{"title":"Exploring the Two-Way Role: Biological and Anti-Epileptic Properties of Imidazole and 2-Mercaptobenzimidazole Derivatives.","authors":"Geetika Goel, Jannat Ul Firdous","doi":"10.2174/0118722083345879250403115017","DOIUrl":"https://doi.org/10.2174/0118722083345879250403115017","url":null,"abstract":"<p><p>Imidazole and 2-mercapto benzimidazole analogues are a group of molecules that have various biological activities and good therapeutic potential in the treatment of epilepsy. This review explores their dual role, focusing on their biological properties and anti-epileptic effects. A spectrum of biological activities is displayed by imidazole derivatives and 2- mercaptobenzimidazole, such as antifungal, antioxidant, anti-inflammatory, and antimicrobial actions, leading to their therapeutic flexibility apart from epilepsy treatment. Imidazole derivatives mechanistically modulate Gamma-Aminobutyric Acid (GABA) receptors, inhibit ion channels, and exert neuroprotective effects, enabling them to be used for seizure control. Their mechanisms of action involve modulation of oxidative stress pathways as well as providing neuroprotective effects against epilepsy. In terms of structure, both imidazole and 2-mercaptobenzimidazole derivatives have gone through extensive structure-activity relationship studies to enhance their biological and pharmacological aspects. However, numerous concerns, such as bioavailability, selectivity, and side effects, hinder their effective application in the treatment of various diseases. Looking forward, further research into novel derivatives and formulation strategies holds promise for enhancing efficacy and reducing adverse effects. This review consolidates current knowledge, emphasizing the multifaceted roles of imidazole and 2-mercapto benzimidazole derivatives in biological systems and their potential as anti-epileptic agents, thus providing insights for future research and clinical applications.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virendra S Gomase, Suchita P Dhamane, Swati C Jagdale
{"title":"Intellectual Property Rights Effects on India's Pharmaceutical Industry.","authors":"Virendra S Gomase, Suchita P Dhamane, Swati C Jagdale","doi":"10.2174/0118722083344893250411032817","DOIUrl":"https://doi.org/10.2174/0118722083344893250411032817","url":null,"abstract":"<p><p>The Indian pharmaceutical industry took full advantage of the \"process patent regime\". It aggressively pursued the expansion of its market share by offering the most reasonably priced generic versions of pharmaceuticals to emerging and developing nations. The Indian government remained neutral over the implementation of the TRIPS agreement until 2005. Indian pharmaceutical patent law is distinct from legislation in other nations in several ways, some of which are among the most critical intellectual property issues in the nation. Over the past thirty years, the lack of product patent protection has been a significant setback for the Indian pharmaceutical business. \"Molecules\" that were patented and protected internationally but which India failed to protect. The Act's ambiguity makes it common for opponents of pharmaceutical patents to file unreasonable serial pre-grant oppositions. In addition, the number of pre-grant opposition filings is surging exponentially. The potential for revocation, oppositions before and after the grant, and counterclaims in cases of infringement are just a few of the challenges that may arise during the process of a patent. The TRIPS Agreement compliance of the Indian patent system will be guaranteed by the Patents (Amendment) Rules, 2005, and the Patents (Amendment) Ordinance, 2004. Nonetheless, another notable accomplishment of the Ordinance and the Rules is the progressive change of the Indian patent prosecution system. In keeping with its international obligations, the Indian government is working to create a patent system that encourages technical development. Additionally, India is working to alleviate concerns about the inadequate enforcement of its current intellectual property rules.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review on Adaption of Microbiomes to Polynuclear Aromatic Hydrocarbons: An Alternate Approach to Environment Sustainability.","authors":"Ruchika Garg, Kiran Dobhal, Sayantan Mukhopadhyay","doi":"10.2174/0118722083343885250326070617","DOIUrl":"https://doi.org/10.2174/0118722083343885250326070617","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbons (PAHs) have been identified as catastrophic pollutants that can damage both the environment and human health. To restore a healthy surrounding, an environmental expert targeted the PAH contamination reduction strategy. Bioremediation techniques are overruling the conventional techniques due to their high disbursement and inefficient outcomes. Several PAHs, including Pyrene (PYR), Chrysene (CHY), Benz[a]anthracene (BaA), Benzo[a]pyrene (BaP), Fluoranthene (FLU) Indenol [1,2,3-cd] pyrene (INP), Benzo[ghi]perylene (BghiP), and, Dibenz [a, h] anthracene (DBA) have been identified by the International Agency for Research on Cancer (IARC) as carcinogenic, mutagenic, and teratogenic. Since PAHs are less hydrophilic and have more lipophilic properties, they are readily absorbed from the GIT of mammals. Grilled beef and chicken meat that had been charcoal-grilled contained Anthracene (ANT), BaP, Benzo[k]fluoranthene (BkF), Phenanthrene (PHE), and PYR. The highest dietary daily intake of BkF was reported to be 1.09 μg/ day in the intestine of grilled beef and 23.22μg/day in the stomach of grilled chicken. A number of bacterial species have been identified in the biodegradation of PAHs, including Mycobacterium gilvum (M. gilvum), Sphingobium chlorophenolicum (S. chlorophenolicum), Bacillus halotolerant, Mycobacterium flavescens (M. flavescens), Micrococcus luteus, Crassostrea gigas, Crassostrea gasar, and Crassostrea rhizosphere, Pseudomonas Putida, Rhodococcus wratislaviensis, and Kocuria rosea. Numerous fungi, including Arbuscular mycorrhiza, Aspergillus ficuum, Aspergillus flavus, and Aspergillus fumigatus, use PAHs as the source of carbon and energy for survival. To a certain extent, algae such as Selenastrum capricornutum and Chlamydomonas reinhardtii (C. Reinhardtian) also depend on PAHs to survive. This review aims to highlight the calamitous effect of high molecular weight PAHs on the surrounding, and humankind, as well as the advancement in bioremediation approaches in recent years. The authors also addressed the newly isolated microbiomes, including bacteria, fungi, algae, and others, as promising candidates for using PAHs as a source of carbon and energy.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extraction and Characterization of Iturin A as a Key Factor in the Antagonism of Bacillus amyloliquefaciens M13RW01 toward Pathogenic Fungi.","authors":"Mahsa Aghaali Marnani, Mahboobeh Madani, Pegah Shakib","doi":"10.2174/0118722083352297250326041149","DOIUrl":"https://doi.org/10.2174/0118722083352297250326041149","url":null,"abstract":"<p><strong>Background: </strong>Bacillus amyloliquefaciens contains several fungal inhibitory compounds, such as peptides and lipopeptides, representing the remarkable potential for biotechnological, agricultural, and biopharmaceutical applications.</p><p><strong>Objectives: </strong>This research aimed to extract and characterize iturin A as the key antagonism factor of Bacillus amyloliquefaciens M13RW01 toward pathogenic fungi, using HPLC and mass spectrometry [MS] analysis.</p><p><strong>Methods: </strong>For this study, Bacillus amyloliquefaciens strain M13-RW01 isolated from Isfahan soil was used. The lipopeptide compounds of B.amyloliquefaciens were examined for antagonistic performance against Aspergillus niger PTCC 5010, Mucor hiemalis PTCC 5292, Fusarium oxysporum CBS 62087, and Penicillium chrysogenum PTCC 5037 by well diffusion and percentage of growth inhibition. The crude extract was run on Waters μBondpak C18 column in the HPLC system to separate the antibiotics. Major antibiotics were analyzed based on MS.</p><p><strong>Results: </strong>HPLC analysis demonstrated that the lipopeptide compound is similar to iturin A. Moreover, MS analysis of these compounds and purified iturin A revealed a high similarity between them, with the same molecular ion peaks identified. Results showed that the produced lipopeptides by Bacillus amyloliquefaciens were of iturin A genum. The molecular ion peaks of the B.amyloliquefaciens M13RW01 methanolic fraction were at 1027.10, 1043.05, 1058, 1066, 1072, 1088.95. These compounds restrained fungal germination and growth. Inhibition growth percentages were 79.28, 76.13, 84.47and 59.15% for Aspergillus niger, Mucor hiemalis, Fusarium oxysporum, and Penicillium chrysogenum, respectively.</p><p><strong>Conclusion: </strong>According to the present study, B.amyloliquefaciens M13RW01 lipopeptides are able to inhibit the growth of some fungi. B.amyloliquefaciens M13-RW01 isolated from Isfahan soil plays an essential part in antagonizing pathogenic fungi. Thus, this antifungal lipopeptide is supposed to be a biological protection agent for farm crops.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Willams Alves da Silva, Igor Lima Soares, Kristiana Cerqueira Mousinho, Afonso Leoncio Saraiva Junior, Isabelle Bruna Menezes Ferreira Alencar, Laisa Graziely Araújo Magalhães, Gabriel da Silva Procopio, Gabriel Maia Menezes, Kellen Miranda Sá, Rafaela Gomes Bezerra, Mary Anne Medeiros Bandeira
{"title":"Pharmacological Applications of Fava d'anta: A Patent Review.","authors":"Willams Alves da Silva, Igor Lima Soares, Kristiana Cerqueira Mousinho, Afonso Leoncio Saraiva Junior, Isabelle Bruna Menezes Ferreira Alencar, Laisa Graziely Araújo Magalhães, Gabriel da Silva Procopio, Gabriel Maia Menezes, Kellen Miranda Sá, Rafaela Gomes Bezerra, Mary Anne Medeiros Bandeira","doi":"10.2174/0118722083349741250325035323","DOIUrl":"https://doi.org/10.2174/0118722083349741250325035323","url":null,"abstract":"<p><p>A significant portion of the population in low-income countries relies on medicinal plants for healthcare. Fava d'anta is an important species in Brazil due to its bioactive compounds like quercetin and rutin. These compounds have various pharmaceutical applications, but the sustainability of their exploitation is challenged by overharvesting, necessitating sustainable management practices and further biotechnological advancements. The study conducted a comprehensive review of Fava d'Anta patents and their applications in various pharmacological activities, which are crucial for the development of new medicines and formulations. Patents were searched in four specialized patent databases: The United States Patent and Trademark Office, the World Intellectual Property Organization (WIPO), Espacenet and the National Institute of Industrial Property (INPI). A total of 109 patents were identified through document collection, with 26 patents meeting the inclusion criteria. The analysis revealed a global concentration of innovation in regions like Europe and the United States. Fava d'anta has demonstrated a wide range of therapeutic properties, including antioxidant and anti-inflammatory effects, largely attributed to polyphenols. These bioactive components have shown potential in diverse applications, from nutraceuticals to cosmetics. Patent registrations highlight the significant potential of Dimorphandra species for phytoproducts, particularly due to compounds like quercetin and rutin, but further studies are needed to explore their mechanisms of action and enhance technological applications, especially in cosmetics.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Aparecida Alexandre, Paulo Afonso Granjeiro, José Antônio da Silva, Daniel Bonoto Gonçalves
{"title":"Renewable and Sustainable Biorefinery: A Patent Review.","authors":"Sara Aparecida Alexandre, Paulo Afonso Granjeiro, José Antônio da Silva, Daniel Bonoto Gonçalves","doi":"10.2174/0118722083343982250312192000","DOIUrl":"https://doi.org/10.2174/0118722083343982250312192000","url":null,"abstract":"<p><strong>Background: </strong>Biorefineries can refer to forms of fuel production through renewable biomass derivatives, using different structures of lignocellulosic material, such as lignin, hemicellulose, and cellulose. From lignin, we can produce natural binders and adhesives, among other products. With hemicellulose, we can produce emulsifiers, resins, or lubricants, for example. Using cellulose, we can produce fuels, such as ethanol and biodiesel, or even solvents. Fuels from biorefineries can replace, totally or partially, non-renewable fuels that pollute the environment, such as oil. Considering the climate emergency, we are experiencing, the tendency to reduce the availability of oil, and the negative environmental impacts caused by it, fuels obtained through the processing of renewable plant materials present themselves as a good alternative to replacing fossil fuels. Firstgeneration ethanol (1G) can be obtained by fermenting, for example, sugar cane juice. Secondgeneration (2G) ethanol can be obtained by processing lignocellulosic waste. In this process, there must be pre-treatment and hydrolysis of the biomass before the fermentation and distillation processes. Third-generation ethanol (3G) can be obtained through the fermentation of substrate present in microalgae. Fourth-generation ethanol (4G), in turn, involves the integration of production processes from other generations, increasing the efficiency of 2G and 3G processes for ethanol production.</p><p><strong>Objective: </strong>The objective of this study was to investigate the scenario of patent registrations filed both on the Google Patents platform and Espacenet, which proposes the production of fuels from biorefineries, that are renewable and sustainable.</p><p><strong>Methods: </strong>Although there are other lignocellulosic products originating from biorefineries, we will limit ourselves to patents aimed at the production of cellulosic ethanol. The search covered patents filed in the last 5 years (2019-2023). The 10 patents from each of the 3 biotechnological areas were selected, classified as agriculture, environment, and bioprocesses/bioengineering, totaling 30 patents to be analyzed. After selecting patents through the insertion of keywords and Boolean operators, the patents were selected by reading the title, its summary, and, finally, the full document to verify which were aligned with the study.</p><p><strong>Results: </strong>Analysis of the documents revealed that, in most cases, China leads the way in patent applications involving the use of fuels, such as cellulosic ethanol, which are environmentally renewable and sustainable. The main strategies for the production of renewable and sustainable fuels in the context of biorefineries explore mechanisms for reusing agricultural waste, pre-treatment of residual biomass, and reuse of biorefinery waste, among other technologies.</p><p><strong>Conclusion: </strong>The future perspective is that the production of renewa","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological Approaches and Innovative Strategies for Individualized Patient Care.","authors":"Amnesh Kumar Verma, Kuldeep Singh, Jeetendra Kumar Gupta, Shivendra Kumar, Divya Jain","doi":"10.2174/0118722083359334250116063638","DOIUrl":"https://doi.org/10.2174/0118722083359334250116063638","url":null,"abstract":"<p><p>Personalized medicine is an evolving paradigm that aims to tailor therapeutic interventions to individual patient characteristics. With a growing understanding of the genetic, epigenetic, and molecular mechanisms underlying diseases, tailored therapies are becoming more feasible and effective. This review highlights the significant advancements in personalized medicine, focusing specifically on pharmacological strategies. The article explores the integration of genomics, transcriptomics, proteomics, and metabolomics in drug development and therapy optimization. Pharmacogenomics, the customization of drug therapy based on an individual's genetic makeup, receives particular emphasis. This leads to the identification of specific biomarkers that can predict therapeutic response, drug toxicity, and susceptibility to various diseases. Together with computational tools and artificial intelligence, these advancements contribute to tailored treatment plans for patients with conditions such as cancer, cardiovascular diseases, and neurological disorders. We also highlight the challenges and ethical considerations in implementing personalized medicine, such as data privacy, cost-effectiveness, and accessibility. We outline future prospects and ongoing research in this field, highlighting the importance of collaborative efforts between researchers, clinicians, pharmacists, and regulatory authorities.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma Yakoub, Hanem Hassan, Samah Mamdouh, Tarek Aboushousha, Fatma B Rashidi, Mohamed A El-Desouky
{"title":"Exploring the Therapeutic Potential of TROP2 Gene Silencing in Hepatocellular Carcinoma.","authors":"Fatma Yakoub, Hanem Hassan, Samah Mamdouh, Tarek Aboushousha, Fatma B Rashidi, Mohamed A El-Desouky","doi":"10.2174/0118722083352578241225130252","DOIUrl":"https://doi.org/10.2174/0118722083352578241225130252","url":null,"abstract":"<p><strong>Background: </strong>Trophoblast Cell Surface Antigen 2 (Trop2) is a transmembrane glycoprotein that has been implicated in the progression and metastasis of various cancers, including hepatocellular carcinoma (HCC). Targeting Trop2 expression may represent a promising approach for the development of novel therapeutic strategies.</p><p><strong>Objectives: </strong>This study aimed to investigate the effects of Trop2 knockdown using small interfering RNA (siRNA) on the phenotypic and molecular characteristics of the HepG2 liver cancer cell line.</p><p><strong>Methods: </strong>HepG2 cells were transfected with different concentrations of Trop2-targeting siRNA (3 nM, 5 nM, and 7 nM) at various time intervals (6, 24, and 48 hrs). The expression of Trop2 was assessed by real-time PCR before and after transfection. The impact of Trop2 knockdown on cell apoptosis, migration, morphology, histopathological features, wound-healing assays, and microscopic analysis was examined. Additionally, the expression of the TPM1 gene was evaluated using immunohistochemical analysis.</p><p><strong>Results: </strong>Trop2 mRNA level was significantly decreased in HepG2 cells in a time- and concentration-dependent manner following siRNA transfection. The downregulation of Trop2 resulted in a marked increase in apoptosis, a reduction in cell migration, and alterations in cell morphology and histopathological characteristics. Furthermore, the expression of the TPM1 gene was found to be upregulated in Trop2-knockdown HepG2 cells.</p><p><strong>Conclusion: </strong>These results highlight the potential of Trop2 as a therapeutic target for the management of hepatocellular carcinoma.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gyanendra Tripathi, Akhtar Hussain, Irum, Saba Firdaus, Priyanka Dubey, Suhail Ahmad, Mohammad Ashfaque, Vishal Mishra, Alvina Farooqui
{"title":"Current Scenario and Global Perspective of Sustainable Algal Biofuel Production.","authors":"Gyanendra Tripathi, Akhtar Hussain, Irum, Saba Firdaus, Priyanka Dubey, Suhail Ahmad, Mohammad Ashfaque, Vishal Mishra, Alvina Farooqui","doi":"10.2174/0118722083322399240927051315","DOIUrl":"10.2174/0118722083322399240927051315","url":null,"abstract":"<p><p>Industrialization and globalization have increased the demand for petroleum products that has increased a load on natural energy resources. The escalating fossil fuel utilization has resulted in surpassing the Earth's capacity to absorb greenhouse gases, necessitating the exploration of sustainable bioenergy alternatives to mitigate emissions. Biofuels, derived from algae, offer promising solutions to alleviate fossil fuel dependency. Algae, often regarded as third-generation biofuels, present numerous advantages owing to their high biomass production rates. While algae have been utilized for their bioactive compounds, their capability as biomass for the production of biofuel has gained traction among researchers. Various biofuels such as bio-hydrogen, bio-methane, bio-ethanol, bio-oil, and bio-butanol can be derived from algae through diverse processes like fermentation, photolysis, pyrolysis, and transesterification. Despite the enormous commercial potential of algae-derived biofuels, challenges such as high cultivation costs persist. However, leveraging the utilization of algae byproducts could improve economic viability of biofuel production. Moreover, algae derived biofuels offer environmental sustainability, cost-effectiveness, and waste reduction benefits, promising novel opportunities for a more sustainable energy future. Moreover, advancements in the field could lead to patents that drive innovation and commercialization in algae-based biofuel technologies.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"276-300"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical Analysis and Antimicrobial Potential of <i>Parthenium hysterophorous</i> and <i>Lantana camara</i>.","authors":"Aliya Firdaus, Syed Khalida Izhar, Shazia Qamar, Arshi Siddiqui, Uzma Afaq","doi":"10.2174/0118722083316748240821151703","DOIUrl":"10.2174/0118722083316748240821151703","url":null,"abstract":"<p><strong>Background: </strong><i>Parthenium hysterophorous</i> and <i>Lantana camara</i> are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from <i>P. hysterophorus</i> and <i>L. camara</i>. For instance, patent extracts from these plants have been utilized in the formulation of pharmaceutical drugs, herbal supplements, cosmeceuticals, and agricultural products. <i>P. hysterophorous</i>, commonly known as Santa Maria feverfew or Congress grass, contains various bioactive compounds like terpenoids, flavonoids, phenolics, and alkaloids.These compounds are the key to its medicinal properties, particularly its antimicrobial activity. On the other hand, <i>L. camara</i>, often referred to as wild sage, is rich in phytochemicals such as terpenoids, flavonoids, and alkaloid glycosides.</p><p><strong>Methods: </strong><i>P. hysterophorous</i> and <i>L. camara</i> plants selected and checking their antimicrobial activity by agar well diffusion method.</p><p><strong>Results: </strong>In our study, we found that the leaf extract of <i>P. hysterophorous</i> exhibited the most potent antibacterial activity against <i>E. coli. P. hysterophorous</i> exhibited the most potent antifungal activity against <i>A. niger</i> and <i>T. viride</i>, with a diameter of inhibition zone measuring 12 mm, followed by <i>A. flavus</i> and <i>A. parasiticus</i>. In case of L. camara, the inhibitory zone ranging from 14 to 18 mm was detected against <i>S. abony, P. aeruginosa, E. coli</i>, and <i>K. pneumonia</i>. The leaf extract of the maximum zone of inhibition in case of <i>L. camara</i> was shown by <i>A. flavus</i> (12 mm).</p><p><strong>Conclusion: </strong>The present study suggests that these two weeds could be useful in the development of bactericides and fungicides.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"251-259"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}