Reproductive biomedicine online最新文献

{"title":"Corticosteroids, androgens, progestogens and oestrogens in the endometrial microenvironment, and their association with endometrial progression and function","authors":"Diana Marti-Garcia ,&nbsp;Almudena Devesa-Peiro ,&nbsp;Elena Labarta ,&nbsp;Marina Lopez-Nogueroles ,&nbsp;Patricia Sebastian-Leon ,&nbsp;Nuria Pellicer ,&nbsp;Marcos Meseguer ,&nbsp;Patricia Diaz-Gimeno","doi":"10.1016/j.rbmo.2024.104377","DOIUrl":"10.1016/j.rbmo.2024.104377","url":null,"abstract":"<div><h3>Research question</h3><div>How does the intracrine action of progestagens, oestrogens, androgens and corticosteroids affect endometrial tissue progression and function?</div></div><div><h3>Design</h3><div>In this prospective observational study, 76 patients (&lt;50 years old, no uterine pathologies and at least one failed IVF cycle) undergoing endometrial biopsy collection for endometrial evaluation between 2018 and 2021 were included. The concentrations of 11 steroid metabolites (cortisone, cortisol, progesterone, oestrone, 2-methoxyestrone, oestradiol, oestriol, testosterone, androstenedione, 17α-hydroxyprogesterone and 17-hydroxypregnenolone) were measured by ultra-performance liquid chromatography-tandem mass spectrometry in the endometrial tissue samples collected during the mid-secretory phase. Endometrial dating and reproductive outcomes (relative to the next good-quality fresh or frozen embryo transfer after the biopsy) were analysed in relation to endometrial steroid concentrations using Barnard's test; correlations between metabolite concentrations were measured by Pearson's correlation co-efficient.</div></div><div><h3>Results</h3><div>Endometrial cortisol concentrations increased with age, whereas oestrone and 17α-hydroxyprogesterone concentrations had inverse relationships with body mass index (all <em>P</em> &lt; 0.05). No statistically significant differences were found in age or body mass index related to endometrial progression and reproductive outcomes. Low endometrial progesterone (&lt;40.07 μg/g), along with high endometrial cortisol (&gt;2.18 ng/g) and testosterone concentrations (≥0.52 ng/g), were mainly associated with out-of-phase endometria. Although low oestrone (&lt;21.27 ng/g) and high androstenedione endometrial concentrations (≥1.35 ng/g) impaired reproductive success, low oestradiol (&lt;1.15 ng/g) endometrial concentrations favoured conception (all <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>In addition to progesterone and oestrogens, other steroid hormones are involved in intracrine signalling, and are probably necessary for acquiring adequate endometrial competence and supporting conception.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104377"},"PeriodicalIF":3.7,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good practice in laboratory diagnostic andrology: Association of Reproductive and Clinical Scientists guidelines 2024","authors":"Meurig T. Gallagher ,&nbsp;Emily Roxburgh ,&nbsp;Gwen Bennett ,&nbsp;Susan Parker ,&nbsp;Jackson C. Kirkman-Brown ,&nbsp;Association of Reproductive and Clinical Scientists","doi":"10.1016/j.rbmo.2024.104373","DOIUrl":"10.1016/j.rbmo.2024.104373","url":null,"abstract":"<div><div>These guidelines update and clarify items relating to diagnostic andrology in the 2012 Association of Biomedical Andrologists Laboratory Andrology Guidelines for Good Practice Version 3. The main change separates diagnostic and therapeutic andrology into individual documents; post-vasectomy semen analysis still references the 2016 guideline. These guidelines seek to incorporate and clarify internationally agreed methodology following the World Health Organization <em>Laboratory Manual for the Examination and Processing of Human Semen</em> 6th edition and publication of ISO 23162:2021. Significant updates include: requiring four-category grading for motility (A, rapidly progressive; B, slowly progressive; C, non-progressive; D, immotile); a four-part morphology assessment (head, midpiece, tail, cytoplasmic droplets) as essential for quality assurance (even if only the percentage of ‘normal’ is reported); and specifying sperm toxicity testing procedures for diagnostic andrology. These guidelines include a section on haematospermia, an observation requiring rapid onward referral. An Association of Reproductive and Clinical Scientists (ARCS) working group wrote these guidelines, with review by ARCS members. The aim is to guide good practice in laboratories but they are not intended as a tool to judge the practice of centres within the UK or beyond.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104373"},"PeriodicalIF":3.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing single blastocyst selection: the role of day 3 embryo morphology in vitrified-warmed blastocyst transfer cycles","authors":"Yu Xiao ,&nbsp;Ping Zhang ,&nbsp;Li Wang ,&nbsp;Yiling Ko ,&nbsp;Min Wang ,&nbsp;Ji Xi ,&nbsp;Chengliang Zhou ,&nbsp;Xiaojun Chen","doi":"10.1016/j.rbmo.2024.104364","DOIUrl":"10.1016/j.rbmo.2024.104364","url":null,"abstract":"<div><h3>Research question</h3><p>Can day 3 embryo morphology serve as an independent criterion for optimal single blastocyst selection?</p></div><div><h3>Design</h3><p>This retrospective, single-centre cohort study included 1517 single vitrified-warmed blastocyst transfer (SVBT) cycles conducted between October 2019 and July 2022. The live birth rate (LBR) and other clinical outcomes of SVBT cycles were evaluated, considering both good-quality and non-good-quality day 3 embryos. The associations of day 3 morphological characteristics, encompassing number of blastomeres and embryo grade, were assessed. Multivariable analyses were undertaken using multiple models adjusted for day of blastocyst development and blastocyst grade.</p></div><div><h3>Results</h3><p>Blastocysts from good-quality day 3 embryos had significantly higher LBR compared with those from non-good-quality embryos for both day 5 (51.5% versus 42.9%; <em>P</em> = 0.013) and day 6 (25.1% versus 17.6%; <em>P</em> = 0.018) blastocysts. LBR did not differ significantly with number of blastomeres on day 3, regardless of day of blastocyst development (day 5/6) or blastocyst grade. LBR varied significantly by day 3 embryo grade for both day 5 (48.0%, 51.5%, 46.6% and 32.7% for grades I, II, III and IV–V; <em>P</em> = 0.005) and day 6 (41.5%, 23.6%, 15.9% and 16.1% for grades I, II, III and IV–V; <em>P</em> = 0.001) blastocysts. Multivariable logistic regression revealed that non-good-quality embryos and lower morphological grade (IV–V) on day 3 were significantly and negatively correlated with LBR, while the number of blastomeres on day 3 was not an independent factor.</p></div><div><h3>Conclusions</h3><p>When selecting blastocysts of equal quality for SVBT cycles, those with higher day 3 morphological scores are preferred. Day 3 morphological evaluation is a valuable supplement to conventional selection methods.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 5","pages":"Article 104364"},"PeriodicalIF":3.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm RNA code in spermatogenesis and male infertility","authors":"Zhongyi Zhao ,&nbsp;Tingting Yang ,&nbsp;Fuping Li","doi":"10.1016/j.rbmo.2024.104375","DOIUrl":"10.1016/j.rbmo.2024.104375","url":null,"abstract":"<div><div>Spermatozoa are traditionally thought to be transcriptionally inert, but recent studies have revealed the presence of sperm RNA, some of which is derived from the residues of spermatocyte transcription and some from epididymosomes. Paternal sperm RNA can be affected by external factors and further modified at the post-transcriptional level, for example N⁶-methyladenosine (m⁶A), thus shaping spermatogenesis and reproductive outcome. This review briefly introduces the origin of sperm RNA and, on this basis, summarizes the current knowledge on RNA modifications and their functional role in spermatogenesis and male infertility. The bottlenecks and knowledge gaps in the current research on RNA modification in male reproduction have also been indicated. Further investigations are needed to elucidate the functional consequences of these modifications, providing new therapeutic and preventive strategies for reproductive health and genetic inheritance.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104375"},"PeriodicalIF":3.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience and andrological follow-up after testicular tissue cryopreservation","authors":"Romane Levade ,&nbsp;Nathalie Rives ,&nbsp;Agnès Liard ,&nbsp;Lucie Grynberg ,&nbsp;Nimrod Buchbinder ,&nbsp;Pascale Schneider ,&nbsp;Ludovic Dumont ,&nbsp;Christine Rondanino ,&nbsp;Aurélie Feraille","doi":"10.1016/j.rbmo.2024.104374","DOIUrl":"10.1016/j.rbmo.2024.104374","url":null,"abstract":"<div><h3>Research question</h3><div>What is the experience and mid- and long-term andrological health follow-up of (pre)pubertal males who have undergone testicular tissue freezing (TTF)?</div></div><div><h3>Design</h3><div>This single-centre longitudinal retrospective cohort study reports on the mid- and long-term andrological health follow-up of (pre)pubertal males and young adults who underwent TTF for fertility preservation between January 2007 and December 2018. Medical characteristics and questionnaire data collected more than 18 months after TTF were analysed.</div></div><div><h3>Results</h3><div>Thirty-six patients were revisited during a medical follow-up consultation. During follow-up after TTF, 72.7% of patients could not recollect their counselling consultation prior to TTF but 42.4% of them found information about the TTF process useful and sufficient. Parents’ or legal guardians’ feedback was more positive about the counselling consultation and the TTF process. After TTF and treatment, the majority of patients (76.9%) who provided a semen sample had non-obstructive azoospermia. Higher serum concentrations of FSH and LH and lower serum concentrations of inhibin B were associated with non-obstructive azoospermia compared with patients with oligozoospermia (<em>P</em> = 0.0182, <em>P</em> = 0.0245 and <em>P</em><strong> = </strong>0.0140 respectively). During cancer treatment, about half of pubertal patients reported sexual dysfunction, decreasing to approximately 20% after treatment. However, two patients had children using sperm donation and one patient had a child through natural pregnancy.</div></div><div><h3>Conclusions</h3><div>The involvement of parents or legal guardians is crucial in the decision-making process for fertility preservation in (pre)pubertal boys. Regular follow-up, including the use of questionnaires, is essential to provide guidance for fertility preservation programmes and information on fertility restoration options and to address the psychosocial aspects of fertility preservation.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104374"},"PeriodicalIF":3.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141700336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between Sjögren's syndrome and recurrent pregnancy loss: a bioinformatics analysis","authors":"Fangxiang Mu ,&nbsp;Cai Liu ,&nbsp;Huyan Huo,&nbsp;Xianghui Zeng,&nbsp;Fang Wang","doi":"10.1016/j.rbmo.2024.104363","DOIUrl":"10.1016/j.rbmo.2024.104363","url":null,"abstract":"<div><h3>Research question</h3><p>As Sjögren's syndrome is an autoimmune disease and an essential factor in recurrent pregnancy loss (RPL), are there gene-related relationships between the pathogenesis of Sjögren's syndrome and RPL?</p></div><div><h3>Design</h3><p>The gene datasets for Sjögren's syndrome and RPL were obtained from the Gene Expression Omnibus database, and the co-expression modules and shared differentially expressed genes were identified through weighted gene co-expression network analysis (WGCNA) and limma analysis based on sample size. Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analyses were applied to reveal the hidden biological pathways. Additionally, shared hub gene identification, gene set enrichment analysis, association of the hub gene with ferroptosis and immunity, drug sensitivity analysis, single-cell RNA sequencing analysis, and construction of the competing endogenous RNA (ceRNA) network were conducted.</p></div><div><h3>Results</h3><p>By intersecting the genes from WGCNA and limma analysis, one shared hub gene (<em>KCNN3</em>) was derived, exhibiting up-regulation in Sjögren's syndrome and RPL. There was a positive relationship between <em>KCNN3</em> and the immune-related gene <em>TLR2</em>. The ceRNA network revealed that <em>XIST</em> was the most shared long non-coding RNA, which may bind competitively with eight microRNA to regulate the expression of <em>KCNN3</em>. Forty-eight drugs were found to be strongly associated with <em>KCNN3</em> expression, including estramustine and cyclosporine. Moreover, <em>KCNN3</em> exhibited high expression in RPL endothelial cells of villous tissue.</p></div><div><h3>Conclusions</h3><p>This is one of the first studies to reveal that Sjögren's syndrome shares common biological pathways with RPL. <em>KCNN3</em> was identified as the hub gene associated with Sjögren's syndrome and RPL, and may be a new target for mechanistic studies on Sjögren's syndrome and RPL.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 6","pages":"Article 104363"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005522/pdfft?md5=1e22d14e74c08d74fecf7009325e1b82&pid=1-s2.0-S1472648324005522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let's not abandon programmed frozen embryo transfers yet: a countercurrent perspective","authors":"Paul Pirtea ,&nbsp;James P. Toner ,&nbsp;Richard T. Scott Jr ,&nbsp;Dominique de Ziegler","doi":"10.1016/j.rbmo.2024.104365","DOIUrl":"10.1016/j.rbmo.2024.104365","url":null,"abstract":"<div><p>The countercurrent opinion given in this paper is that the optimal management of frozen embryo transfers (FET) is not a one-size-fits-all matter, but rather one that should be decided after considering all the various parameters and options. This choice should notably encompass patients’ individual characteristics – including variable risks of obstetric complications – and weigh out the respective advantages of each FET option in each case. While there may be real advantages for natural-cycle FET in many cases, these need to be balanced against both practical and clinical issues. Contrary to several prevailing, sometimes loudly expressed suggestions, there is not a one single effective approach when it comes to choosing a mode of scheduling FET.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 5","pages":"Article 104365"},"PeriodicalIF":3.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are you aware of your citations? A cross-sectional survey on improper citations of retracted articles in assisted reproduction","authors":"Sabrina Minetto ,&nbsp;Domenico Pisaturo ,&nbsp;Greta Chiara Cermisoni ,&nbsp;Valeria Stella Vanni ,&nbsp;Luca Pagliardini ,&nbsp;Enrico Papaleo ,&nbsp;Vincenzo Berghella ,&nbsp;Ben W. Mol ,&nbsp;Alessandra Alteri","doi":"10.1016/j.rbmo.2024.104366","DOIUrl":"10.1016/j.rbmo.2024.104366","url":null,"abstract":"<div><h3>Research question</h3><p>Are authors aware when they have cited a retracted paper in their manuscripts in the medically assisted reproduction (MAR) field?</p></div><div><h3>Design</h3><p>A cross-sectional study based on an online survey was conducted to acquire information on the citation pattern from corresponding authors who had cited a retracted article. A dataset of retracted articles in the MAR field was collected from PubMed and Retraction Watch. A complete list of published articles that cited each retracted article was retrieved. The survey was distributed via e-mail to corresponding authors who had cited a retracted paper in their study.</p></div><div><h3>Results</h3><p>The survey revealed a significant lack of awareness among authors, with 78.7% unaware that they had cited retracted articles. This lack of awareness was attributed to insufficient notification mechanisms within research databases and journals, alongside a reliance on previously stored copies of manuscripts. A notable finding was that reference checks were typically performed by a single author, with no instances of retraction concerns raised during the peer-review process. Only a small fraction (17.8%) of respondents reported verifying retraction notices on both journal websites and scientific databases.</p></div><div><h3>Conclusions</h3><p>Correcting publications that contain references which are subsequently retracted is significant for systematic reviews, meta-analyses and guidelines. Citations of retracted articles perpetuate erroneous scientific data, but assessing the accuracy of citations requires considerable effort. Proper notification of retraction status and cross-checking of citations can help to prevent errors.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 5","pages":"Article 104366"},"PeriodicalIF":3.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assisted reproductive technologies in Africa: The African Network and Registry for ART, 2020","authors":"Paversan Archary ,&nbsp;Liezel Potgieter ,&nbsp;Frissiano Honwana ,&nbsp;Eman Elgindy ,&nbsp;Rudolph Kantum Adageba ,&nbsp;Founzégué Amadou Coulibaly ,&nbsp;Faye Iketubosin ,&nbsp;Gamal Serour ,&nbsp;Silke Dyer ,&nbsp;African Network and Registry for Assisted Reproductive Technology","doi":"10.1016/j.rbmo.2024.104353","DOIUrl":"10.1016/j.rbmo.2024.104353","url":null,"abstract":"<div><h3>Research question</h3><p>What were the utilization, effectiveness and safety of assisted reproductive technology (ART) in Africa during 2020?</p></div><div><h3>Design</h3><p>Cross-sectional, cycle-based and retrospective summary data were collected from voluntarily participating ART centres.</p></div><div><h3>Results</h3><p>During 2020, 37,063 ART procedures were reported by 67 centres in 15 countries. Autologous fresh transfers were predominant at 65.0%, whereas autologous frozen embryo transfers (FET) represented 26.2% and oocyte donation cycles remained less than 10%. Women undergoing autologous fresh embryo transfer had a mean age of 34.9 years and received a mean number of 2.4 embryos per transfer. The clinical pregnancy rate (CPR) per embryo transfer was 37.3% after fresh embryo transfer and 37.8% after frozen embryo transfer. The cumulative CPR per aspiration was 41.9% in autologous cycles.</p><p>Most ART procedures resulted in a multiple delivery rate above 20%. After autologous ART, multiples were predominantly born preterm (twin and triplet deliveries 59.5% versus singleton 21.9% born before 37 weeks), with a substantially increased perinatal mortality compared with ART singletons (59.0‰ versus 22.2‰). Cycle-based data documented that elective single embryo transfer (eSET) provides the optimal balance of effectiveness (eSET CPR per embryo transfer 36.7%) and safety.</p></div><div><h3>Conclusion</h3><p>This fourth report of the African Network and Registry for ART provides real-world evidence of ART utilization, practices and outcomes in Africa, which is relevant to many stakeholders. It critically informs and represents regional ART development based on national, regional and global cooperation.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 5","pages":"Article 104353"},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147264832400542X/pdfft?md5=eb73b8d7389e213bcd31a909509a74c4&pid=1-s2.0-S147264832400542X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periconceptional maternal and paternal alcohol consumption and embryonic and fetal development: the Rotterdam periconception cohort","authors":"M. van der Windt,&nbsp;E.W. Tobi,&nbsp;I. Chidi,&nbsp;S. Schoenmakers,&nbsp;L. van Rossem,&nbsp;R.P.M. Steegers-Theunissen,&nbsp;M. Rousian","doi":"10.1016/j.rbmo.2024.104351","DOIUrl":"10.1016/j.rbmo.2024.104351","url":null,"abstract":"<div><h3>Research question</h3><p>What is the impact of maternal and paternal alcohol consumption in the periconception period on embryonic and fetal development assessed using three-dimensional ultrasound and virtual reality techniques?</p></div><div><h3>Design</h3><p>This prospective observational study was embedded in the Rotterdam periconception cohort (Predict study). Participating women received longitudinal three-dimensional transvaginal ultrasound examinations from week 7 to week 12 of gestation to measure crown–rump length and embryonic volume. Mid-pregnancy fetal size parameters and birth weight were retrieved from medical files. Participants completed a periconception exposure questionnaire and a validated food frequency questionnaire. Linear mixed models were used to analyse the association between parental alcohol consumption, and embryonic and fetal developmental parameters.</p></div><div><h3>Results</h3><p>In total, 1141 female and 987 male participants were included in the analyses. Moderate maternal alcohol consumption in the periconception period resulted in a smaller head circumference (β = -1.85, SE = 0.84, <em>P</em> = 0.03), abdominal circumference (β = -2.65, SE = 0.93, <em>P</em> = 0.004), femur length (β = -0.56, SE = 0.22, <em>P</em> = 0.01) and estimated fetal weight (β = -9.36, SE = 4.35, <em>P</em> = 0.03) at 20 weeks of gestation. Paternal alcohol consumption showed significant positive associations, mainly with fetal size parameters (abdominal circumference: β = 0.033, SE = 0.01, <em>P</em> = 0.008; estimated fetal weight: β = 0.131, SE = 0.06, <em>P</em> = 0.03).</p></div><div><h3>Conclusions</h3><p>Moderate maternal alcohol consumption is negatively associated with fetal growth parameters. Moreover, alcohol is proven to be a strong teratogen, and its consumption before and during pregnancy should be discouraged in both women and men as it affects several parameters of embryonic and fetal development.</p></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 5","pages":"Article 104351"},"PeriodicalIF":3.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1472648324005406/pdfft?md5=31f97ddc7ce72a48ad6e765c28db2ed3&pid=1-s2.0-S1472648324005406-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}