Reproductive biomedicine online最新文献

{"title":"Front Matter - Continued TOC","authors":"","doi":"10.1016/S1472-6483(25)00018-5","DOIUrl":"10.1016/S1472-6483(25)00018-5","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104811"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation before sterilizing treatment: cryopreservation of both ovaries to restore endocrine and reproductive functions","authors":"Catherine Poirot ,&nbsp;Nicolas Foureur ,&nbsp;Claudine Esper ,&nbsp;Marie-Madeleine Dolmans","doi":"10.1016/j.rbmo.2024.104472","DOIUrl":"10.1016/j.rbmo.2024.104472","url":null,"abstract":"<div><div>Ovarian cortex cryopreservation is now a validated fertility preservation technique. Autotransplantation of this tissue allows restoration of ovarian hormone function in more than 90% of patients, and birth of at least one child in 30% of transplanted women. In the case of very highly gonadotoxic treatments, it is recommended that ovarian cortex be cryopreserved as first-line therapy to safeguard future fertility. However, the ovary left in place runs a very high risk of being significantly altered. This raises the question of harvesting both ovaries, looking to restore fertility as well as endocrine function. Indeed, hormone balance in these cancer survivors may be recovered naturally for their entire lifetime. Autotransplantation could also be performed to restore hormone function in women with no wish to have children, with the sole purpose of improving their quality of life. Ethical and legal challenges exist and are discussed in this paper, but they do not constitute an argument against it. Clinical trials investigating this strategy are clearly needed, but this approach truly offers women the chance of having both endocrine and reproductive functions restored and maintained throughout their entire life.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104472"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oocyte yield and live birth rate after follitropin delta dosing and fresh embryo transfer: an individual patient data meta-analysis","authors":"Rita Lobo ,&nbsp;Ali Falahati ,&nbsp;Kelle Moley ,&nbsp;Anja Pinborg ,&nbsp;Samuel Santos-Ribeiro ,&nbsp;Nick S. Macklon ,&nbsp;Ida E. Jepsen","doi":"10.1016/j.rbmo.2024.104451","DOIUrl":"10.1016/j.rbmo.2024.104451","url":null,"abstract":"<div><h3>Research question</h3><div>What number of retrieved oocytes is associated with the optimum chance of achieving a live birth for women undergoing ovarian stimulation with individualized follitropin delta?</div></div><div><h3>Design</h3><div>An individual patient data meta-analysis was performed on 1772 patients from five randomized controlled trials using individualized follitropin delta for ovarian stimulation with fixed daily dosing based on serum anti-Müllerian hormone (AMH) level and body weight. Live birth rate (LBR) and ovarian hyperstimulation syndrome (OHSS) were evaluated in relation to the number of oocytes retrieved. Predicted LBR was obtained using a logistic regression analysis with fractional polynomials. Subgroup analyses were performed based on number of oocytes retrieved, age and AMH level.</div></div><div><h3>Results</h3><div>The analysis included patients treated with follitropin delta who had at least one oocyte retrieved. The mean number of oocytes retrieved was 10.4, and overall LBR was 32.1%. Predicted LBR increased with the number of oocytes retrieved, reaching &gt;34% for patients with 8-14 oocytes retrieved, and peaking at 34.9% for patients with 11 oocytes retrieved. LBR declined gradually beyond retrieval of 14 oocytes. LBR was 27.8%, 33.6% and 30.9% for patients with 1-7, 8-14, and ≥15 oocytes retrieved, respectively. LBR decreased with increasing age: 32.7%, 30.7% and 23.4% at &lt;35, 35–37 and 38–42 years, respectively. The incidence of OHSS (any grade) was 2.1%, 5.2% and 17.0% for patients with 1-7, 8-14, and ≥15 oocytes retrieved, respectively.</div></div><div><h3>Conclusions</h3><div>After ovarian stimulation with individualized follitropin delta, LBR in fresh transfer cycles was highest for patients with 8-14 oocytes retrieved, and peaked in patients with 11 oocytes retrieved. The results support the appropriateness of the follitropin delta dosing algorithm.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104451"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of vitamin D receptor gene polymorphisms, metabolic features and susceptibility to polycystic ovary syndrome: a preliminary study","authors":"Talida Vulcan,&nbsp;Mihaela Iancu,&nbsp;Lucia Maria Procopciuc,&nbsp;Tudor Sergiu Suciu,&nbsp;Gabriela Adriana Filip","doi":"10.1016/j.rbmo.2024.104447","DOIUrl":"10.1016/j.rbmo.2024.104447","url":null,"abstract":"<div><h3>Research question</h3><div>Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (<em>FokI, ApaI</em> and <em>TaqI</em>) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?</div></div><div><h3>Design</h3><div>This case–control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction–restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.</div></div><div><h3>Results</h3><div>Women in the PCOS group had a larger waist circumference (<em>P</em> = 0.0383) and a higher visceral adiposity index (VAI) (<em>P</em> &lt; 0.0001) compared with controls. Total cholesterol (<em>P</em> &lt; 0.0001), high-density lipoprotein cholesterol (<em>P</em> = 0.00001) and triglyceride (<em>P</em> &lt; 0.0001) concentrations were higher in the PCOS group. The VDR-<em>FokI</em> C/C (F/F) genotype was associated with significantly higher odds of PCOS (adjusted OR 6.27, 95% CI 1.53–25.65). The VDR-<em>ApaI</em> genotype was associated with susceptibility to PCOS in the dominant model; the variant genotypes [A/C + A/A (A/a + a/a)] had higher odds of PCOS than the wild genotype [C/C (A/A)] (adjusted OR 3.15, 95% CI 1.07–9.32). Haplotype analysis revealed that the T-C-T (f-A-T) haplotype was significantly associated with lower odds of PCOS (adjusted OR 0.10, 95% CI 0.01–0.95). Women with PCOS carrying the VDR-<em>FokI</em> T/T (f/f) genotype had lower fasting glucose (<em>P</em> = 0.0469) and higher VAI (<em>P</em> = 0.0406) compared with women with the C/T (Ff) + C/C (F/F) genotype.</div></div><div><h3>Conclusion</h3><div>The present findings suggest an association between <em>FokI</em> and <em>ApaI</em> polymorphisms and PCOS susceptibility. Moreover, the VDR-<em>FokI</em> T/T (f/f) genotype could be a marker for decreased fasting glucose in women with PCOS. No association was found between the <em>TaqI</em> polymorphism and PCOS susceptibility in the study population.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104447"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legal framework and IVF outcomes: a comparative analysis of fresh and frozen embryo transfers in Switzerland","authors":"Janna Pape ,&nbsp;Jérémy Levy ,&nbsp;Sofia Makieva ,&nbsp;Michael von Wolff","doi":"10.1016/j.rbmo.2024.104483","DOIUrl":"10.1016/j.rbmo.2024.104483","url":null,"abstract":"<div><h3>Research question</h3><div>To what extent do legislative measures impact standard reproductive outcome parameters?</div></div><div><h3>Design</h3><div>Retrospective cohort study using data from the Swiss national IVF registry analysing the outcomes of 13,908 women undergoing embryo transfers resulting from their first lifetime oocyte retrieval before (2014–2016) or after (2020–2022) revision of the legislation, allowing extended culture for 12 zygotes. Live birth rates (LBR) and cumulative LBR (cLBR) were compared in fresh and frozen embryo transfer strategies in both periods. Adjusted multivariable mixed model analyses were performed to determine OR and incidence rate ratios (IRR).</div></div><div><h3>Results</h3><div>Before revision of the legislation, LBR was higher for fresh embryo transfers compared with frozen embryo transfers (27.2% versus 22.7%; <em>P</em> = 0.006). After revision of the legislation, LBR was lower for fresh embryo transfers (29.3% versus 36.3%; <em>P</em> &lt; 0.001), and cLBR was higher for the freeze-all embryo transfer strategy (59.0% versus 39.8%; <em>P</em> &lt; 0.001). However, in a multivariable analysis, no difference in the odds of live birth was found between fresh and frozen embryo transfers (OR = 1.08, 95% CI 0.95–1.22), and the freeze-all embryo transfer strategy was not found to be more effective than the fresh embryo transfer strategy (IRR = 1.12, 95% CI 0.98–1.27). In a subgroup analysis, fresh blastocyst embryo transfers showed higher LBR than cleavage stage embryo transfers (OR = 2.01, 95% CI 1.62–2.49).</div></div><div><h3>Conclusion</h3><div>The change in national legislation provided the unique opportunity to evaluate the legal impact on reproductive outcomes. Besides a reduction in the number of multiple births, LBR in frozen embryo transfers improved, resulting in comparable success of fresh and frozen embryo transfer strategies. In addition to technological improvement, the legal framework influences the evolution of clinical practice, thereby contributing to enhanced reproductive outcomes.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104483"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Editorial Board","authors":"","doi":"10.1016/S1472-6483(25)00028-8","DOIUrl":"10.1016/S1472-6483(25)00028-8","url":null,"abstract":"","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104821"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted reproductive technologies in Latin America: the Latin American Registry, 2021","authors":"Fernando Zegers-Hochschild ,&nbsp;Javier A. Crosby ,&nbsp;Carolina Musri ,&nbsp;Fanny Petermann-Rocha ,&nbsp;Gustavo Martinez ,&nbsp;Hitomi Nakagawa ,&nbsp;Carlos Morente ,&nbsp;Armando Roque ,&nbsp;Ana Palma-Govea ,&nbsp;Latin American Network of Assisted Reproduction","doi":"10.1016/j.rbmo.2024.104413","DOIUrl":"10.1016/j.rbmo.2024.104413","url":null,"abstract":"<div><h3>Research question</h3><div>What are the trends and impact of new technologies on the effectiveness and safety of assisted reproductive technology (ART) performed in Latin America during 2021?</div></div><div><h3>Design</h3><div>This was a retrospective collection of cycle-based multinational data obtained from ART procedures performed by 204 accredited institutions in 16 countries.</div></div><div><h3>Results</h3><div>In total 127,351initiated cycles resulted in 20,032 deliveries and 22,708 births. ART utilization showed great variability, from 623.5 cycles/million inhabitants in Uruguay to fewer than 35 in Guatemala and El Salvador. The proportion of women aged ≥40 years increased to 35.8%, while that of women ≤34 years dropped to 23.9%. Nonetheless, the proportion of single-embryo transfers (SET) increased from 11.9% in the previous decade to 42.4% in 2021. Of 22,708 babies born, 76.8% were singletons, 22.3% twins and 1.0% triplets or more. Intracytoplasmic sperm injection represented 84.5% of fertilization techniques, and blastocyst transfer increased from 49.6% in 2016 to 79.3% in 2021. The delivery rate after fresh blastocyst elective SET was significantly higher than after the transfer of one frozen embryo from a freeze-all cycle (<em>P</em> &lt; 0.0001). The number of aspirations leading to preimplantation genetic testing has increased 2.8 times in 5 years and significantly increased delivery rates/transfer at all ages, including in oocyte donation (<em>P</em> ≤ 0.002), and reduced miscarriage in women ≥35 years old. In oocyte donation, delivery rates after the fresh transfer of embryos from vitrified-warmed oocyte cycles generated similar outcomes to frozen embryo transfer. Perinatal mortality increased from 7.7‰ in singletons to 21.3‰ in twins.</div></div><div><h3>Conclusion</h3><div>The systematic collection of cycle-based multinational data contributes to cooperative sustained development and helps implement evidence-based reproductive decisions.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104413"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomimetic sperm selection device for routine sperm selection","authors":"Steven A. Vasilescu ,&nbsp;Dale M. Goss ,&nbsp;Kathryn H. Gurner ,&nbsp;Rebecca L. Kelley ,&nbsp;Maria Mazi ,&nbsp;Fabrice K. De Bond ,&nbsp;Jennifer Lorimer ,&nbsp;Fabrizzio Horta ,&nbsp;Farin Y. Parast ,&nbsp;David K. Gardner ,&nbsp;Reza Nosrati ,&nbsp;Majid E. Warkiani","doi":"10.1016/j.rbmo.2024.104433","DOIUrl":"10.1016/j.rbmo.2024.104433","url":null,"abstract":"<div><h3>Research question</h3><div>Can a biomimetic microfluidic sperm sorter isolate motile sperm while minimizing DNA damage in comparison with density gradient centrifugation (DGC)?</div></div><div><h3>Design</h3><div>This was a two-phase study of 61 men, consisting of a proof-of-concept study with 21 donated semen samples in a university research laboratory, followed by a diagnostic andrology study with 40 consenting patients who presented at a fertility clinic for semen diagnostics. Each sample was split to perform DGC and microfluidic sperm selection (one-step sperm selection with 15 min of incubation) side-by-side. Outcomes evaluated included concentration, progressive motility, and DNA fragmentation index (DFI) of raw semen, and sperm isolated using DGC and the microfluidic device. Results were analysed using Friedman's test for non-parametric data (significant when <em>P</em> &lt; 0.05). DFI values were assessed by sperm chromatin dispersion assay.</div></div><div><h3>Results</h3><div>Sperm isolated using DGC and the microfluidic device showed improved DFI values and motility compared with the raw semen sample in both cohorts. However, the microfluidic device was significantly better than DGC at reducing DFI values in both the proof-of-concept study (<em>P</em> = 0.012) and the diagnostic andrology study (<em>P</em> &lt; 0.001). Progressive motility was significantly higher for sperm isolated using the microfluidic device in the proof-of-concept study (<em>P</em> = 0.0061) but not the diagnostic andrology study. Sperm concentration was significantly lower for samples isolated using the microfluidic device compared with DGC for both cohorts (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Channel-based biomimetic sperm selection can passively select motile sperm with low DNA fragmentation. When compared with DGC, this method isolates fewer sperm but with a higher proportion of progressively motile cells and greater DNA integrity.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104433"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transrectal oocyte retrieval for fertility preservation in virginal women","authors":"Michael Fakih ,&nbsp;Ahmad Fakih ,&nbsp;Mouna Fawaz ,&nbsp;Yasmin Sajjad ,&nbsp;Muhammad Ahsan Akhtar ,&nbsp;Fady Sharara","doi":"10.1016/j.rbmo.2024.104475","DOIUrl":"10.1016/j.rbmo.2024.104475","url":null,"abstract":"<div><h3>Research question</h3><div>How safe and effective is transrectal oocyte retrieval (TROR) for fertility preservation in nulliparous virginal women?</div></div><div><h3>Design</h3><div>This was a retrospective single-centre study of 105 nulliparous women from five satellite centres of Fakih IVF, UAE, who underwent TROR for oocyte cryopreservation. Extensive bowel preparation and rectal cleansing was performed prior to oocyte retrieval. Patient characteristics, stimulation protocol, and procedure outcome and safety data were collected. Correlation analyses of the number of follicles and oocyte yield in relation to age and anti-Müllerian hormone (AMH) concentration, and the number of follicles in relation to oocyte yield were performed.</div></div><div><h3>Results</h3><div>This study evaluated 105 patients who underwent 152 cycles of ovarian stimulation and TROR. The most common indication was social fertility preservation. A significant positive correlation was found between the AMH concentration and number of oocytes (<em>r</em> = 0.83, <em>P</em> &lt; 0.003). No intra-operative or postoperative complications were observed.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that TROR is an alternative and clinically effective oocyte harvesting procedure in assisted reproductive technology, producing good results in terms of oocyte yield, with no complications and a good safety profile. Although transvaginal oocyte retrieval remains the gold-standard treatment, TROR is safe and effective for virginal women in whom transvaginal oocyte retrieval is not an option.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"50 2","pages":"Article 104475"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle translocation does not affect euploid blastocyst rate or pregnancy outcomes during preimplantation genetic testing.","authors":"Yun Wang, Yuchao Zheng, Yize Han, Minjie Shao, Liang Chang, Jin Huang","doi":"10.1016/j.rbmo.2025.104806","DOIUrl":"https://doi.org/10.1016/j.rbmo.2025.104806","url":null,"abstract":"<p><strong>Research question: </strong>Do chromosomal translocation segment size and proportion affect embryo euploidy and pregnancy outcomes during preimplantation genetic testing (PGT) cycles in subtle translocation carriers?</p><p><strong>Design: </strong>Retrospective cohort study including 207 couples with reciprocal translocation who underwent 232 PGT for structural rearrangements cycles; euploid blastocysts were selected for transfer. A total of 119 couples completed 155 warming transfer cycles, and 58 cycles resulted in clinical pregnancy. According to the size of the translocation segment (threshold 10 Mb), couples were divided into subtle translocation group 1 (translocation segment on either chromosome was <10 Mb) and control group 1 (translocation segments on both chromosomes were ≥10 Mb). Couples were divided into subtle translocation group 2 (proportion on either chromosome segment was <5% relative to the whole chromosome) and control group 2 (proportions on both chromosome segments were ≥5% relative to the whole chromosome). Rates of euploid blastocysts and clinical outcomes were analysed.</p><p><strong>Results: </strong>No significant differences were found in the rates of euploid blastocysts, (37.11% versus 36.08%; P = 0.817) and clinical pregnancy (32.56% versus 39.28%; P = 0.438) compared with subtle translocation group 1 and control group 1, respectively. Similarly, no significant differences were found in the rates of euploid blastocysts (35.00% versus 36.75%; P = 0.572) and clinical pregnancy (34.28% versus 38.33%; P = 0.663) compared with subtle translocation group 2 and control group 2.</p><p><strong>Conclusions: </strong>The size and proportion of a translocation segment did not significantly affect the rate of euploid blastocysts or pregnancy outcomes during PGT cycles for couples with chromosomal translocations.</p>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":" ","pages":"104806"},"PeriodicalIF":3.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}