Reproductive biomedicine online最新文献

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/S1472-6483(25)00344-X","DOIUrl":"10.1016/S1472-6483(25)00344-X","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 2","pages":"Article 105137"},"PeriodicalIF":3.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(25)00343-8","DOIUrl":"10.1016/S1472-6483(25)00343-8","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 2","pages":"Article 105136"},"PeriodicalIF":3.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(25)00346-3","DOIUrl":"10.1016/S1472-6483(25)00346-3","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 2","pages":"Article 105139"},"PeriodicalIF":3.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'The kids (and adults) are alright:' what can we learn from donor-conceived families that thrive?","authors":"Joanna E Scheib, Sonja Mackenzie","doi":"10.1016/j.rbmo.2025.105132","DOIUrl":"https://doi.org/10.1016/j.rbmo.2025.105132","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"105132"},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(25)00307-4","DOIUrl":"10.1016/S1472-6483(25)00307-4","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 105100"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/S1472-6483(25)00295-0","DOIUrl":"10.1016/S1472-6483(25)00295-0","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 105088"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding embryo development: the effect of clinical variables in morphokinetics and artificial intelligence quality scoring","authors":"Jorge Ten ,&nbsp;M. Carmen Tio ,&nbsp;Pedro Pini ,&nbsp;Korey Kelley ,&nbsp;Jaime Guerrrero ,&nbsp;Adoración Rodríguez-Arnedo ,&nbsp;Alexa Zepeda ,&nbsp;Alex Mutter ,&nbsp;Nerea Diaz ,&nbsp;Miguel Herreros ,&nbsp;Tom Latin ,&nbsp;Adriana Brualla ,&nbsp;Cristina Hickman ,&nbsp;Andrea Bernabeu ,&nbsp;Rafael Bernabeu ,&nbsp;Klaus Wiemer","doi":"10.1016/j.rbmo.2025.104866","DOIUrl":"10.1016/j.rbmo.2025.104866","url":null,"abstract":"<div><h3>Research question</h3><div>Do morphokinetic events (MKS) and patient parameters affect resulting embryo quality scores, and how does this relate to pregnancy outcomes as assessed by a time-lapse incubator using an artificial intelligence (AI) embryologist support tool?</div></div><div><h3>Design</h3><div>Retrospective study analysing data from 6024 embryos retrieved over 1636 cycles. The dataset comprised 3778 donor oocytes and 2246 autologous oocytes. Additionally, 3309 biopsied embryos were included in the PGT-A analysis. Outcome data were derived from 1355 transferred embryos. All embryos were assessed using a time lapse-based AI system (CHLOE EQ™), which assigns an embryo quality score from 0 to 1 based upon established morphokinetic benchmarks. The AI embryo quality score was assigned on day 5 of embryo development. Analysed patient parameters were patient age, fresh or frozen oocyte status and use of own or donor oocytes. Twenty-three MKS were analysed. The effect of morphokinetics on the incidence of ploidy was also assessed.</div></div><div><h3>Results</h3><div>Clinical outcomes are affected by embryo quality and MKS as detected by an AI software. Time to expanded blastocyst (tEB) was the morphokinetic parameter with the strongest correlation coefficient with embryo quality score (–0.816). As the patient's age increases by 1 unit, embryo quality score decreases significantly and time to achieve expanded blastocyst increases by 0.47 h. Similar trends were observed with frozen oocytes, which showed a 2.1 h increase in tEB compared with fresh oocytes. Autologous oocytes were associated with a 6.08 h longer tEB compared with donor oocytes. Additionally, euploid embryos reached tEB 4.72 h earlier than aneuploid embryos. For a one unit increase in embryo quality score, the odds of achieving clinical pregnancy increased by 21.7% and the odds of achieving ongoing pregnancy or live birth increased by 18.5%. Oocyte sources had an effect on miscarriage rates; the use of frozen oocytes resulted in higher miscarriage rates than observed when fresh oocytes were used.</div></div><div><h3>Conclusions</h3><div>AI can successfully evaluate embryo quality and can assist embryologists in decision making. Furthermore, this AI model can delineate the effect of various clinical factors on resulting outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 104866"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undetected pregnancies in luteal phase stimulation − could they prevent ovarian hyperstimulation syndrome becoming a complication of the past?","authors":"Barbara Lawrenz","doi":"10.1016/j.rbmo.2025.105050","DOIUrl":"10.1016/j.rbmo.2025.105050","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 105050"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of extracellular vesicles in reproductive success and uterine diseases – a systematic review","authors":"Aitana Merino-Pérez ,&nbsp;Marina Segura-Benítez ,&nbsp;Antonio Pellicer ,&nbsp;Irene Cervelló ,&nbsp;Hortensia Ferrero","doi":"10.1016/j.rbmo.2025.104862","DOIUrl":"10.1016/j.rbmo.2025.104862","url":null,"abstract":"<div><div>Extracellular vesicles play a key role in endometrium–embryo communication under both physiological and pathological conditions. This systematic review includes 49 studies that highlight how extracellular vesicles help optimize embryo implantation conditions, and 39 evidencing extracellular vesicle contributions to the pathogenesis of uterine diseases, such as endometriosis, endometrial cancer, recurrent implantation failure (RIF), adenomyosis, uterine leiomyoma and endometritis. Under normal physiological conditions, the protein and microRNA cargo of uterine extracellular vesicles regulated endometrial receptivity, maternal tolerance and embryo development, adhesion and implantation. In endometriosis, extracellular vesicles contributed to pathophysiology via angiogenesis, fibrosis, inflammation, lesion progression and reproduction. Extracellular vesicles promoted endometrial cancer progression and metastasis. In RIF, extracellular vesicles hindered embryo invasiveness, migration, survival and implantation. extracellular vesicles contributed to the progression of adenomyosis, negatively impacting decidualization, implantation and embryo development, whereas in uterine leiomyoma and endometritis, extracellular vesicles affected endometrial receptivity, immune tolerance, blastocyst development, migration and invasion. Overall, uterine extracellular vesicles are key mediators of the endometrium–embryo communication required for successful pregnancy. An altered extracellular vesicle cargo from women with uterine disorders may promote disease progression and associated infertility. Therefore, extracellular vesicles represent potential biomarkers and therapeutic targets for uterine disorders.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 104862"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(25)00294-9","DOIUrl":"10.1016/S1472-6483(25)00294-9","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"51 1","pages":"Article 105087"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}