Du , Zhiyi Chen","doi":"10.1016/j.rbmo.2025.105440","DOIUrl":"10.1016/j.rbmo.2025.105440","url":null,"abstract":"<div><div>This commentary delineates the developmental pathway of artificial intelligence (AI) in ultrasound follicular monitoring, highlighting a paradigm shift from automated segmentation to clinical decision support. The deep learning-based CR-Unet and C-Rend models have enabled accurate follicle segmentation and measurement from two-dimensional to three-dimensional imaging, substantially improving boundary segmentation accuracy and measurement consistency. Building on this foundation, the study further establishes two-dimensional follicle area and three-dimensional follicle volume as novel biomarkers, providing quantitative criteria for predicting oocyte maturity and optimizing the timing of human chorionic gonadotrophin triggering. Through seamless integration of algorithms into the Acclarix LXK9 ultrasonography equipment, an intelligent monitoring platform with real-time analytical capabilities has been developed, demonstrating significantly superior measurement accuracy and consistency compared with manual operations. These advancements represent a transformative leap from image segmentation to AI-driven clinical decision making, offering robust technical support for standardized and precise management in assisted reproduction.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 5","pages":"Article 105440"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Risk of placenta accreta spectrum in fresh versus natural, stimulated and programmed cycle frozen-thawed embryo transfer 新鲜与自然、刺激和程序化周期冻融胚胎移植中胎盘增生谱的风险。

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-05-01 Epub Date: 2025-11-15 DOI: 10.1016/j.rbmo.2025.105410

Tomoyuki Fujita , Toshiyuki Yoshizato , Kenta Murotani , Hitoshi Obara , Naotake Tsuda

{"title":"Risk of placenta accreta spectrum in fresh versus natural, stimulated and programmed cycle frozen-thawed embryo transfer","authors":"Tomoyuki Fujita , Toshiyuki Yoshizato , Kenta Murotani , Hitoshi Obara , Naotake Tsuda","doi":"10.1016/j.rbmo.2025.105410","DOIUrl":"10.1016/j.rbmo.2025.105410","url":null,"abstract":"<div><div><strong>Research question:</strong> How does the risk of placenta accreta spectrum (PAS) in pregnancies from natural cycle (NC-FET), stimulated cycle (SC-FET) and programmed cycle (PC-FET) frozen-thawed embryo transfers compare with that in fresh embryo transfer?</div><div><strong>Design:</strong> A total of 174,591 embryo transfer cycles resulting in singleton live births were obtained from the Japanese assisted reproductive technology (ART) registry from 2017 to 2020. A multivariate logistic regression model compared the risk of PAS across different embryo transfer methods. Adjusted factors were maternal age at embryo transfer, indication for ART, number and stage of embryos transferred, use of assisted hatching, presence of placenta praevia and mode of delivery.</div><div><strong>Results:</strong> The incidence of PAS was 0.16% (39/23,827), 0.17% (66/37,787), 0.14% (11/8,143) and 1.48% (1,549/104,834) for fresh embryo transfer, NC-FET, SC-FET and PC-FET, respectively. PC-FET carried a higher risk of PAS versus fresh embryo transfer (adjusted odds ratio [aOR] 9.12, 95% confidence interval [CI] 6.54–12.73), whereas there was no significantly increased risk with NC-FET and SC-FET. Subgroup analyses revealed that, for single cleavage-stage embryo transfer, PC-FET was associated with a higher risk of PAS versus fresh embryo transfer (aOR 11.19, 95% CI 6.55–19.11). NC-FET and SC-FET showed no significantly increased risk. For single-blastocyst transfer, PC-FET carried a higher risk of PAS versus fresh embryo transfer (aOR 5.44, 95% CI 3.26–9.09), whereas NC-FET and SC-FET had a similar risk to fresh embryo transfer.</div><div><strong>Conclusions:</strong> PC-FET carried a higher risk of PAS than fresh embryo transfer, while NC-FET and SC-FET did not. When planning embryo transfer reproductive physicians should recognize that PC-FET is a potential risk factor for PAS.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 5","pages":"Article 105410"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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UK Guidelines for the Medical and Laboratory Procurement and Use of Sperm, Egg and Embryo Donors (2025): Association of Reproductive and Clinical Scientists, British Fertility Society, British Association for Sexual Health and HIV, British HIV Association. 《联合王国医疗和实验室采购和使用精子、卵子和胚胎捐赠者准则》（2025年）：生殖和临床科学家协会、英国生育学会、英国性健康和艾滋病毒协会、英国艾滋病毒协会。

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-04-28 DOI: 10.1016/j.rbmo.2026.105524

Sarah Martins da Silva, Helen Clarke, Marta Jansa Perez, Nicola E Mackie, Tristan J Barber, Jackson C Kirkman-Brown

{"title":"UK Guidelines for the Medical and Laboratory Procurement and Use of Sperm, Egg and Embryo Donors (2025): Association of Reproductive and Clinical Scientists, British Fertility Society, British Association for Sexual Health and HIV, British HIV Association.","authors":"Sarah Martins da Silva, Helen Clarke, Marta Jansa Perez, Nicola E Mackie, Tristan J Barber, Jackson C Kirkman-Brown","doi":"10.1016/j.rbmo.2026.105524","DOIUrl":"https://doi.org/10.1016/j.rbmo.2026.105524","url":null,"abstract":"<p><p>These guidelines replace the previous (2019) UK guidelines for the medical and laboratory screening of sperm, egg and embryo donors and were achieved by a joint working group composed of representatives from the Association of Reproductive and Clinical Scientists (ARCS), the British Fertility Society (BFS), the British Association for Sexual Health and HIV (BASHH) and the British HIV Association (BHIVA), with review and comments from their respective memberships. It was written to guide best practice in clinics but is not intended as a tool to judge the practice of centres within the UK or beyond. Guidance on core information that should be supplied to all parties involved in donation is provided. Screening tests and standards required are summarized, as are specific considerations for known donation and embryo donation. The assessment of genetic risk and heritable disorders has been fundamentally reviewed in light of technological advances. Extended carrier screening is also discussed, although we do not suggest that this is routinely performed.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"105524"},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Inside Front Cover - Affiliations and First page of TOC 内部封面-附属机构和第一页的TOC

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-04-01 Epub Date: 2026-04-17 DOI: 10.1016/S1472-6483(26)00220-8

引用次数: 0

Front Matter - Continued TOC 正面物质-继续TOC

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-04-01 Epub Date: 2026-04-17 DOI: 10.1016/S1472-6483(26)00221-X

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Response to: Is the eternal dilemma dependent on embryo number? 回答：永恒的困境是否取决于胚胎数量？

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1016/j.rbmo.2026.105635

Alessandro Bartolacci , Sofia de Girolamo , Juan J. Fraire-Zamora , Luca Pagliardini , Enrico Papaleo

引用次数: 0

Evaluating the concordance between AI-based and conventional embryo selection: implications for clinical decision-making 评估人工智能与传统胚胎选择的一致性：对临床决策的影响。

IF 3.5 2区医学

Reproductive biomedicine online Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.rbmo.2026.105502

Piotr Wygocki , Tomasz Gilewicz , Paweł Pawlik , Michał Siennicki , Michał Brzozowski , Joanna Kuśmierczyk-Kubiak , Urszula Sankowska , Robert Milewski , Agnieszka Chmielowska , Marta Kordalewska , Małgorzata Różańska , Waldemar Kuczyński , Bartłomiej Wojtasik , Piotr Sankowski , Juergen Liebermann

{"title":"Evaluating the concordance between AI-based and conventional embryo selection: implications for clinical decision-making","authors":"Piotr Wygocki , Tomasz Gilewicz , Paweł Pawlik , Michał Siennicki , Michał Brzozowski , Joanna Kuśmierczyk-Kubiak , Urszula Sankowska , Robert Milewski , Agnieszka Chmielowska , Marta Kordalewska , Małgorzata Różańska , Waldemar Kuczyński , Bartłomiej Wojtasik , Piotr Sankowski , Juergen Liebermann","doi":"10.1016/j.rbmo.2026.105502","DOIUrl":"10.1016/j.rbmo.2026.105502","url":null,"abstract":"<div><h3>Research question</h3><div>Can artificial intelligence (AI) standardize embryo scoring, and help embryologists to identify embryos with the highest likelihood of pregnancy and live birth?</div></div><div><h3>Design</h3><div>Multicentre, retrospective, head-to-head analysis across six centres in five countries. An embryo selection algorithm (ESA) and 20 embryologists of varying seniority independently selected the implanting (i.e. ‘best’) embryo from 1681 pairs (1237 pairs with biochemical pregnancy; 444 pairs with live births), with each pair comprising one embryo with a positive outcome and one embryo with a negative outcome. Accuracy was computed for the ESA and for the embryologists; differences were assessed using McNemar’s test.</div></div><div><h3>Results</h3><div>The accuracy of the ESA was 70.1%. The accuracy of individual embryologists ranged from 64.2% to 68.9% (mean value for embryologists 67.7%), and the accuracy of the expert committee (i.e. majority vote across the 20 embryologists) was 69.5%. McNemar’s test indicated a significant advantage for the ESA compared with 14 of 20 embryologists, and the mean value for embryologists (<em>P</em> < 0.05), but no significant difference between the ESA and the remaining six embryologists or the expert committee.</div></div><div><h3>Conclusions</h3><div>The ESA achieved higher accuracy than most individual embryologists and the mean value for embryologists, supporting its potential as a standardized adjunct to expert judgement. Confirmation of effectiveness and generalizability requires adequately powered, prospective multicentre trials.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 4","pages":"Article 105502"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0