Association of Vitamin D receptor gene polymorphisms (FokI, ApaI, TaqI), metabolic features and susceptibility to polycystic ovary syndrome: a preliminary single center case-control study

IF 3.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Talida Vulcan, Iancu Mihaela, Lucia Maria Procopciuc, Tudor Sergiu Suciu, Gabriela Adriana Filip
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引用次数: 0

Abstract

Are the combined genotypes and haplotypes of VDR gene polymorphisms () associated with PCOS susceptibility and metabolic features of the disease? We performed a case-control study, including 46 women with PCOS and 48 controls. Genotypes of VDR genes were determined using the PCR-RFLP (restriction fragment length polymorphism) method. In all women, the waist circumference, parameters of lipid and glucose metabolism were evaluated. PCOS group presented higher waist circumference and visceral adiposity index (VAI) levels compared to controls. Total cholesterol, LDL-C and triglycerides had higher values in PCOS women. VDR- C/C (F/F) genotype had significantly higher odds of PCOS (adjusted OR = 6.27, 95% CI: 1.53-25.65). VDR- was associated with susceptibility to PCOS in the dominant model, the variant genotype (A/C-A/A) (A/a- a/a) had higher odds of PCOS than the wild genotype C/C (A/A) (adjusted OR = 3.15, 95% CI: 1.07-9.32). Haplotype analysis revealed that T-C- T (f-A-T) haplotype was statistically associated with lower odds of PCOS (adjusted OR = 0.10, 95% CI: 0.01-0.95). PCOS women with VDR-Fokl T/T (f/f) genotype had lower fasting glucose and higher VAI levels compared to C/T (Ff) or C/C (F/F) genotype. The present findings suggest the association between and polymorphisms and PCOS susceptibility. Moreover, T/T (f/f) genotype of VDR- could be a marker of decreased fasting glucose in PCOS. polymorphism did not reveal a relationship with PCOS susceptibility in our study population.
维生素 D 受体基因多态性(FokI、ApaI、TaqI)、代谢特征与多囊卵巢综合征易感性的关系:一项初步的单中心病例对照研究
VDR 基因多态性()的组合基因型和单倍型是否与多囊卵巢综合征的易感性和该病的代谢特征有关?我们进行了一项病例对照研究,其中包括 46 名多囊卵巢综合征妇女和 48 名对照组妇女。采用 PCR-RFLP(限制性片段长度多态性)方法确定了 VDR 基因的基因型。对所有妇女的腰围、血脂和糖代谢参数进行了评估。与对照组相比,多囊卵巢综合征组的腰围和内脏脂肪指数(VAI)水平较高。多囊卵巢综合征妇女的总胆固醇、低密度脂蛋白胆固醇和甘油三酯的数值较高。VDR- C/C(F/F)基因型患多囊卵巢综合症的几率明显更高(调整后 OR = 6.27,95% CI:1.53-25.65)。在显性模型中,VDR- 与多囊卵巢综合征的易感性相关,变异基因型(A/C-A/A)(A/a- a/a)比野生基因型 C/C (A/A)患多囊卵巢综合征的几率更高(调整 OR = 3.15,95% CI:1.07-9.32)。单倍型分析表明,T-C- T(f-A-T)单倍型与多囊卵巢综合征的较低几率有统计学关联(调整后 OR = 0.10,95% CI:0.01-0.95)。与 C/T (Ff) 或 C/C (F/F) 基因型相比,具有 VDR-Fokl T/T (f/f) 基因型的多囊卵巢综合症女性空腹血糖较低,VAI 水平较高。本研究结果表明,和多态性与多囊卵巢综合征易感性之间存在关联。此外,在我们的研究人群中,VDR-的T/T(f/f)基因型可能是多囊卵巢综合征患者空腹血糖降低的标志物。
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来源期刊
Reproductive biomedicine online
Reproductive biomedicine online 医学-妇产科学
CiteScore
7.20
自引率
7.50%
发文量
391
审稿时长
50 days
期刊介绍: Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.
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