Redox Report最新文献_第7页

Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol 在恶唑酮诱导的溃疡性结肠炎中调节肠道生态失调和线粒体功能障碍:β-葡聚糖和/或celastrol的恢复作用

IF 3.8 2区生物学

Redox Report Pub Date : 2022-03-04 DOI: 10.1080/13510002.2022.2046425

Omnia Safwat El-Deeb, Rasha Osama El-Esawy, H. Al-Shenawy, H. Ghanem

{"title":"Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol","authors":"Omnia Safwat El-Deeb, Rasha Osama El-Esawy, H. Al-Shenawy, H. Ghanem","doi":"10.1080/13510002.2022.2046425","DOIUrl":"https://doi.org/10.1080/13510002.2022.2046425","url":null,"abstract":"ABSTRACT Objectives Microbiome–Mitochondria interaction is gaining a significant attention; thus, studying its mechanism emerges as a must to provide restorative lines in managing diseases. The aim is to study the mechanistic effects of β-Glucan and/or Celastrol in oxazolone-induced ulcerative colitis (UC). Methods 75 Wistar rats were allocated into 5 equal groups. Group I: control group. Group II: UC group, Group III: β-Glucan-treated UC group, Group IV: Celastrol-treated UC group & Group V: mutual treatment group. All groups were subjected to the detection of free fatty acid receptor 2 (FFAR-2) and peroxisome proliferator-activated receptor gamma co-activator1α (PGC-1α) mRNA gene expressions. Citrate synthase (CS) activity, mitochondrial membrane potential (MMP), ATP concentration, reactive oxygen species (ROS) were detected. Trimethylamine N-oxide (TMAO) concentration was measured. Results After treatment we monitored significant upregulation of FFAR-2 and PGC-1α mRNA expression. Likewise, ATP level and CS activity were significantly increased. On the contrary, there was a significant lessening in ROS and TMAO levels with improvement of MMP. Conclusion Mutual use of β- Glucan and Celastrol had a greater effect than each alone against UC, which is considered a novel finding highlighting the ameliorative effects of this combined treatment in modulating Microbiome/Mitochondria axis, thus launching promising avenues for UC.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"89 2 1","pages":"60 - 69"},"PeriodicalIF":3.8,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83629372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model. 三苯氧胺的抗氧化作用有助于治疗胶原蛋白诱发的大鼠关节炎模型。

IF 5.2 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.2004047

Guang-Min Yu, Li-Feng Zhou, Bi-Xia Zeng, Jing-Jun Huang, Xiao-Jun She

{"title":"The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model.","authors":"Guang-Min Yu, Li-Feng Zhou, Bi-Xia Zeng, Jing-Jun Huang, Xiao-Jun She","doi":"10.1080/13510002.2021.2004047","DOIUrl":"10.1080/13510002.2021.2004047","url":null,"abstract":"Background: As a chronic autoimmune disease, rheumatoid arthritis (RA) is related to oxidative stress, which may lead to the occurrence and persistence of inflammation in RA. The purpose of this study is to evaluate the potential antioxidant effect of triptolide in collagen-induced arthritis (CIA) rat model.Methods: We examined the severity of arthritis, levels of local and systemic oxidative stress, periarticular bone erosion and weight of organs in CIA rats treated with triptolide.Results: We found that triptolide decreased the paw thickness and clinical arthritis score, significantly. The mRNA expression and activity of myeloperoxidase and inducible nitric oxide synthase were remarkably decreased in the paws of the CIA rats after triptolide treatment. Triptolide significantly inhibited the levels of nitrite and nitrate in serum, as well as the urinary level of dityrosine. Triptolide treatment also markedly increased bone volume of tibia, but suppressed epiphyseal plate thickness of both femur and tibia. In addition, there was no significant difference in the weight of organs after the therapy, except decreased spleen weight.Conclusions: These results suggested that the local and systemic oxidative stress was enhanced in the CIA rats and the therapeutic dose of triptolide had a definite antioxidant effect.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"197-202"},"PeriodicalIF":5.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39740958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway. 莲子碱通过Nrf2-ARE途径改善良性前列腺增生的氧化应激和细胞凋亡。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1871814

Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang

{"title":"Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.","authors":"Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang","doi":"10.1080/13510002.2021.1871814","DOIUrl":"https://doi.org/10.1080/13510002.2021.1871814","url":null,"abstract":"Background: Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation. Our present study aimed to investigate the effect of neferine (NF) in the regulation of oxidative stress and apoptosis in human BPH-1 cells.Methods: BPH epithelial cell line BPH-1 was treated with NF for 24 and 48 h. To measure oxidative stress (OS) we investigated MDA, SOD, and GST expression along with Nrf2 and its downstream gene and protein expression. Cell proliferation and apoptosis regulation was assayed with respective methods.Results: Investigation revealed NF remarkably activate Nrf2 and its downstream proteins HO-1 and NQO1 at 48 h more substantially. Nrf2/Keap1 relative gene and protein expression indicated that NF might trigger Nrf2 upregulation by decreasing Keap1 expression. Both NF concentrations (3 µM and 9 µM) were able to deplete ROS and lipid peroxidation, concurrently, up-regulated SOD and GST. NF reduced cell proliferation significantly along with the regulation of apoptotic proteins Bax, Bcl2, Cyt-C, Caspase 9, and Caspase 3 at the same time (48 h).Conclusion: This study is the first to manifest that NF may potentially regulate BPH by counterbalancing between OS and apoptosis through the activation of Nrf2-ARE pathway.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"1-9"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1871814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38795382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Blood pro-oxidant/antioxidant balance in young men with class II obesity after 20 sessions of whole body cryostimulation: a preliminary study. 20次全身冷冻刺激后II级肥胖青年男性血液促氧化剂/抗氧化剂平衡:一项初步研究

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1881328

Wanda Pilch, Joanna Wyrostek, Anna Piotrowska, Olga Czerwińska-Ledwig, Roxana Zuziak, Ewa Sadowska-Krępa, Marcin Maciejczyk, Małgorzata Żychowska

{"title":"Blood pro-oxidant/antioxidant balance in young men with class II obesity after 20 sessions of whole body cryostimulation: a preliminary study.","authors":"Wanda Pilch, Joanna Wyrostek, Anna Piotrowska, Olga Czerwińska-Ledwig, Roxana Zuziak, Ewa Sadowska-Krępa, Marcin Maciejczyk, Małgorzata Żychowska","doi":"10.1080/13510002.2021.1881328","DOIUrl":"https://doi.org/10.1080/13510002.2021.1881328","url":null,"abstract":"Objectives: In obesity, there is a shift in the pro-oxidative-antioxidant balance towards the oxidationreactions. However, it has been shown that in people with normal body composition, after a series of whole-body cryotherapy (WBC), the balance shifts in the opposite direction. Design: The aim of the study was to assess the impact of 20 WBC treatments on blood pro-oxidative-antioxidant balance. Interventions: Study included 14 obese (BMI > 35) and 10 non-obese volunteers. Methods: The total antioxidative (TAS/TAC) and pro-oxidative status (TOS/TOC) in serum and activity of antioxidant enzymes in erythrocytes were determined before the first and 2 hours after the last cryostimulation. Results: In the obese group, a significantly higher level of TOS/TOC, and its significant decrease after the WBC series, was observed. Cryotherapy had no influence on TAS/TAC level which was similar in both groups. Changes in activity of antioxidant enzymes were multidirectional. An increase in CAT activity in the obese group was observed. OSI, both before and after a series of treatments, was significantly higher in obese subjects. Conclusions: A beneficial effect on the level of TOS/TOC and CAT activity was indicated, but the proposed number of treatments for patients with class II obesity turned out to be insufficient. Trial registration: Australian New Zealand Clinical Trials Registry identifier: ACTRN12619000524190.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"10-17"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1881328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25347905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome. 氧化应激在术后并发症和多器官功能障碍综合征机制中的作用。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1891808

Javier Toro-Pérez, Ramón Rodrigo

{"title":"Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.","authors":"Javier Toro-Pérez, Ramón Rodrigo","doi":"10.1080/13510002.2021.1891808","DOIUrl":"10.1080/13510002.2021.1891808","url":null,"abstract":"Background: The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress could be an unavoidable effect derived even from the surgical procedure itself.Methods: A systematic review was performed following an electronic search of Pubmed and ScienceDirect databases. Keywords such as sepsis, oxidative stress, organ dysfunction, antioxidants, outcomes in postoperative complications, among others, were used. Review articles were preferably used between the years 2015 onwards, not excluding older ones.Results: The vast majority point to the role of oxidative stress in generating greater damage and worse prognosis in postoperative patients without the necessary care and precautions, taking importance on the use of antioxidants to prevent this problem.Discussions: Oxidative stress represents a common final pathway related to pathological processes such as inflammation or ischemia-reperfusion, among others. The expression of greater severity of these complications can result in multiple organ dysfunction or sepsis. The aim of this study was to present an update of the role of oxidative stress on surgical postoperative complications.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"35-44"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25403181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes. 抗坏血酸依赖性和非抗坏血酸依赖性锰卟啉细胞毒性:锰卟啉基SOD模拟物通过抗坏血酸依赖性和非依赖性途径的抗癌活性。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1917214

Bader Hasan, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov

{"title":"Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes.","authors":"Bader Hasan, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov","doi":"10.1080/13510002.2021.1917214","DOIUrl":"https://doi.org/10.1080/13510002.2021.1917214","url":null,"abstract":"Objective: The aim of this study was to investigate how modifications at the periphery of the porphyrin ring affect the anticancer activity of Mn porphyrins (MnPs)-based SOD mimics.Methods: Six compounds: MnTE-2-PyP with a short ethyl chain on the pyridyl ring; MnTnHexOE-2-PyP and MnTnOct-2-PyP with linear 8-atom alkyl chains, but the former with an oxygen atom within the alkyl chain; MnTE-2-PyPhP and MnTPhE-2-PyP with pyridyl and phenyl substituents, were investigated. Cytotoxicity was studied using pII and MDA-MB-231 cancer cell lines. Viability was assessed by the MTT (3-[4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide) assay and cell proliferation was determined by the sulforhodamine B assay.Results: Cellular uptake was increased with the increase of the lipophilicity of the compounds, whereas reduction potential (E½) of the Mn(III)/Mn(II) redox couple shifted away from the optimal value for efficient redox cycling with ascorbate, necessary for ROS production. Amphiphilic MnPs, however, exerted anticancer activity by a mechanism not involving ROS.Conclusion: Two different processes account for MnPs cytotoxicity. MnPs with appropriate E½ act via a ROS-dependent mechanism. Amphiphilic MnPs with suitable structure damage sensitive cellular constituents, leading to the suppression of proliferation and loss of viability. Design of compounds interacting directly with sensitive cellular targets is highly promising in the development of anticancer drugs with high selectivity and specificity.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"85-93"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1917214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38918926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats. 山茱萸、大黄对来曲唑诱导的Wistar大鼠多囊卵巢综合征的改善作用。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1927396

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali

{"title":"Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.","authors":"Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali","doi":"10.1080/13510002.2021.1927396","DOIUrl":"https://doi.org/10.1080/13510002.2021.1927396","url":null,"abstract":"Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated.Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst.Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"94-104"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1927396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38934862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses. 目前的证据支持黄酮类化合物在氧化应激相关皮肤病中的治疗潜力。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1962094

Dehai Xian, Menglu Guo, Jixiang Xu, Yang Yang, Yangmeng Zhao, Jianqiao Zhong

{"title":"Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses.","authors":"Dehai Xian, Menglu Guo, Jixiang Xu, Yang Yang, Yangmeng Zhao, Jianqiao Zhong","doi":"10.1080/13510002.2021.1962094","DOIUrl":"https://doi.org/10.1080/13510002.2021.1962094","url":null,"abstract":"Background: Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out.Objectives: To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders.Methods: Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc.Results: It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases.Conclusion: Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"134-146"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39281800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Validation of magnetic resonance relaxometry R2 value and cyst fluid iron level for diagnosis of ovarian endometrioma. 磁共振弛豫仪R2值和囊肿液铁水平诊断卵巢子宫内膜异位瘤的验证。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1937456

Shogo Imanaka, Yuki Yamada, Naoki Kawahara, Hiroshi Kobayashi

{"title":"Validation of magnetic resonance relaxometry R2 value and cyst fluid iron level for diagnosis of ovarian endometrioma.","authors":"Shogo Imanaka, Yuki Yamada, Naoki Kawahara, Hiroshi Kobayashi","doi":"10.1080/13510002.2021.1937456","DOIUrl":"https://doi.org/10.1080/13510002.2021.1937456","url":null,"abstract":"Objectives: Magnetic resonance (MR) R2 relaxometry is a safe, noninvasive diagnostic modality for the evaluation of iron levels in the contents of ovarian cysts. The study aims to investigate the sensitivity and specificity of the two methods, R2 value and iron level, in diagnosing OMA patients in the validation set.Methods: A prospective cohort study was conducted from 2013 to 2019. We investigated how R2 value was affected by iron-related compounds, antioxidants and bioelements in the cysts.Results: The sensitivity and specificity of CF iron-based diagnosis of OMA was 96.6% and 95.4%, respectively. The sensitivity and specificity for R2 value in diagnosing OMA were 86.2% and 70.7%, respectively. The outcomes of the two tests were highly correlated (r = 0.758; P <0.001). The R2 value was positively correlated with CF levels of iron-related compounds and antioxidants. The R2 value was affected not only by iron ions but also by calcium ions.Conclusion: Preoperative MR relaxometry may provide a noninvasive alternative to CF iron test in diagnosing OMA. The presence of paramagnetic cations in the cyst may be associated with reduced specificity.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"105-110"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1937456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39058418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Sestrin2 in hypoxia and hypoxia-related diseases. Sestrin2在缺氧及缺氧相关疾病中的作用。

IF 3.8 2区生物学

Redox Report Pub Date : 2021-12-01 DOI: 10.1080/13510002.2021.1948774

Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang

{"title":"Sestrin2 in hypoxia and hypoxia-related diseases.","authors":"Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang","doi":"10.1080/13510002.2021.1948774","DOIUrl":"https://doi.org/10.1080/13510002.2021.1948774","url":null,"abstract":"Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an electronic search of PubMed and Medline databases. Keywords included Sestrin2, ROS, hypoxia, and hypoxia-related disease. Articles from 2008 to 2021 were mostly included and older ones were not excluded.Results: Sestrin2 is upregulated under various stress conditions, especially hypoxia. Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway. In addition, Sestrin2 is involved in various hypoxia-related diseases, such as cerebral hypoxic disease, myocardial hypoxic disease, hypoxia-related respiratory disease, and diabetes.Discussion: Sestrin2 is involved in various hypoxia-related diseases and maybe a therapeutic target. Furthermore, most studies focus on cerebral and myocardial ischemia reperfusion. More researches on hypoxia-related respiratory diseases, kidney injury, and diabetes are needed in future.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"26 1","pages":"111-116"},"PeriodicalIF":3.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13510002.2021.1948774","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39072732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8