A R Seddon, C P MacArthur, M B Hampton, A J Stevens
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引用次数: 0
Abstract
Alzheimer's disease is a neurodegenerative disease involving memory impairment, confusion, and behavioural changes. The disease is characterised by the accumulation of amyloid beta plaques and neurofibrillary tangles in the brain, which disrupt normal neuronal function. There is no known cure for Alzheimer's disease and due to increasing life expectancy, occurrence is projected to rise over the coming decades. The causes of Alzheimer's disease are multifactorial with inflammation, oxidative stress, genetic and epigenetic variation, and cerebrovascular abnormalities among the strongest contributors. We review the current literature surrounding inflammation and epigenetics in Alzheimer's disease, with a focus on how oxidants from infiltrating immune cells have the potential to alter DNA methylation profiles in the ageing brain.
阿尔茨海默病是一种神经退行性疾病，患者会出现记忆障碍、意识模糊和行为改变。这种疾病的特征是淀粉样 beta 斑块和神经纤维缠结在大脑中积累，从而破坏神经元的正常功能。目前尚无治疗阿尔茨海默病的方法，由于预期寿命的延长，预计未来几十年阿尔茨海默病的发病率还会上升。阿尔茨海默病的病因是多因素的，其中炎症、氧化应激、遗传和表观遗传变异以及脑血管异常是最主要的致病因素。我们回顾了目前围绕阿尔茨海默病中的炎症和表观遗传学的文献，重点关注浸润免疫细胞的氧化剂如何改变老化大脑中的 DNA 甲基化图谱。
期刊介绍：
Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included.
While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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