Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-06 DOI:10.1080/13510002.2023.2289727

Ahmet Dündar

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引用次数: 0

Abstract

Objectives: Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) are biomolecules that play an important role in the pathogenesis of atherosclerosis. Our aim is to investigate serum IMA, gal-3, PON-1, and MPO activity in acute brucellosis infection.

Materials and methods: Forty patients with acute brucellosis and 40 healthy individuals were included in the study. Serum IMA, gal-3, PON-1, and MPO activity were analyzed by the ELISA method.

Results: In acute brucellosis infection, serum gal-3, IMA, and MPO activities were found to be significantly increased compared to the control group, and PON-1 activity was found to be significantly decreased compared to the control group (p < 0.001). There was a positive correlation between serum IMA, and MPO activity (r = 0.707 p = 0.000) and a negative correlation (r = -0.943, p = 0.000) between PON-1 activity. There was a positive correlation between serum gal-3 and MPO activity (r = 0.683, p = 0.000) and IMA level (r = 0.927, p = 0.000) and a negative correlation between PON-1 activity (r = -0.951, p = 0.000).Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.

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急性布鲁氏菌病患者血清缺血修饰白蛋白、galectin-3、paraoxonase-1 和髓过氧化物酶活性水平的研究。

目的：目前，感染仍是动脉粥样硬化病因学研究的一个重要课题。缺血修饰白蛋白（IMA）、凝血酶原-3（gal-3）、副氧自由基酶-1（PON-1）和髓过氧化物酶（MPO）是在动脉粥样硬化发病机制中起重要作用的生物大分子。我们的目的是研究急性布鲁氏菌病感染者血清中 IMA、gal-3、PON-1 和 MPO 的活性：研究对象包括 40 名急性布鲁氏菌病患者和 40 名健康人。采用 ELISA 方法分析血清 IMA、gal-3、PON-1 和 MPO 活性：结果：与对照组相比，急性布鲁氏菌病感染者的血清 gal-3、IMA 和 MPO 活性明显升高，而 PON-1 活性则明显降低（p r = 0.707 p = 0.000），且 PON-1 活性与对照组呈负相关（r = -0.943，p = 0.000）。血清 gal-3 与 MPO 活性呈正相关（r = 0.683，p = 0.000），与 IMA 水平呈正相关（r = 0.927，p = 0.000），与 PON-1 活性呈负相关（r = -0.951，p = 0.000）。这些结果表明，急性布鲁氏菌病感染时，氧化-抗氧化平衡受损。此外，这些结果还表明，布鲁氏菌感染可能会增加动脉粥样硬化的风险。我们还需要进一步的研究来支持我们的发现。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.