Research in veterinary science最新文献

{"title":"Microbiota composition of an autochthonous Krškopolje pig breed reared in two different organic production systems","authors":"Bojan Papić ,&nbsp;Tim Šteferl ,&nbsp;Jan Plut ,&nbsp;Marina Štukelj","doi":"10.1016/j.rvsc.2024.105449","DOIUrl":"10.1016/j.rvsc.2024.105449","url":null,"abstract":"<div><div>It has been shown that different production systems (conventional vs. pasture-raised pigs) and co-rearing of pigs with other livestock influence the gut microbiota composition in pigs. In this study, two independent trials were conducted to investigate the 16S fecal microbiota of the autochthonous Krškopolje pig. In each trial, three study groups were analyzed: (<em>i</em>) pasture-raised pigs cohabiting with small ruminants (group L1, farm 1), (<em>ii</em>) indoor-raised pigs without contact with other farm animals (group L2, farm 2) and fed the same commercial organic feed as the other two groups, and (<em>iii</em>) pasture-raised pigs cohabiting with cattle (group L3, farm 2). The pigs were sampled four times during the grower-finisher period, corresponding to the different seasons. A total of 18 and 22 pigs were included in trials 1 and 2, respectively. Alpha diversity was comparable between the study groups and the pigs of different age categories. The two predominant bacterial phyla in all three groups were <em>Bacteroidota</em> and <em>Firmicutes</em>. Significant differences in microbiota composition were found between pigs of different age categories in both trials (nonparametric MANOVA, <em>p</em> &lt; 0.008). The microbiota composition of pigs from group L1 was significantly different from that of pigs from groups L2 and L3, whereas groups L2 and L3 tended to be more similar in both trials. The present results indicate that the trial and the farm of origin have a significant influence on the pig gut microbiota, and that their influence is more pronounced than that of the housing system.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105449"},"PeriodicalIF":2.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paeonol attenuates LPS-induced inflammatory injury in mastitis by regulating the MAPK and Nrf2 signaling pathways","authors":"Ming Yang ,&nbsp;Jiaze Han ,&nbsp;Zhengui Yan ,&nbsp;Ke Li","doi":"10.1016/j.rvsc.2024.105481","DOIUrl":"10.1016/j.rvsc.2024.105481","url":null,"abstract":"<div><div>Mastitis is an inflammatory udder disease that causes important economic losses in the animal breeding and dairy product industries. While antibiotics have contributed to disease control, their use presents risks due to drug residues in livestock products that can potentially threaten human health. Paeonol, an active ingredient extracted from the dried root bark of <em>paeonia suffruticosa</em>, exhibits various pharmacological effects, including anti-inflammatory and antibacterial properties, but its role in mastitis remains unclear. In this study, we first evaluated the effects of paeonol on LPS-induced mastitis in mice and further explored the potential anti-inflammatory mechanism of paeonol on bovine mammary epithelial cells (BMECs). The results showed that paeonol alleviated LPS-induced mouse mastitis by inhibiting the infiltration of inflammatory cells and the release of inflammatory factors. Cellular assays further demonstrated that paeonol reduced apoptosis and inhibited inflammation and oxidative stress injury by mechanisms involving activation of Nrf2 signaling and inhibition of MAPK signaling in BMECs. Collectively, our results suggest that paeonol holds promise as a therapeutic agent for alleviating LPS-induced mastitis injury while providing novel insights into potential drug targets for mastitis treatment.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105481"},"PeriodicalIF":2.2,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral red flags for optimizing castration-induced acute pain diagnosis in cattle","authors":"Gustavo Venâncio da Silva ,&nbsp;Rubia Mitalli Tomacheuski ,&nbsp;Flavia Augusta de Oliveira ,&nbsp;Monique Danielle Pairis-Garcia ,&nbsp;Stelio Pacca Loureiro Luna ,&nbsp;Pedro Henrique Esteves Trindade","doi":"10.1016/j.rvsc.2024.105468","DOIUrl":"10.1016/j.rvsc.2024.105468","url":null,"abstract":"<div><div>Unesp-Botucatu Cattle Pain Scale (UCAPS) is widely used in experimental settings, however the high number of UCAPS behaviors might represent a barrier to its implementation in the farm's or hospital's routine. We aimed to identify a smaller combination of UCAPS behaviors that could be used as behavioral red flags for optimizing the acute pain diagnosis in cattle. We hypothesize that a specific set of UCAPS behaviors might be used as behavioral red flags for pain. This would represent a quick and simple pain evaluation and might optimize the acute pain assessment in large-scale systems. Data from two previous studies regarding UCAPS assessments before (pain free condition) and after (painful condition) surgical castration of 59 male cattle was used. We fitted a decision tree, resulting in a logic with two behaviors that we used as behavioral red flags. The logic adapted from the decision tree considered the painful diagnosis when the Activity was scored 2. When Activity was scored less than 2, but Locomotion was scored 1 or 2, the diagnosis was also considered positive for pain. When Activity was below 2 and Locomotion was 0, the diagnosis was considered free pain. Behavioral red flags had an area under the curve of 95.95 % for predicting UCAPS diagnosis and 94.13 % for predicting overall pain free and painful conditions. In conclusion, behaviors in the decision tree logic can work as behavioral red flags for optimizing the acute pain diagnosis in cattle, as a quick assessment in large-scale systems.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105468"},"PeriodicalIF":2.2,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA H19 improves mesenchymal characteristics of buffalo (Bubalus bubalis) bone marrow-derived mesenchymal stem cells under hypoxic conditions","authors":"Lulu Wang ,&nbsp;Jun Zhang ,&nbsp;Sheng Ye ,&nbsp;Fenghua Lu","doi":"10.1016/j.rvsc.2024.105461","DOIUrl":"10.1016/j.rvsc.2024.105461","url":null,"abstract":"<div><div>As adult stem cells with various advantages, Bone marrow-derived mesenchymal stem cells (BMSCs) are valuable resources for veterinary treatment and animal reproduction. Previous studies have shown that hypoxia can induce epithelial-mesenchymal transition (EMT) and improve mesenchymal characteristics of BMSCs in vitro culture. However, the mechanism by which hypoxia improves the interstitial characteristics of buffalo BMSCs (bBMSCs) remains unclear. In this study, the effects of hypoxia on the mesenchymal characteristics of bBMSCs and the expression level of lncRNA H19 were examined, and then the effects of lncRNA H19 on maintaining the mesenchymal characteristics of bBMSCs under hypoxic culture conditions (5 % oxygen) as well as its mechanism also were explored, so as to further understand the molecular mechanism of mesenchymal characteristics maintenance of bBMSCs. The results showed that hypoxic culture conditions promoted EMT of bBMSCs, with lncRNA H19 expression up-regulated. When lncRNA H19 was knocked down in hypoxia, the expression level of Vimentin was down-regulated, the expression level of E-Cadherin was up-regulated, and EMT was inhibited. Meanwhile, the genes (p-PI3K and p-AKT1) involved in PI3K/AKT signaling pathway were inhibited by lncRNA H19 Knockdown. IGF-1 (10 ng/mL), an activator of PI3K/AKT signaling pathway, was added to rescued the inhibition of PI3K/AKT signaling pathway caused by lncRNA H19 Knockdown, with the effects of lncRNA H19 on EMT related genes also partially reversed. These findings not only provide theoretical guidance to elucidate the detailed regulation mechanism of hypoxia on mesenchymal nature maintenance of bBMSCs, but also provide positive support to further establish the stable in vitro culture system of bBMSCs.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105461"},"PeriodicalIF":2.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, in vitro evaluation and therapeutic effect of chitosan coated pluronic F127 micelles containing miltefosine for the treatment of visceral leishmaniasis in domestic dogs naturally infected by Leishmania infantum","authors":"Zahra Alizadeh ,&nbsp;Mehdi Mohebali ,&nbsp;Behzad Aghabarari ,&nbsp;Zabihollah Zarei ,&nbsp;Gholamreza Hassanpour ,&nbsp;Seyed Ebrahim Eskandari ,&nbsp;Mehdi Parsaei ,&nbsp;Shahram Jamshidi ,&nbsp;Abbas Rahimi Foroushani ,&nbsp;Hossein Keshavarz ,&nbsp;Behnaz Akhoundi ,&nbsp;Zahra Heidari ,&nbsp;Fatemeh Mohebali ,&nbsp;Seyedeh Parastoo Yasini ,&nbsp;Akram Hassanpour","doi":"10.1016/j.rvsc.2024.105467","DOIUrl":"10.1016/j.rvsc.2024.105467","url":null,"abstract":"<div><div>There are a limited number of chemotherapeutic agents for the treatment canine visceral leishmaniasis (CVL). This study aimed to formulate and assess micellar formulation of miltefosine (MTF) to increase antileishmanial therapeutic effects in dogs naturally infected by <em>Leishmania (L) infantum</em> for the first time<em>.</em> MTF loaded pluronic F127 (PF/MTF) micelles were formulated and coated with chitosan (Cs/PF/MTF). Toxicity of compounds was evaluated. The <em>in vitro</em> and <em>in vivo</em> antileishmanial effect of Cs/PF/MTF was examined in L. <em>infantum</em> promastigotes and amastigotes as well as naturally infected dogs by L. <em>infantum</em>. <em>In-vitro</em> efficacy studies in promastigotes and amastigotes demonstrated that inhibitory concentration (IC50) of Cs/PF/MTF was significantly lower in comparison to miltefosine. <em>In vivo</em> data showed that Cs/PF/MTF is more effective against CVL compared with miltefosine alone. The result of this study indicated that intravenous injection of new formulation of Cs/PF/MTF was tolerated and treated on L. <em>infantum</em> naturally infected dogs with the dosages of 170 μg/kg daily for 28 days.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105467"},"PeriodicalIF":2.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of point-of-care immunodiagnostic test for Taenia solium cysticercosis in pigs","authors":"Haranahally Vasanthachar Manjunathachar ,&nbsp;Buddhi Chandrasekaran Saravanan ,&nbsp;Chitra Joshi ,&nbsp;Aquil Mohmad ,&nbsp;M. Arvind ,&nbsp;Siju Susan Jacob ,&nbsp;M. Sankar","doi":"10.1016/j.rvsc.2024.105466","DOIUrl":"10.1016/j.rvsc.2024.105466","url":null,"abstract":"<div><div>Cysticercosis, caused by the larval stage of <em>Taenia solium</em>, is a major zoonotic parasitic disease with a global impact, heightened by immigration and transboundary activities. Recognizing its importance, the World Health Organization has prioritized eliminating taeniasis/cysticercosis by 2030, designating it as a priority neglected tropical disease (NTD). Accurate diagnosis is essential for effective disease control, yet traditional methods often fall short due to low sensitivity of the test and the need for specialized laboratory setups. This study focuses on developing a recombinant Ag2 (rAg2)-based dot blot assay to detect <em>T. solium</em> cysticercosis in pigs. The rAg2 antigen was successfully expressed and purified, with immunoreactivity confirmed against sera from naturally infected pigs. The dot blot test evaluated against serological gold-standard enzyme-linked immunotransfer blot (EITB) assay, demonstrated preliminary laboratory sensitivity (89 %, 95 % CI: 68.6–97.1) and specificity (100 %, 95 % CI: 97.6 - 100), highlighting its potential as a reliable alternative diagnostic method. Cost-effectiveness and minimal laboratory requirements make it particularly suited for field use in resource-limited settings.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105466"},"PeriodicalIF":2.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bacillus coagulans on kidney injury caused by Klebsiella pneumoniae in rabbits","authors":"Wenjing Xu ,&nbsp;Qiongxia Lv ,&nbsp;Fan Yang,&nbsp;Wenjuan Wei,&nbsp;Jianing Wang,&nbsp;Xiaoguang Chen,&nbsp;Yumei Liu,&nbsp;Ziqiang Zhang","doi":"10.1016/j.rvsc.2024.105465","DOIUrl":"10.1016/j.rvsc.2024.105465","url":null,"abstract":"<div><div><em>Klebsiella pneumoniae</em> (KP) is a zoonotic conditionally pathogenic bacterium with a high prevalence of infection. It often induces purulent inflammation of the rabbit lungs, kidneys and other tissues, with high morbidity and mortality. <em>Bacillus coagulans</em> (BC) has the ability to regulate the balance of host intestinal flora and improve host immunity. However, the mechanism of the protective effect of BC on KP-induced kidney injury in rabbits is not clear. To explore this, we randomly divided fifty 35-day-old Eyplus rabbits into five groups: control, KP, low-dose BC (LBC), medium-dose BC (MBC) and high-dose BC (HBC). On the 1st day of the experiment, rabbits in LBC, MBC and HBC groups were fed diets containing 1 × 10⁶ CFU/g, 5 × 10⁶ CFU/g and 1 × 10⁷ CFU/g BC, respectively, and rabbits in CK and KP groups were fed basal diets. On the 8th day, each rabbit in the KP, LBC, MBC and HBC groups was infused with 4 mL of 1 × 10¹¹ CFU/mL KP bacterial solution, and the CK group was infused with the same amount of sterilised saline for a total of 7 days. Rabbit kidney tissues were collected on the 15th d. HE staining was used to observe the pathological changes of rabbit kidney tissues, oxidative stress-related indexes were detected by biochemical kits, and the content of inflammatory factors and apoptosis-related factors in kidney tissues were detected by ELISA. The results showed that KP disrupts the normal structure of the kidney, induces oxidative stress and inflammatory responses, and mediates apoptosis by regulating the levels of Bcl-2 family proteins. BC pretreatment significantly reduced kidney structural damage, oxidative stress, inflammatory response, and apoptosis in rabbits. To alleviate KP-induced kidney injury by increasing the activity of antioxidant enzymes and the content of anti-apoptotic proteins. Compared with the LBC group and the HBC group, the remission effect was more pronounced in the MBC group. Therefore, in this study, the effect of 5 × 10⁶ CFU/g BC was more significant.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"181 ","pages":"Article 105465"},"PeriodicalIF":2.2,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar dermatitis in a cynomolgus macaque (Macaca fascicularis)","authors":"Francesca Parisi ,&nbsp;Margherita Orlandi ,&nbsp;Alessandra Carnimeo ,&nbsp;Piero Laricchiuta ,&nbsp;Francesca Millanta ,&nbsp;Francesca Abramo","doi":"10.1016/j.rvsc.2024.105464","DOIUrl":"10.1016/j.rvsc.2024.105464","url":null,"abstract":"<div><div>Chronic exposure to ultraviolet (UV) light can cause cutaneous damage, resulting in specific pathological changes such as actinic keratosis and dermatitis. Despite actinic dermatosis being well documented in both humans and animals, it has rarely been reported in non-human primates (NHPs). Here, we describe a case of chronic UV light exposure in cynomolgus macaque (<em>Macaca fascicularis</em>). An adult female was presented with a seven-month history of multifocal irregular alopecic, erythematous and hyperkeratotic plaques on the dorsum with itching. Skin biopsies were sampled for histopathological analysis. A biopsy of normal skin from the neck region of an adult macaque was used as a control. Histopathological analysis revealed epidermal changes ranging from moderate to marked hyperplasia associated with hyperkeratosis and mild stratification disorders. Fibrosis was observed in the upper dermis, and multiple areas of elastotic material deposition were confirmed in the mid and deep dermis by Van Gieson special staining. The diagnosis was “solar dermatitis with elastosis”. Systemic treatment with nutritional supplements (retinol and omega-3) and firocoxib (5 mg/kg orally once a day for 3 months) did not show any improvement. Concurrently, a topical therapy with aloe gel and a sunscreen spray (SPF50) was added. The lesions did not show further clinical progression. During the period of the study, two other cynomolgus macaques from the same enclosure developed comparable clinical lesions on the dorsum. The authors describe UV-light induced skin damage in a cynomolgus macaque, which remained clinically stable.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"182 ","pages":"Article 105464"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of surfactant apoproteins and Brucella sp. antigens in the lungs of aborted bovine fetuses and neonatal calves delivered weak","authors":"Enver Beytut ,&nbsp;Mahmut Sözmen ,&nbsp;Emin Karakurt ,&nbsp;Hilmi Nuhoğlu","doi":"10.1016/j.rvsc.2024.105445","DOIUrl":"10.1016/j.rvsc.2024.105445","url":null,"abstract":"<div><div>The main objectives of this study were to investigate surfactant apoprotein expression (SP) and to detect <em>Brucella</em> sp. antigens in the lungs of aborted bovine fetuses and neonatal calves delivered weak. The Avidin-Biotin-Peroxidase Complex (ABC) and the indirect immunofluorescence (IF) techniques were applied, using antibodies to the lung surfactant apoproteins (SP-A, SP-B, SP-C) and <em>Brucella</em> sp. antigens. Hyperplasia of type II cells was also assessed by evaluating Thyroid Transcription Factor-1 (TTF-1), Proliferating Cell Nuclear Antigen (PCNA), and Cytokeratin Pan Type I/II (CK-P) markers. The study materials were the lungs of 46 aborted bovine fetuses and 20 neonatal calves delivered weak. <em>Brucella</em> sp.-positive fetal lungs displayed bronchopneumonia in 24 cases. The lungs of the weak-delivered neonates which were positive for <em>Brucella</em> sp. also showed pneumonia. Bacterial culture detected positivity in 11 of 46 fetuses and two neonates. IHC for <em>Brucella</em> sp. antigens found positivity in 22 of 46 fetuses and four neonates. Thus, our research revealed that the IHC technique using anti-<em>Brucella</em> sp. antibodies was useful for detecting <em>Brucella</em> sp. in autolytic and culture-negative fetuses. The study also found that surfactant synthesis begins close to the 7th month of gestation in bovine fetuses. Immunolabeling to SPs occurred in the cytoplasm of both type II and Clara cells, along with SP-C only in type II pneumocytes. The IF yielded dense labeling for <em>Brucella</em> sp. antigens, SP-B, and CK-P, respectively, in the phagocytic cells and epithelium of the airways. Also, pneumonia in newborn calves indicates an intrauterine infection by <em>Brucella</em> sp.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"181 ","pages":"Article 105445"},"PeriodicalIF":2.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment modalities for claw horn lesions and their effects on locomotion scores, gait properties, lesion progression, and nociceptive threshold in dairy cows: A systematic review","authors":"Mohammed Babatunde Sadiq ,&nbsp;Siti Zubaidah Ramanoon ,&nbsp;Sharifah Salmah Syed-Hussain ,&nbsp;Rozaihan Mansor ,&nbsp;Wan Mastura Shaik Mossadeq ,&nbsp;Nurhusien Yimer Degu","doi":"10.1016/j.rvsc.2024.105448","DOIUrl":"10.1016/j.rvsc.2024.105448","url":null,"abstract":"<div><div>This systematic review presents scientific evidence on treatment modalities for claw horn lesions (CHLs) in dairy cows, and their efficacy in restoring normal gait, resolution of claw lesions, and improving nociceptive threshold. A literature search was performed in four databases leading to the synthesis of 10 articles for the final analysis. The types of treatment administered include single (STM), bimodal (BTM) and multimodal treatment modalities (MTM). Locomotion scores (LS) were the most reported outcome measure, followed by the resolution of claw lesion, time to lameness cure, nociceptive threshold and gait properties. Most pairwise comparisons for LS and nociceptive threshold depicted no significant difference between the various treatment groups. Meanwhile, a few pairwise comparisons in terms of resolution of claw lesion and time to lameness cure revealed that cows receiving MTM (claw trimming + hoof block + NSAID) or BTM (claw trimming + hoof block) recorded complete resolution of CHL and significantly less time to recover compared to those treated with an STM (only claw trimming). Despite the various modalities used in CHL treatment, their effects on LS, nociceptive threshold, and gait properties are still unclear. While evidence suggests that MTM and BTM facilitate rapid resolution of CHL and duration of lameness cure, only limited data are available and the association with specific lesions is poorly understood. Several sources of heterogeneity were identified between the studies, particularly duration of follow-up after treatment, LS systems, severity and duration of lameness, and types of treatment administered.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"181 ","pages":"Article 105448"},"PeriodicalIF":2.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}