Research in veterinary science最新文献

{"title":"Serum iron levels as a biomarker for monitoring fracture healing in dogs: A longitudinal study","authors":"Ersoy Baydar ,&nbsp;Ugur Aydogdu ,&nbsp;Feyyaz Kaya ,&nbsp;Muharrem Erol","doi":"10.1016/j.rvsc.2025.105993","DOIUrl":"10.1016/j.rvsc.2025.105993","url":null,"abstract":"<div><div>Iron is an important mineral involved in various physiological processes and can be used as a biomarker, since its serum concentration changes during the inflammatory response. Eight crossbreed dogs with closed fractures in the antebrachium bone were included in the study. The fracture was treated with a closed reduction method and blood samples were taken initially at 0 h and subsequently at 7, 14, 21, 28, and 45 days. Iron, ferritin, hepcidin, tumor necrosis factor-alpha (TNF-α), C reactive protein (CRP), bone alkaline phosphatase (BALP), osteocalcin, total antioxidant status (TAS), total oxidant status (TOS) as well as routine hemogram and biochemistry analyses were performed in the blood samples taken. It was determined that the decrease in serum Fe levels reversed as the process progressed even though hepcidin, ferritin, osteocalcin, BALP, and TNF-α levels increased at the beginning of the healing process. As a result, it can be suggested that the analysis of serum Fe levels may be a useful biomarker in monitoring the fracture healing process.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105993"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheal resection and anastomosis combined with the application of collagen-PVP in a dog with traumatic tracheal rupture: A new approach to improve tracheal healing","authors":"Axel E. Guzmán-Cedillo ,&nbsp;Mariana Silva-Martínez ,&nbsp;Roxana Pulido-Quintero ,&nbsp;Patricia Rizo ,&nbsp;J. Raúl Olmos-Zúñiga","doi":"10.1016/j.rvsc.2025.105978","DOIUrl":"10.1016/j.rvsc.2025.105978","url":null,"abstract":"<div><div>The treatment for tracheal injuries is tracheal resection and anastomosis (TRA). Although there are few reports in the veterinary literature, TRA can be complicated and lead to the development of tracheal stenosis, fistulas, or malacias. In human medicine and experimentally in dogs, to avoid such sequelae, TRA combined with wound healing modulators (WHM), such as polyvinyl-pyrrolidone collagen (collagen-PVP), can be applied. In this report, we present a case of tracheal rupture in a dog caused by a bite and treated with TRA combined with collagen-PVP. We observed that from the first week after surgery, the animal presented good clinical evolution without complications, and at 6 months, tracheoscopy revealed normal scarring of the anastomosis; therefore, we believe further studies are worthwhile for its potential clinical application.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105978"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cost divide: Why veterinary medicinal products for dogs and cats in the EU cost more than their human equivalents","authors":"Alessandro Stasi ,&nbsp;Alfonso Pellegrino","doi":"10.1016/j.rvsc.2025.105977","DOIUrl":"10.1016/j.rvsc.2025.105977","url":null,"abstract":"<div><div>This paper provides a comprehensive analysis of the European Union (EU) pricing policies for <strong>veterinary medicinal products (VMPs)</strong>, focusing on the comparative costs of human and pet veterinary formulations of common medications. It examines market dynamics, regulatory frameworks, and structural factors that influence price disparities, drawing on case studies from Italy, France, and Germany. The analysis highlights the role of Regulation (EU) 2019/6, the evolution of the EU VMP market, and the specific economic and regulatory conditions that allow for significant price differences despite identical active ingredients. Using comparative data on furosemide, amoxicillin, benazepril, and prednisone, the paper identifies how lack of public price negotiation, high VAT rates, concentrated market structure, and limitations in pet insurance coverage contribute to affordability challenges. The findings provide policy-relevant insights into how the EU could better align VMP pricing with principles of accessibility, sustainability, and innovation.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105977"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid-based platforms in livestock: Current advances and future prospects","authors":"Dong-Hyeok Kwon ,&nbsp;Hanbyul Kwon ,&nbsp;Goo Jang","doi":"10.1016/j.rvsc.2025.105985","DOIUrl":"10.1016/j.rvsc.2025.105985","url":null,"abstract":"<div><div>Organoid research has been extensively developed and investigated in humans and rodents; however, its applications in livestock species remain comparatively limited. To address this knowledge gap, this review provides a comprehensive synthesis of the historical evolution, establishment protocols, and current organ-specific applications of livestock-derived organoids, spanning tissues such as the intestine, liver, lung, kidney, testis, mammary gland, and reproductive tract. These self-organizing three-dimensional cultures serve as powerful platforms for investigating fundamental questions in veterinary science, from modeling host–pathogen interactions in infectious diseases to exploring the complex biology of reproduction, toxicology, and productivity. Additionally, recent advances in bioengineering and genome-editing technologies, including CRISPR/Cas9, base editing, and prime editing, are highlighted for their potential to enhance the physiological relevance and reproducibility of livestock organoid systems. Despite ongoing challenges, including the lack of standardized protocols, limited availability of pluripotent stem cell–derived models, and insufficient multicellular complexity, livestock organoids represent a strategically important frontier in veterinary science and agricultural biotechnology. In conclusion, the combination of stem cell biology, microphysiological platforms, and genetic engineering positions livestock organoids as indispensable tools for veterinary medicine, agricultural innovation, and translational biomedical research.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105985"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacilli isolated from chickens of Italian native breeds: Antimicrobial susceptibility profile, probiotic potential and anti-Salmonella activity","authors":"Ilaria Resci ,&nbsp;Marta Raffaelli ,&nbsp;Francesca Pedonese ,&nbsp;Mario Forzan ,&nbsp;Filippo Fratini ,&nbsp;Sonia Salvucci ,&nbsp;Beatrice Torracca ,&nbsp;Margherita Marzoni ,&nbsp;Barbara Turchi","doi":"10.1016/j.rvsc.2025.105988","DOIUrl":"10.1016/j.rvsc.2025.105988","url":null,"abstract":"<div><div>Salmonellosis is the second most prevalent foodborne disease in Europe, with eggs, mixed foods, and broiler meat being the primary sources of transmission. Among human salmonellosis cases, the most prevalent <em>Salmonella enterica</em> serovars are <em>S.</em> Enteritidis, <em>S.</em> Typhimurium, and monophasic S. Typhimurium. However, <em>S.</em> Infantis and <em>S.</em> Newport are the most frequently detected serovars in broiler and turkey meat, respectively. Over time, <em>Salmonella</em> spp. have developed multidrug resistance, and the global rise of antimicrobial resistance has driven the search for alternative strategies to antimicrobials use. Probiotics represent a promising alternative to antimicrobials, with the added benefit of enhancing production performance. This study aimed to isolate lactobacilli from chickens of Italian native breeds to evaluate their antimicrobial susceptibility, probiotic potential (tolerance to acidic pH and bile salts), and anti-<em>Salmonella</em> activity against <em>S. enterica</em> strains previously isolated from poultry meat. Antimicrobial susceptibility testing was carried out on all 205 obtained isolates as a preliminary screening. Only nine isolates (4.4 %) were susceptible to all tested antimicrobials. Among them, one strain exhibited notable probiotic potential and anti-<em>Salmonella</em> activity. <em>Lactobacillus kitasatonis</em> VALFI55 demonstrated survival at acidic pH for up to 120 min and tolerance to bile salt concentrations of 0.3 % and 1 %, with limited reduction in viable cell counts compared to other isolates. Furthermore, <em>L. kitasatonis</em> VALFI55 exhibited the strongest inhibitory effect, particularly against <em>S.</em> Typhimurium and <em>S.</em> Infantis. The VALFI55 strain represents a promising probiotic candidate for application in poultry breeding. However, further in vivo studies are required to confirm its beneficial effects.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105988"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrared pupillometry to measure pupil light reflex in awake cats: Feasibility and evaluation pre- and post-opioid administration","authors":"Mathieu Magnin ,&nbsp;Léa Goffette ,&nbsp;Stéphane Junot ,&nbsp;Jeanne Marie Bonnet-Garin ,&nbsp;Bernard Allaouchiche ,&nbsp;Céline Pouzot-Nevoret","doi":"10.1016/j.rvsc.2025.105982","DOIUrl":"10.1016/j.rvsc.2025.105982","url":null,"abstract":"<div><div>Assessing pupil diameter and pupillary light reflexes (PLR) in a clinical setting can be challenging due to the pupil's sensitivity to light and the rapid nature of these reflexes. Pupillometry is a technique that is helpful in human medicine in anesthesiology and critical care medicine. However, evidence in veterinary medicine is scarce on the application of pupillometry and analgesic response. Therefore, the aim of this pilot observational study was to assess the feasibility and reliability of portable pupillometry in cats, identify individual factors influencing pupillometric parameters, and compare measurements before and after analgesic administration. Twenty-eight cats, including healthy and hospitalized sick cats, underwent pupillometry using a Neurolight® device. Pupil diameter, PLR parameters, and 4 A-VET pain score were measured before and after opioid administration. Test-retest reliability was evaluated, and the influence of factors was analyzed using multivariate models. Pupillometry was feasible in 97 % of cats, with measurements being easier in hospitalized sick cats. Good reliability was observed for pupil diameter measurements, while PLR parameters showed poor reliability. Weight was significantly associated with pupil size, potentially due to the relationship between body weight and eyeball size. No association was found between pain scores and pupil diameter, and no significant changes in pupil size were observed after opioid administration. In conclusion, portable pupillometry using the Neurolight® is feasible in cats and provides reliable pupil diameter measurements. However, the device is not suitable for objective PLR assessment in this species. Further studies are needed to better understand the factors influencing pupillometry measurements in cats.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105982"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental amplification of Wolbachia sequences in fleas (Siphonaptera: Pulicidae) collected from pets in Thailand using 16S rDNA universal primers for hemoplasma detection","authors":"Kritsada Thongmeesee ,&nbsp;Aung Aung ,&nbsp;Duriyang Narapakdeesakul ,&nbsp;Patchana Kamkong ,&nbsp;Apinya Chatchaisuriya ,&nbsp;Phichsita Satidsommon ,&nbsp;Sarun Kerdrojwongkul ,&nbsp;Sasikan Lilertlam ,&nbsp;Sukritta Charoensiri ,&nbsp;Sonthaya Tiawsirisup","doi":"10.1016/j.rvsc.2025.105984","DOIUrl":"10.1016/j.rvsc.2025.105984","url":null,"abstract":"<div><div>Fleas (Siphonaptera: Pulicidae) are common ectoparasites of cats and dogs in Thailand, and they can serve as vectors for various pathogens with zoonotic potential [e.g., <em>Bartonella</em> spp., <em>Rickettsia</em> spp., and hemotropic <em>Mycoplasma</em> spp. (hemoplasmas)]. <em>Bartonella</em> and <em>Rickettsia</em> spp. have been well described in fleas collected from cats and dogs. Contrarily, only one study reported hemoplasmas in fleas collected from cats in Thailand, and information regarding hemoplasmas in fleas collected from dogs is limited. This study used 16S rDNA universal primers in a previous study to investigate hemoplasmas in fleas collected from cats and dogs. Unfortunately, the primers inadvertently amplified the partial sequences of <em>Wolbachia</em> spp. endosymbionts in fleas. All obtained sequences were analyzed using nucleotide BLAST and phylogenetic analysis. Based on the results, the <em>Wolbachia</em> sequences were placed into two subsupergroups (I-1 and I-2) with sequences from <em>Ctenocephalides felis</em> and <em>C. orientis</em>. Although these 16S rDNA primers used in this study might be capable of amplifying hemoplasmas in mammalian hosts, additional Sanger sequencing might be required to confirm PCR products as hemoplasma sequences when these primers are used for cPCR in arthropod samples.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105984"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of cattle movement among premises in Minas Gerais state, Brazil, from 2013 to 2023","authors":"Anna Cecília Trolesi Reis Borges Costa ,&nbsp;Denis Lúcio Cardoso ,&nbsp;Luciana Faria de Oliveira ,&nbsp;Suman Bhowmick ,&nbsp;Marcos Amaku ,&nbsp;José Henrique Hildebrand Grisi Filho ,&nbsp;Andrey Pereira Lage ,&nbsp;Elaine Maria Seles Dorneles","doi":"10.1016/j.rvsc.2025.105957","DOIUrl":"10.1016/j.rvsc.2025.105957","url":null,"abstract":"<div><div>Network analysis allows for the description and comprehension of complex systems, such as cattle movements, contributing to control and surveillance of transmissible diseases by identifying points of intervention. The aim of this paper was to conduct a network analysis of cattle movements having livestock premises as nodes, in Minas Gerais State, Brazil, from January 2013 to August 2023, to identify points of interventions for improvement of disease control strategies. The analysis of the network was performed identifying the following measures: the number of nodes and edges, degree centrality, closeness, betweenness, presence of bridges, average path length, cluster coefficient, diameter, reciprocity, edges density, transitivity, magnitude of the giant strongly connected component (GSCC), weakly component (GWCC), minimum cut and community. The results showed 2014 as the year with a greater number of nodes (206,328) and more number edges (493,668), and 2020 with a smaller number of nodes (184,206) and number of edges (458,386), considering the years with data available for all months (2013 to 2022). Additionally, the mean betweenness was high in all years, with the greatest value in 2019 (361,907.4) and lowest value in 2013 (2,999,391.30) and the GSCC represented around 70 % of the nodes in all years and the GWCC varied from 89 to 93 % of the nodes in the analyzed years (2013 to 2023).Therefore, the cattle movements network in Minas Gerais State, Brazil, was described and characterized allowing for a more strategic custom-built planning for disease control by animal health authority.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105957"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main Salmonella serotypes in free-range Amazon broiler chicken farms: Comparison between collection methods and seasonal period in tropical regions","authors":"Hellen N.C.M. Miranda ,&nbsp;Alessandro J.F. dos Santos ,&nbsp;Katyane de S. Almeida ,&nbsp;José C. Ribeiro-Júnior","doi":"10.1016/j.rvsc.2025.105987","DOIUrl":"10.1016/j.rvsc.2025.105987","url":null,"abstract":"<div><div>Broiler chicken raised in semi-closed or completely free-range systems are challenged by more environmental variables that can compromise the biosecurity and microbiological quality and safety of the final product from this type of production. This study investigated <em>Salmonella</em> serotypes in Brazilian Amazon free-range broiler chicken farms in a tropical climate region, comparing the efficacy of the official collection methods of poultry sheds (drag swabs, footpads, and cecal feces) and the rainy and dry seasons typical of the region. Specific qualitative microbiological cultures, confirmation of identity by genus-specific PCR (<em>invA</em>), and determination of <em>Salmonella</em> serotypes by real-time PCR were performed on all free-range poultry farms in Tocantins, North Brazil. In total, 935 suggestive isolates were recovered using the three collection methods in both seasons, of which 90 (9.5 %) were positive for <em>invA</em>. There were no significant differences (<em>p</em> &gt; 0.05) between the collection methods or between the rainy and dry seasons. <em>Salmonella</em> Mbandaka, <em>S. Panama</em>, and <em>S.</em> Javiana were identified on different free-range poultry farms. Although the main serotypes of importance in poultry and public health were not identified, according to Brazilian regulations, the results did not compromise the processing of batches for fresh trade, reinforcing the need to support surveillance programs, animal health defense, and epidemiological measures of a one-health approach to control the pathogen in the chain of free-range broiler chickens raised in tropical climate regions.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105987"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico characterization of the OSBPL6 gene and its potential role in ascites syndrome in broiler chickens","authors":"M.R. Emami,&nbsp;M. Najafi","doi":"10.1016/j.rvsc.2025.105986","DOIUrl":"10.1016/j.rvsc.2025.105986","url":null,"abstract":"<div><div>Ascites syndrome is a multifactorial metabolic disorder in broiler chickens, characterized by pulmonary hypertension, fluid accumulation, and high mortality, leading to significant economic losses. The oxysterol-binding protein-like 6 gene (OSBPL6) has been associated with ascites susceptibility, but its molecular role remains unclear. Therefore, this study was aimed to perform a comprehensive in-silico analysis of chicken OSBPL6, including analyses of physicochemical properties, structural features, post-translational modifications, protein–protein interactions, promoter motifs, and tissue-specific expression to elucidate its involvement in ascites syndrome pathogenesis in broiler chickens. OSBPL6 encodes a 978-amino acid protein with a molecular mass of 110,905.88 Da, exhibiting predominantly hydrophilic characteristics (GRAVY = −0.583), moderate thermostability (aliphatic index = 76.45), and predicted instability in vitro (instability index = 65.47). Analysis revealed 134 phosphorylation sites and 6 glycosylation sites, indicating extensive post-translational regulation. Subcellular localization predictions suggested cytoplasmic residence with peripheral membrane associations and potential nucleocytoplasmic shuttling capability. Conserved PH, ORD, and FFAT domains were identified, supporting roles in sterol transport and lipid binding functions. Among structural models generated, trRosetta showed the highest reliability (QMEANDisCo =0.66, ERRAT = 94.3 %). Protein–protein interaction analysis linked OSBPL6 to pathways related to cardiac hypertrophy, muscle metabolism, and oxidative stress responses. Promoter analysis identified transcription factor binding sites linked to vascular remodeling, myocardial hypertrophy, and muscle development. Expression profiling showed highest OSBPL6 expression in skeletal muscle and elevated levels in cardiac tissue, consistent with ascites-associated pathophysiology. This integrative analysis highlights OSBPL6 as a candidate regulator of muscle growth and cardiopulmonary remodeling, with potential as a biomarker for genetic selection against ascites in broiler chickens.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"198 ","pages":"Article 105986"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}