Reproductive biomedicine online最新文献

{"title":"Lifetime fiscal impact of IVF-born singletons in Turkey: a female-age-stratified analysis","authors":"Cigdem Lazoglu ,&nbsp;Miray N.C. Kemahli ,&nbsp;İrem Y. Ozbek ,&nbsp;Kasirga Yildirak ,&nbsp;Sezcan Mumusoglu ,&nbsp;Hakan Yarali","doi":"10.1016/j.rbmo.2025.105167","DOIUrl":"10.1016/j.rbmo.2025.105167","url":null,"abstract":"<div><h3>Research question</h3><div>What is the fiscal impact of IVF-born singletons in Turkey stratified by maternal age group?</div></div><div><h3>Design</h3><div>A generational accounting framework was applied to quantify lifetime fiscal interactions between individuals – conceived naturally or using IVF – and the government. Demographic data for a individual born in 2022 were used, assuming a 77-year lifespan divided into seven life stages. Government expenditures (education, healthcare, child benefits, pensions), and individual tax contributions were modelled under a constant 1.93% labour productivity growth rate and a 1.8% discount rate, reflecting Turkey’s actuarial interest assumptions. The cost and success rates of IVF were calculated using data from a single private IVF centre. The lifetime net tax contribution of IVF- or naturally conceived individuals was then estimated across maternal age strata: 20–25, 26–30, 31–35, 36–38, 39–40 and 41–42 years. The break-even age at which net tax contributions become positive was also calculated.</div></div><div><h3>Results</h3><div>The average cost of achieving a live birth was (US)$3785. The average discounted lifetime net tax contribution of an IVF-born individual was $1651. The respective figure for a naturally conceived individual was $5436. The average fiscal break-even age was 40 (range 40–44) years for IVF-born individuals, but 38 years for naturally conceived individuals. The cost of IVF increases with advancing age, resulting in a negative fiscal balance beyond the maternal age of 38 years.</div></div><div><h3>Conclusions</h3><div>IVF represents a sound long-term fiscal investment, supporting the expansion of public funding for fertility treatment. The results also highlight the importance of female age, as cost-effectiveness declines with increased cycle requirements.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105167"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover - Affiliations and First page of TOC","authors":"","doi":"10.1016/S1472-6483(26)00021-0","DOIUrl":"10.1016/S1472-6483(26)00021-0","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105480"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of AdhesioRT-guided personalized embryo transfers: a prospective randomized controlled trial","authors":"Mélanie Chow-Shi-Yée ,&nbsp;Eva Kadoch ,&nbsp;Marie-Eve Stebenne ,&nbsp;Artak Tadevosyan ,&nbsp;Isaac-Jacques Kadoch","doi":"10.1016/j.rbmo.2025.105174","DOIUrl":"10.1016/j.rbmo.2025.105174","url":null,"abstract":"<div><h3>Research question</h3><div>How effective is AdhesioRT in predicting endometrial receptivity, and how does its application affect clinical outcomes, such as pregnancy rates, in the context of personalized embryo transfers (pET)?</div></div><div><h3>Design</h3><div>AdhesioRT was employed to evaluate endometrial receptivity in a cohort of patients undergoing infertility assessment. The study included two endometrial biopsies during a substituted frozen embryo transfer cycle after 6 or 8 full days of progesterone treatment, where the gene expression of 10 specific biomarkers was analysed using quantitative reverse transcription polymerase chain reaction. Samples were categorized as receptive, partially receptive or non-receptive. The AdhesioRT group (<em>n</em> = 50) underwent pET guided by AdhesioRT recommendations, while the control group (<em>n</em> = 54) followed the standard clinic protocol.</div></div><div><h3>Results</h3><div>AdhesioRT identified a potential shift in the window of implantation (WOI) in 64% of the AdhesioRT group, yet pET led to a lower pregnancy rate compared with the control group (28% vs 61%). Transfers after 6 full days of progesterone treatment, as recommended by AdhesioRT, achieved a 59% pregnancy rate, whereas those with a suggested WOI shift (transfer at a different time point than after 6 full days of progesterone treatment) achieved a 20% pregnancy rate.</div></div><div><h3>Conclusion</h3><div>Surprisingly, AdhesioRT-guided embryo transfers did not lead to higher pregnancy rates, indicating that deviating from the standard transfer day (i.e. after 6 full days of progesterone treatment) may reduce the success of embryo implantation.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105174"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vitamin D deficiency on phenotypes and IVF outcomes in PCOS: a prospective study","authors":"Fei Zhao ,&nbsp;Duo Wen ,&nbsp;Lin Zeng ,&nbsp;Lixue Chen ,&nbsp;Rong Li ,&nbsp;Hongbin Chi","doi":"10.1016/j.rbmo.2025.105170","DOIUrl":"10.1016/j.rbmo.2025.105170","url":null,"abstract":"<div><h3>Research question</h3><div>Does vitamin D deficiency affect phenotypes and pregnancy outcomes in women with polycystic ovary syndrome (PCOS) who are undergoing IVF/intracytoplasmic sperm injection (ICSI)?</div></div><div><h3>Design</h3><div>This prospective cohort study recruited 725 infertile women with PCOS undergoing IVF/ICSI at the Reproductive Center of Peking University Third Hospital. The participants were divided into two groups according to the serum vitamin D concentration: the vitamin D deficiency group (serum 25(OH)D &lt;20 ng/ml, <em>n</em> = 491) and vitamin D non-deficiency group (serum 25(OH)D ≥20 ng/ml, <em>n</em> = 234). Measurements were made of serum hormone concentrations and parameters relating to lipid and glucose metabolism. Pregnancy outcomes were clinical pregnancy and early miscarriage.</div></div><div><h3>Results</h3><div>Serum concentrations of anti-Müllerian hormone (<em>P</em> = 0.042), testosterone (<em>P</em> = 0.035) and androstenedione (<em>P</em> = 0.016) were higher in the vitamin D deficiency group than the non-deficiency group. Vitamin D deficiency was still associated with increased androstenedione concentrations after adjustment for confounders (regression coefficient –0.851, 95% confidence interval [95% CI] –1.661 to –0.042, <em>P</em> = 0.039). No significant difference was found in parameters of lipid and glucose metabolism or in clinical pregnancy and early miscarriage rates between two groups. There was no correlation between vitamin D deficiency and clinical pregnancy (odds ratio [OR] 1.193, 95% CI 0.852–1.671, <em>P</em> = 0.303) or early miscarriage (OR 1.360, 95% CI 0.668–2.767, <em>P</em> = 0.397).</div></div><div><h3>Conclusions</h3><div>Vitamin D deficiency is correlated with worse parameters, especially higher androstenedione concentrations in infertile women with PCOS. Vitamin D deficiency has no correlation with clinical pregnancy or early miscarriage in women with PCOS undergoing IVF/ICSI treatment.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105170"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional experience of Danish men during fertility treatment: qualitative study on engagement, hope and loss","authors":"Randi Sylvest ,&nbsp;Lone Schmidt ,&nbsp;Anja Pinborg ,&nbsp;Søren Ziebe","doi":"10.1016/j.rbmo.2025.105217","DOIUrl":"10.1016/j.rbmo.2025.105217","url":null,"abstract":"<div><h3>Research question</h3><div>How does being in fertility treatment affect men, and how can healthcare professionals better involve and support men throughout the process?</div></div><div><h3>Design</h3><div>Semi-structured qualitative interview study with 15 men (aged 31–47 years) undergoing fertility treatment. Four men had used donor semen. Six couples had experienced a pregnancy loss. Participants were recruited through fertility clinics, patient organizations and social media. Data were collected in 2023 and 2024 and analysed using qualitative content analysis.</div></div><div><h3>Results</h3><div>The following themes emerged from the interview data: involvement; hope (becoming a father and keeping positive); loss (psychological burden, control and masculinity); and lasting impact. Involvement and inclusion of men during fertility treatment were of critical importance. The men observed that this entails efforts from healthcare professionals to actively engage them and a recognition of their own responsibility in the process. The men saw the fertility journey as a shared and important issue. All participants expressed a profound sense of hope and motivation rooted in their aspiration to eventually become fathers. The men described experiencing the loss of dreams, hope, sense of masculinity and a sense of control. Experiencing infertility had a lasting effect on them, affecting them mentally, socially, sexually and financially, regardless of whether or not they ended up having children.</div></div><div><h3>Conclusion</h3><div>It is important that men are acknowledged and included in the fertility treatment process. Healthcare professionals need to recognize the effect of infertility on men aspiring to become fathers and their need to play a meaningful role during fertility treatment.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105217"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-luteal serum progesterone concentrations in modified natural cycles for embryo transfer: a prospective blinded study","authors":"Elena Labarta ,&nbsp;Cristina Rodríguez-Varela ,&nbsp;Carmina Vidal ,&nbsp;Jakob Doblinger ,&nbsp;Pilar Alamá ,&nbsp;Alicia Marzal ,&nbsp;Fabio Cruz ,&nbsp;Juan Giles ,&nbsp;José Bellver ,&nbsp;Pep Romero ,&nbsp;Inés Olmo ,&nbsp;Víctor H. Gómez ,&nbsp;José Remohí ,&nbsp;Stefania Paolelli ,&nbsp;Ernesto Bosch","doi":"10.1016/j.rbmo.2025.105171","DOIUrl":"10.1016/j.rbmo.2025.105171","url":null,"abstract":"<div><h3>Research question</h3><div>Does mid-luteal serum progesterone concentration influence pregnancy outcomes in modified natural cycle frozen embryo transfer (mNC-FET) with ovulation triggering and luteal phase support (LPS)?</div></div><div><h3>Design</h3><div>This prospective, blinded, single-centre cohort study was conducted at IVIRMA Valencia (Spain) between February 2020 and June 2021. A total of 241 infertile patients under 50 years old, with body mass index (BMI) &lt;40 kg/m², undergoing mNC-FET were included. Ovulation was triggered with recombinant human chorionic gonadotrophin when the dominant follicle measured ≥16 mm and endometrial thickness was &gt;6.5 mm. LPS was provided with micronized vaginal progesterone 200 mg every 12 h. Serum progesterone was measured within 2 h of embryo transfer, and results were blinded until study completion.</div></div><div><h3>Results</h3><div>Mean serum progesterone on embryo transfer day was 26.2 ± 9.0 ng/ml, with 99% of patients exceeding the clinically relevant threshold (&gt;10 ng/ml). Participants were stratified into quartiles by progesterone concentration, with no significant differences in ongoing pregnancy rates: Q1 (&lt;20.2 ng/ml), 56.7%; Q2 (20.2–24.8 ng/ml), 47.5%; Q3 (24.9–31.1 ng/ml), 51.7%; Q4 (&gt;31.1 ng/ml), 48.3% (<em>P</em> = 0.74). Live birth rates were also comparable (<em>P</em> = 0.66). In multivariable logistic regression, mid-luteal serum progesterone was not significantly associated with ongoing pregnancy (odds ratio 0.86, 95% CI 0.40–1.85; <em>P</em> = 0.70) after adjusting for clinical covariates. Female age, oocyte age, BMI, number of previous transfers, embryos transferred, embryo quality, and oocyte origin were also unrelated to pregnancy probability.</div></div><div><h3>Conclusions</h3><div>In mNC-FET cycles with HCG triggering and LPS, mid-luteal serum progesterone concentrations were consistently adequate and not associated with pregnancy outcomes. Routine progesterone monitoring appears unnecessary in this setting.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105171"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deposition in ovarian endometrioma evaluated by magnetic resonance imaging R2* non-invasively","authors":"Ping Zhang ,&nbsp;Yaan Song ,&nbsp;Meixia Su ,&nbsp;Ying Lin ,&nbsp;Yuxuan He ,&nbsp;Xiaoxuan Liu ,&nbsp;Namei Wu ,&nbsp;Yiqing Lin ,&nbsp;Zihan Wang ,&nbsp;Ming Yuan ,&nbsp;Yan Zhang ,&nbsp;Guoyun Wang","doi":"10.1016/j.rbmo.2025.105024","DOIUrl":"10.1016/j.rbmo.2025.105024","url":null,"abstract":"<div><h3>Research question</h3><div>Is surgery effective in decreasing iron deposition in the ovarian tissue surrounding an ovarian endometrioma?</div></div><div><h3>Design</h3><div>This cohort study was conducted in China between July 2023 and April 2024. Seventy-nine patients with ovarian endometriomas and 45 controls with other ovarian cyst types were enrolled. Magnetic resonance imaging using a relaxation sequence (MRI-R2*) has been proven to be a reliable method for detecting iron deposition. All participants underwent MRI-R2* preoperatively to detect the presence of iron in ovarian tissue, before surgical ovarian cystectomy. Additionally, patients with ovarian endometriosis underwent MRI-R2* 3 months after surgery. The end points were changes in iron content, as reflected by the R2* value of ovarian tissue, surrounding an ovarian endometrioma.</div></div><div><h3>Results</h3><div>The preoperative R2* value of the affected-side ovarian tissue in the ovarian endometriosis group was significantly higher than that in the control group (27.00 [22.50–32.25] Hz versus 23.00 [13.50–26.36] Hz; <em>P</em> = 0.012). In the ovarian endometriosis group, the affected-side ovarian tissue had higher R2* values than the intact side ovarian tissue before (27.00 [22.50–32.25] Hz versus 19.19 [14.43–24.12] Hz; <em>P</em> = 0.019) and after (27.13 [21.80–31.50] Hz versus 21.96 [19.00–27.53] Hz; <em>P</em> = 0.015) surgery. No significant changes were observed in the R2* values of the affected-side ovarian tissue after surgery.</div></div><div><h3>Conclusions</h3><div>In patients with ovarian endometriomas, the affected-side ovarian tissue demonstrated no reduction in iron content within 3 months of ovarian cystectomy. Cystectomy alone is inadequate for complete elimination of local iron deposition. Serial MRI-R2* monitoring could serve as an objective modality for assessing postoperative iron deposition dynamics.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105024"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronan-enriched transfer media in PGT-A cycles: a stratified cohort analysis","authors":"Pierfrancesco Greco ,&nbsp;Flavia Costanzi ,&nbsp;Ilaria Listorti ,&nbsp;Maria Teresa Varricchio ,&nbsp;Katarzyna Litwicka ,&nbsp;Cristiana Arrivi ,&nbsp;Cecilia Mencacci ,&nbsp;Ermanno Greco ,&nbsp;Alessandro Colasante","doi":"10.1016/j.rbmo.2025.105235","DOIUrl":"10.1016/j.rbmo.2025.105235","url":null,"abstract":"<div><h3>Research question</h3><div>Can hyaluronan-enriched transfer medium (HETM) improve reproductive outcomes in frozen single euploid blastocyst transfers after preimplantation genetic testing for aneuploidy (PGT-A)?</div></div><div><h3>Design</h3><div>Retrospective analysis of 445 patients (549 cycles), who had PGT-A embryo transfers that used HETM (EmbryoGlue) versus standard medium. Subgroup analyses were conducted based on blastocyst morphology, maternal age and previous implantation failure.</div></div><div><h3>Results</h3><div>No significant differences were found between HETM and control groups in the main reproductive outcomes, including positive HCG rates (72.27% versus 70.23%, <em>P</em> = 0.648), clinical pregnancy (80.23% versus 84.11%, <em>P</em> = 0.440), live birth rates (66.28% versus 72.85%, <em>P</em> = 0.237), and miscarriage rates (13.95% and 11.26%, <em>P</em> = 0.404).</div><div>Subgroup analyses by blastocyst cohort quality, maternal age and previous implantation failure showed no statistically significant benefit of HETM. On transfers of poor morphology (C-grade) blastocysts, HETM was associated with a significantly higher HCG-positive rate (79.17% for HETM versus 52.94% for the control group, <em>P</em> = 0.021), but this did not translate into improved clinical pregnancy (52.63% HETM versus 68.89% control group; <em>P</em> = 0.231) or live birth rates (47.37% HETM versus 62.22% control group; <em>P</em> = 0.284).</div></div><div><h3>Conclusions</h3><div>HETM did not provide a significant advantage in reproductive outcomes after single euploid blastocyst transfer. Its limited benefit in specific subgroups, such as poor morphology embryos, warrants cautious use and further research.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 2","pages":"Article 105235"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual intercourse and vaginal absorption of progesterone (SexVAP): a cross-over randomized prospective pilot study","authors":"Noemie Ranisavljevic ,&nbsp;Anaïs Rolland ,&nbsp;Marie-Christine Picot ,&nbsp;Manuela Lotierzo ,&nbsp;Fanchon Herman ,&nbsp;Martha Duraes ,&nbsp;Sophie Brouillet ,&nbsp;Tal Anahory","doi":"10.1016/j.rbmo.2025.105166","DOIUrl":"10.1016/j.rbmo.2025.105166","url":null,"abstract":"<div><h3>Research question</h3><div>Does use of male condoms during sexual intercourse affect serum progesterone levels in women taking hormonal replacement therapy (HRT) with vaginal progesterone, compared with unprotected sexual intercourse and sexual abstinence as the reference for progesterone absorption?</div></div><div><h3>Design</h3><div>A prospective, randomized, crossover pilot study was conducted (<em>n</em> = 40 couples). Eligible participants were infertile heterosexual couples. Women (aged 18–40 years; BMI &lt;32 kg/m²) received oestradiol and vaginal micronized progesterone suppositories. Couples were excluded if men reported erectile or ejaculatory disorders. Upon initiation of progesterone, sexual abstinence was mandated, except for two planned intercourses as part of the study, one with and one without a condom. Progesterone serum levels were assessed three times: on day 2 of progesterone (during abstinence), on day 3 (10 h after the first planned sexual intercourse) and day 7 of progesterone (10 h after the second planned sexual intercourse).</div></div><div><h3>Results</h3><div>Among the 40 couples included, 30 couples were suitable for per protocol analysis. On average, serum progesterone levels were 0.21 ng/ml (± 5.26) lower after an unprotected intercourse compared with sexual abstinence; serum progesterone levels were 1.52 ng/ml (± 5.09) higher after an intercourse with a condom compared with sexual abstinence. The linear mixed model showed no significant effect for condom use to affect the variation in progesterone levels (<em>P</em> = 0.08).</div></div><div><h3>Conclusion</h3><div>Sexual intercourse did not significantly affect serum progesterone levels during an HRT cycle using vaginal progesterone suppositories. Vaginal absorption of progesterone was similar regardless of whether a male condom was used.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105166"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-conceptional maternal vulnerability risk score and embryonic growth: the Rotterdam Periconception Cohort","authors":"Teuntje Wieles ,&nbsp;Hilmar Bijma ,&nbsp;Sharissa Smith ,&nbsp;Lotte Voskamp ,&nbsp;Sten Willemsen ,&nbsp;Régine Steegers-Theunissen","doi":"10.1016/j.rbmo.2025.105085","DOIUrl":"10.1016/j.rbmo.2025.105085","url":null,"abstract":"<div><h3>Research question</h3><div>What is the association of peri-conceptional maternal vulnerability, assessed through a weighted multi-domain risk score with embryonic growth?</div></div><div><h3>Design</h3><div>638 pregnancies were included from the Rotterdam Periconception Cohort. Data on nine vulnerability factors (encompassing lifestyle, mental health and environmental factors) were obtained through self-administered questionnaires. The Periconceptional Vulnerability Risk Score (PVRS) was calculated using weighted estimates of associations between vulnerability factors and ‘Big 3’ pregnancy outcomes (congenital anomalies, preterm birth and small for gestational age). Embryonic growth was assessed by repeated first-trimester 3D transvaginal ultrasound measurements of crown-rump length and embyronic volume, analyzed with VR-software.</div></div><div><h3>Results</h3><div>For the total study population, the PVRS ranged from –0.071 to 0.320 (median 0.131). Higher PVRS values were significantly associated with reduced embryonic growth trajectories (CRL: β = –0.58 mm, 95% CI –0.94 to –0.23, <em>P</em> = 0.001; embryonic volume: β = –0.31 cm³, 95% CI –0.49 to –0.13, <em>P</em> = 0.001). Subgroup analyses revealed significant negative associations in naturally conceived pregnancies (CRL: β = –0.82 mm, 95% CI –1.48 to –0.16, <em>P</em> = 0.015; embryonic volume: β = –0.39 cm³, 95% CI –0.71 to –0.08, <em>P</em> = 0.015) and in overweight women (CRL: β = –0.91 mm, 95% CI –1.55 to –0.27, <em>P</em> = 0.006; embryonic volume: β = –0.51 cm³, 95% CI –0.82 to –0.21, <em>P</em> = 0.001).</div></div><div><h3>Conclusions</h3><div>The PVRS provides a weighted measure of maternal vulnerability, significantly associated with reduced embryonic growth, particularly in naturally conceived pregnancies and overweight women. Although no causality can be inferred from this study, the observed associations suggest that a broad peri-conceptional vulnerability assessment could help to identify potentially modifiable risk factors.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"52 1","pages":"Article 105085"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}