Reproductive biomedicine online最新文献

{"title":"Culture media with antioxidants improved preimplantation embryo development and clinical outcomes of patients of advanced age","authors":"Shigetoshi Mizumoto,&nbsp;Yozo Nagao,&nbsp;Hitomi Watanabe,&nbsp;Keiko Tanaka,&nbsp;Takeshi Kuramoto","doi":"10.1016/j.rbmo.2024.104415","DOIUrl":"10.1016/j.rbmo.2024.104415","url":null,"abstract":"<div><h3>Research question</h3><div>What are the clinical effects of using culture media supplemented with antioxidants (AOX) throughout the IVF process?</div></div><div><h3>Design</h3><div>Prospective randomized single-centre study. Cumulus–oocyte complexes and semen samples collected from 127 treatment cycles were divided evenly between the study arm (culture media with AOX) and the control arm (culture media without AOX). The primary endpoint was the good-quality blastocyst (GQB) rate on day 5–6 per metaphase II (MII) oocyte.</div></div><div><h3>Results</h3><div>Fertilization rate and day 5–6 blastocyst rate per MII oocyte differed significantly in favour of the study arm, whereas GQB rate did not. A subgroup analysis, stratified by maternal age, revealed significant improvements in the study arm for day 3 embryo development rate, day 5–6 blastocyst rate, GQB rate and blastocyst utilization rate for patients aged 35–40 years, while the impacts on these endpoints were much smaller in patients aged &lt;35 years. Ninety-four single vitrified blastocyst transfers (SVBT) were performed in each arm. The blastocysts derived from the study arm showed better results of SVBT for patients aged 35–40 years, defined by embryo implantation rate, fetal heartbeat rate and live birth rate, whereas these variables did not differ significantly between the two arms when assessing the results for patients of all ages and patients aged &lt;35 years.</div></div><div><h3>Conclusions</h3><div>Embryo development and SVBT outcomes of treatment cycles of patients aged 35–40 years improved significantly when using AOX-supplemented culture media throughout the IVF process.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104415"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm recovery and ICSI outcomes in non-obstructive azoospermia with cryptorchidism treated by orchiopexy: a systematic review and meta-analysis","authors":"ZiHan Qin ,&nbsp;QiaoHua Xiong ,&nbsp;MingHan Lu ,&nbsp;ShuHua Li ,&nbsp;YuJun Chen ,&nbsp;WenHan Ma ,&nbsp;Ling Ma ,&nbsp;Chun Zhou ,&nbsp;Quanfei Zhu ,&nbsp;YuanZhen Zhang ,&nbsp;Ming Zhang ,&nbsp;JunHao Lei","doi":"10.1016/j.rbmo.2024.104392","DOIUrl":"10.1016/j.rbmo.2024.104392","url":null,"abstract":"<div><div>The aim of this meta-analysis was to quantify the available data concerning sperm retrieval rate (SRR) subsequent to testicular sperm extraction (TESE) and the clinical pregnancy rate (CPR) and live birth rate (LBR) subsequent to TESE and intracytoplasmic sperm injection (ICSI) in patients with non-obstructive azoospermia with cryptorchidism treated by orchidopexy. Furthermore, the aim was to explore the potential predictors of SRR, CPR and LBR within this population. Extensive searches were conducted in <em>PubMed, Embase, Cochrane</em> and <em>Web of Science</em> databases, and 23 articles were included in the study, with 1496 patients. The overall SRR per TESE cycle in the total evaluated trials was 60.9% (55.7–66.2%). Factors such as age at TESE, age at orchidopexy, testicular volume, and FSH, LH and testosterone levels did not affect final SRR. Meta-analyses were conducted on 13 studies each for CPR and LBR, including 913 and 799 ICSI cycles, respectively. The overall CPR per ICSI cycle was 37.6% (29.1–46.1%), and the overall LBR per ICSI cycle was 32.6% (24.9–40.4%). Factors as mentioned above, and the age of women undergoing ICSI, did not affect CPR or LBR per ICSI cycle. Although this meta-analysis extensively investigated outcomes of TESE and potential predictors of SRR, CPR and LBR for patients with non-obstructive azoospermia with cryptorchidism treated by orchidopexy, no effective predictors of outcomes were identified.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104392"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor sperm: only for the rich and straight","authors":"Guido Pennings","doi":"10.1016/j.rbmo.2024.104434","DOIUrl":"10.1016/j.rbmo.2024.104434","url":null,"abstract":"<div><div>Although single women and lesbian couples are given access to donor spermatozoa, all kinds of restrictions limit their actual use of donor insemination. These restrictions are frequently justified by the increase in safety (lowering the genetic risk) or well-being of donor-conceived persons. However, these restrictions directly result in stratified reproduction in which only the rich (those with the necessary financial means) and the straight (those who conform to dominant views of parenthood) are allowed to reproduce.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104434"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(24)00960-X","DOIUrl":"10.1016/S1472-6483(24)00960-X","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 104771"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen cryopreservation for an oncological reason: a retrospective study","authors":"Ana Santana-Plata ,&nbsp;Rocio Rivera-Egea ,&nbsp;Nicolás Garrido","doi":"10.1016/j.rbmo.2024.103898","DOIUrl":"10.1016/j.rbmo.2024.103898","url":null,"abstract":"<div><h3>Research question</h3><div>How do cancer type and treatment affect semen quality before and after treatment, and what effect does it have in their clinical management of infertility? Also, what is the rate of patients using cryopreserved semen samples after treatment?</div></div><div><h3>Design</h3><div>Patients who cryopreserved spermatozoa for oncological reasons between 2000 and 2022 in IVI clinics in Spain were retrospectively reviewed. Semen parameters were analysed before and after treatment, and utilization and destruction rates were calculated. Total motile sperm count (TMSC) was used for assisted reproductive technology (ART) counselling.</div></div><div><h3>Results</h3><div>A total of 724 patients cryopreserved their semen during the study period. The semen parameters of the cancer patients' semen before and after treatment were heterogeneous, with significant differences between cancer type and semen parameters. The utilization rate was relatively low (0.4%), whereas the destruction rate was 23.1%.</div></div><div><h3>Conclusion</h3><div><span>Cancer and antineoplastic treatment affect everyone differently. Therefore, sperm </span>cryopreservation should be offered to all patients before starting treatment to ensure their reproductive future. Furthermore, in addition to considering the semen parameters defined by the World Health Organization, it is important to use TMSC in the diagnosis of men to choose appropriate ART according to type of cancer.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 1","pages":"Article 103898"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal, reproductive and perinatal factors and the risks of birth defects: traditional and emerging factors","authors":"Barbara Luke ,&nbsp;Sarah C. Fisher ,&nbsp;Nina E. Forestieri ,&nbsp;Mahsa M. Yazdy ,&nbsp;Dayana Betancourt ,&nbsp;Caitlin R. Sacha ,&nbsp;Gayathree Murugappan ,&nbsp;Katie Cameron ,&nbsp;Valerie L. Baker ,&nbsp;Mitana Purkayastha ,&nbsp;Carrie Williams ,&nbsp;Alastair G. Sutcliffe ,&nbsp;Melissa A. Richard ,&nbsp;Philip J. Lupo","doi":"10.1016/j.rbmo.2024.104781","DOIUrl":"10.1016/j.rbmo.2024.104781","url":null,"abstract":"<div><h3>Research question</h3><div>Does an association exist between maternal, reproductive and perinatal factors, and the risks of major non-chromosomal birth defects?</div></div><div><h3>Design</h3><div>This population-based cohort study included 1,126,058 naturally conceived singleton live births (21,644 with and 1,104,414 without a major non-chromosomal defect) who were born between 2004 and 2018 in New York, Texas, Massachusetts and North Carolina. All study children were linked to their respective state birth defect registries to identify major birth defects diagnosed within the first year of life, and to state death records. Children with chromosomal defects were excluded. Genitourinary defects were only evaluated in boys. Placental and bleeding issues included placenta previa, placental abruption, uterine bleeding and other excessive bleeding, and, at delivery, blood transfusion or unplanned hysterectomy. Adjusted odds ratios and 95% confidence intervals were modelled using logistic regression.</div></div><div><h3>Results</h3><div>Among major non-chromosomal defects, the highest significant risks were with pre-gestational diabetes (adjusted OR 2.48, 95% CI 2.25 to 2.74), followed by placental or bleeding issues (adjusted OR 1.82, 95% CI 1.66 to 1.99); this pattern was also evident for congenital heart defects, blastogenesis defects, orofacial defects, gastrointestinal defects and musculoskeletal defects. Hypertension (pre-gestational and gestational), prior caesarean delivery, older maternal age and higher body mass index were also significant risk factors.</div></div><div><h3>Conclusions</h3><div>The risk factors most strongly associated with major non-chromosomal birth defects were pre-gestational diabetes and placental or bleeding issues; other significantly increased risks were hypertension (pre-gestational and gestational), prior caesarean delivery, older maternal age and pre-pregnancy body mass index 30 kg/m² or above.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 6","pages":"Article 104781"},"PeriodicalIF":3.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does HCG and LH supplementation during ovarian stimulation improve clinical outcome? A evaluation of 30 years of clinical research","authors":"Bernadette Mannaerts ,&nbsp;Claus Yding Andersen ,&nbsp;Colin M Howles","doi":"10.1016/j.rbmo.2024.104782","DOIUrl":"10.1016/j.rbmo.2024.104782","url":null,"abstract":"<div><div>This review evaluates the effect of HCG and LH supplementation during ovarian stimulation. Controlled trials were divided into four groups comparing the treatment effect of recombinant FSH (r-FSH) with urinary FSH (u-FSH), with human menopausal gonadotrophin (HMG), with r-FSH + recombinant LH (r-LH) and with rFSH + recombinant HCG (r-HCG). First r-FSH seemed to be more potent than u-FSH in downregulated women, which translated into more follicles and oocytes. In line, numerous trials comparing HMG (containing u-FSH + u-HCG) with r-FSH demonstrated that HMG recruited fewer follicles, thus providing fewer oocytes but resulted in slightly higher pregnancy rates after a first fresh embryo transfer. The latter may be explained by the higher potency of r-FSH resulting in more and higher premature progesterone rises. Prospective trials addressing r-FSH + r-LH compared with r-FSH could not demonstrate any difference in pregnancy rates in normal or poor responders. A placebo-controlled trial of r-HCG added to a fixed daily r-FSH dose revealed that r-HCG inhibited the growth of intermediate follicles, resulting in fewer oocytes, fewer embryos and lower pregnancy rates. In conclusion, the beneficial effect of HCG and LH supplementation on clinical outcome has never been definitely proven for any of the combined gonadotrophin products.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 6","pages":"Article 104782"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive staging of endometrial fibrosis using diffusion-weighted imaging: a feasibility study.","authors":"Nan Zhou, Peipei Jiang, Yucan Chen, Ke Ma, Hui Zhu, Huanhuan Liang, Qing Hu, Yali Hu, Zhengyang Zhou, Kefeng Zhou","doi":"10.1016/j.rbmo.2024.104776","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104776","url":null,"abstract":"<p><strong>Research question: </strong>Can diffusion-weighted imaging (DWI) be used to stage endometrial fibrosis?</p><p><strong>Design: </strong>This prospective study included 41 healthy women, 30 patients with mild to moderate endometrial fibrosis (MMEF) and 102 patients with severe endometrial fibrosis (SEF). Endometrial thickness and DWI-related parameters, specifically the mean intensity (ADC_ROI and ADC_VOI) and standard deviation (ADC-SD_ROI and ADC-SD_VOI) of the endometrial apparent diffusion coefficient (ADC) values within a region of interest (ROI) on a mid-sagittal ADC map, and volume of interest (VOI) of the entire endometrium in the corpus uteri, were measured and analysed.</p><p><strong>Results: </strong>Endometrial thickness, endometrial ADC_VOI and ADC_ROI were significantly higher in healthy women (11.7 mm, 1.31  ×  10^-3 mm²/s and 1.36  ×  10^-3 mm²/s) than MMEF patients (7.5 mm, P < 0.001; 1.23  ×  10^-3 mm²/s, P = 0.001; and 1.26  ×  10^-3 mm²/s, P = 0.003) and SEF patients (6.2 mm, 1.15  ×  10^-3 mm²/s and 1.23  ×  10^-3 mm²/s; all P < 0.001). Endometrial ADC-SD_VOI and ADC-SD_ROI were significantly higher in SEF patients (0.24 and 0.24) than healthy women (0.16 and 0.13) and MMEF patients (0.18 and 0.16) (all P < 0.001). The degree of endometrial fibrosis was negatively correlated with endometrial thickness, endometrial ADC_VOI and ADC_ROI (Spearman's rho = -0.662, -0.526 and -0.349) and positively correlated with endometrial ADC-SD_VOI and ADC-SD_ROI (Spearman's rho 0.729 and 0.713) (all P < 0.001). Compared with endometrial thickness measurements, endometrial magnetic resonance imaging parameters, particularly DWI-related parameters, demonstrated excellent accuracy in distinguishing normal endometrium, MMEF and SEF (areas under the curve >0.800).</p><p><strong>Conclusions: </strong>DWI is particularly effective for accurately staging the microstructural changes associated with endometrial fibrosis.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104776"},"PeriodicalIF":3.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient variation in anti-Müllerian hormone concentrations with repeat testing in a fertility clinic setting","authors":"Bridie Lewry ,&nbsp;John C Peek ,&nbsp;Dean Morbeck ,&nbsp;Michael W Pankhurst","doi":"10.1016/j.rbmo.2024.104778","DOIUrl":"10.1016/j.rbmo.2024.104778","url":null,"abstract":"<div><h3>Research question</h3><div>Is it possible for a patient to have low anti-Müllerian hormone (AMH) readings that recover to normal concentrations over the space of months or 1–2 years?</div></div><div><h3>Design</h3><div>This was a retrospective analysis of a fertility clinic patient database. Patients with repeat blood samples were examined to determine the degree of change in AMH concentrations over time. The main analysis consisted of 1871 patients.</div></div><div><h3>Results</h3><div>In 42% of patients with low AMH (&lt;1.5 pmol/l) concentrations at the time of their first blood test, values had risen above this threshold at the time of the second blood test. In blood tests taken less than 6 months apart, AMH concentrations were equally likely to increase or decrease over time. Over longer time frames, AMH concentrations were more likely to show decreases, but this effect was strongest in women over 30 years old and minimal in women under 30. Patients with values in the interquartile range were likely to show a fluctuation of less than 5 pmol/l in AMH in tests taken less than 2 years apart. However, this also shows that larger changes can be expected in a sizeable minority of patients.</div></div><div><h3>Conclusions</h3><div>Serum AMH in younger patients tends to fluctuate without a substantial decline over time. In older patients, values in samples taken within 6–12 months tend to fluctuate in either direction, but declines are more likely over longer time frames. This study demonstrates that a small proportion of patients will have transiently depressed AMH concentrations, but it is possible for concentrations to recover in some cases.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 6","pages":"Article 104778"},"PeriodicalIF":3.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing subjective indicators of health in adults aged 27-38 years conceived with and without assisted reproductive technology.","authors":"Sharon Lewis, Karin Hammarberg, Joanne Kennedy, Sarah Biggs, David J Amor, Anne Glynn, Martha Hickey, John McBain, Jane Halliday","doi":"10.1016/j.rbmo.2024.104777","DOIUrl":"https://doi.org/10.1016/j.rbmo.2024.104777","url":null,"abstract":"<p><strong>Research question: </strong>What are the health outcomes of individuals aged 27-38 years conceived with and without assisted reproductive technology (ART)?</p><p><strong>Design: </strong>An online survey, hosted in REDCap, was used to collect information on self-reported physical, psychological and reproductive health from an established cohort of people conceived with and without ART who were now aged 27-38 years. Questions included lists of common conditions and required tick-box responses to determine prevalence. A validated scale was used to assess psychological well-being.</p><p><strong>Results: </strong>There were 313 ART-conceived (236 IVF and 77 gamete intrafallopian transfer [GIFT]) and 153 non-ART conceived respondents. No marked differences between the ART and non-ART groups were observed in physical or psychological health measures. Similar proportions in both groups had had children and reported using medically assisted reproduction to conceive. More women in the ART than the non-ART group reported at least one reproductive health disorder (P = 0.01). Male reproductive health disorders were rare in both groups.</p><p><strong>Conclusions: </strong>Subjective indicators of health were no different between ART- and non-ART-conceived individuals, except for a slight increase in adverse reproductive health disorders reported by ART-conceived female participants. This warrants closer clinical scrutiny. Overall, a larger sample and objective measures in individuals beyond 30 years of age would provide the ultimate reassurance that ART is not associated with long-term health problems. This study is the first of its kind and may provide some reassurance of safety for people conceived with ART and those who contemplate using it.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104777"},"PeriodicalIF":3.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}