Redox Report最新文献_第8页

Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles 利用纳米气泡和纳米颗粒提高天然抗氧化剂的生物利用率和活性

IF 3.8 2区生物学

Redox Report Pub Date : 2024-04-05 DOI: 10.1080/13510002.2024.2333619

Miroslav Čolić, Sandra Kraljević Pavelić, Željka Peršurić, Andrea Agaj, Aleksandar Bulog, Krešimir Pavelić

引用次数: 0

Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation 高血糖应激通过触发氧化还原体/p66SHC 激活诱导肠胶质细胞氧化损伤

IF 3.8 2区生物学

Redox Report Pub Date : 2024-03-05 DOI: 10.1080/13510002.2024.2324234

Yanmin Jiang, Lan Xu, Xue Zhu, Xiaowei Zhu, Xiang Xu, Jianbo Li

引用次数: 0

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy 减少老年人多重药物治疗的综合方法：探索氧化应激和抗氧化潜能疗法的作用

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-18 DOI: 10.1080/13510002.2023.2289740

Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya, Tommy González-Fernández, Luciano Saso, Ramón Rodrigo

引用次数: 0

Evaluation of oxidative stress level: reactive oxygen species, reduced glutathione, and D-dimer in patients hospitalized due to COVID-19. COVID-19住院患者氧化应激水平评价:活性氧、还原性谷胱甘肽和d -二聚体

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-02 DOI: 10.1080/13510002.2023.2272384

Claudionei Roessler, Karen Cristine Silva de Oliveira, Auricélia Xavier de Oliveira Portella, Paulo Cezar Nunes Fortes, Franciéle Romero Machado, Stífani Machado Araujo, Marina Prigol, Léia Carolina Lucio, Dalila Moter Benvegnú, Lirane Elize Defante Ferreto

{"title":"Evaluation of oxidative stress level: reactive oxygen species, reduced glutathione, and D-dimer in patients hospitalized due to COVID-19.","authors":"Claudionei Roessler, Karen Cristine Silva de Oliveira, Auricélia Xavier de Oliveira Portella, Paulo Cezar Nunes Fortes, Franciéle Romero Machado, Stífani Machado Araujo, Marina Prigol, Léia Carolina Lucio, Dalila Moter Benvegnú, Lirane Elize Defante Ferreto","doi":"10.1080/13510002.2023.2272384","DOIUrl":"10.1080/13510002.2023.2272384","url":null,"abstract":"Elevated D-dimer levels at hospital admission may also indicate a higher likelihood of progressing to a severe or critical state. This study aimed to assess reactive oxygen species (ROS), non-enzymatic antioxidant reduced glutathione (GSH), and D-dimer levels in COVID-19 patients upon admission, examining their association with mortality outcomes. Data was collected from the medical records of 170 patients hospitalized in a referral hospital unit between March 2020 and December 2021. Patients were divided into two groups: the ward bed group (n = 87), comprising 51% with moderate clinical conditions, and the intensive care unit (ICU) group (n = 83), comprising 49% with severe conditions. The mean age was 59.4 years, with a male predominance of 52.4%. The overall death rate was 43%, with 30.6% in the moderate group and 69.4% in the severe group. The average time from symptom onset to hospitalization was 6.42 days. Results showed that non-survivors had high D-dimer and ROS counts, longer ICU stays, and worse saturation levels at admission. In conclusion, elevated ROS and D-dimer levels may contribute to worse outcomes in critically ill patients, potentially serving as specific and sensitive predictors of poor outcomes upon admission.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"1-6"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melittin kills A549 cells by targeting mitochondria and blocking mitophagy flux. 蜂毒素通过靶向线粒体和阻断线粒体自噬通量杀死A549细胞。

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-02 DOI: 10.1080/13510002.2023.2284517

Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li

{"title":"Melittin kills A549 cells by targeting mitochondria and blocking mitophagy flux.","authors":"Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li","doi":"10.1080/13510002.2023.2284517","DOIUrl":"10.1080/13510002.2023.2284517","url":null,"abstract":"Melittin, a naturally occurring polypeptide found in bee venom, has been recognized for its potential anti-tumor effects, particularly in the context of lung cancer. Our previous study focused on its impact on human lung adenocarcinoma cells A549, revealing that melittin induces intracellular reactive oxygen species (ROS) burst and oxidative damage, resulting in cell death. Considering the significant role of mitochondria in maintaining intracellular redox levels and ROS, we further examined the involvement of mitochondrial damage in melittin-induced apoptosis in lung cancer cells. Our findings demonstrated that melittin caused changes in mitochondrial membrane potential (MMP), triggered mitochondrial ROS burst (Figure 1), and activated the mitochondria-related apoptosis pathway Bax/Bcl-2 by directly targeting mitochondria in A549 cells (Figure 2). Further, we infected A549 cells using a lentivirus that can express melittin-Myc and confirmed that melittin can directly target binding to mitochondria, causing the biological effects described above (Figure 2). Notably, melittin induced mitochondrial damage while inhibiting autophagy, resulting in abnormal degradation of damaged mitochondria (Figure 5). To summarize, our study unveils that melittin targets mitochondria, causing mitochondrial damage, and inhibits the autophagy-lysosomal degradation pathway. This process triggers mitoROS burst and ultimately activates the mitochondria-associated Bax/Bcl-2 apoptotic signaling pathways in A549 cells.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"2284517"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnea promotes the progression of lung cancer by modulating cancer cell invasion and cancer-associated fibroblast activation via TGFβ signaling. 阻塞性睡眠呼吸暂停通过TGFβ信号调节癌细胞侵袭和癌症相关成纤维细胞激活，从而促进肺癌的进展。

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1080/13510002.2023.2279813

Zhilei Cui, Zhengshang Ruan, Meigui Li, Rongrong Ren, Yizong Ma, Junxiang Zeng, Jinyuan Sun, Wenjing Ye, Weiguo Xu, Xuejun Guo, Dengfei Xu, Linlin Zhang

{"title":"Obstructive sleep apnea promotes the progression of lung cancer by modulating cancer cell invasion and cancer-associated fibroblast activation via TGFβ signaling.","authors":"Zhilei Cui, Zhengshang Ruan, Meigui Li, Rongrong Ren, Yizong Ma, Junxiang Zeng, Jinyuan Sun, Wenjing Ye, Weiguo Xu, Xuejun Guo, Dengfei Xu, Linlin Zhang","doi":"10.1080/13510002.2023.2279813","DOIUrl":"10.1080/13510002.2023.2279813","url":null,"abstract":"Objective: Obstructive sleep apnea (OSA) is associated with severity of pneumonia; however, the mechanism by which OSA promotes lung cancer progression is unclear.Methods: Twenty-five lung cancer patients were recruited to investigate the relationship between OSA and cancer-associated fibroblast (CAFs) activation. Lung cancer cells (A549) and WI38 fibroblast cells were used to explore the hypoxia-induced TGFβ expression using qPCR, Western blot, and ELISA. Wound healing and transwell assays were performed to evaluate cancer cell migration and invasion. A549 or A549-Luc + WI38 xenograft mouse models were established to detect the intermittent hypoxia (IH) associated with lung tumor growth and epithelial-mesenchymal transition (EMT) in vivo.Results: OSA promotes CAF activation and enrichment in lung cancer patients. Hypoxia (OSA-like treatment) activated TGFβ signaling in both lung cancer cells and fibroblasts, which promoted cancer cell migration and invasion, and enriched CAFs. IH promoted the progression and EMT process of lung cancer xenograft tumor. Co-inoculation of lung cancer cells and fibroblast cells could further promote lung cancer progression.Conclusions: IH promotes lung cancer progression by upregulating TGFβ signaling, promoting lung cancer cell migration, and increasing the CAF activation and proportion of lung tumors.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"2279813"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis. 急性布鲁氏菌病患者血清缺血修饰白蛋白、galectin-3、paraoxonase-1 和髓过氧化物酶活性水平的研究。

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-06 DOI: 10.1080/13510002.2023.2289727

Ahmet Dündar

{"title":"Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis.","authors":"Ahmet Dündar","doi":"10.1080/13510002.2023.2289727","DOIUrl":"10.1080/13510002.2023.2289727","url":null,"abstract":"Objectives: Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) are biomolecules that play an important role in the pathogenesis of atherosclerosis. Our aim is to investigate serum IMA, gal-3, PON-1, and MPO activity in acute brucellosis infection.Materials and methods: Forty patients with acute brucellosis and 40 healthy individuals were included in the study. Serum IMA, gal-3, PON-1, and MPO activity were analyzed by the ELISA method.Results: In acute brucellosis infection, serum gal-3, IMA, and MPO activities were found to be significantly increased compared to the control group, and PON-1 activity was found to be significantly decreased compared to the control group (p < 0.001). There was a positive correlation between serum IMA, and MPO activity (r = 0.707 p = 0.000) and a negative correlation (r = -0.943, p = 0.000) between PON-1 activity. There was a positive correlation between serum gal-3 and MPO activity (r = 0.683, p = 0.000) and IMA level (r = 0.927, p = 0.000) and a negative correlation between PON-1 activity (r = -0.951, p = 0.000).Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"2289727"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deeper insight into ferroptosis: association with Alzheimer's, Parkinson's disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis. 更深入地了解铁下垂:与阿尔茨海默病、帕金森病和脑肿瘤的关系，以及纳米材料诱导铁下垂的可能治疗方法。

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1080/13510002.2023.2269331

Virendra Kumar Yadav, Nisha Choudhary, Amel Gacem, Rakesh Kumar Verma, Mohd Abul Hasan, Mohammad Tarique Imam, Ziyad Saeed Almalki, Krishna Kumar Yadav, Hyun-Kyung Park, Tathagata Ghosh, Pankaj Kumar, Ashish Patel, Haresh Kalasariya, Byong-Hun Jeon, Hassan Ali AlMubarak

{"title":"Deeper insight into ferroptosis: association with Alzheimer's, Parkinson's disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis.","authors":"Virendra Kumar Yadav, Nisha Choudhary, Amel Gacem, Rakesh Kumar Verma, Mohd Abul Hasan, Mohammad Tarique Imam, Ziyad Saeed Almalki, Krishna Kumar Yadav, Hyun-Kyung Park, Tathagata Ghosh, Pankaj Kumar, Ashish Patel, Haresh Kalasariya, Byong-Hun Jeon, Hassan Ali AlMubarak","doi":"10.1080/13510002.2023.2269331","DOIUrl":"10.1080/13510002.2023.2269331","url":null,"abstract":"Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resulting in lipid peroxidation (LiPr). There are mainly three ferroptosis pathways viz. iron metabolism-mediated cysteine/glutamate, and LiPr-mediated. Iron is required by the brain as a redox metal for several physiological activities. Due to the iron homeostasis balance disruption, the brain gets adversely affected which further causes neurodegenerative diseases (NDDs) like Parkinson's and Alzheimer's disease, strokes, and brain tumors like glioblastoma (GBS), and glioma. Nanotechnology has played an important role in the prevention and treatment of these NDDs. A synergistic effect of nanomaterials and ferroptosis could prove to be an effective and efficient approach in the field of nanomedicine. In the current review, the authors have highlighted all the latest research in the field of ferroptosis, specifically emphasizing on the role of major molecular key players and various mechanisms involved in the ferroptosis pathway. Moreover, here the authors have also addressed the correlation of ferroptosis with the pathophysiology of NDDs and theragnostic effect of ferroptosis and nanomaterials for the prevention and treatment of NDDs.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"2269331"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies. 减轻糖尿病视网膜病变的氧化应激:抗氧化治疗策略。

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-02 DOI: 10.1080/13510002.2023.2272386

Jie Gao, Liming Tao, Zhengxuan Jiang

引用次数: 0

Sulforaphane attenuates irradiation induced testis injury in mice. 红豆杉可减轻辐照诱发的小鼠睾丸损伤

IF 3.8 2区生物学

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-05 DOI: 10.1080/13510002.2023.2279818

Yuanshuai Ran, Nengliang Duan, Zhixiang Gao, Yulong Liu, Xiaolong Liu, Boxin Xue

{"title":"Sulforaphane attenuates irradiation induced testis injury in mice.","authors":"Yuanshuai Ran, Nengliang Duan, Zhixiang Gao, Yulong Liu, Xiaolong Liu, Boxin Xue","doi":"10.1080/13510002.2023.2279818","DOIUrl":"10.1080/13510002.2023.2279818","url":null,"abstract":"Objective: The testis is vulnerable to ionizing radiation, sexual dysfunction and male infertility are common problems after local radiation or whole-body exposure. Currently, there are no approved drugs for the prevention or treatment of radiation testicular injury. Sulforaphane (SFN) is an indirect antioxidant that induces phase II detoxification enzymes and antioxidant genes. Herein, we investigated the radiation protective effect of SFN on testicular injury in mice and its potential mechanism.Materials and methods: Mice were randomly divided into blank control group (Ctrl), radiation + no pretreatment group (IR), and radiation + SFN groups (IRS). In the radiation + SFN groups, starting from 72 h before radiation, SFN solution was intraperitoneally injected once a day until they were sacrificed. Mice in the blank control group and the radiation + no pretreatment group were simultaneously injected intraperitoneally with an equal volume of the solvent used to dissolve SFN (PBS with a final concentration of 0.1%DMSO) until they were sacrificed. They were subjected to 6Mev-ray radiation to the lower abdominal testis area (total dose 2Gy). Twenty-four hours after radiation, six mice in each group were randomly sacrificed. Seventy-two hours after radiation, the remaining mice were sacrificed.Results: The results showed that the harmful effects of ionizing radiation on testes were manifested as damage to histoarchitecture, increased oxidative stress, and apoptosis, and thus impaired male fertility. SFN injections can reverse these symptoms.Conclusions: The results showed that SFN can improve the damage of mouse testis caused by irradiation. Furthermore, SFN prevents spermatogenesis dysfunction caused by ionizing radiation by activating Nrf2 and its downstream antioxidant gene.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"28 1","pages":"2279818"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0