Reproductive biomedicine online最新文献

{"title":"Assisted reproductive technology in Latin America: the Latin American Registry, 2022","authors":"Fernando Zegers-Hochschild ,&nbsp;Javier A Crosby ,&nbsp;Carolina Musri ,&nbsp;Fanny Petermann-Rocha ,&nbsp;Gustavo Martinez ,&nbsp;Hitomi Nakagawa ,&nbsp;Carlos Morente ,&nbsp;Armando Roque ,&nbsp;Ana Palma-Govea ,&nbsp;Latin American Network of Assisted Reproduction","doi":"10.1016/j.rbmo.2025.105216","DOIUrl":"10.1016/j.rbmo.2025.105216","url":null,"abstract":"<div><h3>Research question</h3><div>What are the trends and effects of assisted reproductive technology (ART) interventions on the effectiveness and safety of ART carried out in Latin America during 2022.</div></div><div><h3>Design</h3><div>Retrospective collection of cycle-based multinational data obtained from ART procedures carried out by 204 accredited institutions in 16 countries.</div></div><div><h3>Results</h3><div>In total 123,265 initiated cycles resulted in 19,663 deliveries and 22,203 births. Use of ART varied greatly, from 643.3 cycles/million inhabitants in Uruguay to 28.8 in Guatemala. In autologous cycles, the proportion of women aged ≥40 years represents 35.1% of cycles, whereas women &lt;34 years represents only 18.8%. The proportion of single embryo transfers (SET) increased from 42.4% in 2021 to 47.3% in 2022. Out of 22,203 babies born, 77.4% were singletons, 21.7% twins and 0.9% triplets or more. Intracytoplasmic sperm injection represented 85.4% of fertilization techniques, and blastocyst transfer increased from 79.3% in 2021 to 85.3% in 2022. Delivery rate after fresh blastocyst elective single embryo transfer (32.6%) was significantly higher than after the transfer of one frozen embryo transfer (FET) from freeze-all cycle (25.2%) (<em>P</em> = 0.0001). The number of aspirations leading to preimplantation genetic testing increased 2.6 times in 6 years, and significantly increased delivery rates/transfer (<em>P</em> ≤ 0.008) and reduced miscarriage at all ages (<em>P</em> ≤ 0.004) in autologous cycles, but not in oocyte donation cycles. Delivery rates after fresh transfer of embryos from vitrified–warmed donated oocytes, generated similar outcome to FET from fresh oocyte donation cycles (<em>P</em> = 0.5621). Perinatal mortality increased from 7.5‰ in singletons to 22.8‰ in twins.</div></div><div><h3>Conclusion</h3><div>Systematic collection of cycle-based multinational data contributes to cooperative sustained development and helps implement evidence-based reproductive decisions.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105216"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of infertility duration and aetiology, parental factors and ART on the risk of congenital anomalies: a comprehensive review","authors":"Johanna Vivard ,&nbsp;Anthony Atallah ,&nbsp;Emmanuelle Amar ,&nbsp;Bruno Salle-Leyris-De-Campredon ,&nbsp;Mehdi Benchaib ,&nbsp;Elsa Labrune ,&nbsp;Eloïse Fraison","doi":"10.1016/j.rbmo.2025.105169","DOIUrl":"10.1016/j.rbmo.2025.105169","url":null,"abstract":"<div><div>Infertility, affecting one in six people, represents an important global public health issue. Assisted reproductive technology (ART) provides effective treatment options, but concerns remain regarding its safety, particularly in relation to the potential risk of congenital anomalies. This literature review aims to synthesize current evidence on the association between infertility, ART and the occurrence of congenital anomalies.</div><div>A comprehensive search of the MEDLINE, PubMed and Embase databases was made. In total, 727 references were obtained according to the search criteria. The full text of 393 articles was evaluated, and 143 articles were included in the review.</div><div>The literature indicates increased risk of congenital anomalies both in individuals with infertility and in those who conceived using ART. Assessing the risk of congenital anomalies in the context of ART is complex due to the presence of numerous confounding factors, some of which are linked to parental characteristics. Notably, some types of congenital anomaly, such as congenital heart defects, genitourinary anomalies and genetic disorders, are reported more frequently in association with ART.</div><div>In conclusion, the current literature suggests increased risk of congenital anomalies associated with ART. This underscores the need for further research to elucidate the underlying mechanisms and inform clinical strategies aimed at reducing this risk.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105169"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short conventional IVF, big impact: navigating protocol variations towards standardization","authors":"Giorgia Carullo ,&nbsp;Sofia Makieva ,&nbsp;Min Xie ,&nbsp;Maíra Casalechi ,&nbsp;Paola Vigano ,&nbsp;Brigitte Leeners","doi":"10.1016/j.rbmo.2025.105214","DOIUrl":"10.1016/j.rbmo.2025.105214","url":null,"abstract":"<div><div>The field of assisted reproductive technology (ART) has undergone substantial progress in recent years, particularly in the refinement of insemination techniques. Despite the widespread use of various methods, however, a definitive consensus on the optimal insemination protocols, particularly within conventional IVF, remains elusive. From oocyte–sperm incubations lasting mere seconds to extended overnight strategies, the variability in approaches has contributed to inconsistent outcomes and practices across fertility clinics. This review critically examines the range of protocols used in short insemination conventional IVF and scrutinizes the underlying rationale behind different incubation durations and methodologies. By summarizing the available evidence, the aim is to discern patterns that could inform the development of a unified protocol, thereby standardizing short conventional IVF practices. Ultimately, this review emphasizes the urgent need for evidence-based guidelines to streamline conventional IVF procedures, ensuring improved clinical outcomes and greater consistency in practice across the global landscape of ART.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105214"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Offering semen cryopreservation to transgender persons birth-assigned male: qualitative interviews on motivation and attitudes","authors":"Emilie Marie Hyltoft Fuglsang ,&nbsp;Louise Marie Hviid ,&nbsp;Inga María Baldursdóttir ,&nbsp;Elisabeth Dau Sørensen ,&nbsp;Astrid Ditte Højgaard ,&nbsp;Birgitte Schantz Laursen ,&nbsp;Ulrik Schiøler Kesmodel","doi":"10.1016/j.rbmo.2025.105079","DOIUrl":"10.1016/j.rbmo.2025.105079","url":null,"abstract":"<div><h3>Research question</h3><div>What are the considerations and opinions of individuals assigned male at birth (AMAB) when offered fertility preservation in Denmark, where the preservation of gametes is reimbursed?</div></div><div><h3>Design</h3><div>Qualitative study (<em>n</em> = 10); participants were AMAB individuals undergoing or initiating feminizing gender affirming hormone therapy (GAHT) and recruited from a large Centre for Gender Identity in Denmark and through Danish Facebook groups. The participants underwent semi-structured online interviews supported by an interview guide based on a rigorous information retrieval from published research. The interviews were transcribed and thematic analysis conducted.</div></div><div><h3>Results</h3><div>A number of themes emerged from the data, which highlighted important factors influencing the participants’ fertility preservation decision-making. These included discomfort with the thoughts of delivering male genetic material; infertility being the price to pay; and difficulty imagining the future owing to mental unclarity and gender discomfort in general. The participants generally expressed a parental desire, but not exclusively for biological children. Postponing hormonal treatment and financial considerations about fertility preservation were stated as hypothetical barriers, as those were irrelevant to the Danish participants.</div></div><div><h3>Conclusion</h3><div>The findings emphasized the need for comprehensive fertility preservation counselling before GAHT. The themes were comparable to findings in previous international studies apart from the economic and treatment postponement aspects.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105079"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is ovarian reserve associated with an increased risk of miscarriage? A systematic review and meta-analysis","authors":"Lorraine S. Kasaven ,&nbsp;Nicholas Anson ,&nbsp;Benjamin P. Jones ,&nbsp;Rabi Odia ,&nbsp;Javier Cordero ,&nbsp;Jara Ben Nagi ,&nbsp;Efstathios Theodorou","doi":"10.1016/j.rbmo.2025.105041","DOIUrl":"10.1016/j.rbmo.2025.105041","url":null,"abstract":"<div><div>This review determines the association between ovarian reserve markers, anti-Müllerian hormone (AMH) and antral follicle count (AFC), with risk of miscarriage in women undergoing assisted reproductive technology. A systematic search of <em>PubMed, Embase, Cochrane Library</em> and <em>Google Scholar</em> from inception to September 2023 identified 16 retrospective studies, including 43,147 patients. A meta-analysis using a random effects model demonstrated that low AMH concentration is associated with a significantly increased risk of miscarriage compared with medium and high AMH concentration (OR 1.48, 95% CI 1.20 to 1.83, <em>P</em> = 0.0002). When stratified by age, the risk remained significant in women aged younger than 35 years (OR 1.34, 95% CI 1.17 to 1.54, <em>P</em> &lt; 0.0001); however, results were not significant among women aged 35 years or younger (OR 1.29, 95% CI 0.95 to 1.76, <em>P</em> = 0.10). Similarly, low AFC was associated with an increased risk of miscarriage across all ages (OR 1.80, 95% CI 1.33 to 2.45, <em>P</em> = 0.0002). After age adjustment, the association was significant in women aged younger than 35 years (OR 1.61, 95% CI 1.20 to 2.16, <em>P</em> = 0.002), but not among women aged 35 years or older (OR 1.41, 95% CI 0.90 to 2.22, <em>P</em> = 0.14). Therefore, a reduced ovarian reserve is associated with an increased risk of miscarriage, although results are only significant among women aged younger than 35 years.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105041"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value-based outcome measures for ART: much room for improvement","authors":"Bart CJM Fauser ,&nbsp;Arie Franx","doi":"10.1016/j.rbmo.2025.105179","DOIUrl":"10.1016/j.rbmo.2025.105179","url":null,"abstract":"<div><div>No consensus exists on the preferred way to represent the outcomes of assisted reproductive technology (ART). Currently used outcomes are usually procedure driven and generated by healthcare professionals. Value-based healthcare, emphasizing the need to define preferred outcomes with and around patients, has raised much attention in medicine outside fertility care. This commentary outlines how currently used outcome measures could detrimentally affect the way ART is practised, and proposes ways to improve such outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105179"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between endometriosis and endometrial polyps: a systematic review and meta-analysis","authors":"Alexander Fiore ,&nbsp;Maíra Casalechi ,&nbsp;Edgardo Somigliana ,&nbsp;Paola Viganò ,&nbsp;Noemi Salmeri","doi":"10.1016/j.rbmo.2025.105106","DOIUrl":"10.1016/j.rbmo.2025.105106","url":null,"abstract":"<div><div>Endometriosis and endometrial polyps are oestrogen-dependent conditions that frequently co-occur, yet their combined prevalence remains unclear. This study synthesized data on the prevalence of endometrial polyps in women with endometriosis and vice versa. Systematic searches of PubMed, Embase and Scopus were conducted up to 1 October 2024. Observational studies reporting the prevalence of endometrial polyps in women with endometriosis, and vice versa, were included. Random-effects models calculated pooled proportions and risk ratios (RR) with 95% CI. Risk of bias was assessed using the Newcastle–Ottawa scale, and evidence/certainty was graded using the Grading of Recommendations Assessment, Development and Evaluation guidelines. The protocol was registered in PROSPERO (CRD42024595167). Twenty-two studies with 10,928 patients (8154 women with infertility) were included. Women with endometriosis (1757 patients) had a significantly higher risk of endometrial polyps (RR 2.18, 95% CI 1.58–3.00; <em>I</em>² = 83.5%; <em>P</em> &lt; 0.001), and women with polyps (2130 patients) had a significantly higher risk of endometriosis (RR 2.05, 95% CI 1.61–2.62; <em>I</em>² = 82.5%; <em>P</em> &lt; 0.001), compared with controls (5590 and 5217 patients, respectively). Subgroup analyses by infertility status and disease stage confirmed these findings. A gradient effect showed a significantly higher risk of endometrial polyps in women with stage III–IV endometriosis compared with women with stage I–II endometriosis (RR 1.19, 95% CI 1.08–1.32; <em>I</em>² = 0.0%; <em>P</em> &lt; 0.001). Endometriosis and endometrial polyps are strongly associated, particularly in women with infertility. Despite low-quality evidence, these findings emphasize the importance of better detection and targeted interventions to enhance fertility outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105106"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145621536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum progesterone monitoring after embryo transfer","authors":"Jan Tesarik","doi":"10.1016/j.rbmo.2025.105412","DOIUrl":"10.1016/j.rbmo.2025.105412","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105412"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic-activated cell sorting non-apoptotic sperm selection improves DNA fragmentation and reproductive outcomes: systematic review and meta-analysis","authors":"Mar Falquet Guillem ,&nbsp;Rosa Pacheco ,&nbsp;Alma Gisbert-Iranzo ,&nbsp;Marina Cano-Extremera ,&nbsp;María Gil Juliá ,&nbsp;Ana Navarro-Gomezlechon ,&nbsp;Irene Hervas ,&nbsp;Nicolás Garrido","doi":"10.1016/j.rbmo.2025.105152","DOIUrl":"10.1016/j.rbmo.2025.105152","url":null,"abstract":"<div><div>Medically assisted reproduction (MAR) relies on semen quality for success. While conventional sperm selection techniques such as density gradient centrifugation and swim-up are commonly used, they overlook essential molecular sperm characteristics, limiting their effectiveness in predicting the success of MAR. To address this, advanced selection techniques have been developed, including magnetic-activated cell sorting (MACS). This meta-analysis evaluates the effect of MACS compared with conventional sperm selection techniques on MAR reproductive outcomes, seminal parameters, and sperm DNA fragmentation (DNAf) levels. Systematic searches in PubMed, Web of Science and Scopus identified 41 studies that met the inclusion criteria. Results indicate that while MACS reduces sperm DNAf significantly (mean difference = -4.32, 95% CI -6.29 to -2.36; <em>P</em> &lt; 0.0001), it does not significantly improve clinical pregnancy (OR = 1.47, 95% CI 0.94–2.30, <em>P</em> = 0.09), spontaneous miscarriage (OR = 0.92, 95% CI 0.40–2.12; <em>P</em> = 0.85) or live birth (OR = 1.55, 95% CI 0.78–3.11; <em>P</em> = 0.21) rates in artificial insemination cycles. However, in intracytoplasmic sperm injection cycles, MACS demonstrates significant improvements in implantation rate per transferred embryo (OR = 1.28, 95% CI 1.02–1.62; <em>P</em> = 0.04), clinical pregnancy (OR = 1.41, 95% CI 1.19–1.66; <em>P</em> &lt; 0.00001) and live birth (OR = 1.31, 95% CI 1.09–1.58; <em>P</em> = 0.004) rates per embryo transfer, particularly in patients with high DNAf levels. Despite variability in other clinical parameters and study limitations such as data heterogeneity, the study results suggest a potential benefit of MACS in a specific subgroup of infertile patients, underscoring the need for personalized evaluation and further research to refine its clinical indications.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105152"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does systemic LH concentration influence live birth rate in programmed single euploid frozen embryo transfer cycles?","authors":"Laura Marqueta ,&nbsp;Barbara Lawrenz ,&nbsp;Erkan Kalafat ,&nbsp;Raquel Del Gallego ,&nbsp;Francisco Ruiz ,&nbsp;Laura Melado ,&nbsp;Ibrahim El Khatib ,&nbsp;Human Fatemi","doi":"10.1016/j.rbmo.2025.105210","DOIUrl":"10.1016/j.rbmo.2025.105210","url":null,"abstract":"<div><h3>Research question</h3><div>Does systemic LH concentration influence live birth rate (LBR) in programmed single euploid frozen embryo transfer (seFET) cycles?</div></div><div><h3>Design</h3><div>Retrospective cohort study including 758 programmed seFET cycles between January 2018 and September 2023, prepared with oral oestradiol and vaginal progesterone. Serum oestradiol, progesterone and LH were measured at the start of preparation and up to 3 days before initiation of vaginal progesterone. Patients were stratified in percentile groups according to LH concentration before oestradiol and vaginal progesterone administration. The impacts of LH concentration and its slope on LBR were assessed.</div></div><div><h3>Results</h3><div>Pregnancy rate, pregnancy loss rate and LBR were 66.7%, 18.0% and 48.7%, respectively. Outcome groups were comparable in terms of female age at retrieval and transfer, anti-Müllerian hormone, male age, luteal phase support, and hormone concentrations before initiation of oestradiol and vaginal progesterone. No significant differences in LBR were seen between LH percentile groups. No significant trend was seen when categorizing the increase in LH concentration as small, moderate or substantial. Multi-nomial regression analysis showed that poorer embryo quality (inner cell mass grade C versus A; <em>P</em> = 0.005), biopsy on day 6/7 versus day 5 (<em>P</em> = 0.01), and higher body mass index (<em>P</em> = 0.031) were more likely to result in a negative pregnancy test than a live birth. Neither oestradiol nor LH concentrations prior to vaginal progesterone administration, nor their increase, were significantly associated with outcomes.</div></div><div><h3>Conclusions</h3><div>Systemic LH concentration before vaginal progesterone administration does not influence LBR in programmed seFET cycles.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105210"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}