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Front Matter - Continued TOC 正面物质-继续TOC
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-10-01 Epub Date: 2026-09-28 DOI: 10.1016/S1472-6483(26)00482-7
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引用次数: 0
Human menopausal gonadotrophin in a pre-filled injection pen is non-inferior to the US-approved powder formulation 人类绝经期促性腺激素在预填充注射笔不逊色于美国批准的粉末配方。
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-10-01 Epub Date: 2026-06-10 DOI: 10.1016/j.rbmo.2026.105743
Craig Witz, Eric D. Foster, Sarah A. Grover, Patrick W. Heiser, CLARA (Comparison of MENOPUR Liquid and Powder in Women Undergoing ART) trial group
{"title":"Human menopausal gonadotrophin in a pre-filled injection pen is non-inferior to the US-approved powder formulation","authors":"Craig Witz,&nbsp;Eric D. Foster,&nbsp;Sarah A. Grover,&nbsp;Patrick W. Heiser,&nbsp;CLARA (Comparison of MENOPUR Liquid and Powder in Women Undergoing ART) trial group","doi":"10.1016/j.rbmo.2026.105743","DOIUrl":"10.1016/j.rbmo.2026.105743","url":null,"abstract":"<div><h3>Research question</h3><div>Is non-inferiority demonstrated for highly purified human menopausal gonadotrophin (HP-HMG) in an injection pen versus the US approved HP-HMG powder formulation for number of fertilized oocytes in women undergoing ovarian stimulation?</div></div><div><h3>Design</h3><div>Randomised, double-blind, double-dummy, parallel group, multicentre, non-inferiority trial at 19 US reproductive medicine centres enrolling 401 women ages 18‒42 years, randomised 1:1 to HP-HMG pen or HP-HMG powder. After downregulation in a gonadotropin-releasing hormone agonist (GnRHa) cycle, ovaries were stimulated with HP-HMG pen or HP-HMG powder at a starting dose of 225 IU for the first 5 days, with subsequent dose adjustments as needed. The number of fertilized (two pronuclei [2PN]) oocytes 19 ± 2 h after insemination was the primary end point.</div></div><div><h3>Results</h3><div>The primary end point was met, and HP-HMG pen was non-inferior to HP-HMG powder, with the mean ± SD number of fertilized 2PN oocytes 8.2 ± 5.5 and 6.6 ± 4.3, respectively (adjusted treatment difference: 1.50, 95% CI 0.57 to 2.42). The number of oocytes retrieved was 14.3 ± 8.1 with HP-HMG pen and 11.4 ± 6.3 with HP-HMG powder. The mean number of blastocysts was 4.8 ± 3.8 in the HP-HMG pen group and 3.9 ± 3.0 in the HP-HMG powder group. The ongoing pregnancy rate per started stimulation cycle was 45.0% in the HP-HMG pen group and 42.7% in the HP-HMG powder group and the live birth rate was 44.1% and 42.2% after fresh transfer, respectively. The incidence of early ovarian hyperstimulation syndrome was 3.5% in both groups.</div></div><div><h3>Conclusions</h3><div>HP-HMG as a solution for injection in a pre-filled injection pen is an effective and safe alternative to the approved powder formulation.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 4","pages":"Article 105743"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover - Editorial Board 封底外-编辑委员会
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-10-01 Epub Date: 2026-09-28 DOI: 10.1016/S1472-6483(26)00494-3
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引用次数: 0
Inside Front Cover - First page of TOC 内部封面- TOC的第一页
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-10-01 Epub Date: 2026-09-28 DOI: 10.1016/S1472-6483(26)00481-5
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引用次数: 0
Front Matter - Continued TOC 正面物质-继续TOC
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1016/S1472-6483(26)00443-8
{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/S1472-6483(26)00443-8","DOIUrl":"10.1016/S1472-6483(26)00443-8","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 3","pages":"Article 105902"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover - Editorial Board 封底外-编辑委员会
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1016/S1472-6483(26)00445-1
{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(26)00445-1","DOIUrl":"10.1016/S1472-6483(26)00445-1","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 3","pages":"Article 105904"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Front Cover - First page of TOC 内部封面- TOC的第一页
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1016/S1472-6483(26)00442-6
{"title":"Inside Front Cover - First page of TOC","authors":"","doi":"10.1016/S1472-6483(26)00442-6","DOIUrl":"10.1016/S1472-6483(26)00442-6","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 3","pages":"Article 105901"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover - Editorial Board 封底外-编辑委员会
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-08-01 Epub Date: 2026-07-25 DOI: 10.1016/S1472-6483(26)00394-9
{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(26)00394-9","DOIUrl":"10.1016/S1472-6483(26)00394-9","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 2","pages":"Article 105853"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148656921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Front Cover - First page of TOC 内部封面- TOC的第一页
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-08-01 Epub Date: 2026-07-25 DOI: 10.1016/S1472-6483(26)00390-1
{"title":"Inside Front Cover - First page of TOC","authors":"","doi":"10.1016/S1472-6483(26)00390-1","DOIUrl":"10.1016/S1472-6483(26)00390-1","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"53 2","pages":"Article 105849"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148656920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Matter - Continued TOC 正面物质-继续TOC
IF 3.9 2区 医学
Reproductive biomedicine online Pub Date : 2026-08-01 Epub Date: 2026-07-25 DOI: 10.1016/S1472-6483(26)00391-3
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引用次数: 0
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